Reposted by Matt AlexanderAnand Vaidya @anandvaidya17.bsky.social · 02/04/2026Re-Defining Primary Aldosteronism authors.elsevier.com/a/1mqFw2d9GI... @jaccjournals.bsky.social #JACC 053
Reposted by Matt AlexanderStephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 13/03/2026New lipid guidelines are out!!! 2026 ACC/AHA Guideline on the Management of Dyslipidemia www.ahajournals.org/doi/10.1161/...ahajournals.orgAmerican Heart Association Journals 051
Reposted by Matt AlexanderJohn Giacona, PhD, PA-C @giaconajohn.bsky.social · 28/02/2026Excellent overview in The Washington Post on the systemic impact of sustained hypertension — from LVH to CKD and cognitive decline. Kudos to Drs. @drwanpen.bsky.social , John B, and @jordybc.bsky.social for evidence base insight. 🔗 www.washingtonpost.com/wellness/202... #Hypertension #Cardiologywashingtonpost.comWhat high blood pressure does to your bodyHypertension can affect your mind, heart, eyes and more, often without causing any obvious symptoms at all. 086
Reposted by Matt Alexanderthecurbsiders.bsky.social @thecurbsiders.bsky.social · 26/02/2026🧠 Dr. Vaidya’s @anandvaidya17.bsky.social practical approach to primary aldo, distilled into one clean, clinic-ready infographic: This is high-yield, no-fluff, practice-changing stuff. 075
Reposted by Matt Alexanderthecurbsiders.bsky.social @thecurbsiders.bsky.social · 22/12/2025🚨 Fresh Hypertension Guidelines Alert 🚨 Don’t get caught treating high blood pressure like it’s 2024 👀 In Episode #509, West Philly doc Dr. Jordy Cohen @jordybc.bsky.social keeps our hypertension management fresh with a clear walk-through of the new HTN guidelines & more! www.thecurbsiders.com 083
Reposted by Matt AlexanderJ. Brian Byrd @jbrianbyrd.bsky.social · 22/12/2025Dan Batlle & I wrote about testing for primary aldosteronism, bringing a critical lens to the usual approach www.ahajournals.org/doi/full/10....ahajournals.orgAmerican Heart Association Journals 1135
Reposted by Matt AlexanderDr Anastasia S Mihailidou PhD FAHA FCSANZ FESC @anastasiasmihaili.bsky.social · 03/12/2025⏳In 7 days an impt discussion on #BloodPressure across Womens #Lifespan coordinated by #NIH #NHLBI There is still time to register👉🏻 web.cvent.com/event/e7c2bdc3… Looking fwd to presenting & learning! Hope you will join #CardioSky #MedSky 065
Reposted by Matt AlexanderVivek Bhalla, MD, FASN, FAHA @bhallaresearch.bsky.social · 05/11/2025Ahead of #KidneyWk25, we are recruiting a hypertension fellow to the Stanford Hypertension Center for July 2026. Please come find me at ASN. med.stanford.edu/nephrology/e...med.stanford.eduHypertension Fellowship 076
Reposted by Matt AlexanderSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 09/09/2025The new ⌚️ will have hypertensive notifications This doesn’t seem like a cuffless BP - but more like a notification ‘you may have hypertension, go check your BP’ ? From www.apple.com/newsroom/202... @jordybc.bsky.social @drwanpen.bsky.social @spjuraschek.bsky.social @daichishimbo.bsky.social? 10188
Reposted by Matt AlexanderSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 03/09/2025Beta blockers remain overused for #hypertension in the VA (though the tens line is going down, very slowly) jamanetwork.com/journals/jam... in @jama.com from @jordybc.bsky.social et al OTOH: I think ESRD should count as a somewhat compelling indication? Almost all HD pts here are on bisoprolol 083
Reposted by Matt AlexanderJosh Leisring @joshleisring.bsky.social · 15/08/2025Commentary on expanded screening for primary aldosteronism in the new HTN guideline. www.ahajournals.org/doi/10.1161/... 🔓 141
Reposted by Matt AlexanderStephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 15/08/2025If you want fresh, live discussion on the new guidelines, join us in Baltimore this September! Writers will present their rationales and future directions! Hypertension 2025 Scientific Sessions - Professional Heart Daily | American Heart Association share.google/WD0vuS8NuHnF...share.googleHypertension 2025 Scientific SessionsJoin the Hypertension Scientific Sessions to explore the latest research, treatment strategies, and advancements in hypertension management. Register now! 042
Reposted by Matt AlexanderStephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 14/08/2025New AHA Hypertension guidelines are out! professional.heart.org/en/science-n...professional.heart.org2025 High Blood Pressure GuidelineThe 2025 High Blood Pressure Guideline replaces the 2017 ACC/AHA High Blood Pressure Guideline, incorporating updated recommendations based on the latest clinical evidence through early 2025. 031
