Reposted by Xiong LiuDaniel Drucker @danieljdrucker.bsky.social · 25/03/2026The primary cilium functions as a non-redundant signaling compartment essential for GLP-1R action in islet beta cells www.sciencedirect.com/science/arti... 094
Reposted by Xiong LiuJournal of Cell Biology @jcb.org · 03/12/2025Is the #Parkinsons-associated protein TMEM175 a proton channel: Yay or nay? Spencer Freeman and Sergio Grinstein @sickkidsto.bsky.social discuss new study from Riederer et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/... 063
Reposted by Xiong LiuDaniel Drucker @danieljdrucker.bsky.social · 01/12/2025An integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of #islet cells from #T1D donors highlights the importance of α cell dysfunction @albertadiabetes.bsky.social @jci.org @bcellorg.bsky.social www.jci.org/articles/vie... 086
Xiong Liu @xiongliu.bsky.social · 07/11/2025Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment url: academic.oup.com/endo/article...academic.oup.comGlucagon, the Alpha Cell, and Potential Targets for Diabetes TreatmentAbstract. Glucagon is a 29-amino acid hormone synthesized and secreted by the pancreatic alpha cell in the islets of Langerhans. It is the primary glucose 010
Reposted by Xiong LiuScott Soleimanpour @soleimanpourlab.bsky.social · 22/10/2025New from us! Had a question about mitophagy but were afraid to ask? 😂 Excited to review the latest advances in beta cell mitophagy research as a key adaptive response in all forms of diabetes in @cp-trendsendomet.bsky.social. We'd be honored if you have it a read! #T1D #T2D 1279
Reposted by Xiong LiuCIRTN-R2FIC @cirtn.bsky.social · 01/10/2025🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere! 1148
Reposted by Xiong LiuDaniel Drucker @danieljdrucker.bsky.social · 30/09/2025Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie... 1329
Xiong Liu @xiongliu.bsky.social · 22/09/2025Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics | Science www.science.org/doi/10.1126/...science.orgMapping early human blood cell differentiation using single-cell proteomics and transcriptomicsSingle-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem... 010
Reposted by Xiong LiuRebecca Hull-Meichle @rlhull-meichle.bsky.social · 18/09/2025Save the date for the 2026 A-BC Islet Biology meeting! Looking forward to many fantastic presentations by trainees in islet biology from all over Canada as well as great keynote lectures. Please share widely! isletmeeting.weebly.com 0138
Reposted by Xiong LiuCIRTN-R2FIC @cirtn.bsky.social · 12/09/2025Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes. Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC. 11616
Reposted by Xiong LiuBCCHR ResDev (DM) @resdevbcch.bsky.social · 30/08/2025This is awesome. (& who remembers mouth pipetting ✋😱) 1113
Xiong Liu @xiongliu.bsky.social · 22/08/2025www.science.org/doi/full/10....science.orgHeparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic isletsThe binding of heparan sulfate to IL-1α potentiates the inhibitory action of IL-1α on insulin release. 010
Xiong Liu @xiongliu.bsky.social · 09/08/2025I learned that no need to be perfect to move on. Just keep pushing towards the final goal. Working on the details after getting the big picture... 000
Reposted by Xiong LiuEARLY Diabetes @earlydiabetes.bsky.social · 31/07/2025We’re hiring a Postdoctoral Fellow! Exciting opportunity to join our research program @uhn.ca leading community-engaged, equity-driven type 2 diabetes research using qualitative and mixed-methods approaches.🔗: jobs.smartrecruiters.com/UniversityHe... @kristalamb.bsky.social @nhp-uoft.bsky.socialjobs.smartrecruiters.comPostdoctoral Fellow, Qualitative Type 2 Diabetes ResearchCompany Description: UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto West... 053
Xiong Liu @xiongliu.bsky.social · 03/08/2025Imeglimin suppresses glucagon secretion and induces a loss of α cell identity: Cell Reports Medicine www.cell.com/cell-reports...cell.comImeglimin suppresses glucagon secretion and induces a loss of α cell identityIn type 2 diabetes, glucagon dysregulation persists. Tsuno et al. demonstrate that imeglimin suppresses glucagon secretion and induces α cell dedifferentiation via inhibition of Gsα and MafB, respecti... 000
