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Angel Goñi-Moreno

@angelgm.eurosky.social
1.2K followers 172 following 139 posts

Computing with living systems | Synthetic biology. Head of the Biocomputation Lab at the CNB-CSIC @cnb-csic.bsky.social www.biocomputationlab.com

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Angel Goñi-Moreno @angelgm.eurosky.social · 11/09/2026
You remember our #ALife paper from 2023? doi.org/10.1162/isal.... One of my favourites! Experimental results are in, finally. You will most definitely enjoy reading about them. Coming soon! @lewisgrozinger.bsky.social @pglekas.eurosky.social
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Alejandro Requena-Menéndez @redquena.bsky.social · 09/09/2026
This week I’m in Berlin for the International Symposium on Plasmid Biology @plasmidsociety.bsky.social! Much learnings on plasmid biology, new colleagues and, most important, valuable feedback of our project on bacterial conjugation control! If you are around and want to chat, feel free ☺️
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Angel Goñi-Moreno @angelgm.eurosky.social · 07/09/2026
Also next in Lab's conference agenda: the IEEE International Conference on Digital Twin swc-ieee-2026.github.io/digitaltwin/. Jesús @mirobueno.bsky.social will give a talk about our digital twins in microbiology and #synbio.
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Angel Goñi-Moreno @angelgm.eurosky.social · 07/09/2026
Next in Lab's conference agenda: International Symposium on Plasmid Biology plasmid-biology-2026.de. Alejandro @redquena.bsky.social will be presenting poster CM-05 on the engineering of conjugation dynamics. Go talk to him!
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Angel Goñi-Moreno @angelgm.eurosky.social · 03/09/2026
Back to Madrid now. It's been great to engage with this community: computability, completeness, complexity... This conference was dedicated to Mario de Jesús Pérez Jiménez, a true titan of science, who passed away a year ago.
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Angel Goñi-Moreno @angelgm.eurosky.social · 03/09/2026
Just scheduled a meeting for the 14th September... 2027! Not a mistake. We're gonna need a bigger agenda.
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Angel Goñi-Moreno @angelgm.eurosky.social · 31/08/2026
Next in Lab's (busy!) conference agenda: International Conference on Membrane Computing (Sevilla, 1-4 Sep, icmc2026.org). I've always been very close to this community, but never really collaborated. See what happens! I'll be talking about the host cell as an Operating System.
icmc2026.org
ICMC2026
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Angel Goñi-Moreno @angelgm.eurosky.social · 28/08/2026
Next in Lab's conference agenda: the EPIA Conference on AI, next week in Madeira. @lewisgrozinger.bsky.social will talk about the computational evolution of genetic circuits (within the Theory and Methods track). A collaboration with our Brazilian colleagues at Universidade Federal do Maranhão.
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Angel Goñi-Moreno @angelgm.eurosky.social · 13/08/2026
La puesta de sol ayer me pilló desprevenido y fue una maravilla. En Gallegos (Segovia) se vio igual que en la foto de Ángel Bravo.
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Angel Goñi-Moreno @angelgm.eurosky.social · 02/07/2026
Una maravilla esto que edita @principiamagazine.bsky.social sobre María Teresa Toral.
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Angel Goñi-Moreno @angelgm.eurosky.social · 02/07/2026
Happy to be part of this brilliant #synbio network across 22 EU institutions. 40 postdoc positions will be announced soon. www.biochem.mpg.de/syncell-nexu...
biochem.mpg.de
SynCell-nExUs: Training Europe's Next Generation of Leaders in Synthetic Cell Research
On 1 August 2026, the Max Planck Society will launch the SynCell nExUs postdoctoral programme. The five-year programme, coordinated by the Max Planck Institute (MPI) of Biochemistry and the MPI for T...
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Angel Goñi-Moreno @angelgm.eurosky.social · 16/06/2026
The 2026 Systems Biology Department's retreat. What a brilliant crowd! The t-shirt (artist: Marina de la Fuente) has a logo of every lab in the Dept. Our Lab is The logic Doors :-) Kudos to organizers: @angeles-hg.bsky.social, @pglekas.eurosky.social, @lewisgrozinger.bsky.social & Guillermo Gomez.
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Alejandro Requena-Menéndez @redquena.bsky.social · 16/06/2026
This week I’m in Oxford for the EECI International Graduate Course on Biological Control Systems. Previous to the course beggining I could sightsee a bit of the city and, in the afternoon, we started with basic model math & theory control for biologists! A tope for today!
