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Jordy Cohen

@jordybc.bsky.social
1.4K followers 543 following 481 posts

Nephrologist, epidemiologist, methods nerd, climber, hypertension, MedEd, @ PennKidney dbei.med.upenn.edu/staff/jordana-co…

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Reposted by Jordy Cohen
Dr Anastasia S Mihailidou PhD FAHA FCSANZ FESC @anastasiasmihaili.bsky.social · 24/09/2026
In just under 14 days @ahascience.bsky.social #Hypertension26 starts! Looking fwd to many 🔥 @CouncilonHTN @KidneyInCVD sessions❣️ One of ++ highlights for me will be Clinical Track Session on: Early Life Origins & Lifecourse Tracking of #BloodPressure Congrats @jordybc.bsky.social & team👏
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Marwah Abdalla, MD MPH @marwahabdalla.bsky.social · 26/05/2026
We have more ways to measure blood pressure than ever before but not necessarily more confidence in what those measurements mean. Our NHLBI workshop report in @jaccjournals.bsky.social chaired w/ @spjuraschek.bsky.social provides an implementation roadmap. www.sciencedirect.com/science/arti...
sciencedirect.com
Blood Pressure Assessment Across the Lifespan: Improving Clinical Research and Clinical Practice: A National Heart, Lung, and Blood Institute Workshop Report
Hypertension is a modifiable risk factor for cardiovascular disease (CVD) and its prevalence is high in the United States and worldwide. Adequate char…
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 23/05/2026
Some more papers to mix things up: pubmed.ncbi.nlm.nih.gov/35574599/ and pubmed.ncbi.nlm.nih.gov/25915880/ I remember Richard McManus pushing 3 days as being enough - Always a tension (pun entirely intended) between convenience and our thirst for more data
static.klipy.com
Star Wars: Kylo Ren Screams 'MORE!!!'
Alt: Star Wars: Kylo Ren Screams 'MORE!!!'
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John Giacona, PhD, PA-C @giaconajohn.bsky.social · 28/02/2026
Excellent overview in The Washington Post on the systemic impact of sustained hypertension — from LVH to CKD and cognitive decline. Kudos to Drs. @drwanpen.bsky.social , John B, and @jordybc.bsky.social for evidence base insight. 🔗 www.washingtonpost.com/wellness/202... #Hypertension #Cardiology
washingtonpost.com
What high blood pressure does to your body
Hypertension can affect your mind, heart, eyes and more, often without causing any obvious symptoms at all.
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Jordy Cohen @jordybc.bsky.social · 09/02/2026
Excited to share our research letter published today in JAMA on the new Apple Watch Hypertension Notification Feature! jamanetwork.com/journals/jam... 1/n
jamanetwork.com
Smartwatch and Hypertension Notification
This cross-sectional study assesses the potential impact of a smartwatch hypertension notification feature for US adults who have not been diagnosed with hypertension.
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Stephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 21/01/2026
Excited to share our thoughts on the Apple Watch Hypertension alert! @jordybc.bsky.social @deanpicone.bsky.social @alta-schutte.bsky.social Apple Watch for Hypertension Screening | Hypertension www.ahajournals.org/doi/10.1161/...
ahajournals.org
Apple Watch for Hypertension Screening | Hypertension
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thecurbsiders.bsky.social @thecurbsiders.bsky.social · 22/12/2025
🚨 Fresh Hypertension Guidelines Alert 🚨 Don’t get caught treating high blood pressure like it’s 2024 👀 
In Episode #509, West Philly doc Dr. Jordy Cohen @jordybc.bsky.social keeps our hypertension management fresh with a clear walk-through of the new HTN guidelines & more! www.thecurbsiders.com
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Jordy Cohen @jordybc.bsky.social · 18/12/2025
Woah, it’s possible hydralazine may be (rarely) useful outside of preeclampsia! www.science.org/doi/10.1126/... 🤯 H/t @jbrianbyrd.bsky.social
science.org
Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
The decades-old preeclampsia drug hydralazine vasodilates and senesces glioblastoma cells via the same enzyme target, ADO.
