Author summary When and where genes are turned on determine what an organism looks like and how it responds to its environment. The turning on and off of genes is controlled by proteins known as trans...

Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to c...

Transcription factors regulate gene expression with DNA-binding domains (DBDs) and activation domains. It is generally assumed that DBDs are solely responsible for interacting with DNA and chromatin. ...