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Jan-Willem Veening

@veeninglab.com
2.2K followers 1.7K following 166 posts

Professor and director at the Department of Fundamental Microbiology, University of Lausanne, veeninglab.com. Interested in antibiotic resistance, bacterial cell biology, host-microbe interactions.

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Reposted by Jan-Willem Veening
Kate Baker @ksbakes.bsky.social · 25/09/2026
We have an open Assistant/Associate Professor position in Pathogen Biology at the Department of Genetics - come and join us! 🦠 🧫 🧬https://www.cam.ac.uk/jobs/assistantassociate-professor-in-pathogen-genetics-pc51175
cam.ac.uk
Assistant/Associate Professor in Pathogen Genetics
Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...
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Reposted by Jan-Willem Veening
Brian D. Wade @astrobrian.bsky.social · 28/09/2026
Bacterial chromosomal gene positioning is likely shaped by selection on both mean and growth-dependent expression #genomes #genetics #genes #evolution #evoSky #scienceSky journals.plos.org/plosgenetics...
journals.plos.org
Bacterial chromosomal gene positioning is likely shaped by selection on both mean and growth-dependent expression
Author summary Bacterial gene positioning affects gene expression because genes near the origin of chromosomal replication are replicated earlier than those near the terminus and thus have higher gene...
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Reposted by Jan-Willem Veening
Dorentina Humolli @humollidorentina.bsky.social · 25/09/2026
Very happy to share that HIDEN-SEQ is now out in @natmicrobiol.nature.com! Using this technique, we recapitulated decades of established phage genetics and uncovered new gene functions, including previously unknown anti-defense factors against several defense systems. www.nature.com/articles/s41...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 25/09/2026
Here it is online, a week after the teaser talk at #EMBOBacNet... @natmicrobiol.nature.com by @humollidorentina.bsky.social et al from @aharms485.bsky.social with @veeninglab.com Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ www.nature.com/articles/s41...
nature.com
Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ - Nature Microbiology
HIDEN-SEQ (hidden Acr-enabled transposon-insertion sequencing) is a transposon-insertion sequencing method for phages that systematically links their genes to selectable phenotypes.
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Reposted by Jan-Willem Veening
Thomas Ipoutcha @tomipou.bsky.social · 16/09/2026
Finally out! 🎉 After 3 years of postdoc in London, here is my main work, now published in Nature Comm. (and as co-corresponding author!) Using a combination of bioinformatic and experimental approaches, we propose a model of plasmid evolution in Staphylococcus. www.nature.com/articles/s41... ⬇️ 1/4
nature.com
Mobile genetic elements drive a plasmid fusion and deletion lifecycle shaping evolution and antimicrobial resistance - Nature Communications
Plasmids drive bacterial adaptation, but how their diversity arises has remained unclear. Here, they show that in Staphylococcus aureus, mobile genetic elements repeatedly fuse and delete plasmids, re...
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Reposted by Jan-Willem Veening
Dirk-Jan Scheffers 🟥 @dirkscheffers.bsky.social · 22/09/2026
Statements about attractiveness and excellence from @vonderleyen.ec.europa.eu and others in this article notwithstanding I’d like to add some critique 1/ marie-sklodowska-curie-actions.ec.europa.eu/whats-new/ne...
marie-sklodowska-curie-actions.ec.europa.eu
MSCA Postdoctoral Fellowships 2026 receives record number of applications
The 2026 call has attracted considerable interest from the research community with 21,627 applications submitted.
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Jan-Willem Veening @veeninglab.com · 18/09/2026
Assessment of the impact of manual curation in BioCyc #MicroSky doi.org/10.3389/fbin...
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Reposted by Jan-Willem Veening
Nature Microbiology @natmicrobiol.nature.com · 17/09/2026
Out Now! Bacterial growth rate in populations and single cells #MicroSky
go.nature.com
Bacterial growth rate in populations and single cells
Nature Microbiology, Published online: 17 September 2026; doi:10.1038/s41564-026-02449-6In this Perspective, Levin and Wang give a brief history of bacterial growth rate and discuss how it is connected to nutrient availability and macromolecule synthesis, with a focus on (p)ppGpp as a central hub regulating resource allocation and, indirectly, growth rate at the single-cell level.
