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Mohamady El-Gaby

@melgaby.bsky.social
695 followers 276 following 69 posts

Neuroscientist curious about the mechanisms behind the mind: www.psy.ox.ac.uk/research/mind-mech…

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Reposted by Mohamady El-Gaby
Adrian Duszkiewicz @adrian-du.bsky.social · 26/09/2026
Interesting new study from the Frank lab: Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands
cell.com
Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands
Comrie et al. show that the hippocampus flexibly represents different alternative possibilities—including paths ahead, behind, and far away—to meet distinct cognitive demands related to decision-makin...
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Masahiro Nakano @masahironakano.bsky.social · 19/09/2026
My first paper has been published in Hippocampus! bsky.app/profile/masa... Thank you Caswell and Claudia for your support!
bsky.app
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Caswell Barry @caswell.bsky.social · 19/09/2026
Masa's paper is out in Hippocampus. The left-right alternation of hippocampal theta sequences at T-maze choice points, much loved as a 'planning' signal, falls straight out of MEC dynamics. Well done @masahironakano.bsky.social, fun project with @clopathlab.bsky.social doi.org/10.1002/hipo.70131
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Jibran Khokhar @drjkhokhar.bsky.social · 16/09/2026
So grateful to @thetransmitter.bsky.social for the opportunity to talk about a paper that truly shaped how I think about my science by @fowleruci.bsky.social and @paulkennyphd.bsky.social! They helped make causal sense of the association that people call “Mr. Big“ in the context of 🚬!
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Kevin Kelley @kevinkelley.bsky.social · 16/09/2026
1/ I have long dreamed of systems that could causally model human neurobiology across scales, from molecular to behavioral. In @nature.com, delighted to share our efforts at creating xenocortical mice where human organoids grow to occupy most of mouse cortex.
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Terence Tao @teorth.bsky.social · 11/09/2026
A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
mathandai.org
Declaration — Math and AI
Read the declaration and add your name.
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Manfredi Castelli @manfredic.bsky.social · 10/09/2026
Very excited to share a preprint on our new work on how the brain represents time, co-led with Melissa Serrano, Andrew Sharott and David Dupret! ⏳� www.biorxiv.org/content/10.6...
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Lauren Bennett @laurenb29.bsky.social · 09/09/2026
Very excited to share our new paper led with Will de Cothi and @caswell.bsky.social! 🐭🧠 www.nature.com/articles/s41... 1. The subiculum has spatial representations which broadly align to environmental features (boundary cells, corner cells) or patterns of behaviour (axis of travel cells).
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Daniel Reznik 🎶 @reznikdaniel.bsky.social · 08/09/2026
Now out in Hippocampus!! 📣💥 We examined anatomical inputs to the hippocampal region in six species - the tenrec, rat, marmoset, cat, macaque, and human - and found that hippocampal processing operates on fundamentally different types of information across species! (1/3) dx.doi.org/10.1002/hipo...
dx.doi.org
Phylogeny of Cortical‐Hippocampal Projections Reveals Selective Elimination of Input From Sensory Regions
The study of cross-species differences in the organization of the cerebral cortex received significant attention during the past century. However, the evolutionary principles governing changes in bra...
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Adam Rutherford @adamrutherford.bsky.social · 28/08/2026
I've been revisiting my 2021 book How to Argue With a Racist, in light of the Cofnas situation - i didn't name him or the scientifically illiterati with who he breaks bread. But I thought these sections from the end might be of interest.
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Adam Rutherford @adamrutherford.bsky.social · 27/08/2026
This is pretty funny tbh. The US gov wades in with its big bully boots to protect the 'academic freedom' of this scientifically illiterate weird little racist, who actively opposes the academic freedom of others, for a 1 yr postdoc on a subject he shows no track record for. Well done all concerned.
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Adrian Roggenbach @a-roggenbach.bsky.social · 24/08/2026
⚠️PREPRINT ALERT⚠️ How can we better understand distributed brain activity across temporal and spatial scales? In this collaborative project, we combined ultra-flexible electrodes with two-photon imaging to illuminate brain-wide neural dynamics. Link: doi.org/10.21203/rs.... 1/8
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Sam Gershman @gershbrain.bsky.social · 18/08/2026
@arthurpr4t.bsky.social has a new preprint with important results on a famous psychophysical law (Weber's law). It isn't, in fact, a law, because it can be broken. A more fundamental principle (efficient coding) shows when and why Weber's law holds true. www.biorxiv.org/content/10.6...
biorxiv.org
Efficient coding makes and breaks Weber's law
Weber's law is a rare quantitative regularity in psychology, yet its origins remain debated. Here we provide causal evidence that it arises from the more fundamental principle of efficient coding. Thi...
