Reposted by Christian Endisch, MDNEJM.org @nejm.org · 28/01/2026Editorial: Seeing It Through — Lessons from a Retinal Stroke Trial nej.md/3M8qKiT 021
Reposted by Christian Endisch, MDNEJM.org @nejm.org · 16/01/2026CREST-2 trials: For patients with asymptomatic, high-grade carotid-artery stenosis, improvements in carotid endarterectomy, stenting, and medical therapy have challenged our understanding of appropriate treatments. Research findings are summarized in a new Quick Take video. nej.md/4py7Wap 031
Reposted by Christian Endisch, MDNeurocritical Care @neurocritcarej.bsky.social · 12/01/2026Togni et al: Association of Serial Ventricular Routine Cerebrospinal Fluid Findings with Complications and Outcome in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Observational Study Link: link.springer.com/ar... @neurocritical #neurocritcare 021
Reposted by Christian Endisch, MDNature Reviews Neurology @natrevneurol.nature.com · 30/10/2025Distinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypes academic.oup.com/brain/advanc...academic.oup.comDistinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypesLiu et al. show that cutaneous α-synuclein signatures differ between brain-first and body-first subtypes of Parkinson’s disease, providing direct pathologi 011
Reposted by Christian Endisch, MDJAMA @jama.com · 28/10/2025Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients. 📝 This Review discusses PFO-associated stroke management. ja.ma/430lxyZ 072
Reposted by Christian Endisch, MDSfN Journals @sfnjournals.bsky.social · 29/09/2025#eNeuro | SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice doi.org/10.1523/ENEURO.0276-25.2025 011
Reposted by Christian Endisch, MDEuropean Journal of Neurology @europeanjournalofneurology.ean.org · 23/09/2025Chen et al. report in “Efficacy and Safety of Twelve Anti-Dyskinetic Drugs in Parkinson's Disease” that amantadine ER is more effective than IR for dyskinesia, and both reduce OFF time better than other drugs. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... #Neurology @ean.org #WileyNeuro 011
Reposted by Christian Endisch, MDJAMA Network Open @jamanetworkopen.com · 19/09/2025RCT: For patients with spinal cord injury, augmenting mean arterial pressure >85 vs 65 mmHg did not improve 6‐month neurological outcomes, and the MAP >85 group had more respiratory complications, longer mechanical ventilation, and worse organ dysfunction. #NCS2025 ja.ma/4naOW1t 012
Reposted by Christian Endisch, MDMichael Okun @michaelokun.bsky.social · 16/09/2025To shunt or not to shunt, that is the (NPH) question? The first large randomized trial of shunting for normal pressure hydrocephalus (NPH) just dropped in NEJM, and there was clear benefit for walking, and it favored the group receiving shunts. @parkinsondotorg.bsky.social 033
Reposted by Christian Endisch, MDMichael Okun @michaelokun.bsky.social · 01/09/2025What is the 2025 update on antibody therapies for Alzheimer’s? Spoiler alert: think EAC or effectiveness, access and cost. A critically important topic in a recent piece in JAMA. Early adopters enthusiastic, safety signals remain consistent w/ trials, questions remain. @alzassociation.bsky.social 001
Reposted by Christian Endisch, MDGiulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 17/08/2025A new study by Puja Agarwal, Sonal Agrawal, Julie Schneider, et al. @rushalzheimers.bsky.social provides more evidence that #MIND & other diets like it can protect against #Dementia – as well as giving us some clues as to why. Learn More @jamanetworkopen.com 👉 jamanetwork.com/journals/jam... 023
Reposted by Christian Endisch, MDJAMA @jama.com · 28/07/2025Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients. This review discusses PFO-associated stroke management. ja.ma/4orDOyr 173
Reposted by Christian Endisch, MDMaëlan Menétrey @maelanmenetrey.bsky.social · 14/07/2025🚨 New 2-in-1 paper: a review on #EEG brain oscillations (www.sciencedirect.com/science/arti...) and a website with recorded talks from a symposium that featured 8 speakers discussing the present and future of the field (brain-waves-workshop.github.io/2024/). 🧠 #neuroimaging #neuroskyencesciencedirect.comEEG brain waves and alpha rhythms: Past, current and future directionNearly a century after the first EEG recordings, we assess the progress made in EEG research, focusing on the challenges, novel theories and methods, … 1136
