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Dan Liebler

@dliebler.bsky.social
283 followers 308 following 82 posts

Retired biomedical scientist, consulting in chemistry and toxicology. Guitar is my lifelong pastime. I love steel string flattops.

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Reposted by Dan Liebler
Derek Lowe @dereklowe.bsky.social · 02/06/2026
If not now, when? This is an emergency.
science.org
Action! Action Now.
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Eric Lipton NYT @ericlipton.nytimes.com · 02/06/2026
Super important speech here by NYT Publisher AG Sulzberger. Anyone who cares about the role of journalism in our global society-and democracy in the modern world-should read this/reflect on it. AI giants are in the process of wiping out much of the news industry. www.nytco.com/press/a-i-jo...
nytco.com
A.I., Journalism and the Uncertain Future of the Public Square
New York Times publisher A.G. Sulzberger warns A.I. companies are violating settled law and urges news organizations to stand up for their rights to ensure a sustainable future for reporting.
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vijay iyer @vijayiyer.bsky.social · 26/05/2026
“My wishes for the planet in 2024: No killing. No killing. Don't kill anyone, anywhere, for any reason. -S.R.” Tweeted by Sonny Rollins on Dec 31, 2023
Sonny Rollins @sonnyrollins 
“My wishes for the planet in 2024: No killing. No killing. Don't kill anyone, anywhere, for any reason. -S.R.”
2:00 PM • Dec 31, 2023
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 08/04/2026
“This administration has mis-used the term ‘DEI’ to eliminate policies and practices that were intended to broaden the diversity of human study participants,…support studies focused on health disparities,…and foster the inclusion of people with diverse backgrounds…in the scientific workforce.”
scienceandfreedomalliance.substack.com
The “Cure” for This Administration’s Scientific Priorities: Defend Responsible, Ethical Research and Respect Academic Freedom
By Jennifer Troyer, Jenna Norton and Alice Popejoy (all opinions our own)
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Joe Newberry @joenewberry.bsky.social · 04/04/2026
"Go climb the highest mountain. I may not get there with you. Go cross the harshest desert. I may not get there with you. Go swim the deepest ocean. I may not get there with you. But I will join you when I can." I wrote this song in honor of the Rev. Dr. Martin Luther King, Jr. Gone 58 years today.
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The Gairdner Foundation @gairdnerawards.bsky.social · 31/03/2026
Congratulations to John R. Yates III, Ruedi Aebersold and Matthias Mann, recipients of the 2026 Canada Gairdner International Award. Prof. Yates: www.gairdner.org/winner/john-... Prof. Aebersold: www.gairdner.org/winner/ruedi... Prof. Mann: www.gairdner.org/winner/matth... #2026GairdnerAwards
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Ida B Wells' Winchester Rifle @dytsras.bsky.social · 20/03/2026
You could say that Rock n Roll was born 111 years ago today in Arkansas, but probably not where you'd think. Before there was a Chuck Berry or Little Richard, there was those who wanted to be like her. Rosetta Nubin better known as Sister Rosetta Tharpe, the godmother of Rock was born on this day
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Brian PJ Cronin @brianpjcronin.bsky.social · 18/03/2026
It’s insane that America has never put Louie Armstrong or Duke Ellington or Ella Fitzgerald on currency but it’s about to mint a Donald Trump coin.
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 15/03/2026
These protein-like polymers may help target intractable cancer-causing proteins: cen.acs.org/biological-c... #chemsky 🧪
Protein-like polymers induce protein degradation.
Researchers engineered polymers to target two notorious cancer-causing proteins.

by Sarah Braner.
An illustration of one of Grove Biopharma’s protein-like polymers in sky blue and bright yellow.
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Chris Ashwood @cashwood.proteaglyco.com · 23/02/2026
This is great news, and I hope all vendors continue to support THE vendor neutral option for MS data. Regardless, it was a shame that Skyline went without funding for a year from SCIEX My dream is that Skyline is funded by all vendors continuously. All of #teammassspec benefits from the arrangement
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Natalie Turner @natalieturnerau.bsky.social · 16/02/2026
New preprint! We did a systematic comparison of proteases, digestion conditions, and labeling methods for histone PTM analysis by MS-based proteomics in the Yates lab at @scripps.edu. TL;DR: you can get great results in ~3 h of sample prep. 🧵
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MS Bioworks @msbioworks.bsky.social · 09/02/2026
We need to get more mass spec proteomics folks on here and increase the size of our cluster! #Proteomics #TeamMassSpec bluesky-map.theo.io
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National Baseball Hall of Fame and Museum @baseballhall.org · 09/02/2026
We'll pick it up from here. Spring Training and the World Baseball Classic are right around the corner!