Reposted by Matt AlexanderAlex Chang, MD @alexchangmd.bsky.social · 17/07/20252025 AHA/ACC Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults 08/28/25 @ 12:00 pm – 1:30 pm CDT Featuring writing committee members and highlights from the ACC/AHA Committee on Clinical Practice Guidelines targetbp.org/event/target...targetbp.orgTarget BP: Webinar – Target:BP 024
Reposted by Matt AlexanderJosh Waitzman @jwaitz.bsky.social · 16/07/2025A bold guideline from the beginning! “We suggest that all individuals with hypertension be screened for primary aldosteronism”media.tenor.comtwo cats are standing next to each other with the words " it is bold i like it " above themALT: two cats are standing next to each other with the words " it is bold i like it " above them 1218
Reposted by Matt AlexanderJean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 15/07/2025Balancing the risk for clotting and bleeding is constant challenge for cardiologists, so I was very excited to see in this month’s #JACCBTS work on targeting different parts of the coagulation cascade (Factor 11, FXI) to reduce bleeding risk while lowering risk for thrombosis. 🧵: 1/8 121
Reposted by Matt AlexanderWanpen Vongpatanasin @drwanpen.bsky.social · 14/07/2025New PA Endo guideline is also out by experts @anandvaidya17.bsky.social #Cardiosky @hswapnil.medsky.social doi.org/10.1210/clin...doi.orgPrimary Aldosteronism: An Endocrine Society Clinical Practice GuidelineAbstractBackground. Primary aldosteronism (PA), a primary adrenal disorder leading to excessive aldosterone production by one or both adrenal glands, is a 12314
Reposted by Matt AlexanderHeather Gornik @heatherlgornik.bsky.social · 04/06/2025We have an unexpected late opening in our vascular medicine 1 year fellowship program for 2025-2026 @harringtonhvi.bsky.social Outstanding clinical training with multi specialty faculty in a highly collaborative environment. Chat if interested and please help spread the word. #CardioSky 038
Reposted by Matt AlexanderMichael Raddatz @michaelraddatz.bsky.social · 28/05/2025In this month’s issue of #JACCBTS, Jønck, et al. explore the effects of cytokine inhibitors on cardiovascular adaptability in rheumatoid arthritis (RA). Read below to see what they found! 🧵 1/9 @jaccjournals.bsky.social 255
Reposted by Matt AlexanderJoseph Flynn, MD @jostflynnmd.bsky.social · 17/05/2025It's World Hypertension Day #nephsky #medsky mailchi.mp/whleague.org... 097
Reposted by Matt AlexanderSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 12/05/2025There you have it: BEDMED published in @jama.com jamanetwork.com/journals/jam... h/t @drjmluther.bsky.social No difference in bedtime versus morning BP meds - as expected #NephSky #Hypertension 1/ 25628
Reposted by Matt AlexanderSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 06/05/2025Also read the accompanying editorial from @jordybc.bsky.social www.acpjournals.org/doi/10.7326/... Don’t let the complexity of traditional PA screening and confirming diagnosis stop you - just measure renin to start and go from thereacpjournals.orgRethinking Confirmatory Testing in Primary Aldosteronism | Annals of Internal Medicine 183
Reposted by Matt AlexanderJean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 01/05/2025I’ll always remember the first congestive hepatopathy patient I took care of as an intern @vumc.bsky.social. The pathology was so different from anything else, so when I saw an article on this in this month’s #JACCBTS I couldn’t wait to learn more about it. (🧵: 1/10) @jaccjournals.bsky.social 134
Reposted by Matt AlexanderJean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 01/05/2025Follow @michaelraddatz.bsky.social @jeffhsumd.bsky.social and @vascularimmuno.bsky.social and I for more updates on great science from #JACCBTS (🧵: 10/10) 001
Reposted by Matt AlexanderSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 23/04/2025The ASIs have arrived www.nejm.org/doi/full/10.... Aldosterone synthase inhibitors - first one to finish the phase 3 line #Lorundrostat #Hypertensionnejm.orgLorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJMAldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult... 33727
Reposted by Matt AlexanderHypertension Canada @hypertensioncanada.bsky.social · 16/04/2025Register now! site.pheedloop.com/event/HCVirt... 023
Reposted by Matt AlexanderJosh Leisring @joshleisring.bsky.social · 07/04/2025Interesting case report: an unusual (and new to me) etiology of AME. academic.oup.com/jcemcr/artic... #nephskyacademic.oup.comAn Unusual Cause of Hypokalemia to ConsiderAbstract. Apparent mineralocorticoid excess syndrome is a rare disorder that can be acquired through inhibition of the enzyme 11 β-hydroxysteroid dehydroge 022
Reposted by Matt AlexanderHeather Gornik @heatherlgornik.bsky.social · 30/03/2025Great pearls by @jbrianbyrd.bsky.social in evaluating pts for RDN at #ACC25: 1. confirm uncontrolled HTN with out of office measure (Amb BP monitor); 2. trial spironolactone 1st; 3. shared decision making key - care team should include HTN specialists beyond those performing the procedure #cardiosky 087
Matt Alexander @vascularimmuno.bsky.social · 27/03/2025Excited to see this review on GWAS in hypertension out in print with @endocelldoc.bsky.social and Todd Edwards. www.ahajournals.org/doi/full/10....ahajournals.orgGWAS for Defining the Pathogenesis of Hypertension: Have They Delivered? | HypertensionGenome-wide association studies have identified >3500 associated single nucleotide polymorphisms and over 1000 independent loci associated with hypertension. These individually have small effect si... 010
Reposted by Matt Alexanderthecurbsiders.bsky.social @thecurbsiders.bsky.social · 10/03/2025❤️🏥🎙️ #474 Resistant Hypertension the Next Frontier! Treat Hypertension Like No Doctor Has Ever Treated Hypertension Before! @jordybc.bsky.social Treating hypertension never gets boring. Learn about emerging therapies and how to continue to tackle this common diagnosis like a pro. 197
Reposted by Matt AlexanderStephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 07/03/2025Key slide @ahascience.bsky.social #EpiLifestyle25 074
Reposted by Matt AlexanderJean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025Ever get back a genetic report and dread seeing the words “Variant of Unknown Significance (VUS)”😱? The # of VUSs are escalating as more patients get sequenced – join me in learning about how @spfisterer.bsky.social and colleagues are helping tackle the VUS problem 🧬 in this month's #JACCBTS🧵:1/9 032
Reposted by Matt AlexanderBWJones @bwjones.bsky.social · 27/02/2025By @katherinejwu.com "The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,” The NIH is in a struggle for its (and our) lives. This is existential to America:theatlantic.comInside the Collapse at NIHAdministration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now. 11810488
Reposted by Matt AlexanderAnshul Kundaje @anshulkundaje.bsky.social · 21/02/2025Disease diagnostics using machine learning of B cell and T cell receptor sequences www.science.org/doi/10.1126/... TL;DR: BCRs ARE ALL YOU NEED! (Well actually .... keep reading) 1/science.orgDisease diagnostics using machine learning of B cell and T cell receptor sequencesClinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ... 69725
Reposted by Matt AlexanderMichael Raddatz @michaelraddatz.bsky.social · 27/01/2025In this month’s issue of #JACCBTS, Brambilla, et al. explore the role of platelet function in long COVID. Read below ⬇️ to see what they found! 🧵 1/n @jeffhsumd.bsky.social @jaccjournals.bsky.social @vascularimmuno.bsky.social @jeanwassenaar.bsky.social 168
Reposted by Matt AlexanderJustin Van Beusecum @jvanbeusecumlab.bsky.social · 26/01/2025Our recent review on immune cells in the development of hypertension and renal injury is now In Press at AJP-Renal! journals.physiology.org/doi/abs/10.1...journals.physiology.orgRecent Advances on Immunity and Hypertension: The New Cells on the Kidney Block | American Journal of Physiology-Renal PhysiologyOver the last 50 years, contribution of the immune system has been identified in the development of hypertension and renal injury. Both human and experimental animal models of hypertension have demons... 052
Matt Alexander @vascularimmuno.bsky.social · 25/01/2025Interesting interactive case presentation on an under-recognized cause of hypertension. @anandvaidya17.bsky.social @nejm.org www.nejm.org/doi/10.1056/...nejm.orgTargeting a Hormonal Cause of Hypertension | NEJMThis interactive feature describes a woman who received a diagnosis of hypertension and preeclampsia at 27 years of age. After giving birth, her blood pressure remained elevated. Test your diagnost... 164
Matt Alexander @vascularimmuno.bsky.social · 20/01/2025Enjoyed writing this editorial with Jessica Faulkner on a really interesting paper by Maria Pabon and @mchonig.bsky.social on a role for METAP1 in preeclampsia. www.ahajournals.org/doi/10.1161/...ahajournals.orgEndothelial METAP1: Tipping the Angiogenic Scales in Postpartum Preeclampsia | Circulation Research 073
Reposted by Matt AlexanderMichael Honigberg @mchonig.bsky.social · 27/12/2024In our latest led by Maria Pabon (MGB/BWH) now in Circ Res, we sequenced RNA from venous endothelial cells from 🤰 w/ or w/o preeclampsia We 👀 evidence that an aminopeptidase, METAP1, drives EC dysfunction in preeclampsia www.ahajournals.org/doi/10.1161/... #CardioObstetrics @mghcvrc.bsky.social 0129