André Schneider, University of Bern @schneian.bsky.social · 11hThe discovery of mitochondrial DNA? 120
Reposted by André Schneider, University of BernPLOS Biology @plosbiology.org · 22/09/2026How are mitochondrial transcription and DNA replication coordinated in Trypanosoma brucei? Torsten Ochsenreiter &co identify mtTF1, the first mitochondrial #TranscriptionFactor in Kinetoplastea required for #GeneExpression and maxicircle replication.🧪 buff.ly/ZhYVzts 0157
Reposted by André Schneider, University of BernRandall Munroe @xkcd.com · 22/09/2026Tyrannosaurus xkcd.com/3300/ 92121222099
André Schneider, University of Bern @schneian.bsky.social · 17/09/2026Timing can be important (I was surprised this worked so well, considering it's an iphone and no real camera) 000
André Schneider, University of Bern @schneian.bsky.social · 17/09/2026Sometimes you need a helping hand 000
André Schneider, University of Bern @schneian.bsky.social · 12/09/2026It was definitively the first 011
Reposted by André Schneider, University of BernNina Willburger @drnwillburger.bsky.social · 09/09/2026A medieval #ship was reused as basement ceiling in Konstanz (Southern Germany), it reveals rare clues medieval shipbuilding at Lake Constance. archaeologymag.com/2026/08/medi... 726853
André Schneider, University of Bern @schneian.bsky.social · 10/09/2026After a quite medical talk on human cell lines I was attending, somebody was asking the question: What is the relevance for C. elegans? 122
Reposted by André Schneider, University of BernMatthew Cobb @matthewcobb.bsky.social · 07/09/2026Good review by @philipcball.bsky.social of Farmelo’s new biography of Stephen Hawking. In talking to old Cambridge folk for my Crick biography, I was surprised at the animosity some expressed towards Hawking. This shows why.theguardian.comHawking by Graham Farmelo review – the dark side of geniusA biography of the physicist recognises his achievements, but also reveals the selfish narcissist underneath 3143
Reposted by André Schneider, University of BernSFB 1381 - Protein Machineries @sfb1381.bsky.social · 03/09/2026A single amino acid can determine the stability of an entire protein machinery - check out this new publication by SFB 1381 PIs Nora Vögtle and Pitter Huesgen, revealing how precise protein trimming by ICP55 safeguards mitochondrial protein complexes. doi.org/10.1038/s415...doi.orgA single-amino-acid cleavage controls global mitochondrial complex integrity - Nature Structural & Molecular BiologyKücükköse, Luzarowski and colleagues show that removing a single N-terminal amino acid during the maturation of newly imported mitochondrial proteins globally stabilizes mitochondrial protein complexe... 085
Reposted by André Schneider, University of BernPedro Santamaria @p-santamaria.bsky.social · 26/08/2026- Suppose that: Life started two times & Bacteria and archaea probably appeared independently of the, not yet alive, LUCA (organic matter plus rock) www.science.org/doi/10.1126/...science.orgIntermediate stages in the origin of metabolism at a phosphorylating hydrothermal ventEnzymatic metabolism emerged from metal-catalyzed, aqueous reactions of H2, CO2, NH3 and phosphite at a hydrothermal vent. 021
André Schneider, University of Bern @schneian.bsky.social · 13/08/2026Best I could do with my phone 030
Reposted by André Schneider, University of BernChad Topaz Queer DEI Race Traitor @chadtopaz.bsky.social · 31/07/2026🧵🚨: Remember the recent #genAI cheating scandal at Brown? Everyone talks about the average score drop from take-home midterm to proctored final: 95.7 → 48.8. That number alone can't settle anything. But the released data can, and almost nobody has looked at it. So we did! Read on. #AcademicSkyarxiv.orgWhat exam scores can and cannot prove about unauthorized AI assistance: Evidence from a highly public classroom episodeIn spring 2026, an economics professor at Brown University gave a take-home midterm and, after unusually high scores, made the final exam proctored. Among the 59 students who completed the course, ave... 03813
Reposted by André Schneider, University of BernI AM DAD @iamdad.bsky.social · 28/07/2026 158103242146
André Schneider, University of Bern @schneian.bsky.social · 17/07/2026T. brucei KMP11 is tiny, essential, and its function is unknown. Here we show that it localizes to the FAZ/TAC/PFR/MtQ but not to the BB, suggesting that KMP11 may X-link alpha-helical cytoskeletal proteins. Congrats to Salome, Torsten et al. journals.biologists.com/jcs/article-...journals.biologists.com 140
Reposted by André Schneider, University of BernRowan Hooper @rowhoop.bsky.social · 30/06/2026Sure, let's engineer cockroaches to make them MORE indestructible 054
André Schneider, University of Bern @schneian.bsky.social · 30/06/2026Rosetta stone for “The extended central dogma of Mol Biol”. Bottom: b-globin 🧬. Middle: b-globin protein🩸. Top: cell types and organs 🫁 ❤️🧠. We understand the gene to protein transition, we are still working out how cell types are formed. Easteregg at the bottom for @matthewcobb.bsky.social #SciArt 2329
