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Ingo Hartung

@hartungingo.bsky.social
2K followers 788 following 140 posts

discovery chemistry nerd @Merckgroup; oncology, immunology, targeted protein degradation, ADCs; soccer, politics, tapas can slip into the feed; my own views

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Reposted by Ingo Hartung
RSC Medicinal Chemistry @rscmedchem.rsc.org · 02/07/2025
📢We are delighted to share our latest themed collection on Induced-Proximity Pharmacology, guest edited by @lynjoneschembio.bsky.social, @hartungingo.bsky.social & Lindsey James! Explore the articles that make up this fantastic collection, here👇 pubs.rsc.org/en/journals/... #chemsky 🧪
RSC Medicinal Chemistry promotional graphic for the Induced-Proximity Pharmacology collection, with QR code.
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Ingo Hartung @hartungingo.bsky.social · 01/07/2025
Great visit to our longstanding collaboration partners at the ICR discussing how small molecules continue to generate clinical impact. Learned a lot about how Zoran and his team tackle glue degrader discovery to deliver on the promise of expanding the druggable space.
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Ingo Hartung @hartungingo.bsky.social · 05/06/2025
Hi all, our old #sciencetwitter party place is reopening. Just in case you didn‘t get the invite… bring your Popcorn!
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Ingo Hartung @hartungingo.bsky.social · 19/05/2025
This paper sounds interesting. Oh wait… @proxidrugs.bsky.social
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Ingo Hartung @hartungingo.bsky.social · 29/04/2025
Guess who is sitting in front of me…
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Ingo Hartung @hartungingo.bsky.social · 24/04/2025
I guess this means I made it through immigration… #AACR25
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IBC2 @ibc2-gu.bsky.social · 23/04/2025
🚀 An inspiring milestone worth sharing! 🎥 Yesterday marked the official kick-off event for the 2nd phase of our BMBF-funded #Cluster4Future @proxidrugs.bsky.social. Thanks to all scientists, stakeholders, citizens & schools for actively participating and making it a very special day for us!
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Geanncarlo Lugo @gclugo.bsky.social · 14/04/2025
Una copa bien en alto por uno de mis autores favoritos. Gracias por las historias, las palabras, y la valentía. Buen viaje, Mario. 🥂📚 Farewell to the Last Writer of the Latin American Boom www.nytimes.com/2025/04/13/b...
nytimes.com
Mario Vargas Llosa: An Appreciation
The Peruvian author Mario Vargas Llosa was the world’s savviest and most accomplished political novelist.
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Ingo Hartung @hartungingo.bsky.social · 06/04/2025
Life could be worse… unfortunately, a pretty busy working week ahead.
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Ingo Hartung @hartungingo.bsky.social · 06/04/2025
First impressions of comparing #AACR25 coverage on Bluesky with the other place. I am used to check the conference handle regularly to build my conference schedule. Some interesting findings on Twitter, nothing here yet. I hope conference coverage will pick up here as well.
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Ingo Hartung @hartungingo.bsky.social · 22/03/2025
Still difficult for me to judge the reach of this platform. #AACR25 (5 weeks from now) will be the 1st real test for science posting here. The meeting program is packed w/ sessions about novel ADC approaches, degraders/proximity inducers, targeting intracktables, overcoming resistance, using AI.
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Ruprecht Polenz @polenz.bsky.social · 22/03/2025
Besonders die Einleitung des Artikels ist wichtig. Ich frage mich die ganze Zeit: warum sollte Putin warten, bis Europa sich besser verteidigen kann? ME ist das einzige, was ihn noch aufhält, der ukrainische Widerstand.
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Ingo Hartung @hartungingo.bsky.social · 20/03/2025
A bit more than one month til #AACR25 and two months til the ASCMEDI-EFMC symposium - both in Chicago. I never thought that traveling to the US may ever become an issue for political reasons. Let‘s see what the next weeks will bring…
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Ingo Hartung @hartungingo.bsky.social · 19/03/2025
More about rewiring transcription with bifunctional TCIP molecules: biological proof-of-concept in sarcoma cell lines www.biorxiv.org/content/10.1...
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Ingo Hartung @hartungingo.bsky.social · 17/03/2025
A small molecule USP7 activator from the Buhrlage Group! Important information in the SI not to be missed: significant activity differences between enantiomers & an inactive control compound. A very strong data package further enabling studies of USP7 biology.
