Reposted by Jeff Vierstra
GHT-SELEX shows that transcription factors are particular about which genomic loci they bind, and C2H2 zinc finger proteins engage different fingers at different sites.
www.nature.com/articles/s41...
nature.com
GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors - Nature Methods
GHT-SELEX—high-throughput SELEX with fragmented genomic DNA—shows that transcription factors can be rather particular about which genomic loci they bind, and that C2H2 zinc finger proteins often engag...
