Could Ukraine's destruction of Russian data centers really be impacting Elon Musk's engagement on his own platform?

We tested 30 leading AI models on 42 unreliable papers. They went along with the bad premise 93% of the time.

Nature Structural & Molecular Biology, Published online: 14 October 2026; doi:10.1038/s41594-026-01875-8Kjer-Hansen et al. show that alternative splicing reshapes how proteins interact and where they localize in cells, with tiny microexons making a disproportionate contribution to protein organization and cellular function.

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Developing tissues must acquire the correct shape. This study shows that mechanical feedback between the extracellular matrix and Yap sustains timely tissue growth, while Adgrg6 terminates the feedbac...

Low-affinity transcription factor binding sites are functionally important but difficult to map and mechanistically poorly understood. In this issue of Cell Genomics, Weilert et al. leverage sequence-...

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Phenotypes evolve through changes in gene regulatory networks (GRNs), but how changes in network topology contribute to phenotypic evolution is still poorly understood. Butterfly wing color patterns p...

The sexual identity of specific tissues can be altered through cell-autonomous manipulation of the sex determination pathway in the nematode Caenorhabditis elegans . Previously described sexually mosa...

ALT: Grateful Dead Live: Jerry Garcia in 1987

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Classical multilocus theory predicts that selection acting on combinations of loci can maintain non-random associations among allelic states, causing selection to act on multilocus genotypes rather than individual alleles. Across eukaryotic species, pangenome studies have documented thousands of genes that vary in functional status between individuals, yet this variation is analyzed as if each gene evolves independently. Here we test for non-random association within the dispensable pangenome across 1,012 natural genotypes of Arabidopsis thaliana to better understand the structure and evolution of eukaryotic pangenomes. Genome-wide pairwise association testing of loss-of-function alleles across genotypes identified 150,033 significantly covarying gene pairs among 5,679 unique genes after controlling for kinship and population structure. Most associations were between genes on different chromosomes, and covarying gene pairs showed greater co-expression and functional similarity than expected by chance. Network analysis revealed a non-random higher-order architecture comprising stable functional communities with distinct biological functions and structured connectivity among communities. The enriched functions and connectivity of communities revealed a tight coupling of modules involving plant immunity, environmental response, and specialized metabolism, highlighting how these systems integrate and evolve in response to dynamic ecological pressures. Taken together, these results show that the dispensable genome has a complex higher-order structure driven by functionally interacting genes, and that variation in gene content provides a population-scale resource for investigating the organization and evolution of biological systems. ### Competing Interest Statement The authors have declared no competing interest. Division of Integrative Organismal Systems, 2208944

Harvard’s Dr. David Sinclair has claimed achievement of “age reversal” in animal models, prompting a whirlwind of criticism from fellow scientists and his resignation as president of the Academy for H...

“It’s a wholly unethical trial, and it shouldn’t be allowed,” says Dr. Paul Offit of Guinea-Bissau study

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