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Zhijuan Qiu @zhijuanjexpmed.bsky.social · 13/03/2026

1/2 In this #JEMLegacy, we revisit a study published in 1963 by Dr. Irwin Lepow that identified C1q, C1r and C1s as subcomponents of the C1 complement complex (rupress.org/jem/article/...). #immune #complement

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Gaia Trincucci @gaiajexpmed.bsky.social · 21/12/2025

#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia. @RockUPress @RockefellerUniv rupress.org/jem/article/...

rupress.org

SEROLOGICAL REACTIONS IN PNEUMONIA WITH A NON-PROTEIN SOMATIC FRACTION OF PNEUMOCOCCUS

1. Sera from individuals acutely ill with lobar pneumonia possess the capacity to precipitate in high titre a non-protein somatic fraction derived from pne

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Zhijuan Qiu @zhijuanjexpmed.bsky.social · 26/11/2025

Happy Thanksgiving to all who celebrate! This #JEM_Spotlight highlights a study by George Fu Gao et al. that provides insight into how #Coxsackievirus, a common cause of childhood hand-foot-and-mouth disease (#HFMD), induces #onychomadesis (nail shedding). doi.org/10.1084/jem....

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Lucie Van Emmenis @lucie-jexpmed.bsky.social · 21/10/2025

Another excellent #Viewpoint! Thank you to our contributors @priyadevarajan.bsky.social, @rzappasodi.bsky.social, Novalia Pishesha, Jui-Hsia Weng, Kate Alexander, Yadira Soto-Feliciano, and @kedmiranit.bsky.social ✨

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Lucie Van Emmenis @lucie-jexpmed.bsky.social · 09/10/2025

In light of Monday’s #Nobel Prize in Physiology or Medicine announcement, for #JEMLegacy let’s look back at one of Shimon Sakaguchi’s early @jem.org papers from 1985! rupress.org/jem/article/...

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Lucie Van Emmenis @lucie-jexpmed.bsky.social · 09/10/2025

And if you needed any more convincing about the importance of #Tregs, check out this #Viewpoint written by Shimon for @jem.org's 125th anniversary about the role of Tregs in immunological self-tolerance and autoimmunity 👉 rupress.org/jem/article/...

rupress.org

Taking regulatory T cells into medicine | Journal of Experimental Medicine | Rockefeller University Press

Shimon Sakaguchi recounts the work that lead to the identification of regulatory T cells.

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Zhijuan Qiu @zhijuanjexpmed.bsky.social · 02/10/2025

This #JEMLegacy tweet highlights two papers from 1965 by Drs. Phil Gold and Samuel O. Freedman @mcgill.ca on the discovery of the Carcinoembryonic Antigen (CEA), the basis for the widely used CEA blood test. rupress.org/jem/article/... rupress.org/jem/article/... #cancer #biomarker #CEA

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Journal of Experimental Medicine @jem.org · 15/08/2025

#WomenInSTEM becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher: rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 29/07/2025

📢 We're now accepting applications for the JEM Early Career Travel Award, for grad students & early-career postdocs to participate in a scientific conference! This year, the award will support the attendance of #Cytokines2025 @cytokinesociety.bsky.social! Apply here 👉 rupress.org/jem/pages/ea...

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Zhijuan Qiu @zhijuanjexpmed.bsky.social · 10/07/2025

This #JEMLegacy tweet takes you to a 1999 study by Dr. Muriel Moser that demonstrated the functional dichotomy between CD8a+ and CD8a- DCs in driving distinct T helper cell responses. rupress.org/jem/article/... #Immunology #DendriticCell #THelperCell

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Turvey Lab @turveylab.bsky.social · 20/05/2025

📢📢Published today in @jem.org 📢📢 New human inborn error of immunity. We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK. rupress.org/jem/article/... @ubcmedicine.bsky.social @bcchresearch.bsky.social

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Journal of Experimental Medicine @jem.org · 01/05/2025

Our new #immunometabolism collection showcases research on the metabolic regulation of immune cells including CD8+ T cells, macrophages and neutrophils, tumor cells, and endothelial cells. Read new research to accompany @aegeanconf.bsky.social‬ Int'l conference 👉 rupress.org/jem/collecti...

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Zhijuan Qiu @zhijuanjexpmed.bsky.social · 04/05/2025

Heading to ImmunoMetabolism conference. Looking forward to the talks and meeting with everyone there!

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Journal of Experimental Medicine @jem.org · 29/04/2025

Attending #AAI2025 in Honolulu this weekend? Visit our booth #811 during the exhibit hours to chat about your latest research and learn about our journal! Don't forget to pick up a copy of the JEM Immunology collection (rupress.org/jem/collecti...) and take a souvenir 🎁 🏝️

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Journal of Experimental Medicine @jem.org · 01/05/2025

In this review, Plata-Gómez & Ho discusses how aging and diet influence the metabolic reprogramming of the tumor–immune microenvironment, contributing to cancer progression and immune evasion. rupress.org/jem/article/... 📘 In our #Immunometabolism 2025 collection: rupress.org/jem/collecti...