Oxford
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Angel Goñi-Moreno @angelgm.eurosky.social · 08/06/2026
Next conference in the Lab's agenda: the #SynBYSS conference that starts today in Barcelona. The agenda is absolutely spectacular: www.jcvi.org/events/synbyss. If you are around, go visit Crislaine Rocha at poster 17. Her research, on coupling sensors to gates is truly brilliant. #synbio
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Ricard Solé @ricardsole.bsky.social · 04/06/2026
What if living cells compute in ways that silicon never can? Rather than mimicking computers, the future of biocomputation may lie in harnessing the unique information-processing strategies of evolution. Check this paper by @angelgm.eurosky.social and co. www.sciencedirect.com/science/arti....
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Ángeles Hueso-Gil @angeles-hg.bsky.social · 29/05/2026
Paper out!! 🥳 We controlled bacterial growth by tuning native RNAP availability. Then, we studied the impact of growth and this RNAP availability over different NOT gates present in that strain. Great work with @mirobueno.bsky.social and @angelgm.eurosky.social 😀. link.springer.com/article/10.1...
link.springer.com
Growth control as a central regulator for tuning the cellular context - Journal of Biological Engineering
The cellular context decisively shapes genetic circuit performance, but the interplay between host and circuit remains difficult to control rationally. To address this challenge, we replaced the nativ...
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Angel Goñi-Moreno @angelgm.eurosky.social · 22/05/2026
📣 Latest paper out! I'll write a thread about it next week: growth control, cellular context, genetic circuits... A fascinating story by @angeles-hg.bsky.social & @mirobueno.bsky.social #synbio #biocomputation link.springer.com/article/10.1...
link.springer.com
Growth control as a central regulator for tuning the cellular context - Journal of Biological Engineering
The cellular context decisively shapes genetic circuit performance, but the interplay between host and circuit remains difficult to control rationally. To address this challenge, we replaced the nativ...
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Alejandro Requena-Menéndez @redquena.bsky.social · 19/05/2026
Este miércoles, a las 19h, estaré en el Moe’s Club (Madrid) en el @pintofscience.es de Madrid 😄. Representando al @cnb-csic.bsky.social, hablaré de si los ordenadores pueden estar vivos y cómo podemos crearlos en el laboratorio. ¡Nos vemos allí!
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Angel Goñi-Moreno @angelgm.eurosky.social · 14/05/2026
Gene expression noise is not always noise. If expression comes from stable rates and events (blue lines) it is noiseless information (yet stochastic & probabilistic!). If there are sudden perturbations on the channel (green), then there is noise. I find that word particularly misleading 🤔
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Angel Goñi-Moreno @angelgm.eurosky.social · 21/04/2026
This paper is most interesting for us. It'll take us some time to digest; the amount of information in it is near infinite! doi.org/10.1021/acs....
doi.org
Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications
Agriculture is under pressure to provide food for a growing population and the feedstock required to drive the bioeconomy. Methods to breed and genetically modify plants are inadequate to keep pace. W...
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Yolanda Schaerli @yschaerli.bsky.social · 12/04/2026
Interested in synthetic biology & microbiomes? 🧬🧫 We are recruiting a PhD student to develop biosensors to study microbe–microbe & microbe–host interactions. In beautiful Lausanne, Switzerland🏔️⛵ @dmf-unil.bsky.social @fbm-unil.bsky.social Apply by 24.05.2026 👇 shorturl.at/6X7M4 Boosts appreciated!
shorturl.at
Career Opportunities: PhD position in microbial synthetic biology (22753)
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Angel Goñi-Moreno @angelgm.eurosky.social · 07/04/2026
It's all about the Moon now, but here is the Sun from my office window this morning.
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Alex Fedorec @ajfedorec.bsky.social · 20/03/2026
Our special issue "Biology computes: Information processing across biological scales" Editorial - authors.elsevier.com/a/1moUK3si8Q... Contributions from @drmichaellevin.bsky.social, Chris Barnes, Matthias Függer, Thomas Nowak, @angelgm.eurosky.social - www.sciencedirect.com/special-issu...
sciencedirect.com
Seminars in Cell & Developmental Biology | Biology computes: information processing across biological scales | ScienceDirect.com by Elsevier
Over half a century ago, in a time of rapid advances in digital computing, Jacob and Monod’s seminal work on the lac operon was destined to be framed as biological computation. But the history of cell...
