iiinova — where your digital self keeps evolving

Reposted by Gary Brennan

FutureNeuro Centre @futureneuro.bsky.social · 28/08/2025

🎉 Join us for #EuropeanResearchersNight on Friday, Sept 26 at RCSI. FutureNeuro researchers will run hands-on activities for all ages exploring DNA, the brain, and technology. Register now: www.eventbrite.com/e/european-r... @rcsi.bsky.social @tcddublin.bsky.social @researchireland.ie

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Reposted by Gary Brennan

FutureNeuro Centre @futureneuro.bsky.social · 01/09/2025

🏆 Congratulations to our Director, Prof @dchenshall.bsky.social, on receiving the ILAE Ambassador for Epilepsy Award at the 36th International Epilepsy Congress in Lisbon—recognising his global impact on epilepsy research. @ilae-epilepsy.bsky.social @researchireland.ie @epilepsyireland.bsky.social

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Reposted by Gary Brennan

JCI insight @insight.jci.org · 09/08/2025

ICYMI: Temporal lobe epilepsy affects ~50 million people globally @brennan-lab-ucd.bsky.social @futureneuro.bsky.social & team link altered RNA methylation to changes in protein expression, neuronal structure, and seizure susceptibility across models: buff.ly/odAaTRs

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Gary Brennan @brennan-lab-ucd.bsky.social · 05/08/2025

Delighted to see our recent study published @jci-insight.bsky.social . Here we demonstrate profound disruption of m6A in temporal lobe epilepsy and show that it may regulate seizure susceptibility. Huge thanks to all the authors involved. @futureneuro.bsky.social @ucd-sbbs.bsky.social

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Reposted by Gary Brennan

FutureNeuro Centre @futureneuro.bsky.social · 02/07/2025

🚨 New preprint out! Our latest study shows that blocking miR-134 reduces seizures in mice with established epilepsy. Single-cell and network recordings reveal how this microRNA-targeted therapy could reset brain excitability. Read it here: www.biorxiv.org/content/10.1...

biorxiv.org

Attenuated single neuron and network hyperexcitability following microRNA-134 inhibition in mice with drug-resistant temporal lobe epilepsy

The multi-factorial pathophysiology of acquired epilepsies lends itself to a multi-targeting therapeutic approach. MicroRNAs (miRNA) are short noncoding RNAs that individually can negatively regulate ...

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Reposted by Gary Brennan

Igor Ulitsky @igorulitsky.bsky.social · 29/05/2025

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵 biorxiv.org/content/earl...

biorxiv.org

Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression

Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...

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Gary Brennan @brennan-lab-ucd.bsky.social · 30/04/2025

Had a wonderful time at @britishneuro.bsky.social 2025 in Liverpool. Wonderful science, city, people & weather. Also well done @kaushiknarasimhan.bsky.social on giving your 1st poster presentation for the lab. @futureneuro.bsky.social @ucddublin.bsky.social

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Reposted by Gary Brennan

Neuroscience Ireland @neuroscienceirl.bsky.social · 17/04/2025

⏳ Only 1 week left to nominate a brilliant neuroscientist for the #NSI2025 Awards! Let’s celebrate excellence in #Neuroscience 🧠✨ 🗓 Deadline: April 24 Submit here 👉 neuroscienceireland.com/nsi-2025-awa... #NSI #NSIAwards #ScienceIreland

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Reposted by Gary Brennan

Paul Donlin-Asp @pdaphd.bsky.social · 02/04/2025

Thanks to @brennan-lab-ucd.bsky.social for hosting me at UCD. It’s been a fabulous visit to Dublin to chat science and soak up the Irish sun.

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Gary Brennan @brennan-lab-ucd.bsky.social · 27/03/2025

Very proud of the lab who put together a bake sale for Epilepsy awareness Day yesterday. Together they raised over €1000 for @epilepsyireland.bsky.social

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Gary Brennan @brennan-lab-ucd.bsky.social · 16/01/2025

I had a wonderful day at the Centre for Discovery Brain Sciences in Edinburgh presenting some of our recent data and learning lots from the wonderful faculty and staff there. Thanks for having me @pdaphd.bsky.social and looking forward to your visit to Dublin soon!

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