iiinova — where your digital self keeps evolving

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The Lamb Lab @thelamblab.bsky.social · 14/02/2025

Many controversial column takes in the office this week… 🧪🤔 #chemsky how do YOU arrange your column test tubes?

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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 06/02/2025

This is a better summary than anything I've seen in mainstream or alternative media. Essential reading.

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NBC News @nbcnews.com · 29/01/2025

"Kids might die, but Robert Kennedy can keep cashing in," Sen. Elizabeth Warren says during a heated exchange with #RFK Jr. over whether he would agree to not taking fees from suing drug companies.

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Laurel Oldach @laureloldach.bsky.social · 29/01/2025

Literally every time I have filed this story (4x this week), something happened to change it before my editor had a chance to look. But here’s WTF happened at NIH this week (so far) cen.acs.org/policy/US-fu...

cen.acs.org

US funding freeze memo rescinded, NIH confusion persists

Acting NIH director Memoli clarifies communication restrictions as White House moves to freeze US government grants

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Dan Liebler @dliebler.bsky.social · 26/01/2025

MS protein analysis—I’m one of many to follow in his footsteps. Great NIH program officers are the backbone of the extramural system. I owe much to several of them over the years.

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cloudscloud.bsky.social @cloudscloud.bsky.social · 26/01/2025

Just because a paper is highly cited, it doesn’t mean it is correct or truthful. This paper (www.nature.com/articles/nat...) was cited 4504 times and yet it was retracted. There is no penalty for non-compliance. It’s just that someone someday will probably report it to the editors. 1/2

nature.com

RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow - Nature

Nature - RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow

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BWJones @bwjones.bsky.social · 25/01/2025

Mark, with all due respect. Sit down and visit with some folks who are intimately familiar with the NIH, the scientific process, how grants are handled and funded. The NIH is not a business. There are no shareholders. There is no mandate for profit. This is not a business model and should not be.

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George Takei @georgetakei.bsky.social · 11/01/2025

I fear there is deep truth here.

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Jeremy Baskin @jeremybaskin.bsky.social · 03/01/2025

Skimming through the latest paper journals plays a catalytic role in a fascinating decades-long friendship that Roald Hoffmann had with two Chinese chemists, Tang Ao-Qing and Lu Jiaxi. I recommend watching his recounting of a story of geopolitics and chemistry: www.sciencehistory.org/visit/events...

sciencehistory.org

Roald Hoffmann Presents "Tang Ao-Qing and Lu Jiaxi: A Story of China and America"

Join Nobel laureate Roald Hoffmann as he shares an untold story about science and immigration.

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David A. Markowitz @davidamarkowitz.bsky.social · 12/12/2024

Us: "Hey we wrote a spirited defense of basic science funding, showing how it drives startup creation and ultimately GDP. Would you like to publish it as an OpEd?" Major Media Outlets: "No."

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Richard Sever @richardsever.bsky.social · 14/12/2024

Your regular reminder that you can cite unrefereed editorials, reviews, data, news, websites, books, even tweets. Citing preprints isn’t doing anything controversial 1/2

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Olexandr Isayev 🇺🇦 🇺🇸 @olexandr.bsky.social · 14/12/2024

This is what happens when you let computer scientists design molecules 🤯 Oral presentation @neuripsconf.bsky.social #NeurIPS2024 #chemsky

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bioRxiv Immunology @biorxiv-immuno.bsky.social · 14/12/2024

The applying of immuno-RCA for the high-sensitivity detection of the ABO blood group antibodies on the printed glycoarray www.biorxiv.org/content/10.1101/202…

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André Nadler @nadlerlab.bsky.social · 13/12/2024

Beautiful work - I love the analysis of organelle rearrangement in response to changes in lipid flux.

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jamelle @jamellebouie.net · 12/12/2024

i do find it interesting in a bleak way that silicon valley is basically recapitulating 1920s-style american reactionary politics.

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Jason Shepherd @jasonsynaptic.bsky.social · 11/12/2024

The journey of breakthrough medical treatments is long and tortuous. Loved hearing about the pioneering work of Pieter Cullis and the development of lipid nanoparticles! Note on his slide “basic research is important”!

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Bryan Dickinson @chembiobryan.bsky.social · 10/12/2024

Back by popular demand, I present PPI Prediction Challenge #2. My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT. Someone prove me wrong (take two). docs.google.com/forms/d/e/1F... 1/n

docs.google.com

PPI Prediction Challenge #2

For this protein-protein interaction prediction challenge, we present three target proteins: KRAS, RAF (the KRAS binding domain), and Mdm2. For each target protein, we are providing you a list of 8 po...

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Stu Cantrill @stuartcantrill.com · 10/12/2024

It reminds me to point out that Pauling’s PhD Thesis (PDF linked at the bottom of this page: thesis.library.caltech.edu/1791/) is literally a cover page followed by reprints of 5 JACS papers…

media.tenor.com

a man in a suit and tie is saying " boom easy as that "

Alt: a man in a suit and tie is saying “boom easy as that”

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Elisa Fadda @elisafadda.bsky.social · 10/12/2024

Yet another amazing and captivating story by @jeremymberg.bsky.social ⬇️🧵 ++ great (I agree) advice, Prof Pauling, how do you come up with so many good ideas? "I try to come up with many ideas and I throw away the bad ones" LC Pauling 👍🏻😎

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Keith Hornberger @krhornberger.bsky.social · 04/12/2024

I remain impressed that this got published in a high-profile journal. Most med chemists have a visceral, well-founded negative reaction to those structures. I wish we could teach our bio colleagues the structural spidey sense. Tip of the iceberg here when it comes to setting the record straight.

