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Adrien Peyrache

@apeyrache.bsky.social
2.5K followers 519 following 451 posts

Space, Sleep, and Spikes | Associate Prof @ McGill, Montreal Neurological Institute | Co-director, The Quebec Sleep Research Network

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Adrien Peyrache @apeyrache.bsky.social · 25/09/2026
Grant peer review costs a lot: ~$40k per application in reviewer time, with proposals reviewed again and again. In @thetransmitter.bsky.social , I propose a partial lottery: reviewers decide pass/fail, chance picks among the passes, and "unmissable" ideas and ECRs get protected routes.
thetransmitter.org
How about adding an element of chance to grant review?
A process that uses a lottery system saves time and accepts that, above a quality threshold, luck has always played a part in science funding.
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Adrien Peyrache @apeyrache.bsky.social · 28/08/2026
Interesting piece in which @itsneuronal.bsky.social suggests dropping the common bit-per-spike metric & reporting the duration of held-out data to validate a model Seems to be just 120ms of data for a sharply tuned, high firing rate head-direction cell, i.e. just 3-4 spikes arxiv.org/abs/2607.28779
arxiv.org
Bits per Spike as a Betting Game: An Interpretable Unit for Held-Out Log-Likelihood in Neural Data Analysis
Held-out log-likelihood is the standard currency for comparing statistical models of neural spike trains, and is often reported as bits per spike relative to a homogeneous Poisson baseline. The units ...
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Adrien Peyrache @apeyrache.bsky.social · 26/08/2026
end of the summer, time to share some cool recent @elife.bsky.social papers: this *important* study shows how locus coeruleus activity is coordinated with heart rate during sleep, confirming previous work in mice and humans, with a possible role for sleep-dependent memory consolidation
elifesciences.org
Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation
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Adrien Peyrache @apeyrache.bsky.social · 09/04/2026
Really cool article on the modulation of striatal dopamine signals by trajectory errors. Would love to see it during freely moving behavior now :) Kudos to Eleanor Brown, 1st author on this paper and former undergrad in the lab! www.nature.com/articles/s41...
nature.com
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Pynapple @pynapple.bsky.social · 03/03/2026
🚀 New workshop before FENS in Barcelona! Join the Flatiron Institute Center for Computational Neuroscience of the Simons Foundation for a hands-on workshop on pynapple & NeMoS. Learn to analyze and model neural data with open-source tools. Accommodation & meals included. Details ⬇️
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Adrien Peyrache @apeyrache.bsky.social · 25/03/2026
Great piece by the Transmitter on our recent paper on the stability of the head-direction representation over time and environments.
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Adrien Peyrache @apeyrache.bsky.social · 23/03/2026
Terrible accident at Laguardia, a plane from Montreal crashed with an emergency truck. My deepest condolences to the families. Had I accepted an invitation to go to NYC today, I would have certainly been on that plane. www.cbc.ca/news/world/l...
cbc.ca
2 pilots killed after Air Canada plane collides with vehicle at New York's LaGuardia Airport | CBC
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Pynapple @pynapple.bsky.social · 27/02/2026
Checkout the notebook of this epic neuroscience dataset now on @dandiarchive.org and analyzed with pynapple!
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Adrien Peyrache @apeyrache.bsky.social · 27/02/2026
The ratstronaut dataset is available on DANDI! (and analyzed with @pynapple.bsky.social 😍)
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Adrien Peyrache @apeyrache.bsky.social · 23/02/2026
If you think it looks weird and rare, you’re right. It has 24 eyes and has only been filmed twice.
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Adrien Peyrache @apeyrache.bsky.social · 18/02/2026
Excited to this one out! Congrats @dlevenstein.bsky.social for this super cool study and the characterization of neuronal “ground states”.
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Adrien Peyrache @apeyrache.bsky.social · 18/02/2026
You gotta love ripples
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Trends in Neurosciences @cp-trendsneuro.bsky.social · 18/02/2026
'The postsubiculum as a head-direction cortex' by Adrian Duszkiewicz, Desdemona Fricker, Andrea Burgalossi & Adrien Peyrache @adrian-du.bsky.social @desdemonafricker.bsky.social @apeyrache.bsky.social www.cell.com/trends/neuro...
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Adrien Peyrache @apeyrache.bsky.social · 13/02/2026
I fell for it the very first day I recorded an HD cell ensemble. I remember like it was yesterday (13 years ago!). I can even still recall exactly where I had dinner and with whom on that day, thanks to your PhD paper @adrian-du.bsky.social :p www.nature.com/articles/nat...
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Adrien Peyrache @apeyrache.bsky.social · 13/02/2026
Cutting down on cable management. Makes sense.
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Adrien Peyrache @apeyrache.bsky.social · 11/02/2026
New paper alert! 🚨 We found that the brain's compass is remarkably stable at two scales 1️⃣ the system maintains its internal organization for weeks 2️⃣ It "remembers" its orientation for weeks, even after a single visit This may be key to how the brain aligns its other maps. Paper: rdcu.be/e3waP
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Adrien Peyrache @apeyrache.bsky.social · 19/01/2026
"The time for passive consumption has expired. Every scholar should begin contributing their expertise to Wikipedia — not as charity, but as a core duty" www.nature.com/articles/d41...
nature.com
The academic community failed Wikipedia for 25 years — now it might fail us
Artificial-intelligence systems are feeding on Wikipedia without giving back, and academic indifference is threatening the survival of what is arguably the most widely used reference work on the plane...