Reposted by Christian Endisch, MDResuscitation @resuscitation.bsky.social · 25/07/2025Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients www.resuscitationjournal.com/article/S03... #Resuscitation 011
Reposted by Christian Endisch, MDNEJM AI @ai.nejm.org · 21/07/2025SpikeNet2, a deep-learning model shown to achieve expert-level performance in detecting epileptiform discharges from EEG recordings while significantly reducing false positives, demonstrates strong generalizability across diverse datasets. Learn more: nejm.ai/4lq1Qr4 #AI #MedSky #NeuroSky 012
Reposted by Christian Endisch, MDStephane Legriel @stlegriel.bsky.social · 20/07/2025#Cardiacarrest from neurological causes: for whom the brain tolls - Resuscitation www.resuscitationjournal.com/article/S030... @resuscitation.bsky.social @stlegriel.bsky.social #marinepaulresuscitationjournal.comCardiac arrest from neurological causes: for whom the brain tollsCardiac arrest of neurological cause (CA-NC) is an entity whose incidence is unknown. The main reason for this is that the medical literature is mainly concerned with cardiac arrest due to cardiac cau... 264
Reposted by Christian Endisch, MDResuscitation @resuscitation.bsky.social · 19/07/2025Serum neurofilament light chain and multimodal neuroprognostication after cardiac arrest – a retrospective cohort study www.resuscitationjournal.com/article/S03... #Resuscitation 011
Reposted by Christian Endisch, MDResuscitation @resuscitation.bsky.social · 20/07/2025Neurologic etiologies of cardiac arrest are associated with early withdrawal of life-sustaining therapy www.resuscitationjournal.com/article/S03... #Resuscitation 002
Reposted by Christian Endisch, MDThe Lancet Neurology @thelancetneuro.bsky.social · 07/07/2025A pooled analysis of of the four INTERACT trials suggests intensive blood pressure-lowering initiated within several hours of intracerebral haemorrhage onset was safe and improved functional recovery, without a clear effect on haematoma growth. Check it out in our latest issue: tinyurl.com/mrnmv5f6 111
Reposted by Christian Endisch, MDNeurocritical Care @neurocritcarej.bsky.social · 20/06/2025Al-Salahat et al: Outcomes of Spinal Cord Infarction with Thrombolysis: A Nationwide Analysis Link: link.springer.com/ar... @neurocritical #neurocritcare 001
Christian Endisch, MD @christianendisch.bsky.social · 20/05/2025Brain injury after cardiac arrest is not as homogeneous and global as previously thought ❗️ We identified different histopathological phenotypes in 319 (!) patients with postmortem brain autopsies 🧠 🔬 @resuscitation.bsky.social @neurocritical.bsky.social www.sciencedirect.com/science/arti...sciencedirect.comHistopathological patterns of hypoxic-ischemic encephalopathy after cardiac arrest: A retrospective brain autopsy study of 319 patientsUnderstanding the pathophysiology of hypoxic-ischemic encephalopathy (HIE) provides important knowledge for the interpretation of neuroprognostic inve… 042
Reposted by Christian Endisch, MDMichael Okun @michaelokun.bsky.social · 18/05/2025Do we need to rethink near-death experiences? What’s really happening in the brain? NDEs might be a hardwired coping strategy: the dissociation, calmness, and detachment when facing death may actually be an evolutionarily protective response. 051
Reposted by Christian Endisch, MDMichael Okun @michaelokun.bsky.social · 09/05/2025Is the "New Brunswick Neurological Syndrome of Unknown Cause" actually a new disease? The data out strongly suggest NO. We must carefully study and share data on clusters of 'unknown' cases, and especially those cases that draw intense attention from the media. Examine and use pathology. 143
Christian Endisch, MD @christianendisch.bsky.social · 12/04/2025‼️Largest cohort of postmortem 🧠 autopsies after cardiac arrest ‼️ @resusplus.bsky.social @ercresus.bsky.social Correlation between 🧠 🔬 Microscopic brain injury ✳️ Duration of resuscitation ✳️ Regain of consciousness 📖Read more: www.sciencedirect.com/science/arti...sciencedirect.comDuration of resuscitation, regain of consciousness and histopathological severity of hypoxic-ischemic encephalopathy after cardiac arrestTo study the histopathologically quantified severity of hypoxic-ischemic encephalopathy (HIE) in deceased cardiac arrest unbiased by death causes and … 062
Reposted by Christian Endisch, MDNeurocritical Care @neurocritcarej.bsky.social · 10/04/2025Zhang et al: Contralateral Neurovascular Coupling in Patients with Ischemic Stroke After Endovascular Thrombectomy Link:link.springer.com/ar... @neurocritical #neurocritcare 063
