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Christian Endisch, MD

@christianendisch.bsky.social
34 followers 54 following 4 posts

Neurologist interested in neuroprognostication and disorders of consciousness scholar.google.de/citations?user=AG…

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Reposted by Christian Endisch, MD
NEJM.org @nejm.org · 28/01/2026
Editorial: Seeing It Through — Lessons from a Retinal Stroke Trial nej.md/3M8qKiT
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Reposted by Christian Endisch, MD
NEJM.org @nejm.org · 16/01/2026
CREST-2 trials: For patients with asymptomatic, high-grade carotid-artery stenosis, improvements in carotid endarterectomy, stenting, and medical therapy have challenged our understanding of appropriate treatments. Research findings are summarized in a new Quick Take video. nej.md/4py7Wap
A visual representation of the CREST-2 trials, which evaluated whether adding revascularization to intensive medical management would benefit patients with high-grade, asymptomatic carotid stenosis.
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Reposted by Christian Endisch, MD
Neurocritical Care @neurocritcarej.bsky.social · 12/01/2026
Togni et al: Association of Serial Ventricular Routine Cerebrospinal Fluid Findings with Complications and Outcome in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Observational Study Link: link.springer.com/ar... @neurocritical #neurocritcare
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Reposted by Christian Endisch, MD
Nature Reviews Neurology @natrevneurol.nature.com · 30/10/2025
Distinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypes academic.oup.com/brain/advanc...
academic.oup.com
Distinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypes
Liu et al. show that cutaneous α-synuclein signatures differ between brain-first and body-first subtypes of Parkinson’s disease, providing direct pathologi
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Reposted by Christian Endisch, MD
JAMA @jama.com · 28/10/2025
Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients. 📝 This Review discusses PFO-associated stroke management. ja.ma/430lxyZ
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Reposted by Christian Endisch, MD
SfN Journals @sfnjournals.bsky.social · 29/09/2025
#eNeuro | SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice doi.org/10.1523/ENEURO.0276-25.2025
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Reposted by Christian Endisch, MD
European Journal of Neurology @europeanjournalofneurology.ean.org · 23/09/2025
Chen et al. report in “Efficacy and Safety of Twelve Anti-Dyskinetic Drugs in Parkinson's Disease” that amantadine ER is more effective than IR for dyskinesia, and both reduce OFF time better than other drugs. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... #Neurology @ean.org #WileyNeuro
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Reposted by Christian Endisch, MD
JAMA Network Open @jamanetworkopen.com · 19/09/2025
RCT: For patients with spinal cord injury, augmenting mean arterial pressure >85 vs 65 mmHg did not improve 6‐month neurological outcomes, and the MAP >85 group had more respiratory complications, longer mechanical ventilation, and worse organ dysfunction. #NCS2025 ja.ma/4naOW1t
Stacked bar graph showing the percentage of patients with different AIS grades in ABP and CBP groups at baseline and 6 months. The AIS grades are 'Died', 'A', 'B', 'C', and 'D'. Transitions between states are visually represented.
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Reposted by Christian Endisch, MD
Michael Okun @michaelokun.bsky.social · 16/09/2025
To shunt or not to shunt, that is the (NPH) question? The first large randomized trial of shunting for normal pressure hydrocephalus (NPH) just dropped in NEJM, and there was clear benefit for walking, and it favored the group receiving shunts. @parkinsondotorg.bsky.social
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Reposted by Christian Endisch, MD
Michael Okun @michaelokun.bsky.social · 01/09/2025
What is the 2025 update on antibody therapies for Alzheimer’s? Spoiler alert: think EAC or effectiveness, access and cost. A critically important topic in a recent piece in JAMA. Early adopters enthusiastic, safety signals remain consistent w/ trials, questions remain. @alzassociation.bsky.social
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Reposted by Christian Endisch, MD
Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 17/08/2025
A new study by Puja Agarwal, Sonal Agrawal, Julie Schneider, et al. @rushalzheimers.bsky.social provides more evidence that #MIND & other diets like it can protect against #Dementia – as well as giving us some clues as to why. Learn More @jamanetworkopen.com 👉 jamanetwork.com/journals/jam...
