Sign in

chromozz.bsky.social

@chromozz.bsky.social
29 followers 37 following 7 posts
PostsRepliesMedia
Reposted by @chromozz.bsky.social
Science & recherche au Muséum @recherche.mnhn.fr · 17/02/2026
Nouvelle publication sur l'AlphaGenome, une nouvelle avancée en intelligence artificielle pour comprendre les effets des mutations génétiques par Julien Mozziconacci de StrInG & al. parue dans @france.theconversation.com @mnhn.fr
theconversation.com
AlphaGenome, une nouvelle avancée en intelligence artificielle pour comprendre les effets des mutations génétiques
Google vient de sortir un nouveau logiciel d’IA pour explorer les effets des intelligences artificielles. Décryptage de deux spécialistes qui ne font pas partie de l’équipe.
021
chromozz.bsky.social @chromozz.bsky.social · 06/11/2025
Spread the word ! LLMs "mistakes" are features, NOT bugs.
000
Reposted by @chromozz.bsky.social
Arnau Sebé-Pedrós @arnausebe.bsky.social · 08/10/2025
A thoughtful and beautifully written @quantamagazine.bsky.social article about genome regulatory innovation at the origin of animals. Featuring some of our work and highlighting key open questions. Thanks to @philipcball.bsky.social for this fantastic piece.
03511
chromozz.bsky.social @chromozz.bsky.social · 07/10/2025
Agreed! But that's when it would be nice to see actual distributions instead of box plots.
120
chromozz.bsky.social @chromozz.bsky.social · 07/10/2025
the surprise in this plot is that the NRL is not quantized. Would be interesting to see a distribution of NRL for each point.
100
Reposted by @chromozz.bsky.social
Romain Koszul @rkoszul.bsky.social · 19/09/2025
New paper! We generated and/or (re)analyzed ~100 #metagenomics Hi-C datasets to provide a comprehensive analysis of bacterial and viral metagenomes across VERY different environments. Congratulations to all authors especially Amaury Bignaud and @mmarbout.bsky.social for the huge work! #metaHiC
096
Reposted by @chromozz.bsky.social
Harmit Singh Malik @harmitmalik.bsky.social · 17/09/2025
www.cell.com/cell/abstrac... A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
cell.com
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.
411351
Reposted by @chromozz.bsky.social
Nicolas Robine 🇪🇺🇫🇷🇺🇸 @nicorobine.bsky.social · 18/09/2025
"Transposable elements are vectors of recurrent transgenerational epigenetic inheritance" Congrats Vincent Colot and team! www.science.org/doi/10.1126/...
science.org
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
1177
Reposted by @chromozz.bsky.social
Philip Ball @philipcball.bsky.social · 18/09/2025
In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com www.chemistryworld.com/opinion/the-...
chemistryworld.com
The simple machine that visualised atomic orbitals
In 1931, Harvey Elliott White developed a device that traced out the shapes of electron clouds by approximating solutions to the Schrödinger equation
614457
Reposted by @chromozz.bsky.social
siddhartha jena @epijenatics.bsky.social · 11/09/2025
Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9
18832
Reposted by @chromozz.bsky.social
Axel Delamarre @axeldelamarre.bsky.social · 17/07/2025
Our paper is now out in Molecular Cell! Check the thread in this former post: www.cell.com/molecular-ce...
cell.com
Chromatin architecture mapping by multiplex proximity tagging
Delamarre et al. develop a technology named PCP that can simultaneously map complex spatial relationships between millions of molecules. Using PCP, they investigate chromatin structure and describe si...
55628
chromozz.bsky.social @chromozz.bsky.social · 09/09/2025
In @elife.bsky.social: Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes doi.org/10.7554/eLif...
doi.org
Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes
020
Reposted by @chromozz.bsky.social
Axel Visel @axelvisel.bsky.social · 16/07/2025
No new genes needed to fly - just rewire what you have! 🦇🧬 Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social doi.org/10.1038/s415... #EvoDevo #SingleCell #BatWings
doi.org
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
311743
chromozz.bsky.social @chromozz.bsky.social · 16/07/2025
Highly needed !