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Negin Owliaei @neginowl.bsky.social · 15/08/2026
Out of curiosity I did this search for Ben-Gvir and Smotrich and let’s be clear, The Telegraph went way harder on Arday than it did on people actively committing war crimes.
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Mohamady El-Gaby @melgaby.bsky.social · 15/08/2026
This is what british racism looks like in 2026. Everyone makes mistakes but ethnic minority mistakes are met with lynch mobs. Beyond disproportionate. RIP Jason Arday.
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Neil Burgess @neilburgess10.bsky.social · 08/08/2026
Great to see Ellie Spens’ model out! Interplay btwn episodic (hippo) & semantic (neocort’l) systems, in encoding, consolidatn, recall & problem solving with sequential info, as compressive retrieval-augmented generation. Inc gist-based distortion in stories & inference www.nature.com/articles/s41...
nature.com
Hippocampo-neocortical interaction as compressive retrieval-augmented generation - Nature Communications
Here the authors model interactions between episodic and semantic memory as ‘retrieval-augmented generation’, explaining consolidation of structure from sequential experience, the reconstruction and d...
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Abraham Zelalem Vollan @azvollan.bsky.social · 06/08/2026
Now in Science: How does the brain’s navigation system allocate its limited representational resources during behavior? We found that grid cells sweep toward locations of interest, providing a potential mechanism for allocating spatial attention in the cognitive map.🧵 science.org/doi/10.1126/...
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Tim Behrens @behrenstimb.bsky.social · 06/08/2026
This was a fun chat about getting to mechanisms in cognition…
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Helen Barron @helencbarron.bsky.social · 28/07/2026
***New preprint from the lab*** showing “Generative replay across hippocampal-neocortical circuits”. In sleep we show spiking sequences in V1 (sensory neocortex!) that represent information that has not been directly experienced www.biorxiv.org/content/10.6... @bndu.ox.ac.uk @ndcnoxford.bsky.social
biorxiv.org
Generative replay across hippocampal-neocortical circuits
To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...
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Moufan Li @moufanli.bsky.social · 20/07/2026
Our paper is out in @natmachintell.nature.com! We trained multiple RNNs to perform free recall. The best-performing ones learned a strategy akin to the memory palace technique. See thread below for more info. www.nature.com/articles/s42...
nature.com
A neural network model of free recall learns multiple memory strategies - Nature Machine Intelligence
Li et al. show that recurrent neural networks optimized for free recall discover diverse, human-like memory strategies beyond classical temporal context models, with top models using an index-based me...
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Josh Johansen @jojolab.bsky.social · 16/07/2026
Very sad to hear of Susumu’s passing. His scientific creativity and intuition were inspiring. As director of @RIKEN_CBS, he hired a remarkable group of young scientists, including me, and set us free to pursue bold ideas. news.mit.edu/2026/mit-pro...
news.mit.edu
MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86
Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...
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Lorenzo Posani @lorenzoposani.com · 15/07/2026
Out today on @nature.com! Connecting neural specialization, population geometry, and their functional implications across the cortical hierarchy. So grateful for this beautiful and fun collaboration with @shuqiw.bsky.social, S Muscinelli, L Paninski, and @stefanofusi.bsky.social!
nature.com
Rarely categorical, highly separable representations along the cortical hierarchy - Nature
Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.
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Athena Akrami @athenaakrami.bsky.social · 06/07/2026
The lab is at @fens.org, with 5 posters — spatial & auditory working memory, prefrontal decision-making, dopamine in statistical learning, and a 2-photon rat-brain atlas for BrainGlobe. Unfortunately, I couldn't make it this year, but come find the rest of the lab on Tue, Thurs, & Fri! #FENS2026
Flyer — LIM Lab (Akrami Lab, Sainsbury Wellcome Centre / UCL) posters at FENS Forum 2026, Barcelona, 6–10 July. Tue 7 July board 129 (Arpit Agarwal); Thu 9 July boards 639 (Audra Rybak), 641 (Kyunghye Lee), 022 (Viktor Plattner); Fri 10 July board 353 (Lida Pentousi).
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Jake Watson @jakefwatson.bsky.social · 06/07/2026
If you are at #FENS2026, we have a symposium on human circuits - from single cells and synapses to intact circuit function! It's not easy to investigate how our own brain works, but we will present recent work showing that it is possible at many scales. Wednesday afternoon at 15:40 - Hall E.
