The ability to seek reward and avoid punishment is a fundamental survival instinct. In natural environments, however, the statistics of rewards and punishments can change independently of one another....

Action selection using predictive models of the environment plays a fundamental role in human and animal behaviour, yet is poorly understood at circuit and algorithmic levels. Spatial navigation is an...

Semaglutide showed robust therapeutic effects in treatment-seeking participants with obesity and alcohol use disorder and this trial supports previous preclinical and clinical findings suggesting GLP-...

This randomized clinical trial assesses the effect of a ketogenic diet on mental health outcomes in individuals with treatment-resistant depression.

Antidepressant treatment shouldn't be a guessing game. RELMED is working towards using advanced research to predict which medication is most likely to help each person along their individual path to recovery.

Pramipexole augmentation of antidepressant treatment for treatment-resistant depression (TRD) has been shown to improve symptom burden over 12 weeks b…

Here, we examined the efficacy and target engagement of dopamine agonist pramipexole in treating a cross-diagnostic sample of mood disorders characterized by severe anhedonia. Patients with major depr...

Exclusive: Gulliver Waite signed up after antidepressants and talking therapies failed to alleviate clinical depression

In this trial involving participants with treatment-resistant depression, pramipexole augmentation of antidepressant treatment, at a target dose of 2·5 mg, demonstrated a reduction in symptoms relativ...

Exclusive: Gulliver Waite signed up after antidepressants and talking therapies failed to alleviate clinical depression

Augmentation strategies for treatment-resistant depression (TRD) are limited, with strongest evidence for atypical antipsychotics. Given emerging insi…

This systematic review and meta-analysis examines the presence and incidence of discontinuation symptoms in individuals who stop taking antidepressants.

In this trial involving participants with treatment-resistant depression, pramipexole augmentation of antidepressant treatment, at a target dose of 2·5 mg, demonstrated a reduction in symptoms relativ...

Reinforcement Learning Mechanisms of Pharmacological Treatments for Depression (RELMED)