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Adrien Peyrache @apeyrache.bsky.social · 16/01/2026
To all our Iranian friends: we know how heavy these past few days have been. Please know you have our support, reach out if there is anything we can do. Hang in there.
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Adrien Peyrache @apeyrache.bsky.social · 15/01/2026
So cool to see this one out! Congrats @markbrandonlab.bsky.social and the gang!!!!
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Adrien Peyrache @apeyrache.bsky.social · 29/12/2025
Revealing a universal architecture of sleep by recording from different (and evolutionary distant) species. How cooler can it be??? Congrats to @antbergel.bsky.social and PA Libourel for this masterpiece.
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Hannah Haberkern @hannah-haberkern.bsky.social · 23/12/2025
📢 Join us, the Haberkern lab, @uni-wuerzburg.de for a postdoc studying neural circuit mechanisms of navigation. You’ll spearheading neurophysiology experiments on our brand new 2P! ⏳ Apply by 28th February 2026 Details: www.haberkernlab.de/docs/ENPostd... #neuroscience #academicjobs #postdoc
On the left, the image shows a schematic of a fly head, ring neurons and EPG neurons together with some calcium imaging frames. On the right is a photo of a fly on a ball in virtual reality and another schematic of a VR system.
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Adrien Peyrache @apeyrache.bsky.social · 15/12/2025
Great read by @alexkwan.bsky.social on how fundamental neuroscience research has paved the way for new drug development. I’d also highlight orexin’s role in sleep–wake regulation and the upcoming wave of dual orexin receptor antagonists (DORAs) for sleep disorders (& soon agonists for narcolepsy).
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Adrien Peyrache @apeyrache.bsky.social · 02/12/2025
We all screw up from times to times when reviewing. It’s frustrating for the authors, sure, but the planet keeps rotating. A strong paper will find its readers and its citations anyway. This is a great example.
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Adrien Peyrache @apeyrache.bsky.social · 26/11/2025
An AI agent, run by collaborators on another continent, generated equations that explain the dynamics of the neurons we recorded 🤯 Finally had the time to read the paper after post-SfN recovery. The approach is v cool, & the Gaussian parametrization feels almost embarrassingly obvious in hindsight.
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Adrien Peyrache @apeyrache.bsky.social · 21/11/2025
This important study provides new insights into the synchronization of ripple oscillations in the hippocampus, both within and across hemispheres. While power is correlated across hemispheres, synchrony is significantly higher within a hemisphere than across. doi.org/10.7554/eLif...
doi.org
On CA1 ripple oscillations: reevaluating asynchronicity evidence
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Paul Masset @paulmasset.bsky.social · 19/11/2025
I am recruiting graduate students for the experimental side of my lab @mcgill.ca for admission in Fall 2026! Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
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Henry Denny @hdennyneuro.bsky.social · 15/11/2025
Arrived in San Diego for my first SfN, looking forward to showing you all my work with @apeyrache.bsky.social ; untangling the contribution of inhibition to the thalamic head direction attractor 💍 Come see me tonight at the TPDA poster session or on Tuesday morning with the lab! #SfN25
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Dan Levenstein @dlevenstein.bsky.social · 15/11/2025
Will be presenting a poster on @apeyrache.bsky.social row, Tues AM, with an update our sequential predictive learning preprint: -CA3-like (sparse lognormal) connectivity gives a hippocampus-like (orthogonalized) map -non-spatial representation! splitters, lap/time cells, action plan…we got it all🤑
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Adrien Peyrache @apeyrache.bsky.social · 13/11/2025
Five-star hydrotherapy for hardware that costs more than my car. We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol. (And yes, I don’t have a car).
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Mari Sosa @marisosa.bsky.social · 07/11/2025
The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum. If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
sosaneurolab.com
Sosa Lab - Postdoctoral Researchers
We are seeking postdocs to start in 2026!
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Adrien Peyrache @apeyrache.bsky.social · 07/11/2025
Great study showing how histaminergic signaling shapes head-direction cell activity in the presence of objects, with important implications for how animals get oriented. A huge amount of work, really impressive. www.researchsquare.com/article/rs-7...
researchsquare.com
A Neuromodulatory Circuit Amplifies Object-based Head-direction Tuning for Spatial Memory
While the head-direction (HD) system is well-established as the brain’s internal compass, the mechanisms that allow it to be flexibly shaped by landmarks have remained unclear. Here we discovered that...
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Adrien Peyrache @apeyrache.bsky.social · 05/11/2025
A chemical extracted from carrot roots helped pave the way for flat-screen TVs, and six other discoveries that unintentionally changed the world. Perfect talking points for when you need to defend basic science, whether it’s to your grumpy uncle or your MP. www.nature.com/articles/d41...
nature.com
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
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Juan Gallego @juangallego.bsky.social · 04/11/2025
🚨Job alert🚨 The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour This is part of a collaborative ARIA grant "4D precision control of cortical dynamics" euraxess.ec.europa.eu/jobs/383909
euraxess.ec.europa.eu
3 Postdoctoral Research Fellows
Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr.
