Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to engraft...

Some have already lost grants, while others fear for students and future funding

The United States has been the preeminent force in the world economy for the past 50 years because it has been the leader in technology innovation. The abrupt changes in government funding for scienti...

Genetic code expansion (GCE) enables the incorporation of new amino acids into proteins. Here, authors demonstrate the rapid OrthoRep-driven evolution of aminoacyl-tRNA synthetases for GCE, increasing...

A synthetic biology approach was used to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils, thereby addressing notable threat...

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and be...

Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...

The Women’s Health Initiative has produced numerous influential findings

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Explore how your tax dollars fund life‑saving medical research.

Abstract. Plasmids are extrachromosomal genetic molecules that replicate independent of chromosomes in bacteria, archaea, and eukaryotic organisms. They co

Vaccines have saved millions of lives, yet their importance and safety is repeatedly in question. W e cannot let disinformation campaigns get in the way of global public health – it is not time to def...

Alphaviruses optimize viral polymerase production and polyprotein processing at distinct temperatures via a premature stop codon.

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Cutting-edge photonic devices frequently rely on microparticle components to focus and manipulate light. Conventional methods used to produce these...

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Marlena Fejzo’s groundbreaking work implicates the hormone GDF15 as a key player in this understudied disorder.

A hallmark of retrovirus replication is the translation of two different polyproteins from one RNA through programmed –1 frameshifting. This is a m...

The American Association for the Advancement of Science honored them for scientific excellence and service to their communities.

At the HIRI, we do not just value excellent research. Short distances, an open door policy, and a good working atmosphere—this is what distinguishes us from others. Have a look at our current job post...

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...