Closeup of a hand reaching down to grip a baseball. (Mike Zarrilli/MLB Photos)
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Roxane Gay @roxanegay.bsky.social · 06/02/2026
1. It was not an accident. 2. It was not a staffer. 3. While the president may have dementia his racism is not due to dementia. 4. He isn’t sorry. He means every racist thought he shares. 5. His base agrees with him. 6. He will do it again. 7. No one in power will hold him accountable.
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Neal Harkness @nealharkness.bsky.social · 10/01/2026
#BelfastMaine #IceOut #Maine @pinetreeactivism.org Belfast Maine, Pop. 7500
Anti-ICE protesters in Belfast MaineAnti-ICE protesters in Belfast MaineAnti-ICE protesters in Belfast MaineAnti-ICE protesters in Belfast Maine
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jamelle @jamellebouie.net · 08/01/2026
a few thoughts youtu.be/lERS4kJIQR8
youtu.be
Abolish ICE
YouTube video by Takes™ by Jamelle Bouie
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Shenna Bellows @shennabellows.bsky.social · 08/12/2025
I’m proud to be leading this fight. Thank you to @maddowblog.bsky.social for highlighting this critical issue.
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Slavov Laboratory @slavovlab.bsky.social · 03/12/2025
Our latest article is out in Cell ! Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential. cell.com/cell/fulltex...
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Nikolai Slavov @slavov-n.bsky.social · 27/11/2025
An inspirational example of 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐜𝐫𝐞𝐚𝐭𝐢𝐯𝐢𝐭𝐲, 𝐨𝐫𝐢𝐠𝐢𝐧𝐚𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐫𝐢𝐠𝐨𝐫: Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter Mitchell proposed & rigorously articulated the radical ...
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Kai Kupferschmidt @kakape.bsky.social · 13/11/2025
I’ve been in Toronto at the #astmh meeting these past few days and last night some very good news was presented here: A new malaria drug has proven efficacious in a large trial and could soon be approved.🧪 My story in @science.org (and 🧵on why it's important to come): www.science.org/content/arti...
science.org
‘A sigh of relief’: New malaria drug succeeds in large clinical trial
As existing drugs falter because of resistance, the world gets a backup—but hard choices loom on how to use it
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Stephen Wolf @stephenwolf.bsky.social · 05/11/2025
Maine has voted in a landslide to reject a Republican-supported ballot initiative that would have restricted voting access heading into the critical 2026 midterms
bangordailynews.com
Mainers defeat Republican effort to institute voter ID and limit absentee voting
The no side of Question 1 had 60.2% of votes to 39.8% for the yes side when the Bangor Daily News and its national partner, Decision Desk HQ, called the race at 9:26 p.m. Tuesday.
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Dan Liebler @dliebler.bsky.social · 05/11/2025
Turn the volume up!
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A.R. Moxon @juliusgoat.bsky.social · 27/10/2025
“Tell your children who the cowards were.”
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Nikolai Slavov @slavov-n.bsky.social · 26/10/2025
The antibodies don’t work! The race to rid labs of molecules that ruin experiments Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this. www.nature.com/articles/d41...
nature.com
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
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Bill Grueskin @bgrueskin.bsky.social · 21/10/2025
Let's see how that government ban on White House demolition photos is going. www.pbs.org/newshour/pol...
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Dan Liebler @dliebler.bsky.social · 20/10/2025
Vanderbilt response to the Trump ‘compact’ is too clever by half. Dodging the immoral dominance play and pretending it’s a reasoned conversation. Vandy wishes to play ball as an elite institution on a level with MIT, Penn and UVA. Struck out looking.