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Reposted by Christian Endisch, MD
JAMA @jama.com · 28/07/2025
Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients. This review discusses PFO-associated stroke management. ja.ma/4orDOyr
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Reposted by Christian Endisch, MD
Maëlan Menétrey @maelanmenetrey.bsky.social · 14/07/2025
🚨 New 2-in-1 paper: a review on #EEG brain oscillations (www.sciencedirect.com/science/arti...) and a website with recorded talks from a symposium that featured 8 speakers discussing the present and future of the field (brain-waves-workshop.github.io/2024/). 🧠 #neuroimaging #neuroskyence
sciencedirect.com
EEG brain waves and alpha rhythms: Past, current and future direction
Nearly a century after the first EEG recordings, we assess the progress made in EEG research, focusing on the challenges, novel theories and methods, …
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Reposted by Christian Endisch, MD
Resuscitation @resuscitation.bsky.social · 25/07/2025
Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients www.resuscitationjournal.com/article/S03... #Resuscitation
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Reposted by Christian Endisch, MD
NEJM AI @ai.nejm.org · 21/07/2025
SpikeNet2, a deep-learning model shown to achieve expert-level performance in detecting epileptiform discharges from EEG recordings while significantly reducing false positives, demonstrates strong generalizability across diverse datasets. Learn more: nejm.ai/4lq1Qr4 #AI #MedSky #NeuroSky
Figure 2. The Pipeline of Hard-Negative Mining.
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Reposted by Christian Endisch, MD
Stephane Legriel @stlegriel.bsky.social · 20/07/2025
#Cardiacarrest from neurological causes: for whom the brain tolls - Resuscitation www.resuscitationjournal.com/article/S030... @resuscitation.bsky.social @stlegriel.bsky.social #marinepaul
resuscitationjournal.com
Cardiac arrest from neurological causes: for whom the brain tolls
Cardiac arrest of neurological cause (CA-NC) is an entity whose incidence is unknown. The main reason for this is that the medical literature is mainly concerned with cardiac arrest due to cardiac cau...
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Reposted by Christian Endisch, MD
Resuscitation @resuscitation.bsky.social · 19/07/2025
Serum neurofilament light chain and multimodal neuroprognostication after cardiac arrest – a retrospective cohort study www.resuscitationjournal.com/article/S03... #Resuscitation
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Reposted by Christian Endisch, MD
Resuscitation @resuscitation.bsky.social · 20/07/2025
Neurologic etiologies of cardiac arrest are associated with early withdrawal of life-sustaining therapy www.resuscitationjournal.com/article/S03... #Resuscitation
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Reposted by Christian Endisch, MD
The Lancet Neurology @thelancetneuro.bsky.social · 07/07/2025
A pooled analysis of of the four INTERACT trials suggests intensive blood pressure-lowering initiated within several hours of intracerebral haemorrhage onset was safe and improved functional recovery, without a clear effect on haematoma growth. Check it out in our latest issue: tinyurl.com/mrnmv5f6
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Reposted by Christian Endisch, MD
Neurocritical Care @neurocritcarej.bsky.social · 20/06/2025
Al-Salahat et al: Outcomes of Spinal Cord Infarction with Thrombolysis: A Nationwide Analysis Link: link.springer.com/ar... @neurocritical #neurocritcare
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Christian Endisch, MD @christianendisch.bsky.social · 20/05/2025
Brain injury after cardiac arrest is not as homogeneous and global as previously thought ❗️ We identified different histopathological phenotypes in 319 (!) patients with postmortem brain autopsies 🧠 🔬 @resuscitation.bsky.social @neurocritical.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Histopathological patterns of hypoxic-ischemic encephalopathy after cardiac arrest: A retrospective brain autopsy study of 319 patients
Understanding the pathophysiology of hypoxic-ischemic encephalopathy (HIE) provides important knowledge for the interpretation of neuroprognostic inve…
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Reposted by Christian Endisch, MD
Michael Okun @michaelokun.bsky.social · 18/05/2025
Do we need to rethink near-death experiences? What’s really happening in the brain? NDEs might be a hardwired coping strategy: the dissociation, calmness, and detachment when facing death may actually be an evolutionarily protective response.
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Reposted by Christian Endisch, MD
Michael Okun @michaelokun.bsky.social · 09/05/2025
Is the "New Brunswick Neurological Syndrome of Unknown Cause" actually a new disease? The data out strongly suggest NO. We must carefully study and share data on clusters of 'unknown' cases, and especially those cases that draw intense attention from the media. Examine and use pathology.
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Christian Endisch, MD @christianendisch.bsky.social · 12/04/2025
‼️Largest cohort of postmortem 🧠 autopsies after cardiac arrest ‼️ @resusplus.bsky.social @ercresus.bsky.social Correlation between 🧠 🔬 Microscopic brain injury ✳️ Duration of resuscitation ✳️ Regain of consciousness 📖Read more: www.sciencedirect.com/science/arti...