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Reposted by Jan-Willem Veening
Pedro Beltrao @pedrobeltrao.bsky.social · 04/09/2026
I used Fable 5.1 to run an AI research project given a bioinformatics research idea (cross links +AlphafoldDB), with the objective of producing a submission folder (manuscript, figures, code, supplementary files, cover letter). It did so in about 7h with still fairly poor results. The process:
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Jan-Willem Veening @veeninglab.com · 03/09/2026
In Pseudomonas ICEclc, ~3–5% of cells switch on transfer competence in stationary phase with 3-CBA. Restricting the response to a small subpopulation may limit the fitness cost while preserving spread. Huge thanks to Milena Jaskólska and Jesús Cámara-Almirón for leading this review!
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Jan-Willem Veening @veeninglab.com · 03/09/2026
Gene expression noise, asymmetric division, phase variation and quorum sensing can create cell-to-cell differences. Feedback can lock them into stable ON/OFF states supporting bet-hedging, division of labor and persistence. Synthetic circuits can test when this variation is truly adaptive.
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Jan-Willem Veening @veeninglab.com · 03/09/2026
Clonal does not mean uniform. #MicroSky Our new review explores how genetically identical bacteria adopt different cell states, and how that diversity shapes survival, cooperation, antibiotic responses and gene transfer. 🧵 doi.org/10.1146/annu...
doi.org
Decoding Bistability and Drivers of Phenotypic Variation in Bacteria
In a process known as phenotypic heterogeneity or phenotypic variation, bacteria can produce distinct phenotypes within an isogenic population in response to shifting environmental conditions. Noise i...
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Yolanda Schaerli @yschaerli.bsky.social · 02/09/2026
Excited to share our latest preprint! 🧫 We move beyond observing bacterial Voronoi patterns to actively controlling gaps, anti-gaps, curved boundaries, asymmetric structures, seedless regions, and complex composites. @dmf-unil.bsky.social @fbm-unil.bsky.social www.biorxiv.org/content/10.6...
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Seth Dickey @dickeylab.bsky.social · 28/08/2026
So @thesbhowmick.bsky.social adopted a dual-CRISPRi approach to silence two genes per cell in a highly diverse heterogenous pool. This was done similarly for B. subtilis and S. pneumo by the labs of Carol Gross and @veeninglab.com. 3/10
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Seth Dickey @dickeylab.bsky.social · 28/08/2026
I’m thrilled to share our newest study in which @thesbhowmick.bsky.social y.social developed and applied a genome-wide platform to uncover genetic interactions in Staphylococcus aureus and MRSA. www.biorxiv.org/content/10.6... 1/10
biorxiv.org
A genome-wide genetic interaction platform for MRSA reveals connections between cell division and the cell envelope
The bacterial cell cycle is an ensemble of integrated pathways that coordinates cell growth and division. Although these pathways contain a suite of promising antimicrobial targets, their functional o...
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Jan-Willem Veening @veeninglab.com · 28/08/2026
Cool! Congratulations! On my reading list!
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Jan-Willem Veening @veeninglab.com · 28/08/2026
Maybe that’s the key: there isn’t one “midcell-finding” mechanism. Geometry constrains the possibilities, PG chemistry preserves spatial memory, and chromosome organization coordinates division with the cell cycle. Together they make division remarkably robust! #MicroSky
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Jan-Willem Veening @veeninglab.com · 28/08/2026
One important chicken-and-egg caveat: DacA/B themselves act at an existing division site. So the PG/MapZ model beautifully explains how positional information can be propagated from one generation to the next, but not necessarily how the very first division site is established de novo.
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Jan-Willem Veening @veeninglab.com · 28/08/2026
Chromosome organization/segregation may then provide additional spatial constraints and, through systems such as RocS/CpsD, help ensure that constriction proceeds only when the DNA is safely organized.
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Jan-Willem Veening @veeninglab.com · 28/08/2026
Cell geometry provides a coordinate system and biases the Z-ring to form perpendicular to the long axis. An inherited, DacA/B-dependent PG signature is read by MapZ to more precisely identify the equator and position FtsZ.
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Jan-Willem Veening @veeninglab.com · 28/08/2026
With what we know now, I think the simplest model may be that pneumococcus doesn’t actively “find” its middle. Instead, the previous division event leaves behind spatial information that helps specify the next one.
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Jan-Willem Veening @veeninglab.com · 28/08/2026
I hadn't thought about the problem of division site selection in a long time. Really cool to see these new studies shining fresh light on such a fundamental question. Especially checkout this work by @aducret.bsky.social & Christophe Grangeasse: doi.org/10.1038/s415...
doi.org
Local peptidoglycan composition defines division site selection in Streptococcus pneumoniae - Nature Microbiology
Sequential peptidoglycan carboxylase activity of DacA and DacB generates a local peptidoglycan signature that recruits MapZ and establishes the division site at the Streptococcus pneumoniae cell equat...
