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TRAstonDrs

@castltrastondrs.medsky.network
10K followers 1.9K following 21K posts

"Not all those who wander are lost" JR Tolkien #Clinicalresearcher #DrugDevelopment #Clinicaltrials & Registration 🧬🔬📚🔎🦠🧫 📌 Melbourne 🇦🇺 Oxford 🇬🇧& 🏴󠁧󠁢󠁳󠁣󠁴󠁿 #MedSky🧪

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TRAstonDrs @castltrastondrs.medsky.network · 21h
while the specific genetic lineage or strain variation of the Mycobacterium tuberculosis (Mtb) bacterium plays no significant role in predicting poor treatment outcomes for drug-susceptible cases www.researchgate.net/publication/... pmc.ncbi.nlm.nih.gov/articles/PMC...
researchgate.net
Blood transcriptomic signatures predict poor outcomes in drug-susceptible pulmonary TB in Brazil | Request PDF
Request PDF | Blood transcriptomic signatures predict poor outcomes in drug-susceptible pulmonary TB in Brazil | Background Non-sputum biomarkers to monitor tuberculosis treatment and predict poor out...
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TRAstonDrs @castltrastondrs.medsky.network · 21h
evidence from RePORT-Brazil" In drug-susceptible pulmonary TB, host-related factors, rather than Mtb lineage, were more strongly associated with unfavorable treatment outcomes. Individual patient characteristics (host factors) are the primary drivers of #tuberculosis treatment success or failure,
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TRAstonDrs @castltrastondrs.medsky.network · 21h
#Medsky🧪#iDsky #publichealth The core finding of these studies- Host factors, not #Mycobacteriumtuberculosis lineage, predict unfavorable outcomes in drug-susceptible #pulmonarytuberculosis: www.sciencedirect.com/science/arti... link.springer.com/article/10.1...
link.springer.com
Predictors of unsuccessful tuberculosis treatment outcomes in Brazil: an analysis of 259,484 patient records - BMC Infectious Diseases
Introduction Tuberculosis (TB) causes over 1 million deaths annually. Providing effective treatment is a key strategy for reducing TB deaths. In this study, we identified factors associated with unsuc...
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TRAstonDrs @castltrastondrs.medsky.network · 22h
we will always the product of our composite lived experiences, the sooner we acknowledge this truth, the better.
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TRAstonDrs @castltrastondrs.medsky.network · 22h
This may look counter intuitive in a culture where " moving on" is celebrated as the antidote to all of our travails, yet very profound and deep...we are not machines to be reset by a switch and can start anew on a clean slate all over again every single time,
Between light & dark
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TRAstonDrs @castltrastondrs.medsky.network · 22h
How can I begin anything new with all of yesterday in me? Leonard Cohen, Beautiful Losers
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TRAstonDrs @castltrastondrs.medsky.network · 04/10/2026
With no destination, every step is arrival….
Sunday morning runs Here comes the sunAny given day An autumn morning warms your heart.
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
Steal a little, and they put you in jail. Steal a lot, and they make you king. Bob Dylan
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
No, actually Sir Arthur Conan Doyle (1859–1930) a prolific British writer and physician, globally revered as the creator of the canon of Sherlock Holmes consists of the 56 short stories & 4 novels & Sherlock Holmes history's most celebrated consulting detective.
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
Carl Jung ✍🏼 by Syed sketch stories
Carl Jung quoted &  ✍🏼 by Syed sketch stories
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
The first panacea for a mismanaged nation is inflation of the currency; the second is war. Both bring a temporary prosperity; both bring a permanent ruin. But both are the refuge of political and economic opportunists. Ernest Hemingway
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
You fear losing what was never yours. Nothing belongs to you but your journey. Shams Tabrizi
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
When your morale is low, when the day seems dark, when work becomes monotonous, when hope is nowhere to be found, climb onto a bicycle and ride without thinking of anything else but the path you're taking. Arthur Conan Doyle 🍂 music.apple.com/au/album/aut...
Autumn colours, apple and spice reminiscent of a mountain watery pie.Autumn leaves …
https://music.apple.com/au/album/autumn-leaves/724184066?i=724184803&l=en-GBThe cold and chilly air awakens the souls. Autumn colours of the morning
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
When your morale is low, when the day seems dark, when work becomes monotonous, when hope is nowhere to be found, climb onto a bicycle and ride without thinking of anything else but the path you're taking. Arthur Conan Doyle 🍂 music.apple.com/au/album/aut...
