Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 08/10/2026Targeting C3aR genetically or pharmacologically reduced neuroinflammation and weight gain in male mice. This includes the use of our recently developed C3aR functional antagonist known as DArg10_Aib20 pubmed.ncbi.nlm.nih.gov/40903728/ 000
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 08/10/2026Proud to share our new paper in Journal of Neuroinflammation We identify C3aR as a key driver of high fat diet-induced hypothalamic microgliosis and LAM remodeling. 🔗 link.springer.com/article/10.1... #Microglia #Neuroinflammation #C3aRlink.springer.comComplement 3a receptor mediates high fat diet induced hypothalamic accumulation of lipid associated microglia to regulate neuroinflammation - Journal of NeuroinflammationMicroglia, the resident macrophages of the central nervous system, are recognized for their heterogeneity and integral role in brain function and diseases. In the context of high fat diet (HFD) feedin... 121
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 16/09/2026ALERT: Special Editorial focus issue on "Stress-induced impaired health and accelerated aging" Hosted by "Neurobiology of Stress" and "Neuroscience and Biobehavioral Reviews" co-edited with @mathiasvschmidt.bsky.social Details here: z.umn.edu/bkxb 021
Reposted by Alessandro Bartolomucci LabMathias V. Schmidt @mathiasvschmidt.bsky.social · 20/04/2026𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬 I am thrilled to announce an editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐒𝐭𝐫𝐞𝐬𝐬 and 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐚𝐧𝐝 𝐁𝐢𝐨𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐫𝐚𝐥 𝐑𝐞𝐯𝐢𝐞𝐰𝐬. With @bartolomuccilab.bsky.social, I am co-editing a virtual special issue focused on: 𝘚𝘵𝘳𝘦𝘴𝘴-𝘪𝘯𝘥𝘶𝘤𝘦𝘥 𝘪𝘮𝘱𝘢𝘪𝘳𝘦𝘥 𝘩𝘦𝘢𝘭𝘵𝘩 𝘢𝘯𝘥 𝘢𝘤𝘤𝘦𝘭𝘦𝘳𝘢𝘵𝘦𝘥 𝘢𝘨𝘪𝘯𝘨 1152
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 01/06/2026Don't forget! We're accepting applications for our Pilot & Feasibility awards and the McEwen Fellowship until June 30. If you have a project relevant to Network science, check out our website for more information! @bartolomuccilab.bsky.social @smacklab.bsky.social @jennytung.bsky.social 021
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 04/05/2026Have a project related to animal models to study social aging? We welcome applications from early-career scientists for both our Pilot & Feasibility awards and the Bruce McEwen Fellowship. Applications are open until June 30. See details and apply here: www.animalsocialaging-network.org/funding 021
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 20/04/2026📣Our Research Network's 2026-2027 RFA cycle are now open!📣 Applications for our Pilot & Feasibility awards (up to $20,000) and the McEwen Fellowship (up to $6,000) for early-career scientists are open through June 30. Ready to apply? Click here: www.animalsocialaging-network.org/fundinganimalsocialaging-network.orgFunding | Animal Models for the Social Dimensions of Health and Aging Research Network 011
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 21/04/2026We are really thrilled to host this joint open special issue with among the two journals @mathiasvschmidt.bsky.social We are very interested to receive your best research at the intersection between stress, health and aging. Details here lnkd.in/dGfV24ex and in the linkedin post z.umn.edu/b971linkedin.com𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬: 𝐒𝐭𝐫𝐞𝐬𝐬 𝐚𝐧𝐝 𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞𝐝 𝐀𝐠𝐢𝐧𝐠 I am thrilled to announce a unique editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟… | PD Dr. Mathias V. Schmidt𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬: 𝐒𝐭𝐫𝐞𝐬𝐬 𝐚𝐧𝐝 𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞𝐝 𝐀𝐠𝐢𝐧𝐠 I am thrilled to announce a unique editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐒𝐭𝐫𝐞𝐬𝐬 and 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐚𝐧𝐝 𝐁𝐢𝐨𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐫𝐚𝐥 𝐑𝐞𝐯𝐢𝐞𝐰𝐬. Together ... 075
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 30/03/2026🎉Huge congratulations to McEwen fellow @ewinternelson.bsky.social and Dr. Gagan Wig of UT Dallas on their recent publication in PNAS on large-scale brain network decline across aging mice and humans and its translational relevance. Read the paper here: shorturl.at/gjau5shorturl.atCorrespondence of large-scale functional brain network decline across aging mice and humans | PNASHuman aging is marked by progressive reorganization of large-scale functional brain networks; these brain network changes have been linked to cogni... 083
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 28/10/2025🔦✨ Research Network Spotlight!✨🔦 Sabrina Mederos, PhD candidate at UC Davis, is one of two 2025-2026 Bruce McEwen Fellowship awardees through our Research Network. Check out a description of Sabrina's research below. @bartolomuccilab.bsky.social @jennytung.bsky.social @smacklab.bsky.social 021