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Derek Lowe @dereklowe.bsky.social · 03/12/2024

That awkward moment when someone publishes a paper saying that they can’t find any evidence that your compounds bind to what your own series of papers say that they bind to. . .

science.org

Do They Even Bind?

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Ragothaman Yennamalli @structbioinfo.bsky.social · 08/12/2024

I think I have not developed a thick skin of academia, yet. Manuscript getting desk rejected stings and it is not a great feeling to be in. Ugh!

media.tenor.com

a little girl is sitting in a car seat holding a lollipop

ALT: a little girl is sitting in a car seat holding a lollipop

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Alejandro Brenes @ajbrenes.com · 06/12/2024

You'll notice proteomics has tighter CVs and higher correlation between the cells. Also the average proteome to transcriptome correlation is low (~0.35). Really nice to see this quantified clearly

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Oded Rechavi @odedrechavi.bsky.social · 07/12/2024

Using the word "Kickass" in the presentation of the official Nobel Lecture (Gary Ruvkun) 🤣

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Anne Imberty @anneimb.bsky.social · 17/11/2024

Still time to register to awsome Glycobiology Gordon Research Conference 2025. We have a fantastic line of speakers and this will be top #glycotime in Tuscany !! Register at www.grc.org/glycobiology...

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🧌🥛 🏨 @comraderobot.bsky.social · 05/12/2024

you have seriously fucked it morally if people are posting like this ON LINKEDIN after you pass

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SUgayos @sugayos.bsky.social · 05/12/2024

A ver si así lo entienden.

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Gopalan @arulmari.bsky.social · 05/12/2024

Yes, I did look up the Aim and Scope. Yet.... Appears to be exploiting the supply / demand and ensuring that the basket does not end up with other competitor publishers or society journals! Brand harvesting. Funny trends 🙂

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Gopalan @arulmari.bsky.social · 05/12/2024

Awaiting "Nature C-C bonds", next! 😇

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Michael Gilman @gilman.bsky.social · 04/12/2024

They disrupt nuclear aggregate formation in patient cells, correct relevant splicing defects, and fully reverse myotonia in mice. And they do all this while preserving the things we know and love about small molecules, including broad biodistribution and oral bioavailability.

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George Birchenough @gobletcellguy.bsky.social · 03/12/2024

Very happy (and somewhat shocked) to have been awarded an #ERC #CoG grant to study how cervical #mucus prevents intrauterine infection and #preterm birth... looking forward to meeting a new mucosal community! (Watch this space for project linked job ads 🤩)

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Watanabe Lab @JHU @watanabelab.bsky.social · 02/12/2024

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow!

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Ben Bellenie @chemb.bsky.social · 21/11/2024

Assume all small molecules are unselective for their protein target until proven otherwise. Even if the vendor tells you it’s a selective inhibitor for X, there’s a decent chance it isn’t selective! So how do we find quality molecules for scientific experiments? academic.oup.com/nar/advance-...

academic.oup.com

The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research

Abstract. The Chemical Probes Portal (www.chemicalprobes.org) is a free, public resource, based on expert-reviews, that supports the assessment, selection

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Rajini Rao @madamescientist.bsky.social · 29/11/2024

You only need two lipid species to party! 🥳 🧪

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Maryse Berkhout @maryseberkhout.bsky.social · 29/11/2024

20 years ago, #Akkermansia muciniphila was discovered 🦠🎈. To celebrate two decades of science on this unique bacterium, we reviewed its role in the human gut, some special biological features and potential applications. t.co/UpIHJyIVoQ #microbiology #microbiota

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Edward Nirenberg @enirenberg.bsky.social · 29/11/2024

I am personally annoyed by the fact that hypocalcemia causes tetany and hypercalcemia causes weakness and not the reverse as the electrochemical gradients would imply. Stupid sodium channels

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Xiuzhen Chen @xiuzhenchen.bsky.social · 27/11/2024

Came to a new understanding of 'colocalization' since starting STED microcopy: there is no colocalizaiton, objects cannot occupy the same physical space!

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Ingo Hartung @hartungingo.bsky.social · 21/11/2024

An important part of the visit to Bangalore/Bengaluru was to acknowledge key contributions of our partners at Syngene to our NCE & ADC discovery projects. The value of meeting in person & getting to know each other will never be reached by communication apps.

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Ingo Hartung @hartungingo.bsky.social · 25/11/2024

There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...

nature.com

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications

Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...

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Joachim Goedhart @joachimgoedhart.bsky.social · 25/11/2024

The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation www.biorxiv.org/content/10.1...

Figure 4. Position and type of fluorescent tag affect protein expression and P-body numbers in vivo.

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Maryse Berkhout @maryseberkhout.bsky.social · 25/11/2024

Hello Bluesky 🦋, I am excited to join the Bluesky community! My name is Maryse and I am working on the interaction between #microbes and #mucus at Wageningen University in The Netherlands 🦠 And as you can see in the image - I enjoy crochet!

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Joel Boerckel @jboerckel.bsky.social · 25/11/2024

Revisiting Strunk & White while I edit manuscripts. Part of me wants to just digitize the whole thing, train an LLM on the rules, and tell it to number the changes it makes to our ms accordingly.

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Brady Johnston @bradyajohnston.bsky.social · 25/11/2024

Just got some nice positional averaging inside of #MolecularNodes. Smooth out trajectories across frames when visualising, add subframes, also takes into account periodic boundary crossing so you don't have zooming lipids #b3d #GeometryNodes #GlycoTime #SciArt

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