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Reposted by Matt Luther, MD MSCI

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 16/05/2026

Bigger story? The Japanese company marketing Tavneos, Kissei - has told docs to stop using Avacopan WSJ story (Apple News link; apple.news/A8Woi0mr1QIm...)

“Kissei told doctors Friday to stop prescribing the drug to new patients.
The Japanese drugmaker said the 20 deaths occurred in people who had suffered a serious liver “impairment” and attributed 13 of the deaths to a condition, called vanishing bile duct syndrome, marked by the destruction of the ducts that carry bile out of the liver.
Kissei said causal links to Tavneos hadn’t been confirmed in all 20 deaths. Amgen shares were down more than 2% late Friday.
An Amgen spokeswoman said the 20 deaths occurred among more than 8,500 patients treated in Japan, and that some cases involved deaths where a causal link to Tavneos hadn’t been established. She added that no deaths linked to serious liver injury have been reported among the more than 8,000 U.S. patients who have taken the drug.
CSL, which holds the rights to sell the drug outside the U.S. and licensed it to Kissei for sale in Japan, said it “takes all matters of patient safety seriously” and is committed to working with regulators.
“Kissei has begun providing information to healthcare professionals, urging them to refrain from using this drug for new patients and to carefully assess the continuation of treatment for ”

Excerpt From
“20 People in Japan Died After Taking Amgen Drug”
Xavier Martinez
The Wall Street Journal
https://apple.news/A8Woi0mr1QImP29g7fxzZfQ
This material may be protected by copyright.

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Reposted by Matt Luther, MD MSCI

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 17/09/2025

Hypertension Secrets has been translated into multiple languages, including Lithuanian! Get your copy here: shop.elsevier.com/books/hypert... @edgarvlermamd.bsky.social @drjmluther.bsky.social

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Reposted by Matt Luther, MD MSCI

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 20/08/2025

The CPC from last @ahascience.bsky.social #HypertensionSessions now published in @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/... thanks to @drjmluther.bsky.social and all the education editors for the invite We hope it makes for an educational read!

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Reposted by Matt Luther, MD MSCI

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 05/06/2025

The first #ERA25 simultaneous pub CONFIDENCE trial of empagliflozin + finerenone in N = 579 Greater reduction in ACR and BP Note the impressive GFR dip www.nejm.org/doi/full/10....

Urinary Albumin-to-Creatinine Ratio, Serum Potassium Level, Estimated Glomerular Filtration Rate, and Systolic Blood Pressure over Time.

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Reposted by Matt Luther, MD MSCI

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 29/05/2025

Plenary at @hypertensioncanada.bsky.social with @drjmluther.bsky.social on new drugs He starts of with the really old drugs! #CHC25

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Matt Luther, MD MSCI @drjmluther.bsky.social · 28/05/2025

Matt Luther, Nephrologist/HTN specialist COI: Mineralys consulting #NephJC

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Reposted by Matt Luther, MD MSCI

Mineralys Therapeutics @mineralystx.com · 24/05/2025

Today we presented detailed results from our pivotal Ph3 Launch-HTN trial at #ESH2025, reinforcing the promise of lorundrostat as a new treatment approach for aldosterone driven #hypertension. Read our press release to learn more: ir.mineralystx.com/news-events/... $MLYS #bloodpressure

Mineralys Therapeutics Announces Late-Breaking Presentation of Data from the Launch-HTN Pivotal Trial of Lorundrostat in Uncontrolled or Resistant Hypertension at 34th European Meeting on Hypertension and Cardiovascular Protection (ESH 2025)

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Reposted by Matt Luther, MD MSCI

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 12/05/2025

There you have it: BEDMED published in @jama.com jamanetwork.com/journals/jam... h/t @drjmluther.bsky.social No difference in bedtime versus morning BP meds - as expected #NephSky #Hypertension 1/

Figure of survival curve showing no difference

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Reposted by Matt Luther, MD MSCI

Jordy Cohen @jordybc.bsky.social · 23/04/2025

Aaand it’s official, we have a new antihypertensive class!!!! 🎉🍾🎊 I like this RCT design in particular because it was open to both uncontrolled not-yet-resistant AND resistant hypertensive patients, opening to door to prescribe it as an earlier line agent www.nejm.org/doi/full/10....

nejm.org

Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM

Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...