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Stephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS @spjuraschek.bsky.social · 11/12/2025
Happy to contribute to this important statement @ahascience.bsky.social on cuffless devices led by @jordybc.bsky.social ! Cuffless Devices for the Measurement of Blood Pressure: A Scientific Statement From the American Heart Association | Hypertension ahajournals.org/doi/10.1161/...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 23/11/2025
Agree with your comments It mostly seems an extension/explanation of the ridiculous 2023 ESH guidelines (not to be confused with the superb 2024 ESC guidelines www.escardio.org/Guidelines/C...) A whole section to renal denervation 🤔 And such strong language against BP < 120
escardio.org
ESC Guidelines for the management of elevated blood pressure and hypertension
ESC Clinical Practice Guidelines aim to present all the relevant evidence to help physicians weigh the benefits and risks of a particular diagnostic or therapeutic procedure for the management of ele...
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BJ @bjcohenmd.bsky.social · 21/11/2025
@jordybc.bsky.social this you? Looks like an issue of JACC that needs to be read!
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 29/09/2025
There you go: www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social statement from HT heavyweights
ahajournals.org
The Management of Elevated Blood Pressure in the Acute Care Setting: A Scientific Statement From the American Heart Association | Hypertension
Over the past 3 decades, a substantial body of high-quality evidence has guided the diagnosis and management of elevated blood pressure (BP) in the outpatient setting. In contrast, there is a lack of ...
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Penn Memory Center @pennmemorycenter.bsky.social · 18/09/2025
High blood pressure often shows no symptoms, but raises risk of stroke, heart disease, kidney damage, and dementia. New American Heart Association guidelines: treat it early with diet & exercise. “If you catch it early, you can gain many more years of healthy life,” says Penn’s Dr. Jordana Cohen.
npr.org
The silent killer increases your risk of stroke and dementia. Here's how to control it
New recommendations for early treatment of hypertension to prevent strokes, heart attacks and dementia come as an experimental medication is shown to lower blood pressure in hard-to-treat patients.
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Nephrology Journal Club @nephjc.bsky.social · 17/09/2025
And that’s a wrap! In summary: screen carefully, stratify by risk, account for kidney health, and individualize therapy. For nephrology, the wins are undeniable: albuminuria testing is mainstream, CKD visibility is heightened, and aldosterone is on the radar. #NephJC
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Nephrology Journal Club @nephjc.bsky.social · 17/09/2025
T4l 1️⃣2️⃣No aggressive IV treatment for severe asymptomatic HTN - avoid acute inpatient lowering if no target-organ damage (COR III: Harm, LOE C-LD). 📝Treat the patient (situation) not the number for acute HTN during hospitalization. I have trouble convincing nocturnists of this. #NephJC
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Nephrology Journal Club @nephjc.bsky.social · 17/09/2025
T4j 🔟CKD with albuminuria - ACEi/ARB strongly recommended to delay CKD progression and reduce CVD (COR I, LOE A). 📝Still only 35-50% of eligible patients get them. How do we move the needle on this? #NephJC
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Nephrology Journal Club @nephjc.bsky.social · 17/09/2025
T4i 9️⃣Cognitive protection🧠 - treat to SBP <130 to prevent mild cognitive impairment/dementia (COR I, LOE B-R). 📝Do you think BP control has a significant role in dementia? #NephJC
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Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 17/09/2025
Proposed mechanism in Nature #NephJC www.nature.com/articles/s41...
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Cristina Popa @nephroseeker.medsky.social · 17/09/2025
I would dare to say many people: if too young, if single pill combo is not enough to control BP. PA is more common than we are used to think. Usually, for us nephrologists is even harder to screen when pts are already on 4-5meds #nephjc www.nephjc.com/news/primary...
nephjc.com
Undercover Aldosterone — NephJC
This week, we will discuss the origins of primary hyperaldosteronism in normotensive patients. Could this undetected anomaly be the cause of idiopathic hypertension and CKD?
