Abstract. As embryos transition from maternal to zygotic control, precise clearance of pre-loaded maternal mRNAs is essential for initiating new zygotic ge

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Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

Single-cell Assay for Transposase Accessible Chromatin with sequencing (scATAC-seq) has become a widely used method for investigating chromatin accessibility at single-cell resolution. However, the re...

The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

Jensen et al. show that targeting dCas9-VPR using a multiplexed array of RNA guides results in effective activator recruitment to promoter-distal, previously inaccessible genomic sites, allowing for l...

Thomas, Feng, et al. introduce a synthetic platform that allows the building of complex regulatory landscapes. Integrating the same enhancer at different distances from a promoter uncovered that activ...

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...

Wu et al. perform single-cell analyses to explore the switch from low-grade to high-grade isocitrate-dehydrogenase-mutant glioma and show that it is characterized by oligodendrocyte progenitor cell-li...

Euchromatic and heterochromatic regions of the genome tend not to interact inside the nucleus. Stutzman et al. investigate the role of HP1a binding to histone H3K9 methylation in restricting these interactions. They observe weakening, but not a complete loss, of separation between euchromatin and heterochromatin when the H3K9-HP1a interaction is disrupted.

Most of the human genome is thought to be non-functional, and includes large segments often referred to as “dark matter” DNA. The genome also encodes hundreds of putative and poorly characterized tran...

imageimageA UDR motif in DNMT3A acts in concert with other chromatin reading regions to promote chromatin recruitment. A cryo-EM structure reveals that DNMT3A1 binds to H2AK119ub-marked nucleosomes th...

By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...

RNA molecules are involved in diverse regulatory mechanisms that contribute to gene activation, gene repression, and genome structure. Henninger and Young discuss how the more traditional DNA-protein-...

Dreyer et al. show the broad and rapid impact that acute inhibition of chromatin formation in S-phase has on DNA replication, chromatin stability, and cell-cycle progression. This study sheds light on...

Global health and food supply are endangered by an increasing frequency of antifungal resistance in pathogenic fungi. Wild-type fission yeast, Schizosaccharomyces pombe, can gain resistance to insults...

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Clarivate, the data company for scholarly publications, has decided to continue indexing some content from eLife in Web of Science, after reevaluating the open-access biology journal’s unusual prac…

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