sciencedirect.com
Duration of resuscitation, regain of consciousness and histopathological severity of hypoxic-ischemic encephalopathy after cardiac arrest
To study the histopathologically quantified severity of hypoxic-ischemic encephalopathy (HIE) in deceased cardiac arrest unbiased by death causes and …
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Reposted by Christian Endisch, MD
Neurocritical Care @neurocritcarej.bsky.social · 10/04/2025
Zhang et al: Contralateral Neurovascular Coupling in Patients with Ischemic Stroke After Endovascular Thrombectomy Link:link.springer.com/ar... @neurocritical #neurocritcare
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Reposted by Christian Endisch, MD
The Lancet @thelancet.com · 02/04/2025
Neurological problems are a significant concern for patients receiving CAR T-cell therapy, yet there are no best practice guidelines. In @thelancetoncol.bsky.social, a Review provides guidance on managing neurological issues associated with CAR T-cell therapy: tinyurl.com/3fxd5vtt
Figure showing CAR T-cell therapy-associated neurotoxicities. Copyright: Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
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Reposted by Christian Endisch, MD
The Lancet Respiratory Medicine @lancetrespirmed.bsky.social · 28/03/2025
3/ Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of cohort studies🔗 tinyurl.com/4z6w3vv5
tinyurl.com
Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of two prospective cohort studies
Our findings suggest that WLST decisions are significantly more common in patients with ABI versus patients without ABI and occur earlier in this group. The rationale for early WLST following ABI warr...
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Reposted by Christian Endisch, MD
allen institute @alleninstitute.org · 13/03/2025
OP-ED: "Consciousness or pseudo-consciousness? A clash of two paradigms" by Meritorious Investigator Christof Koch and collaborators 🧠📈 www.nature.com/articles/s41...
nature.com
Consciousness or pseudo-consciousness? A clash of two paradigms - Nature Neuroscience
Integrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th...
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Reposted by Christian Endisch, MD
Nature Neuroscience @natneuro.nature.com · 11/03/2025
Then, Consciousness or pseudo-consciousness? A clash of two paradigms www.nature.com/articles/s41...
nature.com
Consciousness or pseudo-consciousness? A clash of two paradigms - Nature Neuroscience
Integrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th...
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Christian Endisch, MD @christianendisch.bsky.social · 24/02/2025
Pleasure of contributing to Handbook of Clinical Neurology, Vol. 207: „Coma, Stupor, and Related Disorders of Consciousness“ 🌟 @neurocritical.bsky.social Check out our chapter ✅ Title: „Evoked potentials in patients with disorders of consciousness“ www.sciencedirect.com/science/arti...
sciencedirect.com
Evoked potentials in patients with disorders of consciousness
Acute coma in the intensive care unit and persistent disorders of consciousness (DoC) in neuro-rehabilitation are frequent in patients with hypoxic–is…
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Reposted by Christian Endisch, MD
Susanne Muehlschlegel, MD, MPH @smuehlsch.bsky.social · 04/02/2025
Unique considerations in the assessment and management of traumatic brain injury in older adults - The Lancet Neurology www.thelancet.com/journals/lan...
thelancet.com
Unique considerations in the assessment and management of traumatic brain injury in older adults
The age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in ...
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Reposted by Christian Endisch, MD
Michael Okun @michaelokun.bsky.social · 05/01/2025
I am not ready to give up my ophthalmoscope, and I believe that neurologists should continue to peer into the living eye and identify papilledema, optic disc pallor and retinal vascular occlusion. Should we be promoting iphone attached to a newer ophthalmoscope for non-dilated bedside exams?
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Reposted by Christian Endisch, MD
JAMA @jama.com · 24/12/2024
Most viewed in the last 7 days from JAMA: This review summarizes current evidence regarding the epidemiology, pathophysiology, diagnosis, and management of atrial fibrillation. ja.ma/3Dsmaaz
Atrial Fibrillation Stages and the Evolution of Atrial Pathology
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Christian Endisch, MD @christianendisch.bsky.social · 23/12/2024
Tremendous honor to have @thelancet.bsky.social Neuroloy featuring me and our research in the rubric Lifeline ⭐️⭐️⭐️ 🙏 Thanks to all my mentors in the field of @ercresus.bsky.social @neurocritical.bsky.social @jama.com @neurocritcarej.bsky.social @dgn-ev.bsky.social www.thelancet.com/journals/lan...
thelancet.com
Christian Endisch
Christian Endisch is a neurologist in the department of neurology at the Charité Universitätsmedizin Berlin in Germany. He obtained his medical degree from the Charité Universitätsmedizin Berlin, undertaking study visits in Denmark and Sweden, and successfully defended his doctoral thesis with summa cum laude. His main research focus is on neuroprognostication and neurophysiological techniques in patients with disorders of consciousness.
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Reposted by Christian Endisch, MD
DrBreaky @drbreaky.bsky.social · 15/12/2024
A Timeline in Whole Brain Modelling: John Griffiths, Sorenza Bastiaens & Neda Kaboodvand link.springer.com/chapter/10.1...
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