FENS symposium advert stating: Symposium S29 - 			    Wednesday 8th July 2026 15:40 - 17:10. Hall E
 
Untangling the human brain:
characterising the properties of human cells, synapses and circuits

Speakers:
Kimberly Siletti (Utrecht, Netherlands)
Christiaan PJ de Kock (Amsterdam, Netherlands)
Jake F Watson (Klosterneuburg, Austria)
Anna Maslarova (New York, USA)
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Mohamady El-Gaby @melgaby.bsky.social · 06/07/2026
It wouldn’t be FENS if there wasn’t some sort of clash - definitely check out awesome work by @aryabhomick.bsky.social in Friday morning’s poster session tracking learning dynamics of abstract task structure in the PFC as well as evidence for complex hierarchical learning in rodents!
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Mohamady El-Gaby @melgaby.bsky.social · 06/07/2026
We’re at FENS 2026! We’re broadly interested in world and goal models in the PFC and temporal lobe. Come chat to @adamloydharris.bsky.social Mingyu Zhu and Noor AlBarazi as they present some new findings on Wednesday afternoon. #FENS2026 …🧵 1/5
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AntonioFR @antferrui.bsky.social · 06/07/2026
Our work on goal-directed theta sweeps is out! We found two different types of theta sweeps in the rat hippocampus. During random foraging, left-right alternating sweeps dominated (Vollan, 25). However, during memory-guided navigation sweeps pointing to hidden goal locations emerged with learning.
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Adrian Roggenbach @a-roggenbach.bsky.social · 05/07/2026
#FENS2026 poster alert: "Combining flexible electrode recordings with two-photon imaging to investigate brain-wide network coupling" Come to our poster PS01-07AM-375 on Tuesday morning to chat with Linus Meienberg and me, how we use ultra-flexible electrodes together with optical recordings.
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Simon Fisher @profsimonfisher.bsky.social · 05/07/2026
25 years ago, we implicated rare variants of the FOXP2 gene in a severe speech disorder. I’ve spent much time stressing that FOXP2, while interesting, is not the mythical “gene for language”. Weirdly, on occasion I also need to explain why it’s not “proof of aliens”. Full disclosure in this 🧵. 1/n 🧪
Promotional poster for the 2026 science fiction film Disclosure Day.
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Neil Burgess @neilburgess10.bsky.social · 01/07/2026
Ever wondered how the hippocampal cognitive map is read-out? @changmin-yu.bsky.social @zilong-ji.bsky.social with Jake & John, show that, during navigation, theta sweeps indicate remembered goal-directions (cf. current/next movements or perceptual targets) 1/2 www.nature.com/articles/s41...
Decoded locations from place cell firing sweep towards a remembered goal location during each theta cycle irrespective of the current movement or head direction
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Alon Baram @alonbaram.bsky.social · 29/06/2026
How does the human brain extract abstract structure from experience? We show that sensory-independent relational representations emerge in mPFC over several days. Work with @mgarvert.bsky.social and @behrenstimb.bsky.social now out in @currentbiology.bsky.social: www.cell.com/current-biol...
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Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 22/06/2026
SWC & @gatsbyucl.bsky.social are inviting expressions of interest from early career researchers seeking to establish an independent research group in mechanistic theories of neural computation or learning via external fellowship. Please share with your networks and colleagues! Apply by 16 July.
sainsburywellcome.org
Fellowship Sponsorship | Sainsbury Wellcome Centre
The Sainsbury Wellcome Centre for Neural Circuits and Behaviour & Gatsby Computational Neuroscience Unit, University College London, are looking to sponsor early career researchers in theoretical or c...
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Caswell Barry @caswell.bsky.social · 23/06/2026
Really excited about this work with the awesome Will de Cothi & @shipleysj.bsky.social, out in Nature Reviews Neuroscience. We propose acetylcholine is an analogue of dopamine — tracking not reward prediction errors but state-transition prediction errors. doi.org/10.1038/s41583-026-01058-w
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elia ayoub @ayoub.bsky.social · 19/06/2026
Mona Khalil, Lebanon’s most well-known sea turtle conservationist, died of her wounds today after being injured by an Israeli strike I feel sick
MARINE ECOLOGIST MONA
KHALIL HAS PASSED AWAY
AFTER SUSTAINING INJURIES IN AN ISRAELI AIRSTRIKEMona and a turtle in Lebanon
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Thomas Akam @thomasakam.bsky.social · 15/06/2026
Why does dopamine ramp up during approach to predictable rewards? In this preprint with Luke Priestley, we explore the idea that dopamine ramps occur when reward predictions inferred using a world-model are used to train striatal cached values.
biorxiv.org
Dopamine ramps as a normative consequence of dual-process control
Midbrain dopamine neurons are thought to implement a temporal difference (TD) reward prediction error (RPE) that updates cached values stored in striatum. This has been challenged by evidence that dop...