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Journal of Experimental Medicine @jem.org · 28/04/2025

Good morning #AACR25 attendees in Chicago! Come by our booth #3809 in the Exhibit Hall and chat about our journal and learn how @rupress.org journals are making publication experience easier! Pick up our latest #Cancer Collection magazine 📚 and an exclusive zip-up pouch 🎁

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Journal of Experimental Medicine @jem.org · 18/04/2025

We're seeking a dynamic Executive Editor to lead @jem.org in NYC. Responsibilities include guiding journal strategy, managing an editorial team, engaging with researchers, and more. Apply here 👉 careers.rockefeller.edu/jobs/1743?la... #STMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs

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Journal of Experimental Medicine @jem.org · 09/04/2025

Attending the Henry Kunkel Society's "Genes and Immunity" in Belgrade and interested in submitting your research to JEM? Meet our Deputy Editor @gaiajexpmed.bsky.social, who will be attending! ✉️ Email Gaia rupress.org/jem/pages/ed... 📘 See our collection rupress.org/jem/collecti... #HKS2025

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Journal of Experimental Medicine @jem.org · 07/04/2025

Our April issue is here! rupress.org/jem/issue/22... The cover image represents the confocal imaging of periportal-venous fibroblasts in the liver of 8-wk-old Cd34creER;R26tdTomato mice. Fibroblasts are marked by CD34 (green) and Tomato (red). From Shan-Shan Wang et al.: doi.org/10.1084/jem....

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Dan 🐟 C @zebrafish007.bsky.social · 03/04/2025

We recently described the Axillary Lymphoid Organ (ALO) in the #Zebrafish. It's on the OUTSIDE of the fish, making it great for imaging! Learn more by checking out our paper in @jem.org rupress.org/jem/article-...

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Journal of Experimental Medicine @jem.org · 01/04/2025

New: @zebrafish007.bsky.social, @zebrafishmk.bsky.social et al. #WeinsteinLab describe a previously uncharacterized external, experimentally accessible secondary lymphoid organ in the #zebrafish located above the pectoral fin. rupress.org/jem/article/...

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Idoyaga Lab @idoyagalab.bsky.social · 01/04/2025

Our latest @jem.org paper is out! Radiotherapy induces GM-CSF in melanoma, driving monocytes to become regulatory monocyte-derived dendritic cells (moDCs)—traced with Ms4a3-TdTomato mice! Huge shoutout to @Sirimuvva Tadepalli + @Derek Clements for leading this!

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Hannah Peckham (she/her) @hlpeks.bsky.social · 25/03/2025

Thrilled to finally share our paper on how sex hormones and sex chromosomes interact to affect B cell class-switching!🥳 Diversity & inclusion in research recruitment = better science for all!😎 Thanks to @bcellsrosser.bsky.social@emmaschambers.bsky.social@arrdept-ucldom.bsky.social for ++ hard work!🌟

rupress.org

Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes | Journal of Experimental Medicine | Rockefeller University Press

Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in ind

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Journal of Experimental Medicine @jem.org · 19/03/2025

David Jackson @imm.ox.ac.uk discusses a new intravital imaging technique by Cleary et al. (rupress.org/jem/article/...) enabling lung lymphatics and their participation in immune cell trafficking events to be visualized for the first time in mechanically ventilated mice rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 20/03/2025

Bauman, Snow et al. show that impaired T cell receptor–induced CARD11-dependent JNK signaling upregulates GATA3 & NFAT2, two key proteins in TH2 cell development, identifying a new mechanism by which CARD11 variants spur atopic disease. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 20/03/2025

De Sousa, Perkey, Le Corre, Maillard, Labrecque et al. @umontreal.ca show that fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. rupress.org/jem/article/... #InfectiousDisease #HostDefense #LymphocyteBiology

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Journal of Experimental Medicine @jem.org · 12/03/2025

Pestal, Slayden, and Barton demonstrate that group 2 KLF family transcription factors are critical for specifying the identity of distinct tissue-resident #macrophages. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 13/03/2025

Attending @keystonesymposia.bsky.social #KSTumorMetab25 in Vancouver? Get in touch with our Deputy Editor Cindy (Xin) Sun @cindy-jexpmed.bsky.social who will be in attendance and bring all your publication-related questions! Check out our Tumor #Metabolism collection 👉 rupress.org/jem/collecti...