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Jan-Willem Veening @veeninglab.com · 27/08/2026
Also strange the referees didn't pick it up and knew about our work, although 1 referee specifically asked the authors to look at disrupted chromosome replication or segregation and whether this might cause Z-ring misplacement, with shape being secondary. A simple search would have found our paper.
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Jan-Willem Veening @veeninglab.com · 27/08/2026
Our Figs 1 are basically identical + they use a FtsZ-GFP which is likely synthetic sick with MapZ (also shown in our paper). They clearly conclude that MapZ is important for the angle of the division plane, like we observed.
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Jan-Willem Veening @veeninglab.com · 27/08/2026
That is all very cool and builds on your and our previous work. But this is no excuse for them to not discuss our work. The chromosome perturbation experiments we did could have knock-on effects on geometric cues/cell morphology, so discussing our work would have strengthened their findings.
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Jan-Willem Veening @veeninglab.com · 26/08/2026
I have emailed the corresponding author and hope they can (and want) to correct their article and that its an innocent mistake (literature-community blind spot) and not because they omitted citing our work to increase their framed novelty..
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Reposted by Jan-Willem Veening
Renske van Raaphorst 🟥 @vrrenske.bsky.social · 26/08/2026
figure 1 looks very familiar to me 😅
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Jan-Willem Veening @veeninglab.com · 26/08/2026
The 2026 paper's core observation is that MapZ sets plane orientation, not midcell selection, and the chromosome supplies the underlying spatial information. This is exactly the central claim of our 2017 paper...
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Jan-Willem Veening @veeninglab.com · 26/08/2026
Great to see an independent validation of our 2017 PNAS work on MapZ. Less great to not see it even mentioned nor cited.. #MicroSky www.pnas.org/doi/full/10.... febs.onlinelibrary.wiley.com/doi/abs/10.1...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 23/08/2026
Decoding Bistability and Drivers of Phenotypic Variation in Bacteria Annual Reviews in Microbiology by Jesús Cámara-Almirón, Milena Jaskólska, and @veeninglab.com at @dmf-unil.bsky.social www.annualreviews.org/content/jour...
annualreviews.org
Decoding Bistability and Drivers of Phenotypic Variation in Bacteria
In a process known as phenotypic heterogeneity or phenotypic variation, bacteria can produce distinct phenotypes within an isogenic population in response to shifting environmental conditions. Noise i...
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Reposted by Jan-Willem Veening
Kumaran Ramamurthi @ramamurthilab.bsky.social · 20/08/2026
@felixrl.bsky.social told us previously *how* #Staph aureus does orthogonal cell division. In his latest paper he tells us *why*: to arrange cell surface proteins required to form staphylococcal abscess colonies. (Videos S1-S2 are amazing!). 🤯 www.cell.com/cell-reports...
cell.com
Orthogonal cell division mediated by PcdA organizes surface virulence factors to drive staphylococcal abscess community formation
Staphylococcus aureus divides along sequential orthogonal planes, but the function of this geometry has remained unclear. Ramos-León et al. show that orthogonal division promotes uniform deployment of...
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Reposted by Jan-Willem Veening
Johanna Joyce @johannajoyce.bsky.social · 19/08/2026
A fun collection of ideas in #Nature today on how to make lab meetings more engaging, inclusive & useful! Thanks for including our lab’s “flashlight” round in the tips - a simple ritual to give everyone a voice & stay connected to what’s happening across the group 🧪 www.nature.com/articles/d41...
nature.com
Twenty-two easy ways to power up your lab meetings
Scientists share help and advice on how they got their research discussions flowing.
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Dr. Michael D. L. Johnson @copperbae.bsky.social · 12/08/2026
Check it out!
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Jan-Willem Veening @veeninglab.com · 11/08/2026
Looks cool! New work by @elowitzlab.bsky.social: Engineered protein circuits for cancer therapy www.biorxiv.org/content/10.1...
biorxiv.org
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Charles Mullon @charlesmullon.bsky.social · 03/08/2026
Looking for an Associate Prof position? Interested in behavioural ecology & cultural evolution? Come join us at the Dpt of Ecology and Evolution in Lausanne🇨🇭 @dee-unil.bsky.social @unil.bsky.social! Great department & great place to live. Pls RP. Apply here: wwwfbm.unil.ch/releve/appli...
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Jan-Willem Veening @veeninglab.com · 04/08/2026
Congrats specifically to @ayaiizuka.bsky.social and @mvmazzuoli.bsky.social !!
