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Jun Ishigohoka

@junishigohoka.bsky.social
227 followers 279 following 80 posts

Evolutionary biologist. Phenotypic noise < bird migration genomics Tübingen < Plön < Kiel < Sapporo < Tokyo junishigohoka.github.io

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Jun Ishigohoka @junishigohoka.bsky.social · 30/09/2026
www.nature.com/articles/s41...
nature.com
Butterfly wing patterns in flight create powerful illusory motion cues - Nature
Butterfly wing patterns and flight dynamics work in tandem to create powerful visual illusions that confuse predators, potentially representing one of the most successful visual defence strategies in ...
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Jun Ishigohoka @junishigohoka.bsky.social · 29/09/2026
www.nature.com/articles/d41...
nature.com
Brain lipids are organized into zones — and reorganized during pregnancy
A map of fats across the whole mouse brain reveals a spatial architecture that differs from that seen in gene-expression and protein atlases.
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Jun Ishigohoka @junishigohoka.bsky.social · 29/09/2026
cell.com
Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit
Vaughen et al. find that brain sphingolipids are degraded by glial-derived glucocerebrosidase (GBA). Glial gba1b knockout in Drosophila causes selective sphingolipid and phospholipid alterations, cycl...
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Jun Ishigohoka @junishigohoka.bsky.social · 28/09/2026
www.nature.com/articles/s41...
nature.com
Rapid genome-wide purging following tsunami-induced hybridization in a stickleback population - Nature Ecology & Evolution
Species persistence following hybridization in nature requires the purging of introgressed alleles. Genomic monitoring of a tsunami-induced hybrid stickleback population in Japan reveals rapid genome-...
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Reposted by Jun Ishigohoka
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 24/09/2026
Somatic differentiation evolves rapidly and repeatedly through the modification of developmental plasticity www.biorxiv.org/content/10.64898/20…
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Aaron Ragsdale @apragsdale.bsky.social · 20/09/2026
Now out in Genetics: academic.oup.com/genetics/adv...
academic.oup.com
Mean fitness is maximized in small populations under stabilizing selection on highly polygenic traits
Abstract. Stabilizing selection commonly acts on complex traits that affect individual fitness. Here, we relate mean fitness under stabilizing selection to
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Jun Ishigohoka @junishigohoka.bsky.social · 18/09/2026
dx.plos.org/10.1371/jour...
dx.plos.org
Circadian Remodeling of Neuronal Circuits Involved in Rhythmic Behavior
The circadian clock controls a wide array of biological phenomena ranging from basal transcription to overt behavior. Now, new evidence shows that the clock affects a striking remodeling of the circui...
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Jun Ishigohoka @junishigohoka.bsky.social · 18/09/2026
www.ovid.com/journals/dev...
ovid.com
Circadian Changes in Drosophila Motor Terminals : Developmental Neurobiology
ABSTRACT:InDrosophila melanogaster,as in most other higher organisms, a circadian clock controls the rhythmic distribution of rest/sleep and...
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Reposted by Jun Ishigohoka
Nature Portfolio @natureportfolio.nature.com · 05/09/2026
The recently extinct Tasmanian tiger was Australia’s largest marsupial predator and famously likened to dog-family carnivorans. A study in Nature Communications shows that its skull functioned differently in prey capture compared to any living mammalian carnivore. go.nature.com/4r10OFZ #evosky 🧪
This is figure 1, which shows principal component plots of all partition shapes.
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Reposted by Jun Ishigohoka
Haoran Cai @haorancai.bsky.social · 27/08/2026
Now out @molbioevol.bsky.socialGenetic correlations summarize how traits covary, but they can hide different underlying architectures. Distinguishing those architectures can reveal distinct mechanisms generating—and potentially constraining—trait–trait relationships. academic.oup.com/mbe/advance-...
academic.oup.com
Consistent and idiosyncratic pleiotropy in shaping genetic correlations
Abstract. Pleiotropy, the phenomenon where a single mutation influences multiple phenotypic traits, creates genetic correlations that can constrain evoluti
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Reposted by Jun Ishigohoka
Ken Miller @kenmiller.bsky.social · 26/08/2026
This is wild. >1/2 of HC synapses disappear in artificial hibernation, come back in same/similar locations & memories intact. ~1/2 of engram synapses-between two memory-tagged cells-are clustered on dendrites, those preferentially spared. Not biggest synapses. 1/ www.science.org/doi/10.1126/...
