Our results reveal a dynamic pattern of multiple introductions and regionally structured spread of 3III_B.3.2, which may represent a general feature as a similar reconstructed history has also been ob...

Corticostriatal glutamatergic overdrive, through NMDA receptor-dependent signalling, is linked to the amplification and propagation of beta synchronisation across the CBT circuit, highlighting it as a...

Multimodal results (iEEG, fMRI and MEG) of predictions from integrated information theory and global neuronal workspace theory align with some predictions of both theories on visual consciou...

npj Aging - Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

In persons aged 75 years or older receiving statins for primary prevention and with no previous history of ASCVD, discontinuation of statins was non-inferior to continuation in terms of all-cause mort...

Ethiopia is the fifth sub-Saharan African country now meeting WHO confirmation criteria for ART-R. High R622I prevalence and double deletion rates, consistent with distinct selective pressures, repres...

The COVID-19 pandemic was associated with changes in IMD capsular distribution in Scotland, concomitant with a decline in clonal complex 11. In 2025–26, 4 years after physical restrictions eased, geno...

Percutaneous biopsy of PPGLs was associated with a low mortality rate. Serious complication rates were also low, most of which were not catecholamine-related. These findings challenge current recommen...

MiDAS highlights the co-occurrence of multimorbidity with the worst outcomes in difficult-to-treat asthma. These findings strongly indicate that an airway-centric approach is inadequate and that holis...

Background: Rehabilitation has been identified by the World Stroke Organization (WSO) as a key priority to reduce the global burden of stroke. Global access to ...

Obesity affects nearly one in three adults in England, with disproportionate burden among disadvantaged groups and widening disparities since the COVID-19 pandemic. Increasing rates among individuals ...

Zhang et al. reveal that nuclear cGAS promotes breast cancer metastasis by stabilizing β-catenin independently of STING. PKCα-mediated phosphorylation drives cGAS nuclear entry, where it prevents TRIM...

npj Primary Care Respiratory Medicine - AI-driven clinical decision support for early diagnosis and treatment planning in patients with suspected sleep apnea using clinical and demographic data...

Background Individuals with difficult-to-treat migraine, including resistant migraine (ResM) and refractory migraine (RefM), might experience treatment delays, ...

Background and ObjectivesAnti–Kelch-like protein 11 (KLHL11) encephalitis was discovered in middle-aged men with testicular seminoma and rhombencephalitis, defining a new type of paraneoplastic neurol...

Lactate, traditionally regarded as a metabolic byproduct of glycolysis, is now recognized as a critical signaling molecule in the central nervous system. Eme...

Suzuki and Yoshioka et al. show that the garlic-derived metabolite S-1-propenyl-L-cysteine (S1PC) increases circulating eNAMPT, a key NAD+ biosynthetic enzyme, in mice and humans by activating a criti...

Through comprehensive phenotyping of complex mouse models and in vitro studies, the authors uncovered that futile lipid cycling has a sizable thermogenic output. However, in its absence, alternative m...

While classical models propose that lysosomes/vacuoles are acidified using free cytosolic protons, Liu et al. reveal that mitochondrial electron transport provides a substantial proton source through ...

Our findings show that iMBSHH outcomes and prognostic biomarkers are therapy dependent. In our retrospective patient group, non-metastatic iMBSHH treated with high-dose or IVT-MTX chemotherapy-only ha...

Polyendocrine metabolic ovarian syndrome (PMOS), previously named polycystic ovary syndrome (PCOS), affects one in eight women. However, the term PCOS is inaccurate, implying pathological ovarian cyst...

All subgroups of patients with antihypertensive prescriptions had an increased risk of hospitalisation or death due to falls versus those who were unexposed. No significant difference in risk of falls...

This first-in-field diagnostic study focused on intraoperative diagnosis based on surgical resection images in stage IA LUAD and provides insights into the macroscopic morphological features for patho...

A higher 10-year predicted CVD risk was associated with higher MOF and hip fracture risk after adjustment for sociodemographic, lifestyle, and clinical factors. CVD risk may have implications for frac...

The MARV anti-NPct MR assay provides a rapid, high-throughput, species-agnostic tool expected to differentiate natural infection from vaccine-induced immunity, addressing a critical gap in the current...

