Prior expectations guide attention and support perceptual filtering during decision-making. In mice performing a visual discrimination task, choices depended on trial-by-trial differences between cons...

Stimulating the efferocytosis of cellular and myelin debris by microglia after stroke promotes remyelination.

A BCI that works once but becomes harder to tolerate over time is not a mature system; it is an unfinished one.

The anterior cingulate cortex modulates pupil-linked arousal in real time.

Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...

Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...

Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental factors affecting circadian rhythms in metabolic studies in rodents.

To interpret complex sensory scenes, animals exploit statistical regularities to infer missing features and suppress redundant or ambiguous information. Cortical microcircuits might contribute to this...

Dopamine is central to reinforcement learning, classically linked to reward prediction error signaling. However, recent findings suggest a more complex picture, with dopamine neurons responding to ave...

The appropriate form of the drift diffusion model depends on how one wishes to reason about their target with the model. If the goal is to parsimoniously explain the speed-accuracy tradeoff, the appr...

Hocker et al. demonstrate a method for training recurrent neural networks, which they call ‘kindergarten curriculum learning’, involving pretraining on simple cognitive tasks to improve learning effic...

Prescott and Ratté critique the clinical relevance of preclinical studies in the field and highlight areas for improvement.

Natural neuroscience departs from the classical reductionist approach, which emphasizes control at the expense of natural behaviors, by proposing a shift tow...

Stereo olfaction involves comparing odor differences between the two nostrils. Here, using neuronal recordings and a behavioral test, the authors demonstrate that blind mice use stereo olfaction to fo...

Researchers at the U.S. National Institutes of Health have been told they cannot attend scientific conferences and meetings without official permission, even if they pay their own way and go during time off, three current and former NIH scientists told Reuters.

The federal government is reshaping its relationship with the nation’s colleges. Use our new tracker to keep up with the latest.

Novel object recognition tasks are commonly used to assess memory in rodents. These tests rely on an innate preference for exploring objects that are new or have been moved or changed. However, this p...

"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."

BlueBerry is a multi-channel wireless optogenetic system for freely moving mice and rats.

This textbook is an introduction to Systems and Theoretical/Computational Neuroscience, with a particular emphasis on cognition. It consists of three parts:

Although the brain is often characterized as a complex system, theoretical and philosophical frameworks often struggle to capture this. For example, mainstream mechanistic accounts model neural syste...

Using high-density electrophysiological recordings, how internally generated cell assemblies are updated by action plans to meet external goals is explored.

Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...

Meet 10 neuroscientists bringing model diversity back with the funky animals they study.

Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...

If you have a garden, you have probably seen many insects flying around looking for food. Despite having miniature brains, these small creatures can learn and memorize flower features, mainly colors a...

Or: when you don't even see what your model is