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 21/10/2025When Alexander Easton @durhameaston.bsky.social and I stepped in as EIC of Neuroscience & Biobehavioral Reviews, we led the revision of the Aims and Scope of this highly successful journal. Our Editorial outlines major updates/expansions to the Aims & Scope www.sciencedirect.com/science/arti... 054
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 14/10/2025✨🔦Research Network Spotlight!🔦✨ @ctestard.bsky.social at Harvard University is the second recipient of a 2025-2026 Pilot & Feasibility award from our Research Network. Check out a description of Dr. Testard's project below. @bartolomuccilab.bsky.social @jennytung.bsky.social @smacklab.bsky.social 073
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 04/09/2025Proud to announce the publication of our new paper describing the design, chemical synthesis and testing of a novel class of Complement 3a Receptor (C3aR) agonists and antagonists derived from the TLQP-21 peptide @pubs.acs.org Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/... 054
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 03/07/2025Remider! Applications for the McEwen Career Development fellowship in Social Determinants of Health supported by the NIA-BSR High Priority Research Network animalsocialaging-network.org are now open! apply here animalsocialaging-network.org/funding/fell...animalsocialaging-network.orgAnimal Models for the Social Dimensions of Health and Aging Research Network 022
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 15/06/2025📢Applications for the McEwen fellowship are now open! We expect to award 1-3 fellowships (up to $6,000 each) to early-career scientists with a proposal within the broad scope of our research network’s interests. Deadline: July 15 Apply here: www.animalsocialaging-network.org/funding/fell...animalsocialaging-network.orgFellowships | Animal Models for the Social Dimensions of Health and Aging Research Network 142
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 12/06/2025Reminder - funding opportunity available trough the @animalsocaging.bsky.social Pilot & Feasibility Awards Application period - June 1 to June 30 B. McEwen Career Development Fellowship Application period - June 15 to July 15 Small/Working Group Awards Application period - July 1 to July 31 053
Reposted by Alessandro Bartolomucci LabAlessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 19/05/2025📣 @animalsocaging.bsky.social NIA-funded high priority research network - funding available soon!📣 Stay tuned for 3 RFAs: 1. Pilot awards - June 30th 2. The Bruce McEwen Fellowship - July 15 3. Small/working group - July 31 More info on the network: www.animalsocialaging-network.organimalsocialaging-network.orgAnimal Models for the Social Dimensions of Health and Aging Research Network 043
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 09/06/2025New Study alert: “Epigenetic biomarkers of mortality risk in mice under chronic social stress" @geroscience.bsky.social lnkd.in/dqPGrQx4 Mathematical models identified epigenetic biomarkers of mortality risk and an association with blood glucose levels, informing on individual aging trajectories.linkedin.comEpigenetic biomarkers of mortality risk in mice under chronic social… | Alessandro BartolomucciNew Study: “Epigenetic biomarkers of mortality risk in mice under chronic social stress,” just published in GeroScience. https://lnkd.in/dqPGrQx4 Our study used a large cohort of mice (350+) exposed... 031
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 01/06/2025📢Applications are OPEN for our Pilot awards! Individual or mentored projects available with up to $20,000 in total costs! Read the full RFA and apply at the link below! www.animalsocialaging-network.org/funding/pilo... @smacklab.bsky.social @bartolomuccilab.bsky.social @jennytung.bsky.social 065
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 23/05/2025New Research Network publication alert! @sheehanmj.bsky.social and @matthewzipple.bsky.social, both recipients of Network Pilot & Feasibility awards, have published a paper in Aging Cell on ecological realism and epigenetic aging in mice. Congratulations, Mike and Matthew! doi.org/10.1111/acel...doi.orgEcological Realism Accelerates Epigenetic Aging in MiceLiving environment shapes mammalian aging, but laboratory conditions lack the ecological realism of natural social, physical, and microbial environments. Comparing traditionally laboratory-reared and... 065
