iiinova — where your digital self keeps evolving

TRAstonDrs @castltrastondrs.medsky.network · 24m

While there is life there is happiness. There is much, much before us. Leo Tolstoy Talking to myself on Sunday morning

The Northern Lights reflected in the dawn light through the window.

Scottish Highland Autumn evokes a nostalgic feeling of once being truly home.

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TRAstonDrs @castltrastondrs.medsky.network · 8h

A single photo can sometimes clear your mind and offer a glimmer of hope.

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TRAstonDrs @castltrastondrs.medsky.network · 8h

#GuillainBarrésyndrome (GBS) can be triggered by several viral and bacterial pathogens that induce peripheral nerve damage through immune-mediated mechanisms such as molecular mimicry link.springer.com/article/10.1... link.springer.com/chapter/10.1... www.researchgate.net/publication/...

Representation of molecular mimicry, pathophysiological mechanism of GBS. The pathophysiology of GBS is evidenced by the mechanism of molecular mimicry, in which the virus shares epitopes common to neuron components, such as the myelin sheath and axonal lining. Thus, direct virus infection triggers the activation of the immune system and APC precursor cells, which differentiate into T and B lymphocytes. Also, the viral epitope is recognized by the B lymphocyte and the T lymphocyte releases isoleucine such as IL-6 and interleukin 4 (IL-4), in addition to cytokines such as TNF-α and interferon-gamma (IFN-γ) for macrophage activation, triggering local inflammation that can be exacerbated. Thus, there is the production of antibodies (ANTI-GM1) to attack the virus, however, by sharing epitopes, these antibodies also attack components of the neuron. The recruitment of more macrophages increases inflammation, as well as the performance of the microglia that release cytokines such as IFN-γ and interleukin 1 beta (IL-1β). Finally, the neuron is in hyperinflammation and operates with its reduced functionality or loses it definitively, being able to suffer cell death and causing irreversible damage to the patient with this syndrome

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TRAstonDrs @castltrastondrs.medsky.network · 19h

Distance brings sweetness. Absence tames what is near. Christian Bobin

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TRAstonDrs @castltrastondrs.medsky.network · 20h

By establishing a clear microbiome-immune axis, study found that baseline characteristics of your gut bacteria before receiving a 💉 dictate how strongly your body reacts with inflammatory side effects, without impacting the vaccine's protective antibody boost

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TRAstonDrs @castltrastondrs.medsky.network · 10/10/2026

I’m torn between living in a castle and an eco-friendly nurturing house where the river run . Which is the better move? Sometimes the decision is difficult…

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TRAstonDrs @castltrastondrs.medsky.network · 10/10/2026

I will be there to raise the wind. Think it over carefully and then make room for feeling. Pino Daniele

The view from the window on a crisp autumn morning.

A garden filled with autumn spices and a cosy ☕️.

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TRAstonDrs @castltrastondrs.medsky.network · 09/10/2026

🧬The virological profile of PJ.2.1 is characterized by an exceptional binding strength to host cell receptors coupled with a unique structural vulnerability to antibodies

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TRAstonDrs @castltrastondrs.medsky.network · 08/10/2026

We must have felt what it is to die, Morrel, that we may appreciate the enjoyments of life. Live, then, and be happy all human wisdom is contained in these two words, “ Wait and Hope.” By Alexandre Dumas Good Morning - Oxford 🇬🇧51.764° N , -1.258° W

A morning run bathed in the golden glow of the sunrise.

The autumn sun reflects the vibrant colours of life.

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TRAstonDrs @castltrastondrs.medsky.network · 08/10/2026

There is neither happiness nor misery in the world; there is only the comparison of one state with another, nothing more. He who has felt the deepest grief is best able to experience supreme happiness.

