Nature Reviews Endocrinology, Published online: 27 April 2026; doi:10.1038/s41574-026-01239-8The need to consider factors beyond BMI to accurately assess metabolic dysfunction when diagnosing and treating obesity is increasingly recognized. In this Perspective, Lim and colleagues advocate for an approach to assessments for obesity in Asian populations that takes ethnicity-specific factors into account.

In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Nature Reviews Endocrinology, Published online: 09 March 2026; doi:10.1038/s41574-026-01240-1This Review outlines the potential role of hyperinsulinaemia as an independent driver of obesity and obesity-related conditions. Evidence regarding the potential causes of hyperinsulinaemia are summarized, and key research gaps are highlighted.

Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state.

Androgens and oestrogens differentially regulate metabolic processes that impact the development of type 2 diabetes in women. The biological actions of these sex steroids are, however, dependent on th...

Lipedema is a non-inflammatory disorder of subcutaneous fat mainly affecting women, manifesting as non-pitting, diffuse fat accumulation in legs, hips, and upper arms. It progresses through stages: stage 1 has even skin with small, rice-grain-sized fat nodules; stage 2 features uneven, larger fat nodules and fibrosis; stage 3 causes skin deformity from massive fat extrusions. Genome-wide association studies (GWAS) link polymorphisms in VEGFA, GRB14-COBLL1, and other loci related to increased waist-to-hip ratio, and functionally connect vessel formation and lipid storage.

Nature Reviews Endocrinology, Published online: 02 December 2025; doi:10.1038/s41574-025-01208-7Oestrogen levels change after menopause and with weight gain above the normal BMI category, both of which can affect breast cancer risk and outcomes. This Review explores the current understanding of these associations.

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Why do we need urgent action to protect our data? The mandate of the House of Commons Standing Committee on Science and Research is to review and report on topics relating to science and research in ...

Nature Reviews Endocrinology, Published online: 26 September 2025; doi:10.1038/s41574-025-01180-2Oestrogen is a key regulator in many metabolic processes, particularly in adipose tissue. This Review discusses the role of oestrogen in adipose tissue metabolism and its wider implications for systemic metabolic health.

Sharing knowledge is a fundamental principle within the scientific community, yet null and negative results are still being underreported. This Consensus View discusses the problem of such publication...

Ohnishi et al. present the AVID mouse, which enables real-time, multiscale imaging of ATP dynamics in vivo across organs and cell types. This platform reveals spatially heterogeneous changes in energy metabolism during both physiological conditions and pathological states such as myocardial infarction, enabling systems-level analysis of metabolic regulation.

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Nature Metabolism, Published online: 19 August 2025; doi:10.1038/s42255-025-01342-6A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors, and are used to image receptor binding activities in tissues and animals.

An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problem...

Nature Metabolism, Published online: 14 April 2025; doi:10.1038/s42255-025-01267-0The gut hormone tachykinin (Tk) is found to be regulated by protein intake in flies and mice. In flies, Tk is shown to impact food choices, sleep and lifespan.