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Reposted by Matt Luther, MD MSCI

American Journal of Kidney Diseases @ajkd.bsky.social · 12/04/2025

Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization bit.ly/3CEO9n1 #OpenAccess

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Reposted by Matt Luther, MD MSCI

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 03/04/2025

Retatrutide (GLP, GIP, Glucagon receptor agonist) and albuminuria and GFR changes from phase 2 trial now in @kireports.bsky.social Two Ph2 trials, one in T2DM and another in Obesity with about N ~ 300 each uACR reduced in both RCTs (A, B) Much more pronounced when baseline > 30 mg/g (C, D) 1/

Figure 1 Changes in UACR with retatrutide versus placebo. The figure shows the percent change from baseline in UACR. Data are least-squares means with error bars showing standard errors derived from the MMRM of the efficacy analysis set. Percent change from baseline in UACR over time from the MMRM analysis for all participants in the (A) T2D study and (B) obesity efficacy population and among participants with baseline UACR of ≥30 mg/g in the (C) T2D and (D) obesity trials. Abbreviations: MMRM= mixed model repeated measures. RETA=retatrutide. SE=standard error. T2D=type 2 diabetes. UACR=urine albumin-to-creatinine ratio.

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Reposted by Matt Luther, MD MSCI

Matthew Kay @mjskay.com · 30/03/2025

behold the CONNECTED SPLATTERPIE kneel before my works, ye mighty, and despair

A connected splatterpie: a connected scatterplot where the points are pie charts and the connecting lines are splines.

Shows three time series, all increasing from 2013 to 2024: (1) How awesome are spline smooths (out of 10); (2) How many charts are dual-axis charts (going up to ~ 2.0M); (3) % of line charts with splines (going up to ~ 60%).

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Reposted by Matt Luther, MD MSCI

Heather Gornik @heatherlgornik.bsky.social · 30/03/2025

Great pearls by @jbrianbyrd.bsky.social in evaluating pts for RDN at #ACC25: 1. confirm uncontrolled HTN with out of office measure (Amb BP monitor); 2. trial spironolactone 1st; 3. shared decision making key - care team should include HTN specialists beyond those performing the procedure #cardiosky

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Reposted by Matt Luther, MD MSCI

Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 24/03/2025

Chloride depletion alkalosis (as opposed to what was previously called 'contraction alkalosis') #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/22223876/

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Reposted by Matt Luther, MD MSCI

Andrew Glazer @amglazer.bsky.social · 20/03/2025

🧵 I’m excited to share our latest preprint! We studied 252 SCN5A variants found in patients with Brugada Syndrome by automated patch clamp. [1/7]

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Reposted by Matt Luther, MD MSCI

Simone Sanna-Cherchi 🧬 @genetickidneydoc.bsky.social · 18/03/2025

Our #rFSGS biobank is growing and we welcome patients from all over the world! Please reach out to us if you are a patient or a physician caring for one. We are creating a resource for everyone to use with the goal of resolving this disease and find new cures. #KidneyMonth2025 #RareDisease #genetics

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Reposted by Matt Luther, MD MSCI

American Journal of Kidney Diseases @ajkd.bsky.social · 15/03/2025

#Quiz: A man in his 40s with untreated hypertension presented with right-sided neurologic deficits and slurred speech. His hypertension & age prompted investigation for a secondary etiology of his hypertension. What is the differential diagnosis? bit.ly/3gyO2ie (FREE)

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Reposted by Matt Luther, MD MSCI