Reposted by André Schneider, University of BernWouter Masselink @woutermasselink.bsky.social · 28/06/2026Reminds me of this absolute classic 062
Reposted by André Schneider, University of BernPhilippe Bastin's Lab @bastinlab.bsky.social · 26/06/2026Beautiful videos nicely explaining microtubules! Congratulations to Renaud Chabrier and Casten Janke 👍 www.youtube.com/watch?v=dVbv...youtube.comMicrotubules | Scientific Animated Short Film 2026YouTube video by Drawing Intelligence 0116
Reposted by André Schneider, University of BernRetraction Watch @retractionwatch.com · 23/06/2026A new retraction for an influential evolutionary biologist is raising the question of whether scientific misconduct more than 20 years ago was just a blip in his impressive publication record or further proof, as some claim, that much of his work rests on a shaky foundation.retractionwatch.comA prolific evolutionary biologist caught faking data decades ago notches a new retractionA study claiming a tenfold decrease in bugs splattered on evolutionary biologist Anders Møller’s windshield over two decades has been retracted. shanecotee / iStock Anders Møller, an influential ev… 24718
Reposted by André Schneider, University of BernPolly Mackenzie @pollymackenzie.bsky.social · 21/06/2026My nine year old asked for a Rosetta Stone cake for his birthday 602218152562
Reposted by André Schneider, University of BernEMBO Reports @emboreports.org · 15/06/2026Philipp Rieche, Marten Exterkate, Arnold Driessen et al show that the #lipid divide between #bacteria and #archaea is not as strict as previously thought as bacterial lipid synthesizing enzymes can use both stereo-forms of glycerol-phosphate. #MembraneBiology -> link.springer.com/article/10.1...link.springer.comBacterial lipid synthesizing enzymes PlsY and PlsC utilize both stereo-forms of glycerol-phosphate - EMBO ReportsThe chemical composition of membrane lipids differs between eukarya, bacteria and archaea. The central dogma posits that the stereochemistry of phospholipids in bacteria is distinct from archaea. Bact... 074
Reposted by André Schneider, University of BernAlex von Tunzelmann @alexvont.bsky.social · 08/06/2026This is exactly it. The work is the point. 1460982247
Reposted by André Schneider, University of BernGeoff McFadden @fad1.bsky.social · 07/06/2026Today marks 30 years since we identified the apicoplast, a relict plastid in human and animal parasites (PMID 8632819). Apicoplasts are the target of the widely used antimalarial prophylactic doxycycline, which has saved many thousands of malaria infections. 37932
Reposted by André Schneider, University of BernOded Rechavi @odedrechavi.bsky.social · 08/06/2026Has there ever been a controlled study comparing the good cop/bad cop method with good cop/bad cop/indifferent cop? 2101
Reposted by André Schneider, University of Bern𝙳𝚊𝚟𝚒𝚍 𝙼. 🌎 @davidpmolina.com · 05/06/2026I met a microbiologist yesterday. He was much bigger than I expected. 1053046325
Reposted by André Schneider, University of BernSIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 25/02/2025Essay by André Schneider ( @schneian.bsky.social ) "The controls that got out of control: How failed control experiments paved the way to transformative discoveries" @emboreports.org . buff.ly/4i79rZO @unibern.bsky.social 053
Reposted by André Schneider, University of BernDirk-Jan Scheffers 🟥 @dirkscheffers.bsky.social · 31/05/2026Briefly, we used two fluorescent dyes that were supposed to label newly synthesized cell wall material in bacteria, but found that when we blocked synthesis, one of the two dyes still bound - indicative of a different type of cell wall. 2/ onlinelibrary.wiley.com/doi/10.1111/...onlinelibrary.wiley.comPentapeptide‐rich peptidoglycan at the Bacillus subtilis cell‐division siteThe large macromolecule peptidoglycan, that forms the bacterial cell wall, contains local differences in architecture and chemistry that encode the shape of the wall. We used different probes to labe... 141
Reposted by André Schneider, University of BernDirk-Jan Scheffers 🟥 @dirkscheffers.bsky.social · 31/05/2026We would have never published a paper (see thread) if not for a control that delivered a surprise - that I didn’t believe at first and asked Danae to repeat multiple times before realizing she was on to something. 1/ 162
Reposted by André Schneider, University of BernMax Heiman @heiman.bsky.social · 31/05/2026Fun read! Another classic example is Cynthia Kenyon's discovery that loss of the insulin receptor DAF-2 extends lifespan in C. elegans, which came out of the control for a clever mutant screen in which progeny of single F2s are sent into dauer with daf-2(ts) to track lifespan of the parent. 1226
Reposted by André Schneider, University of BernNeedhi Bhalla 💅🏽 @needhibhalla.bsky.social · 31/05/2026“There are known knowns. These are things we know that we know. There are known unknowns. That is to say, there are things that we know we don't know. But there are also unknown unknowns. There are things we don't know we don't know.” The unknown unknowns are why I LOVE science 🧪 3357
Reposted by André Schneider, University of BernChristelle Sabatier @chsaba.bsky.social · 31/05/2026What a great article! 032