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Mohamady El-Gaby @melgaby.bsky.social · 11/06/2026
This paper is so cool that it’s finally convinced @thomasakam.bsky.social to join Bluesky
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Mohamady El-Gaby @melgaby.bsky.social · 11/06/2026
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Prof Rick Adams @drrickadams.bsky.social · 08/06/2026
Closing in two days!
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Mohamady El-Gaby @melgaby.bsky.social · 06/06/2026
A headline that’s become normalised by this racist state.
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ChristianG @mryeswecan.eurosky.social · 08/05/2026
The slaughter continues. In Gaza, the Israeli military has killed more than 800 people since the truce there was declared in October, striking almost every day. www.theguardian.com/commentisfre...
theguardian.com
The Guardian view on ceasefires that aren’t: Israel never stopped killing in Gaza – allies must reject any escalation | Editorial
Editorial: The US is unlikely to pressure Benjamin Netanyahu to comply with truce terms. Europe must take action
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Edouard Machery @edouardmachery.bsky.social · 06/05/2026
Palestine is the moral issue of our time, as was apartheid in the 1970s and 80s. your stance and your silence define you.
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Tim Behrens @behrenstimb.bsky.social · 24/04/2026
This looks absolutely amazing. Rats composing long action sequences out of short ones. mPFC constructing the long sequence on the fly. Reusing the primitive representations but composing them with progression along the composite. One of the most impressive things I have ever seen a rodent do.
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Mohamady El-Gaby @melgaby.bsky.social · 16/04/2026
This is a great opportunity for all Arabic speakers intersted in computational neuroscience - The Introduction to Computational Neuroscience Online School. The whole thing is in Arabic, fully free and TAs are paid. Deadline in 3 days! More here: arabsinneuro.org/school/
arabsinneuro.org
AiN summer school equips you with the essential tools and knowledge to explore the brain through the lens of computers and algorithms. Whether you're a neuroscience enthusiast or a programming wizard, this program empowers you to understand the mind's complex workings through the power of code.
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Jeremy Corbyn @jeremycorbyn.bsky.social · 14/04/2026
The world watched as Israel razed Gaza to the ground. Now, the world is watching as Israel razes Lebanon to the ground. War crimes beget war crimes — and the failure to bring Israel to justice for genocide has emboldened it to destroy human life with total impunity.
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Athena Akrami @athenaakrami.bsky.social · 07/04/2026
Academic friends, It's beyond heartbreaking to watch what's unfolding in Iran & the region. A few of us drafted an open letter calling for protection of civilians & of educational, research, medical & cultural institutions. Please read & sign if you agree: sites.google.com/view/protect... #IranWar
sites.google.com
Protect Academic Life in Iran
We, the undersigned academics and researchers from around the world, express our profound concern over recent military strikes on Iran, the retaliatory responses, and the reported impact on civilian l...
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Mohamady El-Gaby @melgaby.bsky.social · 02/04/2026
If racism was a country: www.bbc.co.uk/news/article... “In addition, the return of more than 600,000 residents of southern Lebanon who evacuated northward will be completely prohibited south of the Litani until the safety and security of northern (Israeli) residents are ensured”
bbc.co.uk
Israel says it will keep control over part of southern Lebanon after war with Hezbollah ends
Defence Minister Israel Katz also says houses in Lebanese villages near the Israeli border will be demolished.
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Katharina Schmack @kathaschmack.bsky.social · 31/03/2026
🥁🎉The Psychosis Collective proudly presents our first preprint 𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞 𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴 starring Le He & Harriet Feldman www.biorxiv.org/content/10.6... We wanted to understand how antipsychotics work. Thread🧵
Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.
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Sebastijan Veselic @sebves.bsky.social · 12/03/2026
1/n With Cosyne around the corner, I thought I would: a) make a thread about our “A cognitive map for value-guided choice in the vmPFC” Cell paper (i'm a bit late). shorturl.at/DBA3H
shorturl.at
A cognitive map for value-guided choice in the ventromedial prefrontal cortex
Value-based decision-making can be conceptualized as navigation within a cognitive map of choice values. During choice, the ventromedial prefrontal cortex (vmPFC) compositionally builds cognitive maps...
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Tim Behrens @behrenstimb.bsky.social · 12/03/2026
It's Cosyne time!! Here are some contributions from my lab and some of my close collaborator labs (Thomas Akam, @melgaby.bsky.social, Steve Kennerley, @sameershethmd.bsky.social )
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Helen Barron @helencbarron.bsky.social · 12/03/2026
At #cosyne2026? Check out Sumedha Nalluru’s poster from our lab! Showing that reduced cortical inhibition causes false associations. Friday 13th March from 1:15 - 4:15pm.
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