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Pedro Escoll

@pescoll.bsky.social
99 followers 127 following 29 posts

How the metabolic crosstalk between pathogenic bacteria and host cells impacts infection? @pasteur.fr

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Reposted by Pedro Escoll
Pedro Escoll @pescoll.bsky.social · 04/09/2026
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
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Reposted by Pedro Escoll
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 04/09/2026
Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages www.biorxiv.org/content/10.64898/20…
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Reposted by Pedro Escoll
#SingleCell preprints @prepub-singlecell.bsky.social · 04/09/2026
Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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Pedro Escoll @pescoll.bsky.social · 04/09/2026
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
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Pedro Escoll @pescoll.bsky.social · 10/07/2026
New paper from the team in Plos Pathogens @plos.org : providing macrophages with preferred nutrients lets Salmonella replicate even without its Type III Secretion Systems (T3SS). Work by Francisco Garcia-Rodriguez & Paula Martinez, with @kamovalenz.bsky.social and @joaquinbernal.bsky.social 🧵1/9
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Pedro Escoll @pescoll.bsky.social · 02/03/2026
Our last paper is out at IAI @asm.org . With @cbuch.bsky.social, at @pasteur.fr . Congrats Francisco & Paula ! Mitochondrial Complex I emerges as a common energetic checkpoint distinguishing virulent from secretion-deficient bacteria during Legionella and Salmonella infection of human macrophages.
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Reposted by Pedro Escoll
Waggoner Lab @labwaggoner.bsky.social · 17/10/2025
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages @natcomms.nature.com www.nature.com/articles/s41...
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Pedro Escoll @pescoll.bsky.social · 16/10/2025
New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵
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Reposted by Pedro Escoll
Ákos T Kovács @evolvedbiofilm.bsky.social · 11/10/2025
Extracellular ATP is an environmental cue in bacteria @cp-cellreports.bsky.social www.cell.com/cell-reports...
cell.com
Extracellular ATP is an environmental cue in bacteria
Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular ATP reprograms the tra...
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Reposted by Pedro Escoll
Jean-Yves Tinevez @jytinevez.bsky.social · 07/10/2025
Job alert! We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? See also on the forum: forum.image.sc/t/research-e...
forum.image.sc
Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA
Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...
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Reposted by Pedro Escoll
Pedro Escoll @pescoll.bsky.social · 05/09/2025
New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr
Figure 5. Working model for pathogen-specific ETC modulations that preserve the ∆ψm in hMDMs. (A) L. pneumophila: T4SS effectors dampen OxPhos early during
infection and preserve the ∆ψm by engaging the reverse mode of the FOF1 -ATPase. The ∆ψm remains high enough that ANT stays in forward mode, limiting cytosolic ATP
drain. All ETC complexes (I-IV) contribute to maintaining the ∆ψm. Complex I is uniquely essential during WT infection. (B) S. Typhimurium: T3SS SPI-1/2 effectors reduce
respiration and preserve the ∆ψm without inducing the reverse mode of the FO F1 -ATPase. Virulent bacteria rely on Complex I-driven electron entry with obligatory Complex
III/IV proton pumping, while Complex II contributes in all infection conditions. Secretion-defective mutants fail to establish the Complex I-dependent configuration.
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Reposted by Pedro Escoll
Enninga Lab @enningalab.bsky.social · 18/09/2025
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!
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Reposted by Pedro Escoll
Institut Pasteur | 130 years of biomedical research @pasteur.fr · 17/09/2025
🟢 The Institut Pasteur goes green for Mitochondrial Disease Awareness Week! 🟢 These rare diseases affect 1 in 5,000 people. Mitochondria, the “powerhouses” of our cells, are also thought to play a role in Alzheimer's disease. Research today, cure tomorrow. 🔬 #WorldMitoWeek2025
© Institut Pasteur
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Reposted by Pedro Escoll
Andreas Bäumler @abaumler.bsky.social · 13/09/2025
Hydrogen sulfide production distinguishes Salmonella from close relatives, but its biological significance remains obscure. This study uncovers the secret: Salmonella uses hydrogen sulfide production as a weapon to outcompete E. coli and gain a foothold in the gut. www.pnas.org/doi/10.1073/...
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Reposted by Pedro Escoll
Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 06/09/2025
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
science.org
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
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Pedro Escoll @pescoll.bsky.social · 05/09/2025
New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr
Figure 5. Working model for pathogen-specific ETC modulations that preserve the ∆ψm in hMDMs. (A) L. pneumophila: T4SS effectors dampen OxPhos early during
infection and preserve the ∆ψm by engaging the reverse mode of the FOF1 -ATPase. The ∆ψm remains high enough that ANT stays in forward mode, limiting cytosolic ATP
drain. All ETC complexes (I-IV) contribute to maintaining the ∆ψm. Complex I is uniquely essential during WT infection. (B) S. Typhimurium: T3SS SPI-1/2 effectors reduce
respiration and preserve the ∆ψm without inducing the reverse mode of the FO F1 -ATPase. Virulent bacteria rely on Complex I-driven electron entry with obligatory Complex
III/IV proton pumping, while Complex II contributes in all infection conditions. Secretion-defective mutants fail to establish the Complex I-dependent configuration.
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Reposted by Pedro Escoll
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 05/09/2025
Complex-I Preserves Mitochondrial Polarization during Infection of Human Macrophages by Secretion-competent Bacteria www.biorxiv.org/content/10.1101/202…
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Reposted by Pedro Escoll
Leigh Knodler @leighknodler.bsky.social · 08/08/2025
That concludes GRC Salmonella 2025. What a fantastic meeting it was - topnotch science, great discussions and a wonderful spirit. I am proud to be part of this amazing scientific community.
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Reposted by Pedro Escoll
Andreas Bäumler @abaumler.bsky.social · 09/08/2025
A Salmonella T3SS-2 mutant grows fine in spleen macrophages, contradicting tissue culture dogma (PMID: 23236281). This observation was largely ignored, but adding certain carbon sources rescues growth in cultured macrophages, hinting that T3SS-2 may be doing something entirely different in vivo.
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Reposted by Pedro Escoll
Serge Mostowy @sergemostowylab.bsky.social · 02/05/2025
Shigella-trained pro-inflammatory macrophages protect zebrafish from secondary infection @cgmargarida.bsky.social
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Reposted by Pedro Escoll
Pedro Escoll @pescoll.bsky.social · 16/05/2025
New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with @kamovalenz.bsky.social and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
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Reposted by Pedro Escoll
SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 17/05/2025
New study reveals that Salmonella can replicate inside macrophages even without its T3SSs, if the nutrient conditions are right! Metabolic heterogeneity of host cells is a game-changer in bacterial replication dynamics. #MicroSky ✍️ @pescoll.bsky.social and coll. @pasteur.fr 📖 shorturl.at/a9a06
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Enninga Lab @enningalab.bsky.social · 06/05/2025
Our latest paper is out! Congratulations to @leaswistak.bsky.social et al for this amazing #cryoET work that elucidates the initial stages of #T3SS dependent vacuolar damage during #Shigella infection. We will do a deep-dive later! journals.plos.org/plosbiology/...
journals.plos.org
The bacterial type three secretion system induces mechanoporation of vacuolar membranes
Many intracellular bacteria breach vacuolar membranes to replicate in the host cytosol, but the precise mechanisms remain unclear. This study shows that the human pathogen Shigella flexneri uses its t...
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Reposted by Pedro Escoll
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 16/05/2025
Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems www.biorxiv.org/content/10.1101/202…
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Pedro Escoll @pescoll.bsky.social · 16/05/2025
New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with @kamovalenz.bsky.social and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV
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Reposted by Pedro Escoll
Camila Valenzuela, PhD @kamovalenz.bsky.social · 16/05/2025
Another very cool story I was lucky enough to be involved in! Congrats @pescoll.bsky.social and Francisco! Now let’s hope for a smooth submission!
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Jose A Escudero @jaescudero.bsky.social · 08/05/2025
🧪 Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉 Short 🧵 www.science.org/doi/10.1126/...
science.org
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
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Pedro Escoll @pescoll.bsky.social · 04/04/2025
Hello world !
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