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Casanova Lab @casanovalab.bsky.social · 24/01/2025

1/ 📢 Register for the 2025 Henry Kunkel Society Meeting on "Genes & Immunity" and join us in Belgrade from April 10-12, 2025. www.henrykunkelsociety.org/meetings/ #HKS2025 #Immunology 🧬🔬

henrykunkelsociety.org

Meetings – Henry Kunkel Society

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Journal of Experimental Medicine @jem.org · 13/03/2025

🎥 New video summary of a study from Vidyanath Chaudhary, Franck Barrat and colleagues (rupress.org/jem/article/...) showing that mechanosensing regulates pDC activation in the skin through NRF2 activation. youtu.be/9Namb9CJnrM

youtu.be

Mechanosensing regulates plasmacytoid DC activation in the skin through NRF2 activation

YouTube video by Journal of Experimental Medicine

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Bella Rauch @rauchlab.bsky.social · 13/03/2025

Let's not forget that apart from science advocacy the Rauch lab also does kick-ass science! Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!

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Joanna Groom @groomlab.bsky.social · 11/03/2025

Very excited our work out in @jem.org “Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection” @wehi-research.bsky.social led by talented (and determined) PhD student @benjbroom.bsky.social Thread below.

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Montse Cols @montse-jexpmed.bsky.social · 28/02/2025

#RareDiseaseDay2025 @jem.org where we remain committed to publishing studies that identify inborn errors of immunity, elucidate underlying mechanisms and propose potential treatments for rare diseases. Some recent examples: doi.org/10.1084/jem.20240827 doi.org/10.1084/jem.20240843

doi.org

HMCN1 variants aggravate epidermolysis bullosa simplex phenotype | Journal of Experimental Medicine | Rockefeller University Press

Mutations in the KRT14 gene cause epidermolysis bullosa simplex (EBS), featuring abnormal basement membrane zone (BMZ) function. We identified deleterious

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Zhijuan Qiu @zhijuanjexpmed.bsky.social · 28/02/2025

Today is the #RareDiseaseDay2025. @jem.org is committed to publishing studies that identify inborn errors of immunity, elucidate underlying mechanisms and propose potential treatments for rare diseases. Here are excellent examples. #IEI #Immunity doi.org/10.1084/jem.... doi.org/10.1084/jem....

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Eric Topol @erictopol.bsky.social · 27/02/2025

Tomorrow is #RareDiseaseDay. An exciting discovery today for COPA syndrome, a rare heritable autoimmune disease. Finding a protective allele that has the potential to lead to a cure rupress.org/jem/article/...

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Zhijuan Qiu @zhijuanjexpmed.bsky.social · 27/02/2025

At today’s #JEMjc, we discussed three interesting studies about #Treg differentiation as well as function during #inflammation, #homeostasis and #regeneration. @cp-immunity.bsky.social www.nature.com/articles/s41... www.cell.com/immunity/ful... www.science.org/doi/10.1126/...

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Journal of Human Immunity @jhumimmunity.org · 26/02/2025

Journal of Human Immunity (JHI) @jhumimmunity.org is here! Read the inaugural editorial by @casanovalab.bsky.social outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. buff.ly/4hRGpOb #OpenAccess

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Journal of Experimental Medicine @jem.org · 24/02/2025

Insights: Kevin Coughlin and Ledong Wan @stonybrooku.bsky.social discuss new work by Krishnamoorthy et al. (buff.ly/41bIjCm) which identifies the loss of the splicing factor RBM10 as a driver of #metastasis in thyroid cancer through the regulation of RNA splicing. buff.ly/4hTcQMg

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Journal of Experimental Medicine @jem.org · 24/02/2025

New: Krishnamoorthy, Fagin et al. @mskcancercenter.bsky.social show that RBM10 loss leads to exon inclusion of transcripts regulating ECM–cytoskeletal interactions and RAC1-GTP activation, sufficient to promote metastatic fitness. buff.ly/41bIjCm

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Journal of Experimental Medicine @jem.org · 19/02/2025

New article by Cleary, Qiu, Looney et al. reports an intravital microscopy approach for imaging lymphatic vessels in the lungs. This technique can also reveal cellular dynamics in other understudied tissue structures. buff.ly/41msQjZ @maxkrummel.bsky.social

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Zhijuan Qiu @zhijuanjexpmed.bsky.social · 24/02/2025

In this #JEM_Spotlight, we highlight the study by John Harty & colleagues @uipathology.bsky.social on the #regeneration of #CD8+ #lung #TRM cells after targeted #radiation exposure doi.org/10.1084/jem....

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Eric Topol @erictopol.bsky.social · 23/02/2025

For decades, we underestimated the importance of our lymphatic vessels to suppress cancer and its spread. Here's a new, open-access, outstanding review rupress.org/jem/article/...

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