This shows the visual abstract and a paragraph from the extended abstract of the linked article.
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Reposted by Jun Ishigohoka
Journal of Evolutionary Biology @jevbio.bsky.social · 25/08/2026
Does habitat use drive morphological variation in snakes? Our new study of over 400 species shows how distinct environments shape head and body traits, revealing a complex balance between adaptation and specialisation 🐍 Hudry & Herrel 2026 #Ecomorphology #SnakeEvolution doi.org/10.1093/jeb/...
doi.org
From head to tail: Does habitat use drive morphological variation in snakes?
Abstract. Convergence, defined as lineages evolving to be more similar to one another than their ancestors due to selective pressures is a hallmark of adap
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Reposted by Jun Ishigohoka
Timothy Fuqua @timothyfuqua.bsky.social · 19/08/2026
@vakirlis.bsky.social and I are proposing a new term in the de-novo genes / molecular evolution cinematic universe. The term is: "Emergence Bias" and our perspective piece describing it was published in @genomebiolevol.bsky.social today! So, what is an emergence bias? (1/7)
academic.oup.com
Emergence Biases in Molecular Evolution
Abstract. Biases in molecular evolution can significantly influence evolutionary trajectories. They have been described in a variety of contexts, such as d
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Reposted by Jun Ishigohoka
Genome Biology and Evolution @genomebiolevol.bsky.social · 24/08/2026
@timothyfuqua.bsky.social & @vakirlis.bsky.social formalize “emergence bias” as the molecular predisposition that, upon mutation, biases a genetic sequence toward or against manifesting new or latent functions or phenotypes 🔗 academic.oup.com/gbe/article/... #societyjournal #genome #evolution
academic.oup.com
Emergence Biases in Molecular Evolution
Abstract. Biases in molecular evolution can significantly influence evolutionary trajectories. They have been described in a variety of contexts, such as d
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Reposted by Jun Ishigohoka
Nature @nature.com · 22/08/2026
“It’s the best thing that has ever happened to me” - this is the first approved drug designed to treat the cause of narcolepsy go.nature.com/4hMj3fL
go.nature.com
First-of-its-kind narcolepsy drug opens door to new therapies for the brain
Nature - The drug, called Orzeyful, takes aim at the root cause of the sleep disorder rather than at its symptoms.
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Jun Ishigohoka @junishigohoka.bsky.social · 21/08/2026
Social behavior and activity are decoupled in larval and adult fruit flies academic.oup.com/beheco/artic...
academic.oup.com
Social behavior and activity are decoupled in larval and adult fruit flies
Lay Summary. The adaptive decoupling hypothesis explains the prevalence of complex life cycles in animals by stating that antagonistic selection leads to t
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Reposted by Jun Ishigohoka
FlyBase @flybase.bsky.social · 20/08/2026
Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...
nature.com
Treat biological databases as infrastructure, not projects
Letter to the Editor
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Molecular Biology and Evolution @molbioevol.bsky.social · 18/08/2026
McQueen, Yang & Wittkopp show that epistatic interactions between new mutations and as little as one nucleotide change impacting gene regulation can alter the distribution of mutational effects on gene expression. 🔗 doi.org/10.1093/molb... #societyjournal #evobio #molbio
doi.org
Epistatic impacts of cis- and trans-regulatory mutations on the distribution of mutational effects for gene expression in Saccharomyces cerevisiae
Abstract. Epistasis can influence evolution by causing the distribution of phenotypic effects for new mutations to vary among genotypes. Here, we investiga
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Reposted by Jun Ishigohoka
Lisandro Milocco @milocco.bsky.social · 17/08/2026
What can development contribute to predicting evolution? I argue it sets what evolution can access, and this depends on timescale since different parts of development evolve at different rates. Hence coarse-graining: keep only what matters 📣 New in @evojlinnsoc.bsky.social doi.org/10.1093/evol...
