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Structure of vaccinia entry fusion complex reveals a unique multiprotein architecture for poxvirus entry.

Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.

Mikulski et al. identify a distinct chromatin structure at clustered GBP innate immune genes that preserves a mitotically heritable memory of prior priming by interferon-γ.

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Advanced methods for protein structure prediction, such as AlphaFold2, greatly expand our capability to identify protein domains and infer their likely functions and evolutionary relationships. This i...

Associate Professor/Professor of Infection and/or Immunity in the Department of Pathology at the University of Cambridge.