Nature Reviews Genetics - Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors...

INCEPTION symposium 2025 - Focus on GWAS: paving the way for the future of genetics.

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

How embryo selection exploits our flawed intuitions about risk

FIMM-EMBL Group Leaders in Molecular Medicine

SuShiE is a multiancestry fine-mapping method for molecular quantitative trait loci that leverages linkage disequilibrium heterogeneity to improve resolution, infer cross-ancestry effect size correlat...

Ancestrally diverse biobanks where medication, disease, and genetics are linked provide an opportunity to understand treatment response to major depressive disorder (MDD). We developed polygenic risk ...

Cell Symposia: Precision genomics in human health

Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.

The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonis...

Nature Genetics - Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across...

Advances in genetic testing and artificial intelligence are changing what’s possible for those undergoing I.V.F. Are we ready for the future of fertility?

Tired of spending countless hours on peer reviews? An AI-assisted workflow could help.

Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and...

The lack of computational methods capable of detecting epistasis in biobanks has led to uncertainty about the role of non-additive genetic effects on complex trait variation. The marginal epistasis fr...

Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...

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Noor Siddiqui founded Orchid so people could “have healthy babies.” Now she’s using the company’s gene technology on herself—and talking about it for the first time.

Susztaklab Kidney Biobank