iiinova — where your digital self keeps evolving

Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 05/09/2025

Obesity is a major risk factor for HFpEF. Join me in learning about a new HFpEF model that Valero-Munoz et al developed to study how adipose tissue changes in a 🐁 model and human patients🚶‍♂️in this month's #JACCBTS @jaccjournals.bsky.social . 🧵: 1/8

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 15/07/2025

Balancing the risk for clotting and bleeding is constant challenge for cardiologists, so I was very excited to see in this month’s #JACCBTS work on targeting different parts of the coagulation cascade (Factor 11, FXI) to reduce bleeding risk while lowering risk for thrombosis. 🧵: 1/8

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JACC Journals @jaccjournals.bsky.social · 30/04/2025

This #FINEHEART pooled analysis, published in #JACC, demonstrated that finerenone significantly reduced the risk of new-onset atrial fibrillation/atrial flutter across the CKM spectrum. www.jacc.org/doi/10.1016/... #AFib

jacc.org

Finerenone Reduces New-Onset Atrial Fibrillation Across the Spectrum of Cardio-Kidney-Metabolic Syndrome: The FINE-HEART Pooled Analysis

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Jeff Hsu, MD, PhD @jeffhsumd.bsky.social · 01/05/2025

🚨Last day to secure Advanced Registration rates for ACC Care of the Athletic Heart! Virtual seats still available for the Hybrid meeting To learn the latest in #SportsCardio from the experts who authored the recently updated guidelines, register today acc.org/Education-and-…

Flyer advertising the ACC Care of the Athletic Heart meeting, taking place from June 12-14 in Washington DC and available virtually

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 01/05/2025

I’ll always remember the first congestive hepatopathy patient I took care of as an intern @vumc.bsky.social. The pathology was so different from anything else, so when I saw an article on this in this month’s #JACCBTS I couldn’t wait to learn more about it. (🧵: 1/10) @jaccjournals.bsky.social

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025

In summary, @spfisterer.bsky.social and co-authors created a semi-automated way to predict how variants in the LDLR gene will affect cholesterol and CVD risk, to tackle the ever-growing VUS problem! Read more in this month’s #JACCBTS! @jaccjournals.bsky.social 🧵:8/8

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025

Finally, the authors used their new classification to categorize variants in UKBB and found that the patients with variants categorized as loss of function or defective had higher cholesterol and more CVD, whereas ClinVar and In Silico predictions were less robust. 🧵:7/8

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025

This type of classification would potentially recategorize many of the variants (including majority of the VUS’s) currently in ClinVar for the LDLR gene. 🧵:6/9

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025

Based on LDL uptake and LDLR expression, they categorized each variant to different functional groups. 🧵:5/9

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025

For each variant, they evaluated LDL content and LDLR presence under 3 different conditions (lipid rich, lipid poor, and lipid poor + statin). 🧵:4/9

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025

They then created a library of 350+ plasmid constructs each a VUS within LDLR (A), confirmed it with NGS (B), transfected LDLR KO cells with each construct (C), and imaged each cell with confocal 🔬 and analyzed both the LDL and LDLR content of each cell (D). 🧵: 3/9

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025

The authors first created a reporter cell line by knocking out the LDL receptor (LDLR) in the HepG2 liver cancer cell line (left) then stably transfected these cells with a GFP-labeled LDLR (right).🧵: 2/9

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/03/2025

Ever get back a genetic report and dread seeing the words “Variant of Unknown Significance (VUS)”😱? The # of VUSs are escalating as more patients get sequenced – join me in learning about how @spfisterer.bsky.social and colleagues are helping tackle the VUS problem 🧬 in this month's #JACCBTS🧵:1/9

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Reposted by Jean Wassenaar, MD PhD

Annika Barber @annikabarber.bsky.social · 24/02/2025

Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...

docs.google.com

2025 Study section tracking

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Reposted by Jean Wassenaar, MD PhD

Eric Topol @erictopol.bsky.social · 01/03/2025

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

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Amy Klobuchar @amyklobuchar.com · 01/03/2025

During Rare Disease Week, patients and advocates were in D.C. for an event with the NIH, FDA, and HHS to highlight work being done on treatments and cures. It was abruptly canceled. Why? The administration fired the people organizing this important event and advancing this work.

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 24/02/2025

Felt really unmotivated to go to work today (Mondays are my VA clinic) because of the "Five Things that You Did Last Week" email over the weekend. But then I convinced a veteran to try to quit smoking. I'll take that small victory.

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 18/02/2025

going to be relying on this heavily this week as I plan a resubmission. 😩

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Michael Raddatz @michaelraddatz.bsky.social · 27/01/2025

In this month’s issue of #JACCBTS, Brambilla, et al. explore the role of platelet function in long COVID. Read below ⬇️ to see what they found! 🧵 1/n @jeffhsumd.bsky.social @jaccjournals.bsky.social @vascularimmuno.bsky.social @jeanwassenaar.bsky.social

Title page of paper entitled "Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment"

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Jean Wassenaar, MD PhD @jeanwassenaar.bsky.social · 03/12/2024

PSA to fellow cyclists: I have finally found the solution for biking to work in 20F mornings, after trying 2 different pair of "windproof" gloves, double gloving, and still having frozen fingers by the time I get there... nitrile lab gloves underneath the cycling gloves is 👌.

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Daniel Fehrenbach @djfehrenbach.bsky.social · 17/11/2024

Come join a community of enthusiastic scientists exploring the intersection of immunology and cardiovascular disease! go.bsky.app/ErKF727

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