A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrog...

Protein AMPylation is a post-translational modification in which adenosine monophosphate (AMP) from ATP is covalently attached to a target protein via a phosphodiester bond. This reaction is catalyzed...

In this issue of Molecular Cell, Ham et al.1 demonstrate that the metabolite fumarate, when accumulated in cells, can influence mitochondrial quality …

The Morgridge Institute for Research, in partnership with the Department of Biomolecular Chemistry at the University of Wisconsin-Madison, seeks a joint tenure track assistant professor to lead a vibr...

Background: Osteosarcoma (OS) is a primary malignant bone tumor predominantly affecting adolescents. Chemotherapeutic agents, such as cisplatin, are commonly used in OS treatment; however, drug resist...

Protein lipidation is a pivotal post-translational modification that increases protein hydrophobicity and influences their function, localization, and interaction network. Emerging evidence has shown ...

Dynamic palmitoylation modulates protein localization and function. Here, Jayaraman et al develop a toolkit of engineered depalmitoylases to manipulate protein function with spatial, temporal, and sub...

The authors recommend actions that can be taken by individuals, institutions and policymakers to promote gender equity.

Leaving a high-flying job in consulting, Angela Lee Duckworth took a job teaching math to seventh graders in a New York public school. She quickly realized that IQ wasn't the only thing separating the...

The overall impact of arginine metabolism in tumor progression remains unclear. Using clinical analysis, scRNA-seq, and animal models, Zhu et al. identify cancer cell-macrophage metabolic interplay as the key driver of arginine’s impact in breast cancer. This study provides mechanistic insights into leveraging arginine metabolism to enhance antitumor immunity.

Nature Reviews Cancer, Published online: 04 April 2025; doi:10.1038/s41568-025-00816-9The mechanisms of how pH-dependent cell death, alkaliptosis, is regulated are incompletely understood. Chen et al. now demonstrate that the cholesterol biosynthesis protein CYP51A1 suppresses alkaliptosis induced by the opioid analgesic JTC801.

imageimageATG2 is essential for autophagosome biogenesis as it transfers membrane material from the endoplasmic reticulum to growing phagophores. This study reveals that S-palmitoylation dynamically r...

ALT: a stick figure is sitting on a stool reading a book

The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices…

Nature Metabolism, Published online: 10 March 2025; doi:10.1038/s42255-025-01240-xA new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring…

Nature Reviews Cancer, Published online: 11 March 2025; doi:10.1038/s41568-025-00807-wTargeting metabolic dependencies, such as glucose or lipid metabolism, is a key strategy for anti-cancer therapies. Nguyen et al. developed a new approach, adipose…

Nature Metabolism, Published online: 11 March 2025; doi:10.1038/s42255-025-01243-8Clarke, Hawkinson and colleagues study the contribution of glycogen accumulation in the onset and progression of lung cancer.

From China to Brazil to Germany, huge numbers of people are addicted to shopping, driven in part by companies that use gaming strategies.

La sevillana Patricia Altea dirige a sus 36 años su propio grupo de investigación sobre Regulación Metabólica y Señalización en Cáncer en Cabimer para entender el porqué de la enfermedad

Biologist Tatsuya Amano works to make science a fairer place for non-fluent speakers.

While paying people equitably seems uncontroversial, wage gap data has been subject to misinterpretation by people who question whether the gap actually exists.

Celebrating and supporting the achievements of women in science, and all those who work to encourage girls and young women to engage with STEM subjects and stay in STEM careers around the world.

In Finland, the number of homeless people has fallen sharply. Why? The country applies the "Housing First" concept agains homelessness.

The award recognizes her pioneering research on the mechanisms of dosage compensation and epigenetic regulation, and her commitment to gender equality in science