iiinova — where your digital self keeps evolving

Reposted by Romain Durand-de Cuttoli

Brian Sweis @brianmsweis.bsky.social · 29/10/2025

For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social

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Reposted by Romain Durand-de Cuttoli

Brian Sweis @brianmsweis.bsky.social · 15/07/2025

New paper alert!🚨📝 Paper: tinyurl.com/2cycsy6d Press release: tinyurl.com/yur3j2n8 How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances

tinyurl.com

Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner

Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.

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Reposted by Romain Durand-de Cuttoli

Brian Sweis @brianmsweis.bsky.social · 15/07/2025

This speaks to the importance of cross-species research that is constantly forward- & back-translated between the clinic & lab. The importance of animal models leading to unanticipated discoveries - even in the realm of human psychology - is invaluable, especially in psychiatry🧠 tinyurl.com/yur3j2n8

From the linked press release: “Neuroscientists discover that a non-coding RNA molecule in the prefrontal cortex, which promotes resilience to depression only in women, alters how the female brain ruminates on the past when making certain types of decisions in a mouse model. The single-stranded RNA molecule LINC00473 is depicted in the center. Image generated by OpenAI.”

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