In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and cognition. In vulnerable individuals, acute...

Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...

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Age-related macular degeneration (AMD) is one of the leading causes of central retinal blindness. Here, Campbell and colleagues show that transplanted retinal pigment epithelial cells can be engineere...

The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascul...

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The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

Researchers from RCSI University of Medicine and Health Sciences have uncovered a novel mechanism linking inflammatory bowel disease (IBD) with an increased risk of a serious blood clotting disorder, ...

A non-invasive in vivo positron emission tomography imaging approach detects inflammatory disease using various preclinical models.

A new international study has unveiled critical insights in understanding post-traumatic epilepsy, a condition that can develop following traumatic brain injury.

A claudin5 binding peptide enhances transport across the blood-brain barrier by transiently permeabilizing tight junctions.

Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...

In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a protein-based single-cell profiling ...

The integrity of the blood–retina barrier (BRB) is crucial for phototransduction and vision, by tightly restricting transport of molecules between ...

New research from RCSI has explained how the body’s internal clock influences the inflammatory process of the immune system. More ...

I keep meeting people who are extremely burned out. I meet them so often that I’m beginning to think burnout is something that exists by design

Glial-vascular interactions are critical for the formation and maintenance of brain blood vessels and the blood-brain barrier (BBB) in mammals, but their role in the zebrafish BBB remains unclear. Using three glial gene promoters—gfap, glast, and glastini (a truncated glast)—we explored glial-vascular development in zebrafish. Sparse labeling showed fewer glial-vascular interactions at early stages, with glial coverage and contact area increasing with age. Stable transgenic lines for glast and glastini revealed similar developmental increases, starting at ∼30% coverage at 3 days post-fertilization (dpf) and peaking at ∼60% by 10 dpf, and consistently higher glial coverage in the forebrain and midbrain than in the hindbrain.

Disrupted endothelial function underlies the multiorgan complications of COVID-19

Nature Medicine - A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells.