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Matt Alexander

@vascularimmuno.bsky.social
168 followers 59 following 4 posts

Physician-scientist. Cardiovascular medicine, hypertension, immunology, vascular biology. Views my own.

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Reposted by Matt Alexander
Anand Vaidya @anandvaidya17.bsky.social · 02/04/2026
Re-Defining Primary Aldosteronism authors.elsevier.com/a/1mqFw2d9GI... @jaccjournals.bsky.social #JACC
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Stephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 13/03/2026
New lipid guidelines are out!!! 2026 ACC/AHA Guideline on the Management of Dyslipidemia www.ahajournals.org/doi/10.1161/...
ahajournals.org
American Heart Association Journals
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John Giacona, PhD, PA-C @giaconajohn.bsky.social · 28/02/2026
Excellent overview in The Washington Post on the systemic impact of sustained hypertension — from LVH to CKD and cognitive decline. Kudos to Drs. @drwanpen.bsky.social , John B, and @jordybc.bsky.social for evidence base insight. 🔗 www.washingtonpost.com/wellness/202... #Hypertension #Cardiology
washingtonpost.com
What high blood pressure does to your body
Hypertension can affect your mind, heart, eyes and more, often without causing any obvious symptoms at all.
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thecurbsiders.bsky.social @thecurbsiders.bsky.social · 26/02/2026
🧠 Dr. Vaidya’s @anandvaidya17.bsky.social practical approach to primary aldo, distilled into one clean, clinic-ready infographic: This is high-yield, no-fluff, practice-changing stuff.
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Matt Alexander @vascularimmuno.bsky.social · 15/02/2026
Really interesting case!
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thecurbsiders.bsky.social @thecurbsiders.bsky.social · 22/12/2025
🚨 Fresh Hypertension Guidelines Alert 🚨 Don’t get caught treating high blood pressure like it’s 2024 👀 
In Episode #509, West Philly doc Dr. Jordy Cohen @jordybc.bsky.social keeps our hypertension management fresh with a clear walk-through of the new HTN guidelines & more! www.thecurbsiders.com
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J. Brian Byrd @jbrianbyrd.bsky.social · 22/12/2025
Dan Batlle & I wrote about testing for primary aldosteronism, bringing a critical lens to the usual approach www.ahajournals.org/doi/full/10....
ahajournals.org
American Heart Association Journals
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Dr Anastasia S Mihailidou PhD FAHA FCSANZ FESC @anastasiasmihaili.bsky.social · 03/12/2025
⏳In 7 days an impt discussion on #BloodPressure across Womens #Lifespan coordinated by #NIH #NHLBI There is still time to register👉🏻 web.cvent.com/event/e7c2bdc3… Looking fwd to presenting & learning! Hope you will join #CardioSky #MedSky
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Vivek Bhalla, MD, FASN, FAHA @bhallaresearch.bsky.social · 05/11/2025
Ahead of #KidneyWk25, we are recruiting a hypertension fellow to the Stanford Hypertension Center for July 2026. Please come find me at ASN. med.stanford.edu/nephrology/e...
med.stanford.edu
Hypertension Fellowship
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 09/09/2025
The new ⌚️ will have hypertensive notifications This doesn’t seem like a cuffless BP - but more like a notification ‘you may have hypertension, go check your BP’ ? From www.apple.com/newsroom/202... @jordybc.bsky.social @drwanpen.bsky.social @spjuraschek.bsky.social @daichishimbo.bsky.social?
Hypertension Notifications

Building on its suite of advanced health features, Apple Watch Series 11 introduces groundbreaking hypertension notifications, which can alert users if signs of chronic high blood pressure — or hypertension — are detected.5 Hypertension is the leading modifiable risk factor for heart attack, stroke, and kidney disease, and impacts approximately 1.3 billion adults globally. It is frequently undiagnosed because it often has no symptoms, many people do not see a doctor regularly, and even during a clinical visit, it can be easily missed with a single measurement.
Hypertension notifications on Apple Watch use data from the optical heart sensor to analyze how a user’s blood vessels respond to the beats of the heart. The algorithm works passively in the background reviewing data over 30-day periods, and will notify users if it detects consistent signs of hypertension. These notifications provide users with valuable insights into their health as it relates to this widespread condition simply by wearing their Apple Watch, so they can begin making potentially lifesaving behavioral changes, or start treatment to reduce their risk of serious, long-term health events.
 Replay video: Apple Watch Series 11 Hypertension Notifications
 
Hypertension notifications use data from the optical heart sensor on Apple Watch to analyze how a user’s blood vessels respond to the beats of the heart.
Like all of Apple’s health features, hypertension notifications are grounded in rigorous scientific validation. The feature was developed with advanced machine learning and training data from multiple studies totaling over 100,000 participants. Its performance was then validated in a clinical study of over 2,000 participants. While hypertension notifications will not detect all instances of hypertension, with the reach of Apple Watch, the feature is expected to notify over 1 million people with undiagnosed hypertension within the first year.
 
Hypertension notifications use data from the optical heart sensor on Apple Watch to analyze how a user’s blood vessels respond to the beats of the heart.
Like all of Apple’s health features, hypertension notifications are grounded in rigorous scientific validation. The feature was developed with advanced machine learning and training data from multiple studies totaling over 100,000 participants. Its performance was then validated in a clinical study of over 2,000 participants. While hypertension notifications will not detect all instances of hypertension, with the reach of Apple Watch, the feature is expected to notify over 1 million people with undiagnosed hypertension within the first year.
“Hypertension is the leading preventable cause of heart attack and stroke, yet millions remain undiagnosed,” said Harlan Krumholz, MD, SM, cardiologist and scientist at Yale University and Yale New Haven Hospital. “Making accurate detection easy and part of daily life can help people get care earlier and prevent avoidable harm.”
 A user’s iPhone and Apple Watch Series 11 show “Possible Hypertension” and offer more details.
Hypertension notifications were developed with advanced machine learning and training data from multiple studies totaling over 100,000 participants.
If users receive a hypertension notification, it is recommended that they log their blood pressure for seven days using a third-party blood pressure cuff and share the results with their provider at their next visit, which is consistent with the latest American Heart Association guidelines for the diagnosis and management of hypertension.
Clearance for hypertension notifications from the FDA and other regulators is expected soon, and the feature will be available in more than 150 countries and regions — including the U.S. and the EU — this month. Hypertension notifications will be available on Apple Watch Series 9 and later, and Apple Watch Ultra 2 and later, with watchOS 26.
Hypertension Notifications

Hypertension notifications use data from the optical heart sensor on Apple Watch to analyze how a user’s blood vessels respond to the beats of the heart.
Like all of Apple’s health features, hypertension notifications are grounded in rigorous scientific validation. The feature was developed with advanced machine learning and training data from multiple studies totaling over 100,000 participants. Its performance was then validated in a clinical study of over 2,000 participants. While hypertension notifications will not detect all instances of hypertension, with the reach of Apple Watch, the feature is expected to notify over 1 million people with undiagnosed hypertension within the first year.
“Hypertension is the leading preventable cause of heart attack and stroke, yet millions remain undiagnosed,” said Harlan Krumholz, MD, SM, cardiologist and scientist at Yale University and Yale New Haven Hospital. “Making accurate detection easy and part of daily life can help people get care earlier and prevent avoidable harm.”
 A user’s iPhone and Apple Watch Series 11 show “Possible Hypertension” and offer more details.
Hypertension notifications were developed with advanced machine learning and training data from multiple studies totaling over 100,000 participants.
If users receive a hypertension notification, it is recommended that they log their blood pressure for seven days using a third-party blood pressure cuff and share the results with their provider at their next visit, which is consistent with the latest American Heart Association guidelines for the diagnosis and management of hypertension.
Clearance for hypertension notifications from the FDA and other regulators is expected soon, and the feature will be available in more than 150 countries and regions — including the U.S. and the EU — this month. Hypertension notifications will be available on Apple Watch Series 9 and later, and Apple Watch Ultra 2 and later, with watchOS 26.
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 03/09/2025
Beta blockers remain overused for #hypertension in the VA (though the tens line is going down, very slowly) jamanetwork.com/journals/jam... in @jama.com from @jordybc.bsky.social et al OTOH: I think ESRD should count as a somewhat compelling indication? Almost all HD pts here are on bisoprolol
Figure 2.  Fully Adjusted Prevalence Ratios (PRs) for Factors Associated With β-Blocker InitiationFigure 1.  Compelling Indication Status Among Veterans Who Initiated a β-Blocker for Hypertension Treatment, 2000 Through 2022
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Josh Leisring @joshleisring.bsky.social · 15/08/2025
Commentary on expanded screening for primary aldosteronism in the new HTN guideline. www.ahajournals.org/doi/10.1161/... 🔓
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Stephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 15/08/2025
If you want fresh, live discussion on the new guidelines, join us in Baltimore this September! Writers will present their rationales and future directions! Hypertension 2025 Scientific Sessions - Professional Heart Daily | American Heart Association share.google/WD0vuS8NuHnF...
share.google
Hypertension 2025 Scientific Sessions
Join the Hypertension Scientific Sessions to explore the latest research, treatment strategies, and advancements in hypertension management. Register now!
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Stephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 14/08/2025
New AHA Hypertension guidelines are out! professional.heart.org/en/science-n...
professional.heart.org
2025 High Blood Pressure Guideline
The 2025 High Blood Pressure Guideline replaces the 2017 ACC/AHA High Blood Pressure Guideline, incorporating updated recommendations based on the latest clinical evidence through early 2025.
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Alex Chang, MD @alexchangmd.bsky.social · 17/07/2025
2025 AHA/ACC Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults 08/28/25 @ 12:00 pm – 1:30 pm CDT Featuring writing committee members and highlights from the ACC/AHA Committee on Clinical Practice Guidelines targetbp.org/event/target...
targetbp.org
Target BP: Webinar – Target:BP
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Josh Waitzman @jwaitz.bsky.social · 16/07/2025
A bold guideline from the beginning! “We suggest that all individuals with hypertension be screened for primary aldosteronism”
media.tenor.com
two cats are standing next to each other with the words " it is bold i like it " above them
ALT: two cats are standing next to each other with the words " it is bold i like it " above them
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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 15/07/2025
Balancing the risk for clotting and bleeding is constant challenge for cardiologists, so I was very excited to see in this month’s #JACCBTS work on targeting different parts of the coagulation cascade (Factor 11, FXI) to reduce bleeding risk while lowering risk for thrombosis. 🧵: 1/8
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Wanpen Vongpatanasin @drwanpen.bsky.social · 14/07/2025
New PA Endo guideline is also out by experts @anandvaidya17.bsky.social #Cardiosky @hswapnil.medsky.social doi.org/10.1210/clin...
doi.org
Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline
AbstractBackground. Primary aldosteronism (PA), a primary adrenal disorder leading to excessive aldosterone production by one or both adrenal glands, is a
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Heather Gornik @heatherlgornik.bsky.social · 04/06/2025
We have an unexpected late opening in our vascular medicine 1 year fellowship program for 2025-2026 @harringtonhvi.bsky.social Outstanding clinical training with multi specialty faculty in a highly collaborative environment. Chat if interested and please help spread the word. #CardioSky
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Michael Raddatz @michaelraddatz.bsky.social · 28/05/2025
In this month’s issue of #JACCBTS, Jønck, et al. explore the effects of cytokine inhibitors on cardiovascular adaptability in rheumatoid arthritis (RA). Read below to see what they found! 🧵 1/9 @jaccjournals.bsky.social
Title page of a paper titled IL-6 inhibitors and TNF inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis
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Joseph Flynn, MD @jostflynnmd.bsky.social · 17/05/2025
It's World Hypertension Day #nephsky #medsky mailchi.mp/whleague.org...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 12/05/2025
There you have it: BEDMED published in @jama.com jamanetwork.com/journals/jam... h/t @drjmluther.bsky.social No difference in bedtime versus morning BP meds - as expected #NephSky #Hypertension 1/
Figure of survival curve showing no difference
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 06/05/2025
Also read the accompanying editorial from @jordybc.bsky.social www.acpjournals.org/doi/10.7326/... Don’t let the complexity of traditional PA screening and confirming diagnosis stop you - just measure renin to start and go from there
acpjournals.org
Rethinking Confirmatory Testing in Primary Aldosteronism | Annals of Internal Medicine
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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 01/05/2025
I’ll always remember the first congestive hepatopathy patient I took care of as an intern @vumc.bsky.social. The pathology was so different from anything else, so when I saw an article on this in this month’s #JACCBTS I couldn’t wait to learn more about it. (🧵: 1/10) @jaccjournals.bsky.social
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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 01/05/2025
Follow @michaelraddatz.bsky.social @jeffhsumd.bsky.social and @vascularimmuno.bsky.social and I for more updates on great science from #JACCBTS (🧵: 10/10)
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 23/04/2025
The ASIs have arrived www.nejm.org/doi/full/10.... Aldosterone synthase inhibitors - first one to finish the phase 3 line #Lorundrostat #Hypertension
nejm.org
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM
Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...
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Hypertension Canada @hypertensioncanada.bsky.social · 16/04/2025
Register now! site.pheedloop.com/event/HCVirt...
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Josh Leisring @joshleisring.bsky.social · 07/04/2025
Interesting case report: an unusual (and new to me) etiology of AME. academic.oup.com/jcemcr/artic... #nephsky
academic.oup.com
An Unusual Cause of Hypokalemia to Consider
Abstract. Apparent mineralocorticoid excess syndrome is a rare disorder that can be acquired through inhibition of the enzyme 11 β-hydroxysteroid dehydroge
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Heather Gornik @heatherlgornik.bsky.social · 30/03/2025
Great pearls by @jbrianbyrd.bsky.social in evaluating pts for RDN at #ACC25: 1. confirm uncontrolled HTN with out of office measure (Amb BP monitor); 2. trial spironolactone 1st; 3. shared decision making key - care team should include HTN specialists beyond those performing the procedure #cardiosky
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Matt Alexander @vascularimmuno.bsky.social · 27/03/2025
Excited to see this review on GWAS in hypertension out in print with @endocelldoc.bsky.social and Todd Edwards. www.ahajournals.org/doi/full/10....
ahajournals.org
GWAS for Defining the Pathogenesis of Hypertension: Have They Delivered? | Hypertension
Genome-wide association studies have identified >3500 associated single nucleotide polymorphisms and over 1000 independent loci associated with hypertension. These individually have small effect si...
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thecurbsiders.bsky.social @thecurbsiders.bsky.social · 10/03/2025
❤️🏥🎙️ #474 Resistant Hypertension the Next Frontier! Treat Hypertension Like No Doctor Has Ever Treated Hypertension Before! @jordybc.bsky.social Treating hypertension never gets boring. Learn about emerging therapies and how to continue to tackle this common diagnosis like a pro.
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Stephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 07/03/2025
Key slide @ahascience.bsky.social #EpiLifestyle25
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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025
Ever get back a genetic report and dread seeing the words “Variant of Unknown Significance (VUS)”😱? The # of VUSs are escalating as more patients get sequenced – join me in learning about how @spfisterer.bsky.social and colleagues are helping tackle the VUS problem 🧬 in this month's #JACCBTS🧵:1/9
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BWJones @bwjones.bsky.social · 27/02/2025
By @katherinejwu.com "The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,” The NIH is in a struggle for its (and our) lives. This is existential to America:
theatlantic.com
Inside the Collapse at NIH
Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
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Anshul Kundaje @anshulkundaje.bsky.social · 21/02/2025
Disease diagnostics using machine learning of B cell and T cell receptor sequences www.science.org/doi/10.1126/... TL;DR: BCRs ARE ALL YOU NEED! (Well actually .... keep reading) 1/
science.org
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ...
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Michael Raddatz @michaelraddatz.bsky.social · 27/01/2025
In this month’s issue of #JACCBTS, Brambilla, et al. explore the role of platelet function in long COVID. Read below ⬇️ to see what they found! 🧵 1/n @jeffhsumd.bsky.social @jaccjournals.bsky.social @vascularimmuno.bsky.social @jeanwassenaar.bsky.social
Title page of paper entitled "Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment"
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Justin Van Beusecum @jvanbeusecumlab.bsky.social · 26/01/2025
Our recent review on immune cells in the development of hypertension and renal injury is now In Press at AJP-Renal! journals.physiology.org/doi/abs/10.1...
journals.physiology.org
Recent Advances on Immunity and Hypertension: The New Cells on the Kidney Block | American Journal of Physiology-Renal Physiology
Over the last 50 years, contribution of the immune system has been identified in the development of hypertension and renal injury. Both human and experimental animal models of hypertension have demons...
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Matt Alexander @vascularimmuno.bsky.social · 25/01/2025
Interesting interactive case presentation on an under-recognized cause of hypertension. @anandvaidya17.bsky.social @nejm.org www.nejm.org/doi/10.1056/...
nejm.org
Targeting a Hormonal Cause of Hypertension | NEJM
This interactive feature describes a woman who received a diagnosis of hypertension and preeclampsia at 27 years of age. After giving birth, her blood pressure remained elevated. Test your diagnost...
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Matt Alexander @vascularimmuno.bsky.social · 20/01/2025
Enjoyed writing this editorial with Jessica Faulkner on a really interesting paper by Maria Pabon and @mchonig.bsky.social on a role for METAP1 in preeclampsia. www.ahajournals.org/doi/10.1161/...
ahajournals.org
Endothelial METAP1: Tipping the Angiogenic Scales in Postpartum Preeclampsia | Circulation Research
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Michael Honigberg @mchonig.bsky.social · 27/12/2024
In our latest led by Maria Pabon (MGB/BWH) now in Circ Res, we sequenced RNA from venous endothelial cells from 🤰 w/ or w/o preeclampsia We 👀 evidence that an aminopeptidase, METAP1, drives EC dysfunction in preeclampsia www.ahajournals.org/doi/10.1161/... #CardioObstetrics @mghcvrc.bsky.social
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