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CSIC @csic.es · 13/03/2026
🦠Un equipo del #CSIC ‘domestica’ mediante ‘computación viva’ una bacteria clave para el control de patógenos vegetales  🌱Este conocimiento es clave para la utilización de esta especie bacteriana como herramienta biotecnológica en suelos ➡️ tinyurl.com/yf7nus3r
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Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · 13/03/2026
El equipo de @angelgm.eurosky.social en el CNB-CSIC domestica P protegens, una bacteria clave para controlar patógenos vegetales con gran valor medioambiental  Más información: f.mtr.cool/ugejpdzuir Artículo en Cell Systems: f.mtr.cool/dwxrylxwkm
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Angel Goñi-Moreno @angelgm.eurosky.social · 06/03/2026
Just migrated to @eurosky.social. I guess all my data is in EU servers now. Everything else looks the same: network, apps, etc.
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Ricard Solé @ricardsole.bsky.social · 05/03/2026
Can we engineer the resilience of fragile ecosystems? In this paper with @vmaull.bsky.social @lizashpilkina.bsky.social & @vdlorenzo.bsky.social, we discuss "Emergent Bioengineering" bringing together complexity, #synbio and ecology across scales www.preprints.org/manuscript/2...
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Angel Goñi-Moreno @angelgm.eurosky.social · 05/03/2026
(1/5) As promised, here a short thread about this work. Why Pseudomonas protegens Pf-5? It is a key environmental host with unique interactions with soil’s biotic and abiotic compounds. Thus great for our Lab’s goal: ecosystems computing. We needed to know how this host interacts with circuits.
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Angel Goñi-Moreno @angelgm.eurosky.social · 27/02/2026
Latest paper out! This piece was a challenge: logic, predictability, decidability, non-model organisms, design... Kudos to @juanricomol.bsky.social & Pablo Japón #syntheticbiology #synbio #biocomputation (I'll post more on this next week) www.sciencedirect.com/science/arti...
sciencedirect.com
Dynamics of genetic circuits in Pseudomonas protegens
Genetic circuit engineering enables new cellular functions, yet most circuits are developed in the model host Escherichia coli, limiting their availab…
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Angel Goñi-Moreno @angelgm.eurosky.social · 09/02/2026
Back at the lab after a week in Copenhagen for @aliceworkshop.org! A brilliant week—full of ideas and enthusiastic colleagues. So many things to discuss with the lab now. Kudos to the organizers, and thanks for bringing this energy to #ALIFE topics.
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Angel Goñi-Moreno @angelgm.eurosky.social · 01/02/2026
On my way to Copenhagen for the ALICE workhsop @aliceworkshop.org! Discussions around #ALIFE topics for a full week — looking forward. I'll be talking about cellular computing (what else? :-)
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Angel Goñi-Moreno @angelgm.eurosky.social · 19/01/2026
New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/
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Angel Goñi-Moreno @angelgm.eurosky.social · 15/01/2026
Next in Lab's conference agenda: AI, Engineering Biology and beyond. It starts today in Bristol hosted by @chofski.bsky.social. Looks great: aiebab.github.io. From our side, @lewisgrozinger.bsky.social will be talking about our approach to the use of evolutionary algorithms for biocomputation.
aiebab.github.io
AIEBaB-2026
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Angel Goñi-Moreno @angelgm.eurosky.social · 12/01/2026
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Angel Goñi-Moreno @angelgm.eurosky.social · 12/01/2026
Just published our workflow for genotyping transposon libraries. All methods, files, scripts... are open source and publicly available. 🔗 link.springer.com/article/10.1...
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Angel Goñi-Moreno @angelgm.eurosky.social · 08/01/2026
The biological messiness, as the quantum weirdness, as a source of (unconventional) computing.
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Angel Goñi-Moreno @angelgm.eurosky.social · 08/01/2026
New paper out!📢 Exploring the computing power of microbes that shapes the environment. In this short review we talk about the "complexity gap", the distance between bottom-up genetic circuits and microbial information processes. Key questions to improve #biocomputation. 🔗 doi.org/10.1016/j.mi...