010
Reposted by @chromozz.bsky.social
Jacob Schreiber @jmschreiber91.bsky.social · 30/06/2025
Today marks the end of en-JUNE-eering, the month where I focused mostly on the nitty gritty of improving genomics ML infrastructure. Here are some of the highlights:
1205
Reposted by @chromozz.bsky.social
Gilles FISCHER @gillesfischer.bsky.social · 09/06/2025
📢 New paper out in Mol Syst Biol! During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬 🔗 www.embopress.org/doi/full/10....
13414
Reposted by @chromozz.bsky.social
mara lawniczak @marakat.bsky.social · 04/06/2025
tree of life core lab has put together such a manuscript, detailing a lot of information on the lab work needed for reference genomes for biodiversity which you can find here: www.biorxiv.org/content/10.1...
biorxiv.org
On the path to reference genomes for all biodiversity: lessons learned and laboratory protocols created in the Sanger Tree of Life core laboratory over the first 2000 species
Since its inception in 2019, the Tree of Life programme at the Wellcome Sanger Institute has released high-quality, chromosomally-resolved reference genome assemblies for over 2000 species. Tree of Li...
183
Reposted by @chromozz.bsky.social
Daniel Ibrahim @danielibrahim.bsky.social · 27/05/2025
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...
rdcu.be
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
7247111
Reposted by @chromozz.bsky.social
Axel Delamarre @axeldelamarre.bsky.social · 30/05/2025
Hi everyone! The latest method from the Whitehouse lab: PCP 
PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level: Out soon, check the updated BioRxiv – little thread: 1/11 www.biorxiv.org/content/10.1...
14320
chromozz.bsky.social @chromozz.bsky.social · 03/06/2025
We wrote a piece a few years back discussing the existence of a gene regulatory "code". The take home message is that if you define properly what are: the "encoded objects", the "codewords" and the "adaptor" it can make sense to use this word. www.sciencedirect.com/science/arti...
sciencedirect.com
The 3D Genome Shapes the Regulatory Code of Developmental Genes
We revisit the notion of gene regulatory code in embryonic development in the light of recent findings about genome spatial organization. By analogy w…
100
Reposted by @chromozz.bsky.social
Gilles FISCHER @gillesfischer.bsky.social · 19/05/2025
🚨 We're hiring! 🚨 A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential. 🔗 More info here: docs.google.com/document/d/1... Please repost! #Postdoc #Genomics #Yeast #Polyploidy #Evolution
docs.google.com
Postdoc_Evol_Genomics_Sorbonne.docx
Postdoctoral position in Yeast Evolutionary Genomics Hosting unit Laboratory of Computational, Quantitative, and Synthetic Biology (CQSB). The CQSB is an interdisciplinary research unit within the ...
065
Reposted by @chromozz.bsky.social
Axel Delamarre @axeldelamarre.bsky.social · 13/11/2024
Interested in chromatin architecture?
 Checkout our new method - PCP - that can map genome organization as multi-way interactions as well as nucleosome footprint and nucleosome spacing at very high resolution. www.biorxiv.org/content/10.1...
biorxiv.org
Chromatin architecture mapping by multiplex proximity tagging
Chromatin plays a pivotal role in genome expression, maintenance, and replication. To better understand chromatin organization, we developed a novel proximity-tagging method which assigns unique DNA b...
34518
chromozz.bsky.social @chromozz.bsky.social · 02/05/2025
Great opportunity to work at the frontier between genomics and deep learning. research.pasteur.fr/en/job/perma...
research.pasteur.fr
Group Head in AI and Mathematical Modeling Applied to Genomics - Research
The Bioinformatics and Biostatistics Hub at Institut Pasteur provides computational biology support to research units and platforms at the Institut Pasteur. Our mission is to: As the head of the Algor...
000
Reposted by @chromozz.bsky.social
Denis Duboule @denisduboule.bsky.social · 10/04/2025
Last call: Tomorrow friday April 11th 🤘
163
Reposted by @chromozz.bsky.social
Science & recherche au Muséum @recherche.mnhn.fr · 10/04/2025
@sorbonne-universite.fr et @mnhn.fr organise cet échange entres spécialistes sur les applications actuelles, les perspectives d’avenir et les verrous méthodologiques liés à l’adoption de l’IA dans l’étude et la conservation de la biodiversité. Gratuit, sur inscription
sorbonne-universite.fr
L'IA pour comprendre et préserver la biodiversité
Dans le cadre du Sommet pour l'action sur l’IA 2025, du lancement de PostGenAI@Paris, et de l’initiative « IA responsable », SCAI propose un cycle de conférences sur les enjeux et les risques liés à l...
