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Alessandro Bartolomucci Lab

@bartolomuccilab.bsky.social
1.3K followers 212 following 24 posts

Scientist interested in stress physiology, aging biology, social determinants of health, adipose tissue, sympathetic nervous system, metabolic diseases and much more. Professor at Univ. of Minnesota and Univ. of Parma bartolomuccilab.umn.edu

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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 16/09/2026
ALERT: Special Editorial focus issue on "Stress-induced impaired health and accelerated aging" Hosted by "Neurobiology of Stress" and "Neuroscience and Biobehavioral Reviews" co-edited with @mathiasvschmidt.bsky.social Details here: z.umn.edu/bkxb
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 20/04/2026
𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬 I am thrilled to announce an editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐒𝐭𝐫𝐞𝐬𝐬 and 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐚𝐧𝐝 𝐁𝐢𝐨𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐫𝐚𝐥 𝐑𝐞𝐯𝐢𝐞𝐰𝐬. With @bartolomuccilab.bsky.social, I am co-editing a virtual special issue focused on: 𝘚𝘵𝘳𝘦𝘴𝘴-𝘪𝘯𝘥𝘶𝘤𝘦𝘥 𝘪𝘮𝘱𝘢𝘪𝘳𝘦𝘥 𝘩𝘦𝘢𝘭𝘵𝘩 𝘢𝘯𝘥 𝘢𝘤𝘤𝘦𝘭𝘦𝘳𝘢𝘵𝘦𝘥 𝘢𝘨𝘪𝘯𝘨
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 01/06/2026
Don't forget! We're accepting applications for our Pilot & Feasibility awards and the McEwen Fellowship until June 30. If you have a project relevant to Network science, check out our website for more information! @bartolomuccilab.bsky.social @smacklab.bsky.social @jennytung.bsky.social
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 04/05/2026
Have a project related to animal models to study social aging? We welcome applications from early-career scientists for both our Pilot & Feasibility awards and the Bruce McEwen Fellowship. Applications are open until June 30. See details and apply here: www.animalsocialaging-network.org/funding
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 20/04/2026
📣Our Research Network's 2026-2027 RFA cycle are now open!📣 Applications for our Pilot & Feasibility awards (up to $20,000) and the McEwen Fellowship (up to $6,000) for early-career scientists are open through June 30. Ready to apply? Click here: www.animalsocialaging-network.org/funding
animalsocialaging-network.org
Funding | Animal Models for the Social Dimensions of Health and Aging Research Network
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 21/04/2026
We are really thrilled to host this joint open special issue with among the two journals @mathiasvschmidt.bsky.social We are very interested to receive your best research at the intersection between stress, health and aging. Details here lnkd.in/dGfV24ex and in the linkedin post z.umn.edu/b971
linkedin.com
𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬: 𝐒𝐭𝐫𝐞𝐬𝐬 𝐚𝐧𝐝 𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞𝐝 𝐀𝐠𝐢𝐧𝐠 I am thrilled to announce a unique editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟… | PD Dr. Mathias V. Schmidt
𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬: 𝐒𝐭𝐫𝐞𝐬𝐬 𝐚𝐧𝐝 𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞𝐝 𝐀𝐠𝐢𝐧𝐠 I am thrilled to announce a unique editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐒𝐭𝐫𝐞𝐬𝐬 and 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐚𝐧𝐝 𝐁𝐢𝐨𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐫𝐚𝐥 𝐑𝐞𝐯𝐢𝐞𝐰𝐬. Together ...
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 30/03/2026
🎉Huge congratulations to McEwen fellow @ewinternelson.bsky.social and Dr. Gagan Wig of UT Dallas on their recent publication in PNAS on large-scale brain network decline across aging mice and humans and its translational relevance. Read the paper here: shorturl.at/gjau5
shorturl.at
Correspondence of large-scale functional brain network decline across aging mice and humans | PNAS
Human aging is marked by progressive reorganization of large-scale functional brain networks; these brain network changes have been linked to cogni...
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 28/10/2025
🔦✨ Research Network Spotlight!✨🔦 Sabrina Mederos, PhD candidate at UC Davis, is one of two 2025-2026 Bruce McEwen Fellowship awardees through our Research Network. Check out a description of Sabrina's research below. @bartolomuccilab.bsky.social @jennytung.bsky.social @smacklab.bsky.social
An announcement of Sabrina Mederos's fellowship and a description of her research.
