Transcription factors (TFs) form dynamic, high-concentration clusters, condensates, or hubs, proposed to increase TF binding frequency at target enhancers. However, how enhancer sequence shapes hub pr...

Researchers in the Human Biology Division use deep mutational scanning to parse epistatic effects on Vif evolution

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The emergence of reproductive barriers between closely related populations is a fundamental step in speciation, yet the underlying genetic mechanisms remain poorly understood in mammals. Here we resol...

A recent study reveals how a single stop codon helps alphaviruses evade immune defenses in both mosquitoes and humans

"The only constant in life is change." — Heraclitus Genetic conflicts — the good, the bad, and the ugly — shape our lives over time We aim to understand why even the most essential genes and chrom...

Fungal pathogens often carry dispensable chromosomes (DCs) that confer a selective advantage in adverse environments or during host infection but can be spontaneously lost under non-selective conditio...

Technological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve…

Annual award to honor the bold, creative, pioneering spirit embodied by Hal Weintraub. The Harold M. Weintraub Graduate Student Award recognizes outstanding achievements during graduate studies in…

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Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...

Transposable elements (TEs) are key contributors to genome evolution, yet their macroevolutionary roles in adaptive radiations remain poorly understood, as high-quality genomic resources at sufficient...