We have systematically optimized the concentrations of 20 components of a previously published serumfree medium (Brewer and Cotman, Brain Res 494: 65-74, 1989) for survival of rat embryonic hippocamp...

This project uses cutting-edge 3D gastruloid models to reveal how the integration of Wnt and Notch (Wntch) signalling pathways drives cell fate decisions in the early mammalian embryo. The student wil...

Summary: Endometriosis cannot be accurately modelled in laboratory animals. Our in vitro peritoneal endometriosis model uses patient-derived cells to accelerate understanding of disease onset processe...

Highlighted Article: This work explores the cellular and molecular sensitivity of the mouse gastruloid model system to variations in N2B27 media formulations, highlighting the need for careful media s...

Highlighted Article: This work explores the cellular and molecular sensitivity of the mouse gastruloid model system to variations in N2B27 media formulations, highlighting the need for careful media s...

Highlighted Article: This work explores the cellular and molecular sensitivity of the mouse gastruloid model system to variations in N2B27 media formulations, highlighting the need for careful media s...

PhD Project - MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool, listed on FindAPhD.com

Highlighted Article: Genetic lineage tracing and expression analyses reveal insights into the developmental lineage of smooth muscle cells in the intestine and mesentery, specified by WT1 expression d...

Background Inosine monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyses the rate-limiting step of guanine nucleotides. In mouse embryonic stem cells (ESCs), IMPDH2 forms large multi-prot...

The Wilms’ Tumour protein (WT1) was previously linked to the mesothelial and vascular smooth muscle cell (vSMC) lineage in the mouse intestine, with evidence suggesting that intestinal vSMCs arise fro...

A DNA memory device, DNA Typewriter, uses sequential prime editing to record the order of multiple cellular events.

Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...

Background Inosine monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyses the rate-limiting step of guanine nucleotides. In mouse embryonic stem cells (ESCs), IMPDH2 forms large multi-prot...

Peritoneal endometriosis causes pelvic pain and infertility, but the underlying mechanisms related to these symptoms are not fully understood. Endometriosis diagnosis is typically delayed; thus, patie...

Gastruloids are 3D aggregates of pluripotent stem cells grown in suspension culture that mimic many aspects of gastrulation and early axial elongation. The N2B27 basal medium in which mouse gastruloid...

Nodal and Wnt signalling play an important role in the emergence of the mammalian body plan, primarily by orchestrating gastrulation and primitive streak formation. While the literature suggests that ...

PhD Project - MRC DiMeN Doctoral Training Partnership: Understanding skeletal tissue responses to sex and menopause in osteoarthritis at University of Liverpool, listed on FindAPhD.com