Enterovirus D68 (EV-D68), a respiratory pathogen increasingly associated with acute flaccid myelitis (AFM),1,2,3 represents a growing unmet need for vaccination. Kunishima et al. report an mRNA vaccin...

Genetic muscle diseases are difficult to treat due to challenges in delivering gene editors to muscles throughout the body. Here, authors engineer muscle-specific virus-like particles that fuse with s...

LION-delivered replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge.

/PRNewswire/ -- HDT Bio Corporation, a U.S.-based clinical-stage biotechnology company advancing immune-enhancing solutions for global health, biodefense, and...

Lipid nanoparticles (LNPs) are a modular, non-viral nucleic acid delivery system. Here, Eygeris and colleagues report that addition of saponin molecules, such as quillaic acid, to LNP formulations can...

Sudan virus (SUDV) outbreaks in Uganda created public health concerns due to a lack of approved vaccines. In this study, the authors develop a repRNA SUDV vaccine and demonstrate full protection of a ...

Our data demonstrate that our repNP vaccine and NP-specific antibody can protect against CCHFV in non-human primates.

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

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The House Committee on Science, Space and Technology

Background Toscana virus (TOSV) is transmitted to humans through bites of infected sand flies. Neuroinvasive TOSV infections are leading causes of meningitis/encephalitis in southern Europe and notifi...

Here the authors show that a replicating RNA vaccine encoding the hemagglutinin (HA) of contemporary H5N1 strains confers single shot protection against lethal H5N1 challenge in mice, while an RNA enc...

Since late 2021, a panzootic of highly pathogenic H5N1 avian influenza virus has driven significant morbidity and mortality in wild birds, domestic poultry, and mammals. In North America, infections i...

npj Vaccines - Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice

Simufilam did not show a significant reduction in cognitive or functional decline versus placebo in patients with mild-to-moderate Alzheimer’s disease in...

In humans, misprocessed mRNAs containing intact 5′ Splice Site (5′SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K, a ...

The website for the 44th Annual Meeting of the American Society for Virology.