iiinova — where your digital self keeps evolving

Cassie Manrique @cassiemanrique.bsky.social · 02/12/2025

Thank you to everyone who attended my Developmental Biology Department colloquium talk yesterday! I thoroughly enjoyed talking about my work comparing two muscle stem cell models, and I appreciate everyone’s interest, questions, and feedback. Looking forward to more talks in the future! 💪 🧫

Cassie, a white brunette female, is standing behind a brown podium. Behind her is an immunofluorescence image of skeletal muscle cells in culture. The title of her talk is “Cell Origin Dictates Skeletal Muscle Maturity In Vitro”

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Cassie Manrique @cassiemanrique.bsky.social · 19/11/2025

I had a great time attending and presenting my work at the MSK Center for Epigenetics Research Symposium! Thank you to everyone who stopped by my poster to chat, as well as the organizers for hosting such a successful event, and my mentors for all their guidance. 🧬 Hope to do this again next year!

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Cassie Manrique @cassiemanrique.bsky.social · 17/09/2025

If you see this, quote with the energy you bring to Bluesky. (Like Freckles, I prefer lurking from the comfort of a pile of blankets)

Freckles, a brown tabby cat, is snuggled under a soft grey blanket. Her head rests on the corner of an open silver MacBook with the screen off. She appears content.

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Cassie Manrique @cassiemanrique.bsky.social · 17/09/2025

Initial reaction to MacOS Tahoe: not a fan. “Liquid glass”? I just want decently high contrast icons, etc., not a bunch of weird rounded edges and bubbles. It looks pretty, but I don’t need my computer to be pretty, I need it to be easy to use quickly and efficiently. /rant

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Dr Sian Gramates @drglam.bsky.social · 11/08/2025

I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.

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Jess McLaughlin, PhD (they/them) @jfmclaughlin92.bsky.social · 04/08/2025

okay y'all, i'm compiling a list of suggested readings for students in my Biology, Society and Culture class to use as a starting point for choosing papers for our weekly discussions. i obvs have a long list, but always looking for more suggestions! here's the weeks i need suggestions for:

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Ming Tommy Tang @tommytang.bsky.social · 20/07/2025

1/ No, you do not always need single-cell RNA-seq. Here's why bulk RNA-seq might still be the smarter move for your experiment.

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Cassie Manrique @cassiemanrique.bsky.social · 04/07/2025

Happy Gotcha Day to my best feline friend, Freckles. 🍓 When I adopted her 4 years ago, the closest she would get is sitting on a designated pillow on the couch. Now, she’s my cuddle buddy; most nights she’s asleep on top of my head on “our” pillow, 💕 But she still yells at me if I’m home too late 😆

Four images of a tabby cat named Freckles. In the top left, she is lying down on a grey pillow. She is quite small. In the top right, she is sitting on the kitchen floor with her mouth open like she is yelling. In the bottom left, she is grown up and wearing a strawberry collar. Cassie, a brunette woman with glasses, is peering over from behind Freckles. In the bottom right, Freckles is lying down with a paw out, looking at the camera.

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Cassie Manrique @cassiemanrique.bsky.social · 02/07/2025

Freckles has chosen to demonstrate a left-sided sleeping position! (She often alternates between sides)

Freckles, a dark brown tabby cat, is lying on her side showing off her soft, light brown belly and black toe beans. She is asleep, lying on her left side on a pink blanket.

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Jeremy Yoder says no war @jbyoder.org · 01/07/2025

Cannot emphasize enough that, if you dislike doing the things academics do (reading, writing, developing and expressing opinions about things you've read) enough to try to make a chatbot do them for you, there are lots of actual humans who would be happy to take that unpleasant job off your hands

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Cassie Manrique @cassiemanrique.bsky.social · 24/06/2025

So thankful to have spent the past week in Puerto Rico at #2025ICDB #2025SDB! 🌴 This was my first conference outside of NYC, and it was great to hear from so many renowned developmental biologists and receive feedback on my research.

Cassie, a short brunette, is wearing a bright pink linen dress with her hair pulled back in a clip. She is wearing glasses and a lanyard with her name. She is smiling and standing in front of a pixelated scientific poster with the title “Multi-Omic Analysis to Identify Barriers to hPSC-derived Skeletal Muscle Maturation”. The title is white font on a sky blue background.

A photograph of the ocean of El Escambrón beach in San Juan, Puerto Rico. The sky is partially cloudy and light blue. The ocean is a blue-green color with a few peaceful waves. In the background are palm trees.

A photograph over a cliff near the fortress Bastión de San Sebastian in San Juan, Puerto Rico. The grass of the cliff is a vibrant green with dark green foliage. The sky is clear and a pale blue. The ocean is calm and a medium blue color. The edge of the brick fortress is barely visible along the right edge of the photograph.