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 19/05/2025📣 @animalsocaging.bsky.social NIA-funded high priority research network - funding available soon!📣 Stay tuned for 3 RFAs: 1. Pilot awards - June 30th 2. The Bruce McEwen Fellowship - July 15 3. Small/working group - July 31 More info on the network: www.animalsocialaging-network.organimalsocialaging-network.orgAnimal Models for the Social Dimensions of Health and Aging Research Network 043
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 16/05/2025📣New network funding available soon!📣 The Request for Applications for our Research Network's pilot awards (June 1-June 30), the Bruce McEwen Fellowship (June 15-July 15), and small/working group awards (July 1-July 31) will be live on our website (www.animalsocialaging-network.org) in two weeks!animalsocialaging-network.orgAnimal Models for the Social Dimensions of Health and Aging Research Network 151
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 14/05/2025That`s a big one! congrats to the outstanding team of co-authors 000
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 13/05/2025Our NIA funded High Priority Research network on Animal Models for the Social Dimension of Health and Aging just landed on Bsky @animalsocaging.bsky.social - follow us for updates and new RFAs www.animalsocialaging-network.org @smacklab.bsky.social @jennytung.bsky.social 022
Reposted by Alessandro Bartolomucci LabAnimal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · 12/05/2025🎤Hey, is this thing on? The Animal Models for the Social Dimensions of Health and Aging Research Network is on Bluesky! We are an NIA-funded network headquartered at UMN, ASU, UNC, and Duke that supports early-career scientists using animal models to study social aging. New funding available soon! 052
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 08/05/2025🚨 Great opportunity for an excellent post doc with a fantastic international group of top notch scholars. 010
Reposted by Alessandro Bartolomucci LabBjörn Schumacher @bjornschumacher.bsky.social · 30/04/2025Read here our original article showing the biological age prediction by accumulating stochastic variation alone. With @meyer.bsky.social and a wonderful cover art designed by @maayanvisuals.bsky.social www.nature.com/articles/s43... 084
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 25/04/2025Post on the study by the first author @claudiagil93.bsky.social bsky.app/profile/clau... 040
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 25/04/2025Food insecurity drives obesity and adiposity, but how is unclear. A recent study by @clemmensenc.bsky.social developed a mouse model for this phenomenon lnkd.in/d8pEp2qv Happy to share a commentary written with @johnspeakman4.bsky.social with our take on that study doi.org/10.1002/oby....doi.orgScarce and unpredictable, yet obesogenic: modeling the impact of food insecurity on adiposity in miceClick on the article title to read more. 175
Reposted by Alessandro Bartolomucci LabProceedings of the National Academy of Sciences @pnas.org · 07/04/2025The gap in life expectancy between the richest and poorest Swedes widened between 1960–2021. The cause of this trend was not increased inequality or a decline in social spending but an embrace of healthy lifestyles by the affluent. In PNAS: www.pnas.org/doi/10.1073/... 0143
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 08/04/2025bad news for freshwater quality in minnesota and midwest, very bad in the Twin Cities. 010
Reposted by Alessandro Bartolomucci LabElvira De Leonibus @deleonibuslab.bsky.social · 03/04/2025🧠💥 For #Dopamine (DA) & #Memory lovers! 📢 New paper!! we show that memory capacity (MC) in mice can be expanded from 6 to 8 objects using low doses of a D1 receptor agonist. Higher doses? Paradoxically, they reduce MC. #Tigem #Consiglio Nazionale delle Ricerche lnkd.in/d9skfGeb 142
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 02/04/2025We recently published @geroscience.bsky.social the development and validation of the mouse social frailty index (mSFI) link.springer.com/article/10.1... We now report a detailed step-by-step resource paper describing how to conduct the mSFI. bio-protocol.org/en/bpdetail?... 0114
Reposted by Alessandro Bartolomucci LabCláudia Gil @claudiagil93.bsky.social · 27/03/2025🌟 Exciting News! 🌟 I am thrilled to share that my first paper as the first author, Food insecurity promotes adiposity in mice, is now published in #ObesityJournal #ObesitySociety doi.org/10.1002/oby.... #Foodinsecurity #Obesity #PhD 1/9🧵👇doi.orgFood insecurity promotes adiposity in miceObjective The obesity epidemic, driven by a complex interplay of environmental and biological factors, remains a significant global health challenge. Herein, we investigate the impact of food insecu... 2208
Reposted by Alessandro Bartolomucci LabAndrea Galmozzi @andreagalmozzi.bsky.social · 25/03/2025Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social 01911