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Genetics Society of America @genetics-gsa.bsky.social · 13/08/2026
Happy birthday to Friedrich Miescher! In 1869, Miescher became the first scientist to isolate what he called “nuclein” from the nuclei of white blood cells—the substance we now know as #DNA. Read more in #GENETICS: buff.ly/0wReMtD
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Daohan "Rex" Jiang @rexjiang.bsky.social · 07/08/2026
I am organizing a symposium titled "How microevolutionary mechanisms produce macroevolutionary patterns" for the annual meeting of the Society for Evolutionary Studies, Japan this year. The conference will take place from Aug. 19-22 in #Nagoya. sesj2026.agr.nagoya-u.ac.jp/program_en.h...
sesj2026.agr.nagoya-u.ac.jp
Schedule & Program | The 28th Annual Meeting of the Society for Evolutionary Studies, Japan (Nagoya Meeting 2026)
This is the program page for the 28th Annual Meeting of the Society for Evolutionary Studies, Japan. Information on symposiums, oral presentations, poster sessions, and other program details will be p...
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Matthew Hahn @3rdreviewer.bsky.social · 31/07/2026
Very cool pair of papers demonstrating little link between amount of additive genetic variation and amount of nucleotide variation within species: journals.plos.org/plosbiology/... www.pnas.org/doi/10.1073/...
journals.plos.org
Levels of additive genetic variation vary substantially between species
Adaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th...
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Jun Ishigohoka @junishigohoka.bsky.social · 30/07/2026
academic.oup.com/mbe/article/...
academic.oup.com
The life history of recessive deleterious alleles as seen through the eyes of a honey bee (Apis mellifera)
Abstract. Deleterious mutations arise continually in natural populations, yet their full life histories—from origin to elimination—are rarely observed dire
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Reposted by Jun Ishigohoka
Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
New paper out in Phil. Trans. B! We set out to understand how seasonal migration evolves by combining a common garden experiment and scATAC-seq of the hypothalamus in ancestral migratory and derived resident populations of the Eurasian blackcap. 1/n
doi.org
Differential epigenetic regulation underlies evolutionary transition of seasonal migration
Abstract. Seasonal migratory animals can evolve residency through adaptation. The threshold model of quantitative genetics predicts that residency evolves
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Jun Ishigohoka @junishigohoka.bsky.social · 26/07/2026
www.nature.com/articles/s41...
nature.com
Theoretical morphospace reveals mixed optimisation of the avian wing planform for flight style - Nature Communications
Here, the authors examine bird wing planform shape and functional performance using theoretical morphospace and phylomorphospace. They find that, in a sample of 1138 extant bird taxa, planform shape i...
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
New paper out in Phil. Trans. B! We set out to understand how seasonal migration evolves by combining a common garden experiment and scATAC-seq of the hypothalamus in ancestral migratory and derived resident populations of the Eurasian blackcap. 1/n
doi.org
Differential epigenetic regulation underlies evolutionary transition of seasonal migration
Abstract. Seasonal migratory animals can evolve residency through adaptation. The threshold model of quantitative genetics predicts that residency evolves
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Reposted by Jun Ishigohoka
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 23/07/2026
Genotype-by-environment-by-environment (GxExE) interactions have the potential to shape adaptation in response to multiple stressors www.biorxiv.org/content/10.64898/20…
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Nature @nature.com · 22/07/2026
Researchers have discovered a contagious cancer in catfish – just the fourth example of tumour cells that spread naturally from one animal to another go.nature.com/4fsoLR3
go.nature.com
Rare contagious cancer discovered in wild catfish
Transmissible tumours have been found in only a few types of animal, but there might be many more out there.
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Reposted by Jun Ishigohoka
Cristian Gutierrez-Ibañez @gallinaciega.bsky.social · 22/07/2026
Neural correlates of seed-eating in songbirds royalsocietypublishing.org/rspb/article... Our new paper showing that songbirds that dehusk seeds with the beak and tongue have an enlarged trigeminal nucleus in the brainstem, particularly the part where the tongue is represented.
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Reposted by Jun Ishigohoka
Cauã Westmann @cauawest.bsky.social · 22/07/2026
Our latest paper on how transcription factor binding sites for global regulators can evolve in bacteria is now published in eLife! Mutation by mutation, we are uncovering the regulatory landscapes of bacteria. elifesciences.org/digests/1037...
elifesciences.org
Step by mutational step
New bacterial regulatory interactions can evolve more readily than previously appreciated, providing new insights into the evolution of gene regulation.
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Reposted by Jun Ishigohoka
Craig MacLean @craigmaclean.bsky.social · 27/06/2026
New #microsky#AMR Perspective paper with @penamiller.bsky.social rdcu.be/fqBJo ANTIBIOTIC RESISTANCE (IE MIC) AND TOLERANCE ARE NOT BACTERIAL TRAITS! Please read on if you want an explanation for this provocative claim.
rdcu.be
Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells
Nature Communications - Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells
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Reposted by Jun Ishigohoka
Violeta Caballero-Lopez @viocablop.bsky.social · 09/07/2026
📢 happy to share our new paper in @molecology.bsky.social Common chiffchaff subspecies diverge in the same migration-related region as willow warblers (see thread): onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Common Chiffchaffs (<fi>Phylloscopus collybita</fi>) Diverge in a Genomic Region Associated With Migration Differences in Willow Warblers (<fi>Phylloscopus trochilus</fi>)
Despite technological advances in both tracking and sequencing technologies, finding the genetic mechanisms behind migratory traits remains a challenge. Recent studies have shown that migratory direc...
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Reposted by Jun Ishigohoka
ERGA - European Reference Genome Atlas @ergabiodiv.bsky.social · 15/07/2026
#ERGAReads | 🐦‍⬛ 🦜 🪶 Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of Birds academic.oup.com/gbe/article/... #genomes #birds #convergentevolution #birdgenomics @genomebiolevol.bsky.social @erichjarvis.bsky.social
academic.oup.com
Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of Birds
Abstract. Vocal learning, the ability to imitate sounds, is a complex convergent trait crucial for spoken language and observed in a few independent lineag
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Reposted by Jun Ishigohoka
Earl K. Miller @earlkmiller.bsky.social · 15/07/2026
MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86 news.mit.edu/2026/mit-pro... #neuroscience
news.mit.edu
MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86
Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...
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Sergio Hidalgo Sotelo @sergiohidalgo.bsky.social · 15/07/2026
I am very happy to share that our article, "Splicing of a core circadian clock gene regulates seasonal adaptations by a winter gating mechanism," is now available in Science Advances. 🎊 (1/4) www.science.org/doi/10.1126/...
science.org
Splicing of a core circadian clock gene regulates seasonal adaptations by a winter gating mechanism
The circadian clock integrates photoperiodic and temperature cues by RNA splicing to promote seasonal plasticity.
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Chris Kyriazis @ckyriazis.bsky.social · 01/04/2026
New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6...
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Jun Ishigohoka @junishigohoka.bsky.social · 15/07/2026
www.science.org/doi/10.1126/...
science.org
CD4+ T cells reactive to Epstein-Barr virus late lytic antigens are enriched in individuals with multiple sclerosis
CD4+ T cells in MS preferentially recognize EBV viral particles rather than latent antigens, and responses are reduced by B cell–targeting therapies.
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Reposted by Jun Ishigohoka
PLOS Biology @plosbiology.org · 10/07/2026
How do aerodynamic constraints and evolutionary pressures shape the diversity of flight in true flies? By integrating wing shape, wing motion and #aerodynamics, this study uncovers similarities as well as striking divergences in flight performance. 🧪 #AcademicSky #evolution plos.io/4b4LMbJ
A graph of wing shape variation across Diptera, quantified using a Principal Component Analysis (PCA). The two first principal components (PC1 and PC2), together with the associated shape changes and percentage of the variation explained by the principal components. Shown wing shapes represent the extreme values associated with each PC axis. Each data point shows a species-average wing shape. Species for which flight was quantified are highlighted with black circles.
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PLOS Biology @plosbiology.org · 03/07/2026
Immune cells exist as continuous clouds, not discrete categories. In this Perspective, @tal-shay.bsky.social &co reframe immune identity through systems biology, and propose that immunotherapies should aim at dynamics of the cell cloud. 🧪 #AcademicSky #immunology plos.io/4oWuoLG
The cell cloud model. (a) Historically, discrete cell types were defined by histology or standard flow cytometry. (b) “Cell clouds” represent cells as the probability distribution of transcriptional states they occupy. Cell clouds serve as the empirical manifestation of attractor basins. Canalization produces tighter clouds, and cellular plasticity produces broader clouds. The panels in this Figure were generated with the assistance of Google Gemini.