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TRAstonDrs @castltrastondrs.medsky.network · 07/10/2026

And you'll also learn to listen to yourself, to value yourself, to love yourself. So, be kind to yourself, and savour the beauty of the world! Guy Gilbert

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TRAstonDrs @castltrastondrs.medsky.network · 07/10/2026

You'll learn that the world is magnificent if you know how to contemplate it; that nature brings joy if we respect it and work in harmony with it; that humans are fascinating, that they deserve our attention, within the family, at work, in the circle of our friends

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TRAstonDrs @castltrastondrs.medsky.network · 07/10/2026

We don't look anymore, we channel-surf. We don't live anymore, we just get by… It's urgent to make time for slowness. Refuse the rush, keep time for yourself.

Nice tried to sing along… Simba with his basses cracking bark…

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TRAstonDrs @castltrastondrs.medsky.network · 05/10/2026

This may look counter intuitive in a culture where " moving on" is celebrated as the antidote to all of our travails, yet very profound and deep...we are not machines to be reset by a switch and can start anew on a clean slate all over again every single time,

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TRAstonDrs @castltrastondrs.medsky.network · 04/10/2026

With no destination, every step is arrival….

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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026

Carl Jung ✍🏼 by Syed sketch stories

Carl Jung quoted & ✍🏼 by Syed sketch stories

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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026

When your morale is low, when the day seems dark, when work becomes monotonous, when hope is nowhere to be found, climb onto a bicycle and ride without thinking of anything else but the path you're taking. Arthur Conan Doyle 🍂 music.apple.com/au/album/aut...

Autumn colours, apple and spice reminiscent of a mountain watery pie.

Autumn leaves …
https://music.apple.com/au/album/autumn-leaves/724184066?i=724184803&l=en-GB

The cold and chilly air awakens the souls.

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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026

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TRAstonDrs @castltrastondrs.medsky.network · 01/10/2026

What once existed is taken apart, not to be preserved, but to be understood. This is not reuse. It is re-authorship. Between structure and collapse, past and present. No fixed identity. No fixed form. Only what becomes….

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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026

Let me sit here, on the threshold of two worlds. Lost in the eloquence of silence Rumi

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TRAstonDrs @castltrastondrs.medsky.network · 29/09/2026

The available summary does not list more specific adverse event categories beyond these two outcomes

SAPPHIRE found that giving more antimicrobial prophylaxis doses during surgery did not reduce 30-day surgical site infections, but it did increase antimicrobial side effects and other postoperative complications in a dose-related way

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TRAstonDrs @castltrastondrs.medsky.network · 29/09/2026

It doesn't matter how many languages you speak, speaking the language of the heart is what matters. Rumi Just be kind today

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TRAstonDrs @castltrastondrs.medsky.network · 29/09/2026

pmc.ncbi.nlm.nih.gov/articles/PMC... Beyond major developmental diagnoses, congenital TORCH infections are linked to poorer academic performance later in life, indicating they can cause more subtle, long-term cognitive differences.

BS: brainstem; BG: basal ganglia; CC: corpus callosum; CH: cerebellar hypoplasia; CHD: congenital heart defect; CR: chorioretinitis; HSM: hepatosplenomegaly; ICH: intracranial hemorrhage; IUGR: intrauterine growth restriction; IVH: intraventricular hemorrhage; SNHL: sensorineural hearing loss; ON: optic nerve atrophy; PMG: polymicrogyria; PV: periventricular; SC: subcortical; TMP-SMX: trimethoprim-sulfamethoxazole; VM: ventriculomegaly

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TRAstonDrs @castltrastondrs.medsky.network · 28/09/2026

If everything around you is looking dark, look again, you might be the light… Rumi

The morning light reflected on the loch.

The morning light, the autumn sky and the perspective.

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TRAstonDrs @castltrastondrs.medsky.network · 27/09/2026

- Structured Pulmonary Rehabilitation A gradual, tailored physical therapy program focusing on diaphragmatic breathing, core stabilization, and autonomic conditioning helps re-train the body to handle orthostatic stress without triggering a respiratory mismatch

Summary Comparison: Orthostatic Markers in Long COVID

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TRAstonDrs @castltrastondrs.medsky.network · 27/09/2026

The world exists as you perceive it. It is not way you see, it is how you see it. Rumi

Captured the moon from the window last night

After a 526-miles drive from 🏴󠁧󠁢󠁳󠁣󠁴󠁿 to Oxford, the view of the sky is incredibly rewarding. It’s a welcome sight and a worthy reward for the journey home.