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 21/10/2025
When Alexander Easton @durhameaston.bsky.social and I stepped in as EIC of Neuroscience & Biobehavioral Reviews, we led the revision of the Aims and Scope of this highly successful journal. Our Editorial outlines major updates/expansions to the Aims & Scope www.sciencedirect.com/science/arti...
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 14/10/2025
✨🔦Research Network Spotlight!🔦✨ @ctestard.bsky.social at Harvard University is the second recipient of a 2025-2026 Pilot & Feasibility award from our Research Network. Check out a description of Dr. Testard's project below. @bartolomuccilab.bsky.social @jennytung.bsky.social @smacklab.bsky.social
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 04/09/2025
Proud to announce the publication of our new paper describing the design, chemical synthesis and testing of a novel class of Complement 3a Receptor (C3aR) agonists and antagonists derived from the TLQP-21 peptide @pubs.acs.org Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 15/06/2025
📢Applications for the McEwen fellowship are now open! We expect to award 1-3 fellowships (up to $6,000 each) to early-career scientists with a proposal within the broad scope of our research network’s interests. Deadline: July 15 Apply here: www.animalsocialaging-network.org/funding/fell...
animalsocialaging-network.org
Fellowships | Animal Models for the Social Dimensions of Health and Aging Research Network
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 12/06/2025
Reminder - funding opportunity available trough the @animalsocaging.bsky.social Pilot & Feasibility Awards Application period - June 1 to June 30 B. McEwen Career Development Fellowship Application period - June 15 to July 15 Small/Working Group Awards Application period - July 1 to July 31
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 19/05/2025
📣 @animalsocaging.bsky.social NIA-funded high priority research network - funding available soon!📣 Stay tuned for 3 RFAs: 1. Pilot awards - June 30th 2. The Bruce McEwen Fellowship - July 15 3. Small/working group - July 31 More info on the network: www.animalsocialaging-network.org
animalsocialaging-network.org
Animal Models for the Social Dimensions of Health and Aging Research Network
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 09/06/2025
New Study alert: “Epigenetic biomarkers of mortality risk in mice under chronic social stress" @geroscience.bsky.social lnkd.in/dqPGrQx4 Mathematical models identified epigenetic biomarkers of mortality risk and an association with blood glucose levels, informing on individual aging trajectories.
linkedin.com
Epigenetic biomarkers of mortality risk in mice under chronic social… | Alessandro Bartolomucci
New Study: “Epigenetic biomarkers of mortality risk in mice under chronic social stress,” just published in GeroScience. https://lnkd.in/dqPGrQx4 Our study used a large cohort of mice (350+) exposed...
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 01/06/2025
📢Applications are OPEN for our Pilot awards! Individual or mentored projects available with up to $20,000 in total costs! Read the full RFA and apply at the link below! www.animalsocialaging-network.org/funding/pilo... @smacklab.bsky.social @bartolomuccilab.bsky.social @jennytung.bsky.social
A graphic describing the details related to applying for the Pilot awards of the Animal Models Social Aging network. Visit animalsocialaging-network.org for details.
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 23/05/2025
New Research Network publication alert! @sheehanmj.bsky.social and @matthewzipple.bsky.social, both recipients of Network Pilot & Feasibility awards, have published a paper in Aging Cell on ecological realism and epigenetic aging in mice. Congratulations, Mike and Matthew! doi.org/10.1111/acel...
doi.org
Ecological Realism Accelerates Epigenetic Aging in Mice
Living environment shapes mammalian aging, but laboratory conditions lack the ecological realism of natural social, physical, and microbial environments. Comparing traditionally laboratory-reared and...
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 16/05/2025
📣New network funding available soon!📣 The Request for Applications for our Research Network's pilot awards (June 1-June 30), the Bruce McEwen Fellowship (June 15-July 15), and small/working group awards (July 1-July 31) will be live on our website (www.animalsocialaging-network.org) in two weeks!
animalsocialaging-network.org
Animal Models for the Social Dimensions of Health and Aging Research Network
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 14/05/2025
That`s a big one! congrats to the outstanding team of co-authors
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 13/05/2025
Our NIA funded High Priority Research network on Animal Models for the Social Dimension of Health and Aging just landed on Bsky @animalsocaging.bsky.social - follow us for updates and new RFAs www.animalsocialaging-network.org @smacklab.bsky.social @jennytung.bsky.social
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Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 12/05/2025
🎤Hey, is this thing on? The Animal Models for the Social Dimensions of Health and Aging Research Network is on Bluesky! We are an NIA-funded network headquartered at UMN, ASU, UNC, and Duke that supports early-career scientists using animal models to study social aging. New funding available soon!