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Christian Mosimann @chrmosimann.bsky.social · 19/06/2025

PSA: around 5-8% of the population has a color vision impairment for red/green. Many talks at #2025ICDB still use red-green LUTs on slides that are not accessible to everyone. Changing to more accessible colors is doable and easy. We can do better. #devbio #ICDB2025 #WeTheColorBlind

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Cassie Manrique @cassiemanrique.bsky.social · 19/06/2025

So excited to be in Puerto Rico for #2025ICDB #2025SDB! Come visit me at my poster (#C36) Saturday to hear about multi-omic sequencing to mature hPSC-derived skeletal muscle, and see my lab mate and friend Isabelle’s talk (session 4.1) on lamin B loss in muscle nuclei! 💪

A selfie of Isabelle and Cassie, two young adult women, sitting in front of steps in Old San Juan. Both are smiling at the camera.

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Cassie Manrique @cassiemanrique.bsky.social · 10/06/2025

Freckles would like to remind everyone to VOTE in your local elections! 🗳️ They might not be as publicized as federal elections, but local and state elections influence your schools, taxes, infrastructure, and more.

Freckles, a brown tabby cat, is standing on a pink bedspread with her front paws on a sealed early voting ballot envelope. Her mouth is open, like she is talking to the screen. She is also wearing a pink strawberry collar charm.

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Scott Delaney @scott-delaney.bsky.social · 14/05/2025

My ongoing request: If your NSF or NIH grant was terminated--whether at Harvard or elsewhere--please report it here. NSF: grant-watch.us/submit-nsf.h... NIH: grant-watch.us/submit-nih.h... Our trackers are actively used in lawsuits and are often the only record that terminations ever occurred.

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Jeff Vierstra @jeffvierstra.bsky.social · 13/05/2025

PSA: We just finished processing nearly all public ATAC-seq datasets from SRA (about 22,000 datasets). (Not?) Surprisingly, we had to throw-out nearly ~50% because they were low-quality (low signal-to-noise, duplicate rate, etc.). Check quality before analysis (TSS-enrichment is not sufficient!).

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Cassie Manrique @cassiemanrique.bsky.social · 06/05/2025

The basic subunit of chromatin, the nucleosome, consists of a segment of DNA wrapped around eight HISStone proteins 🐱

A schematic of the nucleosome, but the core histone proteins are replaced with four tabby cats in circular formation. The histone tails are represented by lines coming out of each histone or tabby cat, with letters indicating the amino acids and their modifications.

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Andrea Love, PhD | Biomedical Scientist @drandrealove.bsky.social · 05/05/2025

Which FDA-approved vaccines had randomized, placebo-controlled trials? ALL OF THEM. Polio? Measles, mumps, rubella? Haemophilus influenzae B? Diphtheria, tetanus, pertussis? Meningococcus? Varicella? Pneumococcus? Rotavirus? RSV? Hepatitis B? Influenza? HPV? COVID-19? Shingles? YEP. A thread🧵 1/

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Caroline Bartman @cbartman.bsky.social · 02/05/2025

The average American has 3 friends

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Scott Delaney @scott-delaney.bsky.social · 04/04/2025

An important point getting overlooked: When NIH cancels "diversity" grants (e.g., diversity supplements, Fs, Ks, etc), they aren't canceling the grants based on *what* the grant studies. They're cancelling them based on *who* is doing the research. And that disallowed "who" is anyone not white.

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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 28/04/2025

Live thread on @60minutes.bsky.social coverage of #NIH. First, it’s ironic that one of the first commercials was for Keytruda, the cancer therapy developed with heavy NIH investment over decades. Without NIH, there would be no Keytruda. 1/ 🧵

KEYTRUDA IS AN IMMUNOTHERAPY
KEYTRUDA®
Need help with medication costs?
Visit keytruda.com or call 855-257-3932

Keytruda commercial

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Thanh Neville, MD, MSHS @thanh-neville.bsky.social · 15/04/2025

I'm sorry, but rich, privileged women going on a space fieldtrip is not inspiring. The people are who ARE inspiring are the hardworking women working in STEM. You know, the ones who are at risk of losing their jobs and grants. #SaveOurScience

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Molly Schumer @mollyschumer.bsky.social · 15/04/2025

Does anyone know what software/packages generate these nice color-coded visualizations of structural rearrangements (this one from Jeong et al. 2025 Nature Genetics)?

Plot of chromosome alignments from recent paper

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Jason Koebler @jasonkoebler.bsky.social · 04/04/2025

Petabytes of critical government research that is marked for possible deletion cannot be archived because of technical and legal restrictions, meaning it is very likely to be lost forever: www.404media.co/nih-archives...

404media.co

Massive, Unarchivable Datasets of Cancer, Covid, and Alzheimer's Research Could Be Lost Forever

Days before Robert F. Kennedy Jr. announced that 10,000 HHS staffers would lose their jobs, a message appeared on NIH research repository sites saying they were "under review."

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Tyler, from the Internet (Haunted) @tylerfromtheinternet.com · 04/04/2025

we need a totally revised constitution and I think we should call it the Consti2tion

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Jess McLaughlin, PhD (they/them) @jfmclaughlin92.bsky.social · 17/03/2025

I'm not a "we should teach every kid to code" person but dear lord can we at least teach basic computational concepts or something, this is *embarrassing*

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Cassie Manrique @cassiemanrique.bsky.social · 13/03/2025

My F31 diversity keeps getting unassigned and reassigned and unassigned to study section… all this limbo is so nerve wracking (especially for young scientists whose first experience with funding submissions and the NIH is *this*).