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Nephrology Journal Club @nephjc.bsky.social · 17/09/2025
T0b Is HTN still a problem worth our attention? Haven’t we conquered this ‘Silent Killer’ yet? Answers: YES it’s a problem, NO we’ve not conquered it. #NephJC
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Nephrology Journal Club @nephjc.bsky.social · 17/09/2025
T0c Check out these sobering stats: ➡️More than 1.3 billion with HTN globally, 1.2 billion without control ➡️46.7 % HTN prevalence in the US from 2017 to 2020 ➡️Leading cause of death and disability worldwide #NephJC
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Jordy Cohen @jordybc.bsky.social · 17/09/2025
Jordy Cohen from University of Pennsylvania here for what’s certain to be an exciting #nephjc! I’m perhaps biased as a member of the writing committee of the 2025 AHA/ACC BP guideline… No other COIs
media.tenor.com
a stuffed animal wearing a hockey helmet and a beard
Alt: Gritty giving two peace signs
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Nephrology Journal Club @nephjc.bsky.social · 17/09/2025
⏰2 hours until #NephJC chat 🔍 Tonight we are talking about the 2025 ACC/AHA Blood Pressure guidelines! Eight years have passed since the last update. What’s different? What’s the same? Tonight we tackle it all!
ahajournals.org
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | Hypertension
AIM: The “2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults” retires and replaces the “2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults.” METHODS: A comprehensive literature search was conducted from December 2023 to June 2024 to identify clinical studies, reviews, and other evidence performed on human subjects that were published since February 2015 in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE: The focus of this clinical practice guideline is to create a living, working document updating current knowledge in the field of high blood pressure aimed at all practicing primary care and specialty clinicians who manage patients with hypertension.
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Wanpen Vongpatanasin @drwanpen.bsky.social · 05/09/2025
Congratulations @robynwei.bsky.social RD/ PhD candidate for her poster #Hypertension25 highlighting underutilization of salt substitute use in the US @giaconajohn.bsky.social details in AHA News release newsroom.heart.org/news/u-s-sur... @ahascience.bsky.social
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Wanpen Vongpatanasin @drwanpen.bsky.social · 05/09/2025
Dr Karol Watson starts with impactful message top 10 take away message #Hypertension25 high BP as predictor dementia and treatment reduces cognitive decline or dementia by 15% . Once you hit 120/80 , trajectory to high BP is steep. Don’t sit on high BP! @ahascience.bsky.social
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Dr Anastasia S Mihailidou PhD FAHA FCSANZ FESC @anastasiasmihaili.bsky.social · 04/09/2025
Congratulations @ahascience.bsky.social @accintouch.bsky.social 2025 #BloodPressure #GLs Writing TaskForce incl @jordybc.bsky.social @drwanpen.bsky.social @daichishimbo.bsky.social @ycommodore.bsky.social ♥️ format #GLs 🔦 are presented with #patient case Hx & mgt 🥇 #Hypertension25
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 03/09/2025
Beta blockers remain overused for #hypertension in the VA (though the tens line is going down, very slowly) jamanetwork.com/journals/jam... in @jama.com from @jordybc.bsky.social et al OTOH: I think ESRD should count as a somewhat compelling indication? Almost all HD pts here are on bisoprolol
Figure 2.  Fully Adjusted Prevalence Ratios (PRs) for Factors Associated With β-Blocker InitiationFigure 1.  Compelling Indication Status Among Veterans Who Initiated a β-Blocker for Hypertension Treatment, 2000 Through 2022
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Nephrology Journal Club @nephjc.bsky.social · 03/09/2025
Up next! New AHA/ACC hypertension guidelines #NephJC @ahascience.bsky.social @accintouch.bsky.social
ahajournals.org
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | Circulation
AIM: The “2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults” retires and replaces the “2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults.” METHODS: A comprehensive literature search was conducted from December 2023 to June 2024 to identify clinical studies, reviews, and other evidence performed on human subjects that were published since February 2015 in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE: The focus of this clinical practice guideline is to create a living, working document updating current knowledge in the field of high blood pressure aimed at all practicing primary care and specialty clinicians who manage patients with hypertension.
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 30/08/2025
The era of ASIs is slowly dawning www.nejm.org/doi/full/10.... (Yeah spironolactone is just as good and cheaper) Disclosure: we recruited patients for this one
nejm.org
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension | NEJM
Aldosterone dysregulation plays an important pathogenic role in hard-to-control hypertension. In several studies, baxdrostat, an aldosterone synthase inhibitor, reduced the seated systolic blood pr...