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Rebecca Spang @rlspang.bsky.social · 18/10/2025
I repeat myself: this is a town of 6000 people in Waldo County, Maine
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The Audacity! Creative Action Together in Midcoast Maine @theaudacitymaine.bsky.social · 18/10/2025
1700 people out for No Kings in rural Rockland, Maine today… more than 4% of the population of Knox County. #NoKings #Maine #MEPolitics
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Gerald Weinand @dirigoblue.bsky.social · 18/10/2025
#NoKings rally Rockland Maine
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Zen Faulkes @doctorzen.net · 17/10/2025
Speculation: There has been a recency bias in citations for a long time, because the newer work should contain more up-to-date knowledge. This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.
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Bri Barbu @bribarbu.bsky.social · 13/10/2025
Turns out, boron-based heterocycles are anything but boring! In fact, some of them are pretty magical...1,2-oxaborines, for example, can be used as precursors to 11(!) other ring systems! Read more in my latest for @cenmag.bsky.social cen.acs.org/synthesis/sh...
cen.acs.org
These shape-shifting rings create customizable cores
1,2-oxaborines can shift into 11 different ring shapes to make modifying molecular cores easy
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J H @jpjh88.bsky.social · 12/10/2025
People need to start highlighting that Miller is actually the shadow President and the one calling the shots. When it was Musk who was doing it, it caused a rift between them so big that after he was out, Musk was bashing Trump claiming he is in the Epstein files.
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Eric Topol @erictopol.bsky.social · 17/09/2025
Low dose aspirin (160mg/d) reduced recurrence in people with colon cancer and PI3K mutations. Emblematic of precision, individualized medicine since the data for aspirin across all colon cancer has been mixed. www.nejm.org/doi/full/10....
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David Wessel @davidmwessel.bsky.social · 09/09/2025
Elaine Buckberg: To address "range anxiety," states should enact laws that require fast chargers to report real-time status that any EV mapping app can access via @brookings.edu Hutchins Center. www.brookings.edu/articles/cha...
brookings.edu
Charger data transparency: Curing range anxiety, powering EV adoption | Brookings
Proposal for states to require fast chargers to report real-time status accessible by any EV mapping app, so drivers can reliably navigate to chargers.
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Phil Lewis @phillewis.bsky.social · 28/08/2025
70 years ago, on this date, Emmett Till was kidnapped and brutally murdered by white men. His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary
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Mark Zaid, Esq @markzaidesq.bsky.social · 28/08/2025
Abbe Lowell and I represent CDC Director #SusanMonarez. Contrary to govt statements, Dr. Monarez has neither resigned nor yet been fired. She will not resign. We have issued the following statement:
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Nikolai Slavov @slavov-n.bsky.social · 23/08/2025
If you measure and interpret RNA levels in single cells, read this: "𝑂𝑢𝑟 𝑟𝑒𝑠𝑢𝑙𝑡𝑠 𝑠𝑢𝑔𝑔𝑒𝑠𝑡 𝑡ℎ𝑎𝑡 𝑖𝑛𝑠𝑡𝑎𝑛𝑡𝑎𝑛𝑒𝑜𝑢𝑠 𝑚𝑅𝑁𝐴 𝑎𝑏𝑢𝑛𝑑𝑎𝑛𝑐𝑒 𝑜𝑓 𝑐𝑎𝑛𝑜𝑛𝑖𝑐𝑎𝑙 𝑚𝑎𝑟𝑘𝑒𝑟𝑠 𝑖𝑠 𝑡𝑒𝑛𝑢𝑜𝑢𝑠𝑙𝑦 𝑙𝑖𝑛𝑘𝑒𝑑 𝑡𝑜 𝑡ℎ𝑒 𝑐ℎ𝑜𝑛𝑑𝑟𝑜𝑔𝑒𝑛𝑖𝑐 𝑝ℎ𝑒𝑛𝑜𝑡𝑦𝑝𝑒 𝑎𝑡 𝑡ℎ𝑒 𝑠𝑖𝑛𝑔𝑙𝑒-𝑐𝑒𝑙𝑙 𝑙𝑒𝑣𝑒𝑙." 1/2
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Nikolai Slavov @slavov-n.bsky.social · 22/08/2025
Protein degradation is often considered as a final step in regulating gene expression. It also regulates the first step: Transcription Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥: ⬛️ It has a key advantage. 👇
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Moira Donegan @moiradonegan.bsky.social · 22/08/2025
The homeless are painful to look at because they remind us of how unfair our world is, of how much suffering it contains, of how arbitrary and undeserved and precarious our own comforts and health are, of how we have failed to be sufficiently generous and merciful to others.