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Paul Gribble 🇨🇦 @gribblelab.org · 04/11/2025
a gross parliamentary overreach — article by @picardonhealth.bsky.social in the globe and mail; #academicsky #neuroskyence #psychscisky www.theglobeandmail.com/gift/91587b9...
theglobeandmail.com
How much are MPs entitled to know about research grants? Not as much as they think
A parliamentary committee is asking for academics’ private information on a strange anti-DEI crusade
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Adrien Peyrache @apeyrache.bsky.social · 24/10/2025
New lab colormap, courtesy of the tree outside my house.
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Martin Vinck @martinavinck.bsky.social · 24/10/2025
Various theoretical properties derived for gamma oscillations based on canonical E-SOM-PV microcircuit connectivity using mean-field modelling, which moves beyond classic Wilson-Cowan models in important ways biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
biorxiv.org
A mean-field model of neural networks with PV and SOM interneurons reveals connectivity-based mechanisms of gamma oscillations
Classic theoretical models of cortical oscillations are based on the interactions between two populations of excitatory and inhibitory neurons. Nevertheless, experimental studies and network simulatio...
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Adrien Peyrache @apeyrache.bsky.social · 20/10/2025
Looking forward to seeing all the great science that will come out of @adrian-du.bsky.social’s lab, aka the DuLab!! Congrats Adrian!
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Adrian Duszkiewicz @adrian-du.bsky.social · 15/10/2025
Really excited to share this Opinion piece we've been working on with fellow head-direction cell geeks @apeyrache.bsky.social @desdemonafricker.bsky.social and (bsky-less?) Andrea Burgalossi! While head-direction cells pop up in many cortical regions, we think that one of them is quite unique (1/8)
sciencedirect.com
The postsubiculum as a head-direction cortex
The organisation of thalamocortical networks follows a conserved structure. Traditionally, these are divided into primary sensory systems that receive…
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Adrien Peyrache @apeyrache.bsky.social · 15/10/2025
🚨new paper: the head-direction circuit as a model of primary thalamocortical system. Check this out 👇 kudos to @adrian-du.bsky.social for the huge amount of work put into this opinion piece, starting with the beautiful figures comparing the different thalamocortical systems 🤩
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Adrien Peyrache @apeyrache.bsky.social · 15/10/2025
Totally agree with @gershbrain.bsky.social. Science will never explain art. Yet the two share an important trait: a constant search for new representations of nature, of data, of reality, of emotions, in forms that make sense of what once seemed inscrutable.
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Dan Levenstein @dlevenstein.bsky.social · 08/10/2025
The Wu Tsai Institute at Yale is hiring another faculty member in neurocomputation. Come work with us in a growing community at the interface of neuroscience and AI! More info below 👇
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Adrien Peyrache @apeyrache.bsky.social · 07/10/2025
Every neuroscience lecture ever, summarized in one dog video.
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Manfredi Castelli @manfredic.bsky.social · 02/10/2025
I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social ! With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics
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Boris Bernhardt @borismontreal.bsky.social · 02/10/2025
🚨 New paper in Nature Methods: HippoMaps: multiscale cartography of the human hippocampus Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG) Led by @jordandekraker.bsky.social docs: hippomaps.readthedocs.io paper: doi.org/10.1038/s415...
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Kevin Mitchell @wiringthebrain.bsky.social · 01/10/2025
Just the most remarkable person and truly a beautiful soul
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D. Earl Stephens @dearlstephens.bsky.social · 01/10/2025
🕊️ The world has lost a revered conservationist -- a colossal power for what is truly good. 🕊️ Jane Goodall is a legend who helped open the door to science to the best humans among us: woman. 🕊️ She was brave, brilliant and introduced us to the best things among us: animals. 🕊️ I grieve her passing.
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Brokoslaw Laschowski @drlaschowski.bsky.social · 05/09/2025
Come join us at University of Toronto. We're hiring a Professor of computational cognitive neuroscience. #neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca
Professor - Computational Cognitive Neuroscience
Professor - Computational Cognitive Neuroscience
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Adrien Peyrache @apeyrache.bsky.social · 21/09/2025
Post-tenure mid-life crisis project: complete ✅ 3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…
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Adrien Peyrache @apeyrache.bsky.social · 19/09/2025
Fascinating work! It pinpoints the origin of dopaminergic signaling as a filter of striatal activity computing temporal difference. Excited to dig into this manuscript.
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Adrien Peyrache @apeyrache.bsky.social · 18/09/2025
So happy to see Morgane Butler, a former and brilliant undergrad student in the lab, publishing her PhD work. Looks super interesting. www.nature.com/articles/s41...
nature.com
Repeated head trauma causes neuron loss and inflammation in young athletes - Nature
Repetitive head impacts from contact sports are associated with brain inflammation, vascular damage and neuron loss that are independent of hyperphosphorylated tau pathology.
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