American Journal of Hypertension @amjhypertension.bsky.social · 10/03/2025

Bladder Symptoms Provoked by Short, Rapid-Acting Loop Diuretics: A Frequent but Often Overlooked Problem academic.oup.com/ajh/article/... Dr. Wilcox and colleagues @gumedcenter.bsky.social

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Reposted by Matt Luther, MD MSCI

NPR @npr.org · 07/03/2025

Dolly Parton's husband, Carl Dean, died on Monday. On Friday at midnight, Parton released the song "If You Hadn't Been There" in his memory.

npr.org

Dolly Parton pays homage to late husband Carl Dean with 'If You Hadn't Been There'

Dolly Parton's husband, Carl Dean, died on Monday. On Friday at midnight, Parton released the song "If You Hadn't Been There" in his memory.

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Reposted by Matt Luther, MD MSCI

Tim Plante, MD MHS @tbplante.bsky.social · 07/03/2025

DASH diet with low sodium lowers BP in DM, even when sglt2-i or glp-1 agonists are used! #epilifestyle25

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Reposted by Matt Luther, MD MSCI

Rip Van Cremastericle @yourpaljohn.bsky.social · 06/03/2025

me [watching RFK jr bite the head off a freshly killed gila monster]: huh are you doing that for like natural glp-1? RFK jr: for what now?

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Reposted by Matt Luther, MD MSCI

ASN Publications @asnpublications.bsky.social · 01/03/2025

Genetic regulation of plasma sodium concentration is variable and pathways involving the pituitary gland have an important role. There is no evidence of genetic predisposition for the plasma sodium-lowering effect of thiazides. bit.ly/JASN0622 #ASNJASN #BasicResearch

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Reposted by Matt Luther, MD MSCI

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 01/03/2025

Very interesting regions indeed ajkdblog.org/2025/03/01/w... #NephMadness #BlueRibbonFail incoming

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Reposted by Matt Luther, MD MSCI

Josh Leisring @joshleisring.bsky.social · 26/02/2025

I joined Endocrine Society to request a copy. Turns out it is an open link to a surveymonkey site. I checked and they said it was ok to share. Please share your thoughts! www.surveymonkey.com/r/endopacpg

surveymonkey.com

Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline

Take this survey powered by surveymonkey.com. Create your own surveys for free.

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Reposted by Matt Luther, MD MSCI

Endocrine Society @endocrinesociety.bsky.social · 21/02/2025

Primary Aldosteronism Guideline Now Available for Open Comment | Society members are invited to review and provide feedback for our new development of a new guideline, which was provided to them via email. The comment period will close on Tuesday, March 4. #aldosteronism #endocrinology #EndoSky

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Joel Topf @kidneyboy.bsky.social · 24/02/2025

Do you know why Bluesky limits you to 4 images? Because that is enough to get the entire manuscript by O Müller-Plathe in a single post pubmed.ncbi.nlm.nih.gov/3126258/ This is the reference from Chapter 17 of Burton Rose

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Reposted by Matt Luther, MD MSCI

Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 22/02/2025

Check out the latest Channel Your Enthusiasm Podcast 🎧 covering Chapter 17: Introduction to Simple and Mixed Acid Base Disorders #Nephpearls This discussion brings back memories of the Davenport Diagram 🧪 👉🏼 www.rosebook.club/episodes/202...

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European Journal of Endocrinology @eurojendo.bsky.social · 16/02/2025

Mild autonomous #cortisol secretion in patients with aldosterone-producing adenoma and risk for cardiac remodeling and diastolic dysfunction by Cheng-Hsuan Tsai et al EJE Vol 192, Issue 1, January 2025 Full paper 👉 doi.org/10.1093/ejen... ESE Members via 👉 my.ese-hormones.org

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Reposted by Matt Luther, MD MSCI

Nashville Severe Weather @nashseverewx.com · 16/02/2025

8:42 pm, Just to give an idea of ETAs, if the storm crossing the TN River keeps its current speed, it would get to Davidson Co about 10pm. I'd be where you're gonna be by 9:30 ish.