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Jun Ishigohoka @junishigohoka.bsky.social · 02/07/2026
Glad to see my former study species blackcap appear in the final plenary by @mexpositoalonso.bsky.social #smbe2026
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Science Magazine @science.org · 01/07/2026
Seafaring turtles navigate by moving in one direction at a time during ocean migrations, even when doing so causes them to go off course for a while, new research suggests. Learn more in #ScienceAdvances: scim.ag/4xNAwtR
scim.ag
Records of compass heading for long-distance ocean migrators show mid-ocean reorientation
Records of compass headings show that migrating green turtles only occasionally reorient during ocean crossings.
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 01/07/2026
From migrants to residents: Genomic insights into adaptive strategies in European robins (Erithacus rubecula) www.biorxiv.org/content/10.64898/20…
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Luisa F. Pallares @luisapallares.bsky.social · 28/06/2026
The lab is at #SMBE2026! Come see @junishigohoka.bsky.social talk on Wednesday in the "Fitness Landscapes" symposium @3:50pm. Jun will talk about our theoretical and experimental efforts to understand the implications of *probabilistic* GP maps for evolution (in contrast w *deterministic* GP maps).
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Jun Ishigohoka @junishigohoka.bsky.social · 01/07/2026
#SMBE2026 I will talk about **evolutionary roles of non-genetic variation**. If you care about expression noise, developmental instability, microenv. variance, or selection experiments (or if you don't believe in genetic determinism), come join me in S20 "mapping fitness landscapes" (17:30, Pjerrot)
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Jun Ishigohoka @junishigohoka.bsky.social · 28/06/2026
www.nature.com/articles/s41...
nature.com
Distinct genetic architecture in the tails of complex traits - Nature
Genome-wide analyses in multiancestry and European cohorts show that in complex traits, rare alleles have disproportionately large effects at the tails of the phenotypic spectrum compared with common ...
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Reposted by Jun Ishigohoka
Jun Ishigohoka @junishigohoka.bsky.social · 16/06/2026
Paper alert!🧬🐦💻 Divergent selection is the textbook explanation for narrow inversion clines. Our blackcap inversion cline doesn't fit: it is wide, and the inversion is always the rarer arrangement. We show that negative frequency-dependent selection shifting between populations underlies this!
onlinelibrary.wiley.com
Shifting Balancing Selection Underlies an Inversion Cline in Eurasian Blackcap
We investigated what factor contributes to a cline of a chromosomal inversion of the Eurasian blackcap, which differs from typical inversion clines maintained by divergent selection. Using a simulati...
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Reposted by Jun Ishigohoka
eLife @elife.bsky.social · 19/06/2026
A fundamental study of individual variation and contribution of learning to behavioural individuality. Conclusions are supported by compelling, rigorous analysis across a number of experiments in thousands of individuals across genotypes and conditions.
buff.ly
Learning is a fundamental source of individuality
Altmetric provides a collated score for online attention across various platforms and media.See more details
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Reposted by Jun Ishigohoka
liedvogel lab @genmig.bsky.social · 16/06/2026
awesome work by @junishigohoka.bsky.social highlighting the underappreciated role of shifting balancing selection. jun used demography inference, pogen simulation under our blackcap demography, and ABC to (i) identify the type of balancing selection and (ii) estimate its spatially varying parameters
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Jun Ishigohoka @junishigohoka.bsky.social · 16/06/2026
Paper alert!🧬🐦💻 Divergent selection is the textbook explanation for narrow inversion clines. Our blackcap inversion cline doesn't fit: it is wide, and the inversion is always the rarer arrangement. We show that negative frequency-dependent selection shifting between populations underlies this!
onlinelibrary.wiley.com
Shifting Balancing Selection Underlies an Inversion Cline in Eurasian Blackcap
We investigated what factor contributes to a cline of a chromosomal inversion of the Eurasian blackcap, which differs from typical inversion clines maintained by divergent selection. Using a simulati...
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Jun Ishigohoka @junishigohoka.bsky.social · 05/06/2026
logistic regression according to BioRender
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