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Dan Liebler @dliebler.bsky.social · 08/08/2025
talkingpointsmemo.com
talkingpointsmemo.com
Talking Points Memo | Breaking News and Analysis
Talking Points Memo (TPM) is an independent news organization that publishes reporting and analysis about American politics, public policy and political culture.
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Nikolai Slavov @slavov-n.bsky.social · 08/08/2025
Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer
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Sasha Senderovich 🌻 @returnstosender.bsky.social · 15/07/2025
Holocaust and genocide scholar Omer Bartov makes it clear why “genocide” is the correct word to use to describe what Israel is doing in Gaza — with all the many legal, moral, ethical, and commemorative implications that flow from this necessary recognition. Gift link: www.nytimes.com/2025/07/15/o...
nytimes.com
Opinion | I’m a Genocide Scholar. I Know It When I See It.
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Michael MacCoss @maccoss.bsky.social · 02/07/2025
If you asked me 5 years ago if it would be possible to use a de novo tool on DIA data, I would have thought it would only exist in science fiction. Love being proved wrong. Great work from Justin Sanders. #proteomics #massspectrometry www.nature.com/articles/s41...
nature.com
A transformer model for de novo sequencing of data-independent acquisition mass spectrometry data - Nature Methods
Cascadia is a mass spectrometry-based de novo sequencing model that uses a transformer architecture to handle data-independent acquisition data and achieves substantially improved performance across a...
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ElieNYC @elienyc.bsky.social · 27/06/2025
Make no mistake, the SCOTUS decision about birthright citizenship IS ALSO ABOUT *birthright citizenship.* The Court is using nationwide injunctions as the tail, wagging the dog, to take us back to an Antebellum view of citizenship. That way led to war once. My latest in @thenation.com
thenation.com
The Supreme Court's Birthright Citizenship Ruling Is a Five-Alarm Catastrophe
In Trump v. CASA, the court hands the president yet more unaccountable authority—and yanks us into a neo-Confederate legal nightmare.
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Eric Topol @erictopol.bsky.social · 23/06/2025
This is wild! Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol) www.nature.com/articles/s41... www.nature.com/articles/s41...
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Alexandria Ocasio-Cortez @aoc.bsky.social · 11/06/2025
I will be damned if I allow a bunch of Confederate-waving January 6th apologists give the American people a lecture on flag waving. There is ZERO reason to enter an argument about patriotism with people who still worship traitors to America 150+ years later. They. Are. Breaking. The. Law.
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Dan Liebler @dliebler.bsky.social · 17/05/2025
A Path Forward to Save American Bio-Medical Research talkingpointsmemo.com/edblog/a-pat...
talkingpointsmemo.com
A Path Forward to Save American Bio-Medical Research
Over the past four months, I’ve spoken to dozens of biomedical researchers...
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Dan Liebler @dliebler.bsky.social · 15/05/2025
Broad industry support for Skyline and ProteoWizard has been one of the best things about our field. It has made all vendors’ instruments equally valuable in our marketplace of data. Don’t be penny wise and pound foolish #Sciex.
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Senator Bernie Sanders @sanders.senate.gov · 12/05/2025
What is happening in Gaza will be a permanent stain on the world's collective conscience. History will never forget how our government was complicit in enabling and sustaining this ongoing humanitarian disaster. We must end funding for the Netanyahu war machine.
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Michael MacCoss @maccoss.bsky.social · 11/05/2025
CVs are an important part of the validation process. However, it's possible to be measuring the wrong thing with precision. These assays need to provide data validating the specificity and linearity in addition to specificity. academic.oup.com/clinchem/adv...
academic.oup.com
The Need for Better Validation: Evaluating Aptamer and Proximity Extension Assays for Large-Scale Clinical Proteomics Studies
Proteins are not simple. Due to germline polymorphisms, editing of messenger RNA, and posttranslational modifications, the concept of “a protein” is a gros
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