Reposted by Christian Endisch, MDThe Lancet @thelancet.com · 02/04/2025Neurological problems are a significant concern for patients receiving CAR T-cell therapy, yet there are no best practice guidelines. In @thelancetoncol.bsky.social, a Review provides guidance on managing neurological issues associated with CAR T-cell therapy: tinyurl.com/3fxd5vtt 0319
Reposted by Christian Endisch, MDThe Lancet Respiratory Medicine @lancetrespirmed.bsky.social · 28/03/20253/ Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of cohort studies🔗 tinyurl.com/4z6w3vv5tinyurl.comDecisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of two prospective cohort studiesOur findings suggest that WLST decisions are significantly more common in patients with ABI versus patients without ABI and occur earlier in this group. The rationale for early WLST following ABI warr... 012
Reposted by Christian Endisch, MDallen institute @alleninstitute.org · 13/03/2025OP-ED: "Consciousness or pseudo-consciousness? A clash of two paradigms" by Meritorious Investigator Christof Koch and collaborators 🧠📈 www.nature.com/articles/s41...nature.comConsciousness or pseudo-consciousness? A clash of two paradigms - Nature NeuroscienceIntegrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th... 1224
Reposted by Christian Endisch, MDNature Neuroscience @natneuro.nature.com · 11/03/2025Then, Consciousness or pseudo-consciousness? A clash of two paradigms www.nature.com/articles/s41...nature.comConsciousness or pseudo-consciousness? A clash of two paradigms - Nature NeuroscienceIntegrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th... 152
Christian Endisch, MD @christianendisch.bsky.social · 24/02/2025Pleasure of contributing to Handbook of Clinical Neurology, Vol. 207: „Coma, Stupor, and Related Disorders of Consciousness“ 🌟 @neurocritical.bsky.social Check out our chapter ✅ Title: „Evoked potentials in patients with disorders of consciousness“ www.sciencedirect.com/science/arti...sciencedirect.comEvoked potentials in patients with disorders of consciousnessAcute coma in the intensive care unit and persistent disorders of consciousness (DoC) in neuro-rehabilitation are frequent in patients with hypoxic–is… 020
Reposted by Christian Endisch, MDSusanne Muehlschlegel, MD, MPH @smuehlsch.bsky.social · 04/02/2025Unique considerations in the assessment and management of traumatic brain injury in older adults - The Lancet Neurology www.thelancet.com/journals/lan...thelancet.comUnique considerations in the assessment and management of traumatic brain injury in older adultsThe age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in ... 011
Reposted by Christian Endisch, MDMichael Okun @michaelokun.bsky.social · 05/01/2025I am not ready to give up my ophthalmoscope, and I believe that neurologists should continue to peer into the living eye and identify papilledema, optic disc pallor and retinal vascular occlusion. Should we be promoting iphone attached to a newer ophthalmoscope for non-dilated bedside exams? 061
Reposted by Christian Endisch, MDJAMA @jama.com · 24/12/2024Most viewed in the last 7 days from JAMA: This review summarizes current evidence regarding the epidemiology, pathophysiology, diagnosis, and management of atrial fibrillation. ja.ma/3Dsmaaz 082
Christian Endisch, MD @christianendisch.bsky.social · 23/12/2024Tremendous honor to have @thelancet.bsky.social Neuroloy featuring me and our research in the rubric Lifeline ⭐️⭐️⭐️ 🙏 Thanks to all my mentors in the field of @ercresus.bsky.social @neurocritical.bsky.social @jama.com @neurocritcarej.bsky.social @dgn-ev.bsky.social www.thelancet.com/journals/lan...thelancet.comChristian EndischChristian Endisch is a neurologist in the department of neurology at the Charité Universitätsmedizin Berlin in Germany. He obtained his medical degree from the Charité Universitätsmedizin Berlin, undertaking study visits in Denmark and Sweden, and successfully defended his doctoral thesis with summa cum laude. His main research focus is on neuroprognostication and neurophysiological techniques in patients with disorders of consciousness. 020
Reposted by Christian Endisch, MDDrBreaky @drbreaky.bsky.social · 15/12/2024A Timeline in Whole Brain Modelling: John Griffiths, Sorenza Bastiaens & Neda Kaboodvand link.springer.com/chapter/10.1... 26218