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Hadley Sikes

@sikeslab.bsky.social
478 followers 501 following 20 posts

Willard Henry Dow Professor MIT Chemical Engineering, PI in AMR IRG, SMART, Singapore Clinical diagnostics, mathematical modeling, protein engineering, redox metabolism

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Hadley Sikes @sikeslab.bsky.social · 23/04/2025
This is very sad and wasteful. A lot of the value comes from longitudinal data. Stopping early wastes all of the startup costs. NIH cancels its first and largest study centered on women | Science | AAAS www.science.org/content/arti...
science.org
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
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Hadley Sikes @sikeslab.bsky.social · 23/03/2025
Wonderful essay by @francesarnold.bsky.social! A few points of wisdom resonating with me: finding that exploration/exploitation balance, navigating chemistry/engineering tension in differing motivations and values, importance of taking time to enjoy life with kids, importance of high expectations.
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Hadley Sikes @sikeslab.bsky.social · 08/02/2025
My representative in Congress is holding a conference call now- my cellphone rang and I was given the option to stay on the line to join. She's taking questions from constituents live. It's remarkable direct outreach and people are giving voice to problems the chaos in government has created.
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Reposted by Hadley Sikes
Aidan Milliff @aidanmilliff.com · 08/02/2025
Cuts to the NIH are a strategy to strangle research universities not “reduce waste”
Graphic from United for Medical Research showing that NIH funding produces $2.46 in economic activity for every $1.00 awardedGraphic from United for Research showing that NIH funding produced over $92B in economic activity in FY 2023Graphic from United for Research showing that $914M in NIH grants to Florida institutions supported 14,688 jobs and produced $2.78B in economic activity
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Hadley Sikes @sikeslab.bsky.social · 25/01/2025
Another engaging #AMR IRG January workshop is in the books. The group voted on what talks they wanted to hear, and we had a fun dinner at Umami10, celebrating another year working on diagnostics, therapies, and deeper understanding to allow both. #Singapore - #MIT Alliance, #CREATE Campus
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Hadley Sikes @sikeslab.bsky.social · 24/01/2025
We have an opening for a postdoctoral researcher with protein engineering skills in #AMR IRG at the CREATE campus in #Singapore, as part of the Singapore-MIT Alliance for Research and Technology. Here's the link to apply: portal.smart.mit.edu/careers/care... Fun group, interesting project!
portal.smart.mit.edu
Job Application - SMART
× Processing Please wait, form submission in progress ...
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Hadley Sikes @sikeslab.bsky.social · 15/01/2025
Banishing jetlag with a lunchtime walk in Clementi Woods Park #Singapore Weather is cool after all the rain!
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Hadley Sikes @sikeslab.bsky.social · 15/12/2024
Good morning #Singapore! Excited for a week of working on diagnostics and new ventures in #AMR Singapore-MIT Alliance for Research and Technology and for our year end company party #Thrixen
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Reposted by Hadley Sikes
Bryan Dickinson @chembiobryan.bsky.social · 10/12/2024
Back by popular demand, I present PPI Prediction Challenge #2. My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT. Someone prove me wrong (take two). docs.google.com/forms/d/e/1F... 1/n
docs.google.com
PPI Prediction Challenge #2
For this protein-protein interaction prediction challenge, we present three target proteins: KRAS, RAF (the KRAS binding domain), and Mdm2. For each target protein, we are providing you a list of 8 po...
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Hadley Sikes @sikeslab.bsky.social · 10/12/2024
"polyclonal antibody ... that recognizes hyperoxidized PRDX3 ... Owing to the limited supply, this antibody has been unavailable since publication of that study" Peroxiredoxins, super important and rudimentary tools for analysis! www.cell.com/molecular-ce...
cell.com
5H7c: A rabbit monoclonal antibody detecting ferroptotic cells
Ferroptosis, a cell death pathway triggered by iron-catalyzed peroxidation of phospholipids, has been implicated in both disease progression and cancer treatment.1 A major challenge in studying ferroptosis has been the difficulty in detecting ferroptotic cells under physiological conditions, owing to the lack of a specific marker for ferroptosis.1 This obstacle was recently overcome by our study published in Molecular Cell, which identified hyperoxidized PRDX3 as a specific marker for ferroptosis.
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Hadley Sikes @sikeslab.bsky.social · 07/12/2024
Exciting things to come from this new lab! Prof. Kim does elegant work analyzing reaction mechanisms and transport phenomena and students will greatly benefit from learning from him! His latest paper: onlinelibrary.wiley.com/doi/full/10.... Congrats to DGIST on an excellent hiring decision.
onlinelibrary.wiley.com
Size‐Dependent Photocatalytic Reactivity of Conjugated Microporous Polymer Nanoparticles
Decreasing the size of conjugated microporous polymer (CMP) nanoparticles is proposed to overcome diffusional resistance of substrates in the porous polymer photocatalysts and improve energy efficien....
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Hadley Sikes @sikeslab.bsky.social · 25/11/2024
I always wonder if the common biomarkers in diagnostic tests are the best (including most abundant/technically easiest) or if some are common because there was some existing data and test developers all jumped on board. Glad this dataset exists! www.cell.com/cell/fulltex...
cell.com
Atlas of the plasma proteome in health and disease in 53,026 adults
A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying promising biomarkers...
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Hadley Sikes @sikeslab.bsky.social · 25/11/2024
In awe of the many lab members I've coauthored with who make it look easy when it isn't, and as a journal editor am always careful not to reject solid results on the basis of language (can be revised). Much respect to those researchers who have this extra skill.
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