Xiong Liu @xiongliu.bsky.social · 31/07/2025The antigen presentation landscape of cytokine-stressed human pancreatic islets: Cell Reports www.cell.com/cell-reports...cell.comThe antigen presentation landscape of cytokine-stressed human pancreatic isletsNanaware et al. characterize peptides presented by MHC proteins in inflamed human pancreatic islets and test them for reactivity with CD4 and CD8 T cells from patients with T1D. These results identify... 020
Reposted by Xiong LiubioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 26/07/2025CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion. www.biorxiv.org/content/10.1101/202… 011
Reposted by Xiong LiuPatrick MacDonald🇨🇦 @bcellorg.bsky.social · 25/07/2025The official post: apps.ualberta.ca/careers/post...apps.ualberta.caPostdoctoral Fellow in Islet Biology - Careers@UAlberta.caUniversity of Alberta: Careers@UAlberta.ca 058
Reposted by Xiong LiuPatrick MacDonald🇨🇦 @bcellorg.bsky.social · 24/07/2025Official posting coming soon, but here's a heads-up: #Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome! www.bcell.org 11416
Reposted by Xiong LiuScott Soleimanpour @soleimanpourlab.bsky.social · 21/07/2025Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/nnature.comLONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature MetabolismLONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c... 46124
Reposted by Xiong LiuJAMA @jama.com · 19/07/2025Early-career researchers looking to gain experience within peer reviewing are invited to apply for the JAMA Network Peer Review Academy. Applications are due Monday, July 21. ja.ma/3TgYmv5 037
Reposted by Xiong LiuThe Royal Society @royalsociety.org · 16/07/2025Our University Research Fellowships are now open for applications. These fellowships are for outstanding early career scientists to pursue cutting-edge scientific research and build an independent research career. Find out more: #RSGrants royalsociety.org/grants/unive... 31920
Xiong Liu @xiongliu.bsky.social · 10/07/2025ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...science.orgROS transfer at peroxisome-mitochondria contact regulates mitochondrial redoxMaintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito... 010
Reposted by Xiong LiuDiabetologia @diabetologiajnl.bsky.social · 10/07/2025Up front & free to read in our July issue #editorspicks: TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion link.springer.com/article/10.1...link.springer.comTMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion - DiabetologiaAims/hypothesis Diabetes is associated with the dysfunction of glucagon-producing pancreatic islet alpha cells, although the underlying mechanisms regulating glucagon secretion and alpha cell dysfunct... 032
Reposted by Xiong LiuPatrick MacDonald🇨🇦 @bcellorg.bsky.social · 08/07/2025We are launching a new initiative to support experimental design, data management/analysis and bioinformatics. Early days yet, but check it out here. www.bcell.org/adi-datasci.... 11311
Reposted by Xiong LiuMathew Kiang @mathewkiang.com · 25/06/2025Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...ki.seCall for 20 Assistant Professor positionsKarolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce... 1278277
Reposted by Xiong LiuPatrick MacDonald🇨🇦 @bcellorg.bsky.social · 25/06/2025Review on metabolism in stem cell derived beta cells from former PhD student with us, Frank Lin. Cell Reports @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...sciencedirect.comGlucose metabolism and regulation in establishing human stem cell-derived β cell maturationEfforts to generate mature stem cell-derived β (SC-β) cells have been ongoing for decades, yet their functional performance still falls short of prima… 0116
Reposted by Xiong LiuCahir O'Kane @cahirokane.bsky.social · 21/06/2025Great advice here. The palettes with up to 8 colours look excellent for graphs and objects. (I'm a colourblind reader) 011
Reposted by Xiong LiuFrancis Lynn 🇨🇦 @nictitate.bsky.social · 21/06/2025Stem cell islets for those living with T1D! www.nejm.org/doi/full/10....nejm.orgStem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJMZimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle... 0108
Reposted by Xiong LiuEISG 2025 @eisg2025.bsky.social · 13/06/2025Mark Huising from University of California, Davis, presents research on how dynamic crosstalk within the islet shapes insulin release. 🗣️ Don’t miss today's debate “Are alpha cells and glucagon needed for islet function and glucose homoeostasis?”, chaired by Mark @huisinglab.bsky.social #EISG2025. 0102