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 08/01/2026
Bacteria do compute and can be reprogrammed for new capacities—but not exactly by following Turing’s rules. Evolution, context dependence, and the soft-matter nature of living hardware redefine what computation means in biology. From @angelgm.bsky.social Lab 👉🏻 www.sciencedirect.com/science/arti...
sciencedirect.com
Exploring the computing power of microbes that shapes the environment
Microbes process input information into output responses through diverse genetic and metabolic mechanisms, effectively making them physical systems th…
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Angel Goñi-Moreno @angelgm.eurosky.social · 22/12/2025
Side story: NAND gates where one input deals directly with growth control, and it is the actual physical body doing the computation. This is our initial approach to morphological computing in living cells. #biocomputation #alife Our new strain KT-TTX is truly fascinating. Feedback welcome!
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Ángeles Hueso-Gil @angeles-hg.bsky.social · 21/12/2025
Preprint of our work tuning bacterial growth, something that changes context for genetic circuits and therefore, their behaviour. Very interesting observations from both experimental results and a model describing it in this piece of work with @mirobueno.bsky.social and @angelgm.bsky.social! :)
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Angel Goñi-Moreno @angelgm.eurosky.social · 20/12/2025
Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1
biorxiv.org
Growth control as a central regulator for tuning the cellular context
The cellular context interacts with genetic circuits, decisively defining their performance. However, contextual dependencies (the interplay between the host and the circuit) are often difficult to en...
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ALIFE Conference 2025 @alife2025.bsky.social · 04/12/2025
🔔 Exciting News from the ALIFE Community 🔔 We are pleased to share that the proceedings of ALIFE 2025, the 2025 edition of the premier conference on artificial life, held in Kyoto are now published and accessible - direct.mit.edu/isal/proceed...
direct.mit.edu
ALIFE ISAL 2025 Complete Proceedings PDF
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Angel Goñi-Moreno @angelgm.eurosky.social · 12/12/2025
This book is brilliant. Impossible to read without current scenarios in mind...
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Angel Goñi-Moreno @angelgm.eurosky.social · 12/12/2025
Huge news for #biocomputation! In a major call (€30M total) for AI proposals, Spain just funded an initiative for implementing AI with living matter using #synbio as the programming tool. The 'AI in vivo project' is a massive, official recognition of biocomputation as a leading field in computing.
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Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · 12/12/2025
2⃣ equipos #CNB participan en nuevos proyectos de investigación en #InteligenciaArtificial 'GRAINS', coordinado desde la @uc3m.es, y 'AI en vivo', coordinado por @upm.es ➡️Iniciativas subvencionadas en la convocatoria de la #AEI ( @cienciagob.bsky.social) www.cnb.csic.es/nuevos-proye... @csic.es
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Angel Goñi-Moreno @angelgm.eurosky.social · 09/12/2025
The CSIC @csic.es Doctoral Programme in #SyntheticBiology is currently offering 10 PhD positions on a number of projects. Good opportunities! syntheticcell.eu/synbio-csic-...
syntheticcell.eu
SynBio CSIC is recruiting 10 doctoral researchers
The doctoral programme in synthetic biology, run by the Spanish National Research Council, is recruiting 10 doctoral researchers
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Angel Goñi-Moreno @angelgm.eurosky.social · 05/12/2025
El disco de Ana Crismán es alucinante! Como aficionado al flamenco me ha encantado. Muy valiente, muy bonito. Como guitarrista me he quedado un poco descolocado 😅 arpaflamenca.es
arpaflamenca.es
Ana Crismán Arpa Flamenca | Única arpista flamenca en el mundo
Bienvenido a la página oficial de la arpista flamenca de Jerez Ana Crismán. Única arpista flamenca en el mundo. Informate aquí de todo lo que le acontece.
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Angel Goñi-Moreno @angelgm.eurosky.social · 01/12/2025
Our #ALIFE2025 paper is out! 🎉 We show that even when two circuits produce the same output, their evolutionary potential can differ greatly. #Evolution at the smallest scale. “Parameter Evolvability in Gene Expression Models Drives Phenotypic Adaptation” 🔗 direct.mit.edu/isal/proceed...
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Angel Goñi-Moreno @angelgm.eurosky.social · 14/11/2025
In Wikipedia, the German entry for DNA computer mentions the cellular supremacy de.wikipedia.org/wiki/DNA-Com...
de.wikipedia.org
DNA-Computer – Wikipedia
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Angel Goñi-Moreno @angelgm.eurosky.social · 11/11/2025
Next in the Lab's conference agenda: Synthetic Biology UK #SBUK. Always a target event for us! Look for Lewis @lewisgrozinger.bsky.social to hear about biocomputation and evolution: "Evolutionary algorithms to design biocomputing circuits beyond logic gates" - an upgrade of our #ALIFE 2023 story.
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