IL-27 constrains B-cell haematopoiesis and B-ALL progression through coordinated progenitor inhibition and BM niche remodelling, revealing a cytokine-driven strategy with the potential to enhance leuk...

ACEs were associated with lower educational attainment, irrespective of genetic predisposition to education. A potential novel variant, rs2743239, was linked to educational resilience specifically amo...

In adults with type 2 diabetes on basal insulin plus modern therapies, real-time CGM improved glycaemic control versus SMBG during self-management and under clinician-supported management.

Shi et al. delineate an interplay among tumor cells, immune cells, and the nervous system that drives cancer cachexia and anorexia. Specifically, tumor-derived CSF1 induces macrophage GDF15, which sig...

Wang et al. report that LUAD cells entering dormancy transition into a TGFβ-induced atypical mesenchymal state characterized by a soft spheroidal morphology and strong EMT signature, which protects di...

Synergizing with senescence-inducing therapies, uPAR CAR T cells eradicate primary and metastatic solid tumors with minimal myelodepletion by targeting both tumor cells and the stroma in preclinical m...

Sacroiliac bone marrow oedema affects nearly one-third of adults, showing associations with pregnancy, overweight, and occupational physical stress rather than inflammatory disease. This prevalence ex...

These real-world data suggest that the kidney-protective benefits of GLP-1 receptor agonists observed in randomised trials of individuals with type 2 diabetes might also extend to individuals already ...

AZU1 was identified as a novel marker of disease severity in bronchiectasis, associated with bacterial infection and exacerbation, and targeted by DPP1 inhibition.

These validated, publicly available PRSs can improve risk stratification for type 2 diabetes onset and complications across diverse ancestries, supporting their further evaluation in clinical settings...

ObjectivesKLHL11 encephalitis is often associated with vestibular symptoms and ataxia. However, the specific disorders of the vestibular and oculomotor systems have only been partially investigated so...

Bui et al. map immune escape from DCIS to IBC by using single-cell transcriptomic profiling of large clinical cohorts, identifying cycTreg as key IL-33-driven immune suppressors supported by heightene...

New approach methodologies that are human-centered, such as stem cells, organoids, and in silico models, can span the full drug discovery pipeline—from disease modeling to efficacy testing—and hold pr...

Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

Though successful in hematologic cancers, cell therapies face major barriers in solid tumors. Chen et al. review functional and translational obstacles undermining autologous and allogeneic cell-based...

The wildlife trade affects a quarter of terrestrial vertebrates and creates opportunities for cross-species pathogen transmission, but its precise role in shaping animal-human pathogen exchange remain...

BMC Infectious Diseases - Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains a major public health problem worldwide. The development of effective drugs and vaccines remains...

The Intermediate-mass Black Hole in Omega Centauri: Constraints on Accretion from JWST, Chen, Steven, Hare, Jeremy, Kargaltsev, Oleg, Yang, Hui, Cioffi, Denis, Häberle, Maximilian, Seth, Anil

Kumar et al. identify a metabolically controlled trait of CD4+ T cells in autoimmune disease. Exposed to fatty acids in rheumatoid joints, they form lipid droplets containing pore-forming gasdermin D and its activator zDHHC5. These droplets induce plasma membrane lysis, resulting in the leakage of intracellular contents and tissue inflammation.

Compartmentalized BCAA metabolism regulates CRC dissemination through UMP-mediated stabilization of vimentin, leading to pro-migrative traits. Targeting of BCAA metabolism by dietary restriction or repurposing of UMP biosynthesis inhibitors arrests CRC dissemination. Compartmentalized BCAA metabolism is a pan-cancer biomarker for poor survival. Our study thus links metabolic reprogramming to CRC metastasis.

Our work reveals the plasticity of pancreatic ductal adenocarcinoma tumor cell states and their interactions with the tumor microenvironment during chemotherapy, highlighting CD276/B7-H3 as a key regu...

Hubbi et al. reveal that hypoxia and pancreatic tumor interstitial fluid cooperate to suppress ferroptosis in pancreatic cancer through HIF-2 activity. By transcriptionally regulating glutathione meta...

Background: Epidemiological evidence suggests associations between substance use disorders and risk of stroke, but whether these are due to confounding or are t...