Reposted by Xiong LiuDavid Solecki @so-lets-kilab70.bsky.social · 09/06/2025Our home-brewed PI3P and PI4P probes in neurons feels like blowing bubbles as a kid: fleeting, a little magical. I’m a Doubting Thomas at ❤️ & why I spend so much time learning to image & build probes. I need to see it to believe it. Too late for #fluorescencefriday but in time for #microscopymonday 2689
Reposted by Xiong LiuDr Peter Senior @islettx.bsky.social · 06/06/2025edmonton.citynews.ca/2025/06/05/u...edmonton.citynews.caU of A celebrates 25th anniversary of the Edmonton Protocol, advancing diabetes treatment | CityNews EdmontonVerlyn Olsen has experienced terrifying moments since being diagnosed with type 1 diabetes in the 80s. 021
Xiong Liu @xiongliu.bsky.social · 06/06/2025Exciting news, although I guess the logic here seems to be that if you can buy genius, why train your own🤔. 000
Xiong Liu @xiongliu.bsky.social · 03/06/2025Like this sentence:" If I received this review, would I view it as fair?"😀 020
Reposted by Xiong LiuYasin Dagdas @plantophagy.bsky.social · 02/06/2025Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...erc.europa.euChanges to the 2026 and 2027 Work ProgrammesWith the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai... 04930
Reposted by Xiong LiuOded Rechavi @odedrechavi.bsky.social · 09/05/2025Got the job without having any CNS papers 6816
Reposted by Xiong LiuDiabetologia @diabetologiajnl.bsky.social · 08/05/2025New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...link.springer.comEukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition - DiabetologiaAims/hypothesis The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabetes. The alternative eukaryotic translation initiation factor 2A... 0158
Reposted by Xiong LiuDaniel Drucker @danieljdrucker.bsky.social · 08/05/2025Interrogation of Proglucagon-derived peptide secretion using human stem cell-derived alpha (SC-α) cells www.cell.com/stem-cell-re...cell.comModeling diabetic alpha cell dysfunction using stem cell-derived alpha cellsShrestha et al. report the development of an in vitro human model of pancreatic alpha cells using pluripotent stem cells (SC-alpha cells). SC-alpha cells recapitulate the gene expression, proglucagon ... 0113
Reposted by Xiong LiuAdam Parkhomenko @adamparkhomenko.bsky.social · 03/05/2025This is one of the best ads I have ever seen and I can’t believe I missed it 173210974958
Reposted by Xiong LiuDaniel Drucker @danieljdrucker.bsky.social · 01/05/2025EIF2A is a novel target for beta cell protection and the circumvention of EIF2S1-mediated translational repression #islets #diabetes @jimjohnsonsci.bsky.social @diabetologiajnl.bsky.social link.springer.com/article/10.1...link.springer.comEukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition - DiabetologiaAims/hypothesis The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabetes. The alternative eukaryotic translation initiation factor 2A... 0135
Reposted by Xiong LiuRichard Benninger @bennyscience.bsky.social · 29/04/2025Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this! www.biorxiv.org/content/10.1...biorxiv.orgRole of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu... 0113
Reposted by Xiong LiuFrancis Lynn 🇨🇦 @nictitate.bsky.social · 29/04/2025Thrilled to share our latest work, which was the outstanding doctoral work of @samanthajsyoon.bsky.social academic.oup.com/endo/advance... 1/12academic.oup.comNPAS4 depletion in POMC neurons protects from obesity and alters the feeding-regulated transcriptome in male miceAbstract. Immediate Early Genes (IEGs), such as Neuronal PAS domain protein 4 (Npas4), are induced as part of the response to environmental stimuli. In the 13213
Reposted by Xiong LiuPatrick MacDonald🇨🇦 @bcellorg.bsky.social · 19/04/2025Molecular Correlates of Glycine Receptor Activity in Human β Cells www.sciencedirect.com/science/artic… 084
Reposted by Xiong LiuPatrick MacDonald🇨🇦 @bcellorg.bsky.social · 19/04/2025“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is” www.theglobeandmail.com/gift/aaa9fe… 717547
Xiong Liu @xiongliu.bsky.social · 18/04/2025When failed at the fellowship, I got this... Never stop, keep trying!!! 000
