Seminal #drosopphila study alert! Excellent job turning over the assumption that #mushroombody odour coding is random! Definitely food for thought (pun intended)
Ariel K. Frame
@arielframe.bsky.social
1.2K followers 413 following 105 posts
BSc Biology || PhD Neuroscience || Postdoc with Andrew Lin @andrewclin.bsky.social at University of Sheffield @sheffielduni.bsky.social || Drosophila, aging, learning and memory, neurobiology. Host: linktr.ee/quitecurious bit.ly/ArielFrame_GoogleScholar
![Hypergravity induces impairment in adult Drosophila melanogaster negative geotactic behavior. (A) A custom-built hypergravity simulator consisting of a circular plate attached to an AC motor via a rotating shaft. (B) Experimental timeline for assessing negative geotaxis following acute hypergravity exposure. SING, startle-induced negative geotaxis. (C) Climbing score on days 1–7, calculated as the proportion of flies that climbed 15 cm within 5 s [mean±s.e.m., generalized linear mixed model, GLMM, n=34 (1 g), n=32 (4 g); n=30 (1 g), n=29 (7 g); n=30 (1 g), n=28 (10 g); n=30 (1 g), n=30 (13 g)]. (D) Total distance moved within 5 min in the absence of startle stimuli at 0, 2 and 24 h post-hypergravity treatment [means±s.e.m., mixed-effects model, n=30 (1 g); n=29 (4 g); n=29 (7 g); n=30 (10 g); n=28 (13 g)]. (E) Mean velocity of flies over 5 min in the absence of startle stimuli at 0, 2 and 24 h post-hypergravity treatment [means±s.e.m., mixed-effects model, n=30 (1 g); n=29 (4 g); n=29 (7 g); n=30 (10 g); n=28 (13 g)]. For C–E: 1 g control flies (blue), 4 g (yellow), 7 g (red), 10 g (burgundy) and 13 g (purple). (F) Representative individual trajectories for flies in the negative geotaxis assay in the absence of startle stimuli at 0 and 24 h post-hypergravity treatment [individual control (blue) and hypergravity-exposed (other colors)]. Data represent biologically independent samples from three trials. All statistical tests were two-tailed. False discovery rate (FDR) correction was applied for multiple comparisons. Asterisks denote statistically significant differences between hypergravity-exposed flies and 1 g controls (*P<0.05; **P<0.01; ***P<0.001).](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ywwbhwuq4sszjve7kdshnahd/bafkreiftggfqgq73bx6kf72wtjwnaur2hwhqvgi6ly5rbo7hobminffyly)
