Transcription factors (TFs) form dynamic, high-concentration clusters, condensates, or hubs, proposed to increase TF binding frequency at target enhancers. However, how enhancer sequence shapes hub pr...

Many animal species replace histones with protamines during spermatogenesis. Although essential for sperm function, protamines evolve rapidly for reasons that remain unknown. Using in vivo gene replac...

Professor Tung Le, John Innes Centre – contact me Professor Jonathan Todd, Quadram Institute & UEA Dr Ngat Tran, John Innes Centre Horizontal gene transfer (HGT) is a major driver of bacterial…

PhD Project - Eastbio: Mechanism and consequences of lethal zygosis in bacteria restricting AMR plasmids. at University of St Andrews, listed on FindAPhD.com

Technological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve…

Senior Downing Street officials reach out to thinktanks and pollsters as they look to test backing for reversing Brexit Senior Downing Street officials have been reaching out to thinktanks and pollsters as they look to test public support for the UK rejoining the EU. Aides to Andy Burnham have been talking to EU experts in a range of organisations about how the public would view a promise to rejoin, as momentum builds behind including such a pledge in the next Labour manifesto. Continue reading...

Symbiotic relationships of microorganisms are predicted and cataloged with a machine learning tool.

Using bioinformatics, biochemistry, NMR, as well as the newly characterized enzyme ArmA from methanogenic archaea, we revised the existing knowledge on archaeal peptidoglycan structure. At the same ti...

Ancient symbioses may enable ants to thrive in diverse niches, but how these relationships are regulated remains unclear. This study reveals that some ants can dynamically regulate symbiont-derived be...

Cyclic transcription is a hallmark of the cell cycle. While transcriptional waves in eukaryotes are driven by oscillations in cyclin-dependent kinase (CDK) activity, many archaea have an ordered cell ...

Cyclic transcription is a hallmark of the cell cycle. While transcriptional waves in eukaryotes are driven by oscillations in cyclin-dependent kinase (CDK) activity, many archaea have an ordered cell ...

While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim...

Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

Ruault et al. reveal how budding yeast telomeres reorganize from peripheral foci to a central hypercluster in long-lived quiescent cells. They show that th

Academic survival guides teach junior researchers how to live with the judgements of senior scholars. No corresponding genre gives young researchers authority to advise the people who judge them.

Structural bioinformatics aims to answer biological questions by considering biomolecular structures at scale. This Perspective argues that now that we have accurate predictions, we need to ask what w...