Emmerson et al. demonstrate that the CXCR3-CXCL10 chemokine signaling pathway is important for brain-infiltrating T cells in tau-mediated neurodegeneration. Blocking CXCR3 reduces T cell entry and pro...

The aryl hydrocarbon receptor (AHR) is a transcription factor activated by various endogenous and exogenous ligands. Here, the authors demonstrate that selective AHR activation in epithelial cells by ...

Changes in gene expression have been observed in the aging human brain, but our understanding of the underlying regulatory mechanisms remains limited. To unravel these complexities, we analyzed single...

A new atlas identifies 1,067 unannotated microproteins in the human frontal cortex with strong spectral grades. A subset is differentially expressed in Alzheimer’s disease independently of their canon...

Aging disrupts tissue homeostasis across organ systems. Here, we identify tissue-resident macrophages (TRMs) as central coordinators of age-related organ decline through impaired clearance of senescen...

The authors identify peripheral dendritic cell priming of T cells as a key driver of brain inflammation and neurodegeneration in a mouse model of tauopathy, providing new insights into immune mechanis...

O’Shea and colleagues establish that optimisation of charge and stability is sufficient to enable any single-chain variable fragment intrabody to function within the cell. The authors use AI-led inver...

Background: Observational studies report a protective association between herpes zoster (HZ) vaccination and dementia, but they have methodological limitations or examined a live attenuated vaccine no...

Young, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability...

Aging disrupts microglial function, but factors that rejuvenate these cells are poorly characterized. Here, the authors show the youth-associated protein TIMP2 revitalizes microglia by altering inflam...

Related News Novel markers of brain blood flow and oxygenation may offer early clues to Alzheimer’s risk February 24, 2026 NIH investment totaling 30.7M will expand USC-led AI effort to […]

Physics-informed AI reveals brain fluid flow from MRI, key to understanding brain health and neurological diseases.

Nature - Somatic mutations reveal the ontogeny of microglia in human aging

The common marmoset is a key primate model for human disease, yet large regions of its genome have remained unresolved until now. A complete, end-to-end assembly reveals centromere organization, a rib...

Mitochondrial dysfunction features prominently in tauopathies. The mechanistic link between tau and mitochondria remains uncertain. Li et al. show that tau enters mitochondria and interacts with compl...

A study led by NYU Langone Health finds that eliminating three risks extends dementia-free lifespans by 13 years on average.

Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate that they result from the dual...

Dietary fibers are a primary energy source for gut bacteria and shape the composition and function of the microbiome. Now, an active learning approach integrating explainable machine learning, Bayesia...

The authors find that nutrient consumption enhances memory through vagus nerve-mediated septo-hippocampal acetylcholine signaling. Either surgical ablation of this pathway or Western diet exposure, wh...

Microglia cellular changes underlie divergent resilience-associated mechanisms in human aging.

Background As longevity increases and the population over age 65 expands, advancing age remains the most reliable predictor of cognitive decline, highlighting the need to identify biological mechanism...