Nuclear pore complex assembly is an intricate process occurring in the double bilayer of the nuclear envelope. In this issue of Molecular Cell, Fischer et al. Maslennikova et al. and Wang et al. integ...

A Yale School of Medicine-built platform uncovers genes associated with dysfunctional molecular clusters in cells—and drug candidates to prevent them.

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Nature Cell Biology - Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties...

The endoplasmic reticulum (ER) is structurally and functionally diverse, yet how its functions are organized within morphological subdomains is incomp…

Despite tubulin’s evolutionary conservation, microtubule dynamics are highly temperature sensitive. Troman et al. use natural tubulin variants from closely related Xenopus species to show that a decrease in tubulin’s apparent activation energy and weakening of lateral lattice contacts stabilize microtubules in cold-adapted frogs.