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Michael Honigberg

@mchonig.bsky.social
1.3K followers 465 following 32 posts

Cardiologist and researcher at Mass General / Broad Institute / Harvard Med. Preventive cardiology, women’s health, genomics. honigberglab.mgh.harvard.edu

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Reposted by Michael Honigberg
JAMA Network Open @jamanetworkopen.com · 12/08/2026
Among parous Black and/or Latina women, #AdversePregnancyOutcomes were associated with greater health-related social need burden, with higher burden observed as the number of different adverse pregnancy outcome types increased. ja.ma/4bMXIPv
Bar chart illustrating APOS, % on the y-axis (0-80) and Burden of HRSNs (0-2, 3-5, 6-8, 9-11, 12-13) on the x-axis. APOS % increases with higher HRSN burden, rising from approximately 37% for 0-2 HRSNs to about 68% for 12-13 HRSNs.
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Reposted by Michael Honigberg
CardioOB @cardioob.bsky.social · 13/05/2026
🚀 Issue #12 90-Second Cardio-OB Journal Scan with @cardioobdