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Julian Stamp

@julian-stamp.bsky.social
20 followers 33 following 12 posts

PhD Candidate @ Center for Computational Molecular Biology, Brown University

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Reposted by Julian Stamp
The American Journal of Human Genetics @ajhgnews.bsky.social · 29/07/2025
📣Online now! 📄Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies 🧑‍🤝‍🧑 @lcrawford.bsky.social @julian-stamp.bsky.social & co
cell.com
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
The sparse marginal epistasis test overcomes computational limitations of previous mapping approaches by focusing its epistatic search to regions of the genome that have some known functional relation...
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Julian Stamp @julian-stamp.bsky.social · 02/06/2025
Looking forward to presenting my work at ISMB 2025! www.biorxiv.org/content/10.1...
biorxiv.org
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
The lack of computational methods capable of detecting epistasis in biobanks has led to uncertainty about the role of non-additive genetic effects on complex trait variation. The marginal epistasis fr...
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Julian Stamp @julian-stamp.bsky.social · 07/03/2025
Our recent R-package for the Sparse Marginal Epistasis test (smer) is mentioned on a blog post about the Top 40 New CRAN packages! www.r-bloggers.com/2025/02/janu...
r-bloggers.com
January 2025 Top 40 New CRAN Packages | R-bloggers
In January, one hundred eighty-six new packages made it to CRAN. Here are my Top 40 picks in sixteen categories: Archaeology, Artificial Intelligence, Computational Methods, Ecology, Epidemiology, Fin...
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Reposted by Julian Stamp
Lorin Crawford @lcrawford.bsky.social · 17/01/2025
Quick post to close out the week - in our newest preprint, @julian-stamp.bsky.social scales the marginal epistasis test to work on biobanks! The key is that using trait-specific information to induce sparsity in the modeled gene-interactions greatly improves both runtime and power
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Julian Stamp @julian-stamp.bsky.social · 17/01/2025
Can we find epistasis in human traits? To help, in our preprint, we present the most scalable and powerful framework for detecting epistasis to date: the “sparse marginal epistasis test” (SME). Thank you @lcrawford.bsky.social, @sampatsmith.bsky.social, Dan Weinreich! doi.org/10.1101/2025... 1/6
doi.org
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
The lack of computational methods capable of detecting epistasis in biobanks has led to uncertainty about the role of non-additive genetic effects on complex trait variation. The marginal epistasis fr...
162
Reposted by Julian Stamp
Rike Stelkens @stelkens.bsky.social · 15/10/2023
I know I’m not supposed to judge a book by it’s cover but this is so beautiful, Daniel Weinreich! Love Ernst Haeckel‘s drawings.
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Reposted by Julian Stamp
bioRxivpreprint @biorxivpreprint.bsky.social · 14/01/2025
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies www.biorxiv.org/content/10.1101/202…
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Reposted by Julian Stamp
bioRxiv Genetics @biorxiv-genetic.bsky.social · 14/01/2025
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies www.biorxiv.org/content/10.1101/202…
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