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 08/05/2025
🚨 Great opportunity for an excellent post doc with a fantastic international group of top notch scholars.
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Björn Schumacher @bjornschumacher.bsky.social · 30/04/2025
Read here our original article showing the biological age prediction by accumulating stochastic variation alone. With @meyer.bsky.social and a wonderful cover art designed by @maayanvisuals.bsky.social www.nature.com/articles/s43...
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 25/04/2025
Food insecurity drives obesity and adiposity, but how is unclear. A recent study by @clemmensenc.bsky.social developed a mouse model for this phenomenon lnkd.in/d8pEp2qv Happy to share a commentary written with @johnspeakman4.bsky.social with our take on that study doi.org/10.1002/oby....
doi.org
Scarce and unpredictable, yet obesogenic: modeling the impact of food insecurity on adiposity in mice
Click on the article title to read more.
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Proceedings of the National Academy of Sciences @pnas.org · 07/04/2025
The gap in life expectancy between the richest and poorest Swedes widened between 1960–2021. The cause of this trend was not increased inequality or a decline in social spending but an embrace of healthy lifestyles by the affluent. In PNAS: www.pnas.org/doi/10.1073/...
A woman riding a bicycle in Stockholm, Sweden, on September 14, 2018.
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 08/04/2025
bad news for freshwater quality in minnesota and midwest, very bad in the Twin Cities.
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Elvira De Leonibus @deleonibuslab.bsky.social · 03/04/2025
🧠💥 For #Dopamine (DA) & #Memory lovers! 📢 New paper!! we show that memory capacity (MC) in mice can be expanded from 6 to 8 objects using low doses of a D1 receptor agonist. Higher doses? Paradoxically, they reduce MC. #Tigem #Consiglio Nazionale delle Ricerche lnkd.in/d9skfGeb
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 02/04/2025
We recently published @geroscience.bsky.social the development and validation of the mouse social frailty index (mSFI) link.springer.com/article/10.1... We now report a detailed step-by-step resource paper describing how to conduct the mSFI. bio-protocol.org/en/bpdetail?...
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Cláudia Gil @claudiagil93.bsky.social · 27/03/2025
🌟 Exciting News! 🌟 I am thrilled to share that my first paper as the first author, Food insecurity promotes adiposity in mice, is now published in #ObesityJournal #ObesitySociety doi.org/10.1002/oby.... #Foodinsecurity #Obesity #PhD 1/9🧵👇
doi.org
Food insecurity promotes adiposity in mice
Objective The obesity epidemic, driven by a complex interplay of environmental and biological factors, remains a significant global health challenge. Herein, we investigate the impact of food insecu...
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Andrea Galmozzi @andreagalmozzi.bsky.social · 25/03/2025
Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social
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Dena Dubal @denadubal.bsky.social · 06/03/2025
"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @margaretgadek.bsky.social in Science Advances. www.science.org/doi/10.1126/...
science.org
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
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Magdalena Skipper @magdalenaskipper.bsky.social · 06/03/2025
In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”…. 🧪 #AcademicSky www.nature.com/articles/d41...
nature.com
Exclusive: NIH to terminate hundreds of active research grants
Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
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Nature @nature.com · 06/03/2025
Women tend to live longer than men and are often more resilient to cognitive decline as they age. Now researchers might have uncovered a source for this resilience: the second X chromosome in female cells that was previously considered ‘silent’ go.nature.com/3F40x10
go.nature.com
Why women’s brains are more resilient: it could be their ‘silent’ X chromosome
Study in mice and human cadavers hints that a brain-protective gene in the chromosome becomes more active with age.
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Eric Topol @erictopol.bsky.social · 27/02/2025
Outdoor heat in older adults and accelerated biological (epigenetic) aging www.science.org/doi/10.1126/...
