Researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and their collaborators have uncovered a crucial mechanism that cells use to control when to start DNA copying. Thi...

DNA replication depends on loading Cdc45 onto the MCM2-7 helicase to start DNA unwinding. Here, the authors use cryo-EM to show how phosphorylation enables Sld3-Sld7 to bind MCM2-7 and position Cdc45 ...

DNA replication begins when inactive helicases are switched on to unwind DNA. Here, the authors map this activation in yeast, revealing where DNA first melts and how helicase splitting, factor release...

Greg was already a world-renowned scientist when appointed Director, and for the community, he was a visionary leader, a cherished mentor, and a singular force of nature whose influence shaped the research landscape.

PhD Project - PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of...

Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...

Apply for funding to carry out independent research within a host laboratory and gain leadership skills.

Almost 700,000 women to be recruited to study as government fires starting gun on cancer strategy.

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