Reposted by André Schneider, University of BernMark Peifer (He, him) @peiferlabunc.bsky.social · 31/05/2026A fun read, unveiling key discoveries revealed because the control "failed" 🧪 3187
Reposted by André Schneider, University of BernGrant Jacobs BioinfoTools/NotJustDNA 🔬🧬🖥️✍️📚🇳🇿 @notjustdna.bsky.social · 01/06/2026A nice reminder to think through _why_ controls failed 031
Reposted by André Schneider, University of BernThe Fromm Lab @frommlab.bsky.social · 02/06/2026This is such a beautiful paper. 021
André Schneider, University of Bern @schneian.bsky.social · 02/06/2026Many Thanks - I see you are working with RNA. Then maybe this something for you as well. It is a chimera between science history and formal review "A short history of guide RNAs" file:///Users/Andre/Downloads/embr.202051918.pdf 120
Reposted by André Schneider, University of BernThe Fromm Lab @frommlab.bsky.social · 23/05/20260/ 💡💡💡Had one of those slightly weird moments reading something today. Two seemingly very different research traditions—starting from opposite directions—appear to be converging on almost the same conclusion about one of biology’s biggest questions: How do genomes generate phenotypes? 👇🧵 163
André Schneider, University of Bern @schneian.bsky.social · 02/06/20261000x linear expansion. Who would have thought this would be possible - From the inventor of the original expansion microscopy - This is absolutely fantastic! - Expansion microscopy is one of the most creative methods I have ever heard of in my 40 years of being a scientist - CONGRATS! 111
Reposted by André Schneider, University of BernSpang Lab @spanglab.bsky.social · 29/05/2026How to determine the proteome of cellular compartments? We established a method to do just that, published n @eLife.bsky.social: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection doi.org/10.7554/eLif...doi.orgSPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection 01910
Reposted by André Schneider, University of BernMeisingerLab@UniFreiburg @meisingermitolab.bsky.social · 26/05/2026Uncovering the initial response: Intra-mitochondrial surveillance activates the UPRmt: Molecular Cell www.cell.com/molecular-ce...cell.comUncovering the initial response: Intra-mitochondrial surveillance activates the UPRmtTaskin, Shankar, Peselj, et al. demonstrate that mitochondria possess an intrinsic surveillance system that senses mild oxidative stress and activates the UPRmt before damage signals reach the cytosol... 195
Reposted by André Schneider, University of BernHouse & Field Negro Quarterly @morethanmud.bsky.social · 23/05/2026the hungry observatory 301200052855
Reposted by André Schneider, University of BernReese Richardson @reeserichardson.bsky.social · 21/05/2026@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro... 1517388
Reposted by André Schneider, University of BernYamuna Krishnan @krishnanyamuna.bsky.social · 17/05/2026What he said. 0154
Reposted by André Schneider, University of BernianVisits @ianvisits.co.uk · 08/05/2026Commiserations to Sir David Attenborough on his 100th birthday, as he is now too old to be allowed to play with LEGO. 151103309
André Schneider, University of Bern @schneian.bsky.social · 08/05/2026GxxxG motifs of the T. brucei mito OM insertase pATOM36 are essential. Similar motifs also occur in its functional analogues: yeast MIM and human MTCH1/2. - Great collaboration between cvb-lab.bsky.social and @schneian.bsky.social. Congratulations to Stephan and Siri. www.jbc.org/article/S002...jbc.orgDisruption of GxxxG motifs in pATOM36 impairs biogenesis of the mitochondrial protein translocase of the outer membrane in Trypanosoma bruceiMitochondrial biogenesis requires efficient import of cytosolically produced proteins and correct segregation of the mitochondrial genome during cytokinesis. In T. brucei, a parasitic protozoan with a... 020
Reposted by André Schneider, University of BernWill Ratcliff @wcratcliff.bsky.social · 06/05/2026Really reading the literature has always given scientists in training a huge advantage. But these days, it seems like a superpower. So many people skim/AI summarize papers, but then you miss out on so much! It's like reading a description of a Van Gogh painting vs. staring at it for 2h. 38518
André Schneider, University of Bern @schneian.bsky.social · 03/05/2026🎨🔬 Interested in the interface between Art & Science?🎨🔬 Check out my assay "Drawing conclusions" about how doodling and drawing catalyzed my scientific creativity link.springer.com/article/10.1... 0141
Reposted by André Schneider, University of Bernc0nc0rdance @c0nc0rdance.bsky.social · 23/04/2026A COLOSSAL 62 ft long (20 m) hyper-predatory octopus in the Late Cretaceous that could comfortably eat a Mosasaur. I have never wanted a time machine MORE. 914224
![Comic. [Person with long hair pointing to diagram with Tyrannosaurus Rex standing next to a person.] PERSON: We now believe the primary prey of Tyrannosaurus Rex was these humans who kept standing next to it for scale.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreih526pxolmi4pgqdcdu435uhkrrldhpwq6rrsnk4hfs6dskbe5r7e)