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John Giacona, PhD, PA-C @giaconajohn.bsky.social · 28/08/2025
❓What’s new in BP care? 🎥 Watch the #TargetBP webinar on the 2025 @AHAScience / @ACCinTouch Hypertension Guidelines w/ @drwanpen.bsky.social , @jordybc.bsky.social , Keith Ferdinand, & Dan Jones 👉 targetbp.org
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Health Nerd @gidmk.bsky.social · 24/08/2025
Fascinating piece on the issues with AI slop in the mathematical research world (spoiler: it's a massive problem). Ping @carlbergstrom.com open.substack.com/pub/bristoli...
open.substack.com
End of the peer show
I would not be convicted by a jury of my peers, still crazy after all these years
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Wanpen Vongpatanasin @drwanpen.bsky.social · 20/08/2025
Join us @jordybc.bsky.social , Keith Ferdinand, and Dan Jones unpacking 2025 AHA/ACC guidelines on Thursday Aug 28 bit.ly/Guideline25W... @UTSWInternalMed @utswheart
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Gary Singer @garysinger.bsky.social · 17/08/2025
Thanks for sharing. So many great recommendations! The devil is in the details, i.e. adoption/implementation. For starters, I suspect very few of the routine lab tests for new diagnosis of HTN are being ordered.
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American Heart Association Journals @ahajournals.bsky.social · 14/08/2025
The AHA/ACC have released the 2025 High Blood Pressure Guideline, emphasizing prevention and early treatment to reduce cardiovascular disease risk. Read the Guideline in #Hypertension & #Circulation and check out our hub with commentaries and more: www.ahajournals.org/guidelines/h... #Cardiosky
AHA/ACC High Blood Pressure Guideline
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Alex Chang, MD @alexchangmd.bsky.social · 14/08/2025
Nice to see new AHA HTN guidelines emphasizing albuminuria detection! "[Urine ACR] (a test that assesses kidney health) is now recommended for all patients with high blood pressure. It was recommended as an optional test in the 2017 guideline." newsroom.heart.org/news/new-hig...
newsroom.heart.org
New high blood pressure guideline emphasizes prevention, early treatment to reduce CVD risk
Guideline Highlights: Nearly half of all adults in the U.S. have high blood pressure (≥130/80 mm Hg), which is the #1 preventable risk factor for cardiovascular disease, including heart attack, stroke...
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Wanpen Vongpatanasin @drwanpen.bsky.social · 14/08/2025
The 2025 AHA/ACC Hypertension GL is out ! @CircAHA www.ahajournals.org/doi/10.1161/... please join us for the Targetbp Webinar as the first platform to digest the GL by @kcferdmd @jordybc.bsky.social and Dan Jones targetbp.org/events/ on August 28
ahajournals.org
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of...
AIM: The “2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults” retires and replaces the...
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Jordy Cohen @jordybc.bsky.social · 14/08/2025
New 2025 AHA/ACC Hypertension Guideline dropped! www.jacc.org/doi/10.1016/... #hypertension #medsky #nephsky
jacc.org
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College o...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 17/07/2025
We screen everyone referred to our hypertension program for many years now We don’t refer anyone to endo Most patients just need Spiro The occasional peeps need AVS and few need an adrenalectomy Confirmatory tests are useless
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 17/07/2025
Indeed I suspect these guidelines are trying to shift the Overton window (did I use the phrase correctly 😎 @jordybc.bsky.social ?) - I don’t think PCPs read the JCEM! Right now even referral centres nephrologists, endocrinologists, cardiologists are doing a shitty job of screening 🤷🏽‍♂️
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Wanpen Vongpatanasin @drwanpen.bsky.social · 14/07/2025
New PA Endo guideline is also out by experts @anandvaidya17.bsky.social #Cardiosky @hswapnil.medsky.social doi.org/10.1210/clin...