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Eric Topol @erictopol.bsky.social · 26/02/2025
This is how you can predict an individual's risk of an age-related disease 2 decades ahead of their showing up. More on this erictopol.substack.com/p/the-emerge...
erictopol.substack.com
The Emergence of Protein Organ Clocks
Predicting and Tracking Organ-Specific Aging, Health and Disease
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Eric Topol @erictopol.bsky.social · 26/02/2025
Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases www.thelancet.com/journals/lan...
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Steve Maren @stevemaren.bsky.social · 20/02/2025
Really awesome work here 👇🏼👇🏼👇🏼
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Scott Russo @scottrussophd.bsky.social · 12/02/2025
1/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social Read it here: www.nature.com/articles/s41...
nature.com
A crucial role for the cortical amygdala in shaping social encounters - Nature
The posterolateral cortical amygdala and other connected brain regions have a key role in mediating the transition from investigative to aggressive behaviour in male mice.
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Nature @nature.com · 12/02/2025
Nature research paper: Macrophages protect against sensory axon loss in peripheral neuropathy go.nature.com/3QfyvC4
go.nature.com
Macrophages protect against sensory axon loss in peripheral neuropathy - Nature
A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.
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Giles Yeo @gilesyeo.bsky.social · 05/02/2025
I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism www.nature.com/articles/s41...
nature.com
A comprehensive spatio-cellular map of the human hypothalamus - Nature
HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.
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Eric Topol @erictopol.bsky.social · 27/01/2025
Spatial multi-omics has just gone to the next level! www.nature.com/articles/s41... www.nature.com/articles/s41... —Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm —"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
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Stephen O'Rahilly @stephenorahilly.bsky.social · 18/01/2025
Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis | Science science.org/doi/10.1126/sc…. Major advance in endocrinology. So fascinating that new important hormonal actions of TGFBeta family members are still being discovered.
science.org
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Alexander Bartelt @barteltlab.bsky.social · 19/01/2025
Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing! 👇 www.cell.com/cell-reports...
Islet from aged mouse vs islet from young mice after 10 weeks of IF - IHC for Nkx6.1
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 18/01/2025
Very interesting structural Cryo-EM study on the C3aR1 receptor confirming our earlier demonstration (pubmed.ncbi.nlm.nih.gov/38072064/) that SB290157 and JR14a are full agonists and not antagonists Luo et al. Cell Discov 11, 7 (2025). doi.org/10.1038/s414...
rdcu.be
Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR
Cell Discovery - Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR
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Waggoner Lab @labwaggoner.bsky.social · 09/01/2025
Review @cp-cellmetabolism.bsky.social Decoding aging clocks: New insights from metabolomics www.cell.com/cell-metabol...
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Caroline Menard @caromenard666.bsky.social · 27/12/2024
Taking 5 min from my 2-week 🎅 Holidays break 🥂 to share our new review out today 🤓 the hard work of 3 super talented 🧪 PhD students *Béatrice *Laura & *Valérie covering implication of 🧠 #vascular #BBB cells in #anorexia #stress #depression #Parkinson #Alzheimer www.sciencedirect.com/science/arti...
sciencedirect.com
Neurogliovascular alterations in brain pathologies across lifespan
Neurological and psychiatric illnesses present significant challenges across different stages of life. Adolescence is associated with a high incidence…
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Eric Topol @erictopol.bsky.social · 08/01/2025
An impressive new issue of Neuron on the science of brain aging with 10 papers on everything from sex differences, role of astrocytes, immune system, waste clearance, autophagy, DNA damage, and rejuvenation cell.com/issue/S0896-...
cover of the dedicated issue on brain aging
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BrunetLab @brunetlab.bsky.social · 18/12/2024
Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵
rdcu.be
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
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Christian Frezza @frezzalab.bsky.social · 15/12/2024
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration www.cell.com/cell/fulltex...
cell.com
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration
Intermittent fasting halts hair follicle regeneration by activating communication between adrenal glands and niche adipocytes, which in turn selectively induces apoptosis of hair follicle stem cells but not epidermal stem cells in the skin.
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 08/12/2024
Worryingly high prevalence of retraction among top-cited researchers By Shaoxiong Brian Xu & Guangwei Hu @nature.com.web.brid.gy www.nature.com/articles/d41...
nature.com
Worryingly high prevalence of retraction among top-cited researchers
Letter to the Editor
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