Reposted by Alessandro Bartolomucci LabDena Dubal @denadubal.bsky.social · 06/03/2025"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @margaretgadek.bsky.social in Science Advances. www.science.org/doi/10.1126/...science.orgAging activates escape of the silent X chromosome in the female mouse hippocampusAging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse. 25123
Reposted by Alessandro Bartolomucci LabMagdalena Skipper @magdalenaskipper.bsky.social · 06/03/2025In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”…. 🧪 #AcademicSky www.nature.com/articles/d41...nature.comExclusive: NIH to terminate hundreds of active research grantsStudies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature. 14163139
Reposted by Alessandro Bartolomucci LabNature @nature.com · 06/03/2025Women tend to live longer than men and are often more resilient to cognitive decline as they age. Now researchers might have uncovered a source for this resilience: the second X chromosome in female cells that was previously considered ‘silent’ go.nature.com/3F40x10go.nature.comWhy women’s brains are more resilient: it could be their ‘silent’ X chromosomeStudy in mice and human cadavers hints that a brain-protective gene in the chromosome becomes more active with age. 312031
Reposted by Alessandro Bartolomucci LabEric Topol @erictopol.bsky.social · 27/02/2025Outdoor heat in older adults and accelerated biological (epigenetic) aging www.science.org/doi/10.1126/... 110626
Reposted by Alessandro Bartolomucci LabEric Topol @erictopol.bsky.social · 26/02/2025This is how you can predict an individual's risk of an age-related disease 2 decades ahead of their showing up. More on this erictopol.substack.com/p/the-emerge...erictopol.substack.comThe Emergence of Protein Organ ClocksPredicting and Tracking Organ-Specific Aging, Health and Disease 410130
Reposted by Alessandro Bartolomucci LabEric Topol @erictopol.bsky.social · 26/02/2025Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases www.thelancet.com/journals/lan... 719557
Reposted by Alessandro Bartolomucci LabSteve Maren @stevemaren.bsky.social · 20/02/2025Really awesome work here 👇🏼👇🏼👇🏼 192
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 13/02/2025congrats @scottrussophd.bsky.social wonderful work! 010
Reposted by Alessandro Bartolomucci LabScott Russo @scottrussophd.bsky.social · 12/02/20251/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social Read it here: www.nature.com/articles/s41...nature.comA crucial role for the cortical amygdala in shaping social encounters - NatureThe posterolateral cortical amygdala and other connected brain regions have a key role in mediating the transition from investigative to aggressive behaviour in male mice. 95321
Reposted by Alessandro Bartolomucci LabNature @nature.com · 12/02/2025Nature research paper: Macrophages protect against sensory axon loss in peripheral neuropathy go.nature.com/3QfyvC4go.nature.comMacrophages protect against sensory axon loss in peripheral neuropathy - NatureA study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy. 0344
Reposted by Alessandro Bartolomucci LabGiles Yeo @gilesyeo.bsky.social · 05/02/2025I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism www.nature.com/articles/s41...nature.comA comprehensive spatio-cellular map of the human hypothalamus - NatureHYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus. 511442
Reposted by Alessandro Bartolomucci LabEric Topol @erictopol.bsky.social · 27/01/2025Spatial multi-omics has just gone to the next level! www.nature.com/articles/s41... www.nature.com/articles/s41... —Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm —"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal" 215449
Reposted by Alessandro Bartolomucci LabStephen O'Rahilly @stephenorahilly.bsky.social · 18/01/2025Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis | Science science.org/doi/10.1126/sc…. Major advance in endocrinology. So fascinating that new important hormonal actions of TGFBeta family members are still being discovered.science.org 2208
Reposted by Alessandro Bartolomucci LabAlexander Bartelt @barteltlab.bsky.social · 19/01/2025Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing! 👇 www.cell.com/cell-reports... 610529
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 18/01/2025Very interesting structural Cryo-EM study on the C3aR1 receptor confirming our earlier demonstration (pubmed.ncbi.nlm.nih.gov/38072064/) that SB290157 and JR14a are full agonists and not antagonists Luo et al. Cell Discov 11, 7 (2025). doi.org/10.1038/s414...rdcu.beStructural insights into the agonist activity of the nonpeptide modulator JR14a on C3aRCell Discovery - Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR 040