Autumn colours, apple and spice reminiscent of a mountain watery pie.Autumn leaves …
https://music.apple.com/au/album/autumn-leaves/724184066?i=724184803&l=en-GBThe cold and chilly air awakens the souls. Autumn colours of the morning
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
A new review @science.org argue that menopause research needs a major rethink, shifting from a one-size-fits-all view of the transition to a precision medicine approach that accounts for differences in symptoms, timing, genetics and hormone treatments.
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
research on strategies for menopause symptom management and optimizing health in the #postmenopausal period is lacking . Menopause research has historically been underfunded and understudied, despite its enormous impact on half of the human population
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TRAstonDrs @castltrastondrs.medsky.network · 03/10/2026
#Medsky🧪 #womenhealth #Menopause is an important biological transition with up to 72 symptoms that shapes aging trajectories across organs and encompasses ~40% of the female lifespan. Although menopause awareness is increasing, www.science.org/doi/10.1126/...
science.org
Reframing menopause and menopause hormone therapy as opportunities for healthy aging
Menopause is an important biological transition with up to 72 symptoms that shapes aging trajectories across organs and encompasses ~40% of the female lifespan. Although menopause awareness is increas...
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TRAstonDrs @castltrastondrs.medsky.network · 02/10/2026
Personal Boundaries Matter Well done you …
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TRAstonDrs @castltrastondrs.medsky.network · 02/10/2026
and more missed opportunities to stop contaminated produce from reaching more people Confidence level: Medium-High — the case for surveillance fragility is strong and internally consistent, but the evidence is indirect because no retrieved source directly studies CDC cuts & cyclosporiasis together.
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TRAstonDrs @castltrastondrs.medsky.network · 02/10/2026
If CDC resources are cut, the likely consequence is not just fewer data points, but slower recognition of clusters, weaker linkage across states,
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TRAstonDrs @castltrastondrs.medsky.network · 02/10/2026
delayed detection and poor recall make community outbreaks harder to solve CDC-developed genotyping systems improve cluster detection and source linkage, but the literature still describes major gaps in standardized molecular epidemiology and timely strain-level comparison
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TRAstonDrs @castltrastondrs.medsky.network · 02/10/2026
Large multistate outbreaks have repeatedly been tied to imported or domestic produce, including raspberries, basil, salad mix, cilantro, lettuce, green onions, and sugar snap peas. Outbreak investigations are more effective when laboratory testing, reporting, and collaboration happen quickly;
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TRAstonDrs @castltrastondrs.medsky.network · 02/10/2026
and is exactly the kind of foodborne parasite outbreak where CDC capacity matters disproportionately with Ineffective response depends on rapid surveillance plus molecular and traceback work @lancetgastrohep.bsky.social www.thelancet.com/journals/lan...
thelancet.com
Cyclosporiasis and CDC cuts: the perfect storm
The 2026 US outbreak of cyclosporiasis, linked to iceberg lettuce sourced from central Mexico, has become the largest ever recorded in the country. At the time of writing, the US Centers for Disease C...
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TRAstonDrs @castltrastondrs.medsky.network · 02/10/2026
#Medsky🧪 #IDsky #microsky #publichealth #cytosporiasis Cyclosporiasis already poses a surveillance challenge because outbreaks are seasonal, often linked to fresh produce, and frequently require rapid epidemiologic and traceback work to identify the source
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TRAstonDrs @castltrastondrs.medsky.network · 02/10/2026
#Medsky🧪 #Microsky #immunosky #publichealth The autoimmune regulator (Aire) promotes #Tcell tolerance through promiscuous #geneexpression in medullary thymic epithelial cells, but growing evidence points to additional roles beyond thymic tolerance @cellpress.bsky.social www.cell.com/immunity/ful...
cell.com
Aire is a cell-intrinsic regulator of natural IgM-secreting cells
The autoimmune regulator (Aire) promotes T cell tolerance through promiscuous gene expression in medullary thymic epithelial cells, but growing evidence suggests that it has functions beyond its canon...
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TRAstonDrs @castltrastondrs.medsky.network · 01/10/2026
What once existed is taken apart, not to be preserved, but to be understood. This is not reuse. It is re-authorship. Between structure and collapse, past and present. No fixed identity. No fixed form. Only what becomes….
1st OCT , looking forward…
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TRAstonDrs @castltrastondrs.medsky.network · 01/10/2026
Fascism is cured by reading, and racism is cured by traveling. Miguel de Unamuno
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TRAstonDrs @castltrastondrs.medsky.network · 01/10/2026
And those traits we detest, sharpness, greed, acquisitiveness, meanness, egotism and self-interest, are the traits of success. And while men admire the quality of the first they love the produce of the second. John Steinbeck
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TRAstonDrs @castltrastondrs.medsky.network · 01/10/2026
It has always seemed strange to me. The things we admire in men, kindness and generosity, openness, honesty, understanding and feeling, are the concomitants of failure in our system.