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Reposted by Matt Luther, MD MSCI

Sarah Melville @sarahkmels.medsky.network · 10/02/2025

Save the Date!, 👀🤓🙌🙏💛 May 29-30, 2025! Hypertension Canada (virtual) conference! Link to register: hypertension.ca/2025-virtual... 2025 #Hypertension Canada clinical guidelines led by Dr. Hundemer & Dr. @goupilremi.bsky.social + soo coool that Dr. @drjmluther.bsky.social will be presenting!🤓🙏

hypertension.ca

2025 Virtual Congress – Hypertension Canada | For Healthcare Professionals

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Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 06/02/2025

Moving defense of childhood #vaccines by Vanderbilt vaccine expert Kathy Edwards in JAMA. Stunning that so many people fear the tools that prevent children from dying and being maimed, rather than the pathogens that resurge when vaccine use declines. jamanetwork.com/journals/jam...

jamanetwork.com

Reflections on the Successes of Pediatric Vaccines

This Viewpoint discusses the importance of early and continued vaccine use in the US.

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Dr Lindsey Fitzharris @drlindseyfitz.bsky.social · 31/01/2025

THE MERITS OF OUR COCAINE - a pharmaceutical advert from 1907. A "first-class, thoroughly reliable preparation" that has "been fully recognized by the majority of physicians, surgeons and chemists."

An advertisement for cocaine, listing the various merits of the drug. It says that it is "a first-class, thoroughly reliable preparation" that has "been fully recognized by the majority of physicians, surgeons and chemists."

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Joseph Flynn, MD @jostflynnmd.bsky.social · 31/01/2025

Thick skin and thicker arteries: case report on a rare cause of hypertension link.springer.com/article/10.1... #hypertension #nephsky

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NEJM.org @nejm.org · 30/01/2025

New in the January 30, 2025, issue of NEJM: Tirzepatide for Heart Failure and Obesity (SUMMIT trial) nej.md/4hRGaTY Continuation of Oral Anticoagulation during TAVI (POPular PAUSE TAVI trial) nej.md/3XllHys Lentiviral Gene Therapy for Hemophilia A nej.md/3Vk5xUA #MedSky

Images and descriptions of what's available on NEJM.org this week

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American Journal of Kidney Diseases @ajkd.bsky.social · 29/01/2025

Effect of Dual RAAS Blockade and Intensive BP Lowering on Risk of ESKD and Death in ADPKD: Long-Term Follow-Up of the HALT-PKD Trials bit.ly/4g6t82A (FREE)

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Simone Sanna-Cherchi 🧬 @genetickidneydoc.bsky.social · 29/01/2025

"Why study genetic diseases when you cannot treat them?" We've seen these comments from grants' reviewers way too many times Wrong! Genetics offers a myriad of possibilities for targeted treatments: here is one and it's happening now! @asnpublications.bsky.social journals.lww.com/jasn/fulltex...

journals.lww.com

Treating the Untreatable: Antisense Oligonucleotides as an... : Journal of the American Society of Nephrology

An abstract is unavailable.

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Matt Luther, MD MSCI @drjmluther.bsky.social · 28/01/2025

This should make my pharmacist's job a little easier to get approval.

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Dr Lindsey Fitzharris @drlindseyfitz.bsky.social · 26/01/2025

Welcome, newbies! “One Night Cough Syrup” from the 1930s contained cannabis, morphine, chloroform, & alcohol. In 1934, the FDA ruled that claims of the cough syrup's therapeutic properties were misleading. Remaining stock was destroyed. Enjoy medical history? Come along and join me!

A photo of the label for ONE NIGHT COUGH SYRUP, showcasing the list of toxic ingredients.

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