Horino et al. identify CD8+ T cells as essential mediators of age-dependent anti-tumor effects of caloric restriction. They show that caloric restriction enhances CD8+ T cell function and is associated with normalization of the tumor vasculature in aged mice.

Mutations accumulate in cells with age, while caloric restriction extends lifespan across diverse animals. Grońska-Pęski et al. study the effect of caloric restriction on mutations genome-wide in mice...

JC polyomavirus infection can result in progressive multifocal leukoencephalopathy, and T cells have been shown to express PD-1. Here the authors show that PD-1 regulates the CD4+ T cell mediated CD8+...

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease driven by gene-environment interactions. Although climatic factors are known to trigger flares, global real-time epidemiologic...

Unlike in other tissues, lung-resident memory T cell populations are not well maintained in mice. Here the authors show that this is not the case in human lungs, where tissue-resident memory T cells specific to a variety of pathogens can persist for many years.

Nature - A ketogenic diet promotes tumour growth in the small intestine in susceptible mice. In people, diet advice might need to be tailored to individual cancer risks.

Antigen-specific T cells underpin immunity, cancer surveillance and autoimmunity, yet remain difficult to study. This Review describes the technologies and computational approaches that are helping to...

Low vitamin D (VD) status is prevalent in children with atopic dermatitis (AD) and, in some populations, is associated with disease severity. Circulating bioavailable and free 25-hydroxyvitamin D (25(...

On June 16, Pew announced the 2026 class of Pew Scholars Program in the Biomedical Sciences, Pew Latin American Fellows Program in the Biomedical Sciences, and Pew-Stewart Scholars Program for Cancer ...

Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 ...

Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 ...