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TRAstonDrs @castltrastondrs.medsky.network · 01/10/2026
Every man is a creature of the age in which he lives and few are able to raise themselves above the ideas of the time. Voltaire
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Reposted by TRAstonDrs
European Medicines Agency @ema.europa.eu · 30/09/2026
🧪 EMA will develop a roadmap by end-2026 to drive change in how women’s health is considered in medicines development and regulation. It follows a workshop with 100+ experts and stakeholders. Read more: www.ema.europa.eu/en/news/wome... #medsky #womenshealth
ema.europa.eu
Women are missing from medicines development: EMA’s roadmap for change | European Medicines Agency (EMA)
10 priorities proposed to drive change in medicines for women’s health
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
Let me sit here, on the threshold of two worlds. Lost in the eloquence of silence Rumi
The park & moring
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
Colours of the morning
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
This, in turn, can further exacerbate BBB disruption and neuronal injury in the context of distinct acute neurological manifestations, especially encephalopathy and inflammatory neurological diseases (IND).
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
These factors may lead to microglial and astrocyte activation, particularly in cases of acute neuroinflammatory syndromes and encephalopathy. The findings support a pathophysiological model where neuroinflammatory processes contribute to a CNS cytokine storm and/or immune cell trafficking.
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
🔥 The study concluded that systemic inflammation in COVID, coupled with the activation of the complement cascade in CNS, is associated with altered markers of endothelial activation and BBB disturbances.
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
The inclusion of uninfected controls allowed for the identification of biological processes specifically associated with neurological manifestations in acute neuroCOVID, by providing a baseline for comparison.
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
Extensive Prior Data: The study was supported by extensive prior data on biomarkers of inflammation and neuronal damage, providing a strong foundation for the current research. Inclusion of Uninfected Controls:
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
🔥 The study highlighted several strengths that contribute to the robustness and significance of its findings: Comprehensive Investigation: It involved a comprehensive investigation of neuroinflammation in a well-characterized cohort of patients with diverse neurological outcomes.
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
of their conditions or the development of LC conditions, which could help identify early disease biomarkers. Unadjusted Patient Groups: Patient groups could not be adjusted for age, sex, and underlying clinical conditions, which might act as potential confounders.
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
The study did not include consecutive CSF and serum samples, which could provide insights into disease progression. No Long-Term Follow-up: There was no long-term follow-up of #neuroCOVID patients to determine the resolution
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
Data Variability: There was variability in the collected data. Limited CSF Volume: The available CSF volume was insufficient to perform validation assays for all proteomic findings. Lack of Consecutive Samples:
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
The study acknowledged several limitations beyond the challenge of definitively attributing proteins to specific brain regions or cell types: Small Sample Size: The study involved a limited number of participants.
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
This indicates that while the mapping analysis can associate proteins with certain regions or cell types based on RNA expression data, it cannot definitively confirm the exact cellular or anatomical origin of the proteins found in the CSF without further experimental validation.
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
when mapping CSF proteins to CNS regions and resident cell types. The paper states that "definitive attribution of these proteins to their specific sources requires labeling experiments that can differentiate proteins based on their cellular or anatomical origins."
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
🔥These findings suggest that the choroid plexus is a critical site where systemic inflammation can impact the CNS, contributing to the diverse neurological outcomes observed in #neuroCOVID. The study acknowledges a limitation regarding the definitive attribution of proteins to their specific sources
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
Such dysfunction can lead to altered immune cell trafficking and exposure of the CNS to circulating inflammatory mediators, contributing to neurological manifestations like encephalopathy and IND.
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
suggests a disruption in the normal function of the choroid plexus, which is crucial for maintaining the integrity of both BBB and the blood-CSF barrier.
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
🔥 Increased choroid plexus volume in neuro-COVID-19 patients is significant because it reflects Central Nervous System (CNS) inflammation and barrier dysfunction. This finding, observed in patients with parainfectious neurological alterations,
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TRAstonDrs @castltrastondrs.medsky.network · 30/09/2026
at the CSF-brain interface by 🦠 has also been demonstrated. Cellular Changes: Single-cell RNA sequencing (scRNA-seq) analysis of COVID patients identified an increased proportion of stromal cells, monocytes, and macrophages in the choroid plexus.
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