doi.org
Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline
AbstractBackground. Primary aldosteronism (PA), a primary adrenal disorder leading to excessive aldosterone production by one or both adrenal glands, is a
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Joel Topf @kidneyboy.bsky.social · 14/07/2025
The latest episode of @freelyfiltered.bsky.social is outstanding. If you are confused about target trial emulation and think of it as a statistical black box, I encourage you to take a listen. @jordybc.bsky.social and Ed Fu do a brilliant job of explaining it. www.nephjc.com/freelyfilter...
nephjc.com
FF 81 Metformin Termination as explored by Target Trial Emulation — NephJC
Metformin Termination as explored by Target Trial Emulation
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 14/07/2025
A medical adrenalectomy? ASIs advance - Baxdrostat in primary aldosteronism now www.nejm.org/doi/full/10.... n = 15 single arm trial from @adinaturcu.bsky.social and @astra-zeneca.bsky.social in @nejm.org ~ 25/10 mm Hg BP lowering and impressive aldosterone level drop #Hypertension #EndoSky
Efficacy and Side-Effect Profile of Baxdrostat in Patients with Primary Aldosteronism.
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 15/06/2025
The Book Club is back Read ‘everything is tuberculosis’ from @johngreensbluesky.bsky.social with the #NephJC crew www.nephjc.com/news/2025/6/...
nephjc.com
NephJC Bookclub returns on August 19th — NephJC
Here at NephJC we know that the summer is a hard time to focus on medical minutia, it is a time to find a comfortable chair and lose yourself in a book so for the 11th year we are doing a book rather ...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 13/06/2025
Hilarious (and sobering) essay on the use of AI in medical research & manuscript writing Read the whole thing! John Daugirdas has been on the cutting edge of tech in meded before #MedEd was thing onlinelibrary.wiley.com/doi/10.1111/... #MedSky #NephSky
onlinelibrary.wiley.com
Use of Artificial Intelligence in Scientific Writing. The Danger of Trying Too Hard to Please
The author describes his experience using several artificial intelligence programs to assist in the process of editing or preparing manuscripts for publication. While the programs were very useful to...
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Mike Johansen @mikejohansenmd.medsky.social · 03/06/2025
The recognition that exercise is delayed gratification (in terms of large mortality benefit) and the lack of inclusion of any long-term exercise measurement in epidemiological studies should chill one's spine
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Sarah Melville @sarahkmels.medsky.network · 30/05/2025
& with this interesting editorial by Dr. Brook (cc: Dr. @jbrianbyrd.bsky.social) & Dr. @jordybc.bsky.social et al too: jamanetwork.com/journals/jam...
jamanetwork.com
New Support for Old Medications in Resistant Hypertension
The term resistant hypertension has been variably applied to patients with high blood pressure (BP) since at least the 1960s.1 Specific definitions have evolved over time to align with advances in tre...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 29/05/2025
Delightful read of the day (with terrible implications) The journey of clonazepam from API in Guangzhou to the tablet being consumed is 63,162 kms www.cfp.ca/content/71/4... From McMaster (school of engineering and family medicine) h/t Chris Hannah of @theglobeandmail.com
Global journey of clonazepam: A) Clonazepam transportation routes and distances. B) API and excipient salt extraction and production. C) Journey through North America.Global journey of clonazepam: A) Clonazepam transportation routes and distances. B) API and excipient salt extraction and production. C) Journey through North America.Global journey of clonazepam: A) Clonazepam transportation routes and distances. B) API and excipient salt extraction and production. C) Journey through North America.
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Jordy Cohen @jordybc.bsky.social · 28/05/2025
Phase 2 trial of the new antihypertensive agent, ultra-long-acting (q6 month), subq, small interfering RNA against angiotensinogen (Zilebesiran), hit JAMA! h/t @drjmluther.bsky.social jamanetwork.com/journals/jam... 1/
jamanetwork.com
Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension
This randomized clinical trial examines the efficacy and safety of zilebesiran vs placebo when added to a standard antihypertensive medication in adult patients with uncontrolled hypertension.
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 28/05/2025
I would really love to use ASIs in the patient with PA (bilateral dz) in whom I am struggling with 200-300 mg of spironolactone @kidneyboy.bsky.social #NephJC
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