A brilliant luminous view makes you realise nature has much to offer.

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TRAstonDrs @castltrastondrs.medsky.network · 26/09/2026

As I walk’d by myself, I said to mysel,And myself said again to me; Look weel to thyself, or not to thyself, There's nobody cares for thee… Robert Burns Cloncaird Castle, a 16th-century in the middle of nowhere. As I Walk to reflect

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TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026

I gorge myself on dreams of stories and secrets… Nothing remains as it is it changes, and me with it Rose Ausländer

The vibrant colours of water lily leaves are on full display.

An evening in the woods as the sun sets.

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TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026

link.springer.com/article/10.1... www.jthjournal.org/article/S153... @nature.com www.nature.com/articles/s41... LC diagnostic marker; the strongest links are indirect and cluster around endothelial injury, thromboinflammation, immune dysregulation & lncRNA/ceRNA regulation of Hippo components

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TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026

& laying the groundwork for liver cirrhosis and cancer progression. 🔥In context of #LongCovid The #Hippopathway is plausibly relevant to both viral infection & LC, but the evidence is strongest for acute host–virus interactions and tissue repair rather than for a direct,

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TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026

those co-activators travel to the nucleus to trigger gene transcription . In the context of a viral infection, the pathway functions like a tug-of-war. The upstream elements generally fight the virus, while downstream elements suppress immunity or are hijacked by the virus

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TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026

Having driven about 500 miles, the view is definitely worth it. Castle in the woods

Water lily is still striving in the autumn

The water lilies reflect the copper and spice hues of autumn. It’s quite different from typical English autumn – far too warm!

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TRAstonDrs @castltrastondrs.medsky.network · 19/09/2026

The best way out is always through. – Robert Frost It’s time to go off grid and time for pause ,to reflect and debrief…

Seeing life through the patterns of autumn fields

A familiar longing for home on my mountain bike…

Sunlight streams through the mountain chasm.

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TRAstonDrs @castltrastondrs.medsky.network · 17/09/2026

Reality, with its unpleasant sides, one cannot deny it. Perhaps there is, nevertheless, a way to “turn it around” to see it differently In a better light... any given morning in September

Life begins with the reflection of the sun

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TRAstonDrs @castltrastondrs.medsky.network · 17/09/2026

#Medsky🧪 #Neurosky #publichealth In a 2025 @sciimmunology.bsky.social Review, The study discussed how interactions between the nervous and immune systems could impact neurological disorders and allergy-related behaviors like food avoidance. www.science.org/doi/10.1126/...

Fig. 1. Interactions between the nervous system and type 2 immunity occur across multiple organs depending on the context of allergic triggers or injury.
The nervous system comprises the CNS and associated sensory nerves (blue) and the autonomic nervous system, which includes sympathetic and parasympathetic nerves (red) and the ENS (purple). The immune system is composed of cells that span the entire body. This includes the meningiocranial immune system, which comprises immune cells important for neural development, brain repair, and brain border protection. Repeated exposure to allergens at mucosal sites (for example, lung, skin, and gut) can trigger local type 2 immunity. Type 2 immune cells signal to neurons across the periphery and brain through cytokines, whereas neurons signal to immune cells via neurotransmitters and neuropeptides. This is not an exhaustive list of cellular players, given that other tissue resident cells (e.g., fibroblasts and glial cells) may also respond to these signals.
CREDIT: A. FISHER/SCIENCE IMMUNOLOGY

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TRAstonDrs @castltrastondrs.medsky.network · 16/09/2026

Imagine if time all happened at once. Every moment of your life laid out around you... Time is a structure relative to ourselves... Time is the space made by our lives Doctor Who

The flower of time in equilibrium.
Morning run in September

Autumn is a second spring when every leaf is a flower
Albert Camus
As the autumn morning leaves display their copper and spice hues, it’s time for a chai latte.