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Better Things Are Possible @internethippo.bsky.social · 22/02/2025

TO: <ALL STAFF> Please respond to this email confirming that I am cool and funny. Failure to do so will be taken as confirmation of the same.

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Jeremy Berg @jeremymberg.bsky.social · 15/02/2025

ATTENTION (PLEASE SHARE) If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread. There are lots of talented and accomplished people who may be looking for new opportunities.

media.tenor.com

a poster that says if life gives you lemon make lemonade on it

ALT: a poster that says if life gives you lemon make lemonade on it

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Jaclyn A. Siegel, PhD @jacasiegel.bsky.social · 11/02/2025

Happy International Day of Women in Science. The National Science Foundation’s list of flagged words includes both “Women” and “Female.”

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Ardem Patapoutian @ardemp.bskyverified.social · 10/02/2025

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

chng.it

Sign the Petition

Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

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Stephen Floor @snf.bsky.social · 09/02/2025

not paying indirect costs for research is like only paying the players in the Super Bowl. can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities

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Ran Blekhman @blekhman.bsky.social · 09/02/2025

Total NIH funding cuts by state. This can be helpful when talking to your representatives www.datawrapper.de/_/Y0Pnk/

datawrapper.dwcdn.net

Funding cuts by state

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David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 08/02/2025

🚨 Revised request for scientist friends who want to do something to help 🚨 Help me find scientific professional societies with significant numbers of US members so I can approach them about a sign-on letter. What societies are you a member of? Send me names, links, etc. DMs open. 🧪🌎🦑

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Dr Craig R McClain @drcraigmc.bsky.social · 29/01/2025

Somewhere in the U.S., there’s a scientist staring at their NSF/NIH grant application wondering why they bother. This post is for you. Science and society both need you. Hang in there and know there is a whole community supporting you.

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GUINNESS @guinnessisacat.bsky.social · 24/01/2025

DO YOU EVER LOOK AT CATS AND WONDER HEY WHY DOES THIS LITTLE ANIMAL LIVE IN MY HOUSE? WHAT IS IT DOING? HOW DID I GET SO LUCKY?

Guinness the black cat lying on a blue duvet with an excellent blep.

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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 09/01/2025

Artists, I have some questions for you. Let's say, hypothetically, there was a science conference coming to your city, all about animals. The scientists are looking for artists to come to the meeting, sit in on the talks, & live-Illustrate what you learn about. This would be paid. My questions...

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Jude P @judepickledplum.bsky.social · 02/01/2025

Cats don't live their nine lives consecutively, they live them concurrently - in nine different dimensions. That's why they stare at nothing (in this dimension) and suddenly bolt around the room. In another dimension they are being chased by a dog (or a demon, depending on the dimension).

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GUINNESS @guinnessisacat.bsky.social · 31/12/2024

HAPPY NEW YEAR EVERYONE BEST WISHES FOR 2025 BE KIND, INCLUDING TO YOURSELF SIT IN MULTIPLE BOXES AT ONCE REMEMBER THAT EVEN A TINY GLEAM WILL LIGHTEN THE DARKNESS

Guinness the black cat sits proudly inside a small cardboard box which is inside a larger cardboard box.

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Cassie Manrique @cassiemanrique.bsky.social · 01/01/2025

Without downloading new pics, what’s your energy going into 2025? (This was Freckles this summer, disoriented and hungry after having dental work done)

Freckles, a brown striped tabby cat, is laying on a light brown hardwood floor in front of a cardboard scratcher. Freckles is looking to her left, but she is blurry. Her pupils are dilated and a square patch of fur on her paw is shaved from having an IV. Her energy is chaotic.

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DrLachie @drlachie.bsky.social · 30/12/2024

Hey microscopy people! Is it my turn to use the New Year's super resolution joke? Or did one of you want to take it this year?

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Bossett @bossett.social · 29/12/2024

I wish I could have captured the skittering but just too much wind

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Marc Somssich @somssich.bsky.social · 20/05/2024

Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 18/12/2024

Cell and developmental biologists: as you start looking at conferences in 2025, consider joining us at the 2025 Cell Contact & Adhesion GRC. We've assembled a strong and diverse program of speakers at the cutting-edge of science in our field 1/n Please repost www.grc.org/cell-contact...

Poster for the meeting including speaker list and location

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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 17/12/2024

Have any of you successfully propagated a fig before? I have a fig that’s becoming too tall for my windowsill.

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Anthony Hessel, PhD @hesselanthony.bsky.social · 16/12/2024

🚨📢Paper alert! Real progress on identifying why residual force enhancement occurs in skeletal muscle! This was a study I dreamed about since grad school. Please share! 🔬💪🧪 www.pnas.org/doi/10.1073/...

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Science News @scinews.bsky.social · 24/11/2024

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...

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Memento (spooky) Morty 🌙 @mementomorty.bsky.social · 15/12/2024

shrimply having a wonderful crustacean time

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