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Jan-Willem Veening @veeninglab.com · 04/08/2026
Wonderful collaboration across @biozentrum.unibas.ch & @dmf-unil.bsky.social @fbm-unil.bsky.social within @nccr-antiresist.bsky.social with Nina Khanna's group as driving force, Dirk, Annelies & all coauthors. Congratulations everyone! Comments & suggestions welcome.
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Jan-Willem Veening @veeninglab.com · 04/08/2026
Targeting Mnh1 alongside antibiotics may help eliminate this hard-to-reach reservoir.
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Jan-Willem Veening @veeninglab.com · 04/08/2026
Knocking down mnhB reduced early phagocytic uptake and intracellular bacterial burden. Importantly, the phenotype held across three distinct S. aureus lineages. Excitingly, when mnhB was depleted, levofloxacin cleared intracellular bacteria more effectively.
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Jan-Willem Veening @veeninglab.com · 04/08/2026
The intracellular and extracellular fitness landscapes separated clearly. The screen recovered known virulence factors and uncovered new genes specifically needed inside phagocytes. Among them: mnhB, part of the Mnh1 cation–proton antiporter.
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Jan-Willem Veening @veeninglab.com · 04/08/2026
To find the genes behind this lifestyle, we built a genome-wide CRISPRi-seq screen targeting 2,865 S. aureus genes in a THP-1 co-infection model, then compared intracellular and extracellular fitness. @veeninglab.com @vincentdebakker.bsky.social
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Jan-Willem Veening @veeninglab.com · 04/08/2026
Why look inside cells? Although S. aureus is mainly extracellular, it can persist within monocytes and macrophages. We found that internalization markedly increased antibiotic survival, making the intracellular niche a potential reservoir for treatment failure.
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Jan-Willem Veening @veeninglab.com · 04/08/2026
New preprint! #MicroSky Led by @ayaiizuka.bsky.social & Maria Vittoria Mazzuoli, we ask what helps Staphylococcus aureus enter, survive inside and evade treatment in human monocytes. www.biorxiv.org/content/10.6...
biorxiv.org
Staphylococcus aureus Mnh1 cation–proton antiporter promotes phagocytic uptake and intracellular survival in human monocytes
While Staphylococcus aureus is predominantly an extracellular human commensal, it can also exhibit an intracellular lifestyle that enables its persistence within diverse host cell types, including mon...
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MEEhubs @meehubs.bsky.social · 29/07/2026
Registration for MEEHubs2026 taking place Aug 3-5 is closing this Friday (July 31, 2026)!! There's still time to join us in Montreal, Ann Arbor, Irvine, Morelia, Zurich, Manchester, Chernihiv, or online. Register here: meehubs.org
meehubs.org
Home
Abstract submission now closed but we now invite all poster presenters to upload their posters to our platform using the above link by July 31, 2026.
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Ákos T Kovács @evolvedbiofilm.bsky.social · 28/07/2026
Join us at Institute of Biology Leiden (IBL) as an Assistant/Associate/Full Professor in Mechanisms of Disease Apply before 31st August, 2026: careers.universiteitleiden.nl/job/Assistan...
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Vaughn Cooper @vscooper.micropopbio.org · 26/07/2026
In 2014, Jason Rosch and I met at a GRC in Tuscany and sketched an idea on a cocktail napkin: what if we evolved S.pneumo in mice, treated them with antibiotics, varied their immune systems and watched what won? 11 years and a huge team effort later, it's out in @cp-cellhostmicrobe.bsky.social 🧵
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Ákos T Kovács @evolvedbiofilm.bsky.social · 23/07/2026
The adaptive landscapes of three global Escherichia coli transcriptional regulators @elife.bsky.social by @cauawest.bsky.social et al elifesciences.org/articles/103...
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Rob Waterhouse @rmwaterhouse.bsky.social · 21/07/2026
#GenevaLovesData Geneva's heart beats to the rhythm of life-science data Léman Bleu interview with @sib.swiss director @dessimoz.bsky.social www.lemanbleu.ch/fr/Actualite...
lemanbleu.ch
#GenevaLovesData: Genève comme carrefour mondial des données
Pour Christophe Dessimoz, la cité internationale possède des atouts uniques.
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Emma Slack @mucosalimmunology.bsky.social · 01/07/2026
We are recruiting a lab manager for my group in Oxford. This is a lovely team doing great things, and you could be an important part of it! See here: www.path.ox.ac.uk/vacancy/lab-... Please spread the word!
path.ox.ac.uk
Lab Manager - Molecular Immunology - Dunn School
Laboratory Manager/Senior Scientist position in the Molecular Mucosal Immunology group at Oxford
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