The passage of time
Any given September morning

The web of time
Our lives are significant precisely because they are woven into a finite timeline. Because we are ephemeral, the moments we choose to create our triumphs, heartbreaks, and everyday experiences become permanent, unerasable architecture in the history of the universe
Sean Carroll

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TRAstonDrs @castltrastondrs.medsky.network · 16/09/2026

The same with my coco the dog .Cat & dog have the same cute habits when you started to scratch them then you have the job for life❣️

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TRAstonDrs @castltrastondrs.medsky.network · 15/09/2026

Slowly fades the summer's light; Leaf falls upon leaf; following the day The day slips into the past. Victor Hugo

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TRAstonDrs @castltrastondrs.medsky.network · 14/09/2026

#Medsky🧪 #IDsky #episky #publichealth #Vaccinesmatter @ecdc.europa.eu Overview of respiratory virus epidemiology in the EU/EEA, week 35, 2026 and the surveillance on recent increases are observed in #SARSCoV2 and #influenzavirus circulation.

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TRAstonDrs @castltrastondrs.medsky.network · 14/09/2026

If they saw me standing still, in the midst of my flowers, as in this instant, they would think that I am giving them a lesson. But instead it is I who listens and they who speak. There, in the midst of them, they teach me light… Nikiforos Vrettakos Colour of the morning

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TRAstonDrs @castltrastondrs.medsky.network · 13/09/2026

May every sunrise hold more promise and every sunset hold more peace. Umair Siddiqui.

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TRAstonDrs @castltrastondrs.medsky.network · 13/09/2026

#Medsky🧪 #Neurosky #publichealth this report 69.3% 20-year dementia incidence in a parkinsonism cohort (67.8% in Parkinson’s disease), @braincomms.bsky.social academic.oup.com/braincomms/a...

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TRAstonDrs @castltrastondrs.medsky.network · 13/09/2026

Knowing how to maintain the right balance between solitude and people, that's the key, that's the tactic, to avoid ending up in the madhouse. Charles Bukowski. Taking a Sunday break with music 🎼, coffee & 💤 music.apple.com/au/album/eri... Another incredible 4 seasons in the morning

The warm, sweet musky scent of the rain and the ground fills my nostrils. A view from the window.

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TRAstonDrs @castltrastondrs.medsky.network · 13/09/2026

alongside more stable T cell immunity and measurable antibody-T cell associations. iro.uiowa.edu/esploro/outp... scholarship.miami.edu/esploro/outp... @nejm.org www.nejm.org/doi/full/10.... www.cochranelibrary.com/cdsr/doi/10....

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TRAstonDrs @castltrastondrs.medsky.network · 13/09/2026

helps preserve protection as antibodies wane . The strongest link between the two is not that they decay at the same rate, but that better helper T cell responses are associated with stronger and more durable antibody responses. multiple independent studies consistently show

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TRAstonDrs @castltrastondrs.medsky.network · 13/09/2026

www.mdpi.com/2076-393X/13... www.mdpi.com/2076-393X/11... Multiple independent longitudinal studies and one meta-analysis agree on higher/higher-breadth responses with prior infection plus vaccination, while the exact effect on waning rate is more mixed.

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TRAstonDrs @castltrastondrs.medsky.network · 13/09/2026

the main difference is that hybrid immunity often starts higher and is sometimes more durable, although one meta-analysis found waning rates were broadly similar once peak levels were accounted for. www.nature.com/articles/s41... link.springer.com/article/10.1... www.cell.com/immunity/ful...

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TRAstonDrs @castltrastondrs.medsky.network · 13/09/2026

This extends the earlier pattern as discussed that antibody levels are higher soon after boosting & then fall over time www.frontiersin.org/journals/pub... www.sciencedirect.com/science/arti... www.mdpi.com/2076-393X/10... www.nature.com/articles/s41... www.frontiersin.org/journals/pub...

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