062
Reposted by @chromozz.bsky.social
Arnaud Krebs @arnaudkr.bsky.social · 02/04/2025
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
211637
Reposted by @chromozz.bsky.social
Simon Gaudin @simongaudin.bsky.social · 03/04/2025
The latest live-cell imaging work from the Boettiger lab measures chromosomal kinetics across genomic scales — it’s moving faster than you think! —, and puts a number on the ‘in vivo’ speed of cohesin loop extrusion itself. www.biorxiv.org/content/10.1...
biorxiv.org
074
Reposted by @chromozz.bsky.social
Teif lab @teiflab.bsky.social · 01/04/2025
Miloshev et al., 2025, Linker Histones Maintain Genome Stability and Drive the Process of Cellular Ageing [review] www.imrpress.com/journal/FBL/... Interesting figure: we did observe NRL increase with ageing (onlinelibrary.wiley.com/doi/10.1111/...). Not sure about about loop sizes, to be checked
084
Reposted by @chromozz.bsky.social
Manuel Mendoza @longchrom.bsky.social · 22/03/2025
Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...
nature.com
Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602
The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.
13429
Reposted by @chromozz.bsky.social
Mark Peifer (He, him) @peiferlabunc.bsky.social · 28/03/2025
The DNA in our cells is not naked but instead is compacted by being wrapped around nucleosomes assembled from histone proteins. In our current view, this produces the chromatin architecture that leaves some regions open for transcription while others are more compacted & transcriptionally silent 1/n
Diagram of chromatin and nucleosomes
from  https://www.genome.gov/genetics-glossary/Nucleosome
39131
Reposted by @chromozz.bsky.social
Teif lab @teiflab.bsky.social · 08/02/2025
We an open postdoc position (UK) generegulation.org/job-opening/
generegulation.org
Postdoc opportunity: nucleosome repositioning in cancer (bioinformatics, genomics) – Gene Regulation – Teif Lab
056
Reposted by @chromozz.bsky.social
Di Jiang @dijiang319.bsky.social · 08/02/2025
🧬🧪🦠🧫 @science.org www.science.org/doi/10.1126/... @rkoszul.bsky.social @leameneu.bsky.social @christophechapard.bsky.social @chromozz.bsky.social @pasteur.fr @sorbonne-universite.fr @institutcurie.bsky.social + PS www.science.org/doi/epdf/10.... @gfudenberg.bsky.social @vram142.bsky.social
0175
Reposted by @chromozz.bsky.social
Denis Duboule @denisduboule.bsky.social · 04/02/2025
Cette année, mon cours @collegedefrance.bsky.social traitera de la régulation des gènes par les séquences enhancers. Une des clés de notre développement. Premier cours le vendredi 21 février à 10h. Entrée libre, salle chauffée. Amis et Collègues parisiens, merci de diffuser!
02728
Reposted by @chromozz.bsky.social
Romain Koszul @rkoszul.bsky.social · 07/02/2025
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇
science.org
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
318275
Reposted by @chromozz.bsky.social
Romain Koszul @rkoszul.bsky.social · 07/02/2025
Deep learning models (@chromozz.bsky.social) trained only on yeast chromosomes predict nucleosome positioning, RNA Poll II and cohesin tracks along foreign DNA, based on the sequence alone. This implies that the behavior of any DNA in a host cell follows deterministic sequence-based rules.
CNN predict nucleosome positions, and RNA Pol II and cohesin deposition
195
Reposted by @chromozz.bsky.social
Tom Ellis @proftomellis.bsky.social · 06/02/2025
What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work. www.science.org/doi/10.1126/...
science.org
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
03614
Reposted by @chromozz.bsky.social
CNRS Biologie @cnrsbiologie.bsky.social · 07/02/2025
#RésultatScientifique🔎 Quand un ADN étranger s'intègre dans une cellule hôte, comment s’adapte-t-il aux règles métaboliques de son nouvel occupant ? @rkoszul.bsky.social et ses collaborateurs ont enquêté ! 🕵️ 🤝 @cnrs.bsky.social @pasteur.fr @mnhn.fr buff.ly/40GvJL2
insb.cnrs.fr
Prédire l’organisation et l’activité d’un ADN étranger dans une cellule hôte
Les transferts d’ADN d’une espèce à une autre sont des événements fréquents et naturels.
12111