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Reposted by Ingo Hartung
Chemical Probes Portal @chemicalprobes.org · 12/03/2025
📢Looking ahead to #AACR25 in Chicago — only 6 weeks away! Join the Meet-the-Expert session with Prof. Paul Workman, where he’ll emphasize the critical role of high-quality chemical probes in drug discovery. 📅 April 29, 2025 | ⏰ 5:00-5:45 PM Learn more👇 #CancerResearch
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Ingo Hartung @hartungingo.bsky.social · 12/03/2025
Summary: 1st Ph3 readout for a #PROTAC; likely path-to-approval in metastatic breast cancer patients w/ ESR1 mutations after having received endocrine therapy & CDK4/6 inhibitors; in line with previous clinical data; stock brokers don‘t understand Ph1/2 data. www.fiercebiotech.com/biotech/pfiz...
fiercebiotech.com
Pfizer, Arvinas post mixed breast cancer survival results in first phase 3 test for a PROTAC degrader
Pfizer and Arvinas’ estrogen receptor (ER) degrader has
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Ingo Hartung @hartungingo.bsky.social · 08/03/2025
What a book! Very well deserved Booker Prize. Must-read recommendation. #ChemistsWhoRead
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Ingo Hartung @hartungingo.bsky.social · 01/03/2025
Tja, das ist mal ein Romanbeginn, der meine Aufmerksamkeit schon im ersten Satz gewonnen hat…
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Ingo Hartung @hartungingo.bsky.social · 22/02/2025
Small molecular weight drug molecules are products of design. Multiple characteristics are designed into one chemical structure. Read about how the combination of experimental data with calculated properties streamlines the discovery of oral designer PROTACs: pubs.rsc.org/en/content/a... @rsc.org
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Ingo Hartung @hartungingo.bsky.social · 21/02/2025
Visiting #Irsee2025 was again a true pleasure. Not only the great science in a unique environment. But also the truly Bavarian weather, food & beer! Already looking forward to 25th til 27th February 2026 for #Irsee2026! @dechema.bsky.social
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Ingo Hartung @hartungingo.bsky.social · 21/02/2025
More biocatalysis at #Irsee2025. It took us a few years to bring Uwe Bornscheuer all the way from the baltic sea to south-western Bavaria. But it was worth the wait… reengineering methyl transferases and monooxygenases. @dechema.bsky.social
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gsbardella.bsky.social @gsbardella.bsky.social · 21/02/2025
The Hit to Lead process is an integral part of contemporary drug discovery. A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead
Best practices for the Hit-to-Lead phase of drug discovery are exemplified in this article, with links to further materials and references as a learning resource. This consensus output was produced b....
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Ingo Hartung @hartungingo.bsky.social · 21/02/2025
The new perspective from the @euromedchem.bsky.social Best Practice Initiative is now online: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... Best practice recommendations for the optimization from a Hit to a Lead. Kudos to Bob Young & Jean Quancard for driving this initiative!
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Ingo Hartung @hartungingo.bsky.social · 21/02/2025
The power & coolness of biocatalysis at #Irsee2025: Rebecca Buller from Zurich University of Applied Sciences about strategies to evolve designer enzymes. Enabling the chlorination of the complex macrolide soraphen and the derivatization of terpenes.
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k. radke @kradke.bsky.social · 16/02/2025
„Was bei diesen Wahlen passiert, wird enorme Auswirkungen auf den Rest der Welt haben.“ Timothy Snyder #Bundestagswahl2025
rnd.de
US-Historiker Snyder: Deutschland „wichtigste Demokratie der Welt“
Nach der Münchner Sicherheitskonferenz bleibt Ratlosigkeit: Welche Lehren sind aus den Ergebnissen der vergangenen Tage zu ziehen? US-Historiker Timothy Snyder findet kritische Worte für Trump – und r...
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jeffreybode.bsky.social @jeffreybode.bsky.social · 12/02/2025
It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find! www.nature.com/articles/s41...
nature.com
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
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Ingo Hartung @hartungingo.bsky.social · 11/02/2025
Talking about VHL-based #PROTACs: Check out our newest publication from the @proxidrugs.bsky.social consortium in which we propose & exemplify a generalizable workflow for the validation of E3 ligands for developing PROTACs. pubs.acs.org/doi/10.1021/...
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Ingo Hartung @hartungingo.bsky.social · 11/02/2025
Still all fine on this side of the sea of greenland (formerly known as the atlantic ocean).
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Ingo Hartung @hartungingo.bsky.social · 10/02/2025
There are many reasons for drug discovery scientists to be interested in #PROTACs. VHL-based PROTACs should not be ignored, there are important use cases for them. @alessiociulli.bsky.social & colleagues now compiled the VHL ligand chemical space in this paper: www.tandfonline.com/doi/pdf/10.1...
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Ingo Hartung @hartungingo.bsky.social · 08/02/2025
I have to for upcoming conferences and speaker invitations. I always enjoyed visiting the US. But this is different now. My visa to enter the US ends in early 2026. So it will be fun with the immigration officers & even more fun with applying for a new one at the US embassy in Germany.
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French Spy @frenchspy.bsky.social · 05/02/2025
Yeah… #Commodore64 ftw www.shutterstock.com/image-photo/...
Picture of a Commodore 64 with tape reader and monitor.
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Ingo Hartung @hartungingo.bsky.social · 05/02/2025
Commodore 64 with floppy disk generation over here 🤷‍♂️
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Chemjobber @chemjobber.bsky.social · 03/02/2025
RIP Amos Smith: www.chem.upenn.edu/news/2025/02... chemsky 🧪⚗️
chem.upenn.edu
Amos B. Smith III (1944-2025) | Department of Chemistry
We are deeply saddened to announce that our friend and colleague Amos B. Smith III, Emeritus Professor of Chemistry, has passed away. Amos received both his B.S. and M.S. degrees in Chemistry from Bucknell University in 1966 and his Ph.D. from The Rockefeller University (with William C. Agostain) in 1972. He joined Penn in 1973 (along with a joint appointment at the Monell Chemical Senses Center). Amos was a mainstay in our organic chemistry division and recently celebrated 50 years of service to Penn. He also served as Department Chair from 1988 to 1996.
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Katie Mack @astrokatie.com · 28/01/2025
I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.
washingtonpost.com
White House pauses all federal grants, sparking confusion
The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.
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Ingo Hartung @hartungingo.bsky.social · 28/01/2025
Random chemist: Only biologists use pubmed, we still got google, scifinder… 😉
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Katrina Ray @heykatray.bsky.social · 16/01/2025
Welcoming the newest members of the #NatureReviews family @natrevbiodiv.bsky.social & @natrevcleantech.bsky.social on their launch week! You can follow them and more Reviews journals (and a few Editors) in this starter pack 🧪 go.bsky.app/KcxvQLp
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Ingo Hartung @hartungingo.bsky.social · 26/01/2025
Und noch eine Roman-Empfehlung mit aktuellem Bezug: Arnold Zweigs Roman “De Vriedt kehrt heim” über einen politischen Mord im britischen Mandatsgebiet Palästina (Erstveröffentlichung 1932!). Neuausgabe aus 2024 der Anderen Bibliothek. Über die Ursprünge des israelisch-palästinensischen Konflikts.
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Ingo Hartung @hartungingo.bsky.social · 26/01/2025
Nach längerer Pause gestern mal wieder im Theater: Faust 1&2 im Schauspiel Frankfurt, Regie Jan-Christoph Gockel, mit “Kommissar Brix” als Mephisto. 4h modernes, multimediales, sehr kurzweiliges Theater. Textkenntnis hilft, kann aber durch die Einführung ersetzt werden. Wieder im März & April.
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Sherry Pagoto, PhD @drsherrypagoto.bsky.social · 24/01/2025
Bluesky appears to be the official social media platform for science: In Jan 2025, a Nature survey of 6,000 scientists found: ▶️ 70% are now on Bluesky ▶️ 53% say they left X ▶️ 13.6% say they use X more than Bluesky www.nature.com/articles/d41...
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The Tired Scientist @thetiredscientist.bsky.social · 25/01/2025
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Ingo Hartung @hartungingo.bsky.social · 25/01/2025
Appropriate reading during these tumultuous days: „Twilight of Democracy“ by @anneapplebaum.bsky.social. A few teasers below for those interested in thinking about the historical perspective for the destructive centrifugal forces currently visible in all Western democracies. amzn.eu/d/1m8dE4G
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Ingo Hartung @hartungingo.bsky.social · 19/01/2025
Sunset are always spectacular when you are at the coast in the south.
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Ingo Hartung @hartungingo.bsky.social · 16/01/2025
Sehr guter Transfer meiner Roten. Jetzt gerne noch einen Stürmer…
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Ingo Hartung @hartungingo.bsky.social · 14/01/2025
In preparation for the inauguration on Monday I ask myself what has happened in the 16 years since this speech: youtu.be/HcOgwJ9uAMQ?... Since the days of cooperation across the aisle. Astonishing that we would look back at George W Bush this way.
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Ingo Hartung @hartungingo.bsky.social · 13/01/2025
Great news today: cKIT inhibitor M4205 aka IDRx-42 (discovered in our medicinal chemistry labs at @merckgroup.bsky.social) found a new home. Our fingers continue to be crossed that the compound will make a difference for GIST patients. New therapies are urgently needed! Congrats to the IDRx team!
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Sarah Reisman @reiswoman.bsky.social · 11/01/2025
Thanks to those who’ve reached out the last few days. I am grateful that my family and home are safe. Many of my friends and colleagues have lost homes. If you want to help Caltech/JPL faculty/students/staff, a relief fund has been established: giving.caltech.edu/areas-to-sup...
giving.caltech.edu
The Caltech and JPL Disaster Relief Fund
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Ingo Hartung @hartungingo.bsky.social · 09/01/2025
Es bleibt zu hoffen, dass sich der Bundestagswahlkampf um Inhalte drehen wird und weniger um „Was hat Söder gesagt und hat ihm Günther widersprochen?“. Im Moment findet die inhaltliche Auseinandersetzung um fundamentale politische Unterschiede nur in wenigen Printmedien statt. Hier z.B. im Cicero.
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Ingo Hartung @hartungingo.bsky.social · 09/01/2025
After having finished Angela Merkel‘s memoirs I am now moving further back in time. The relevance for today‘s situation in Europe is obvious. The author @anneapplebaum.bsky.social is an important voice in discussions about the future of Ukraine, Poland & the Baltic states. #ChemistsWhoRead
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Ingo Hartung @hartungingo.bsky.social · 07/01/2025
The main reason why I am using @duolingoesp.bsky.social is to be able - eventually - to read a book like this in its original version. Unfortunately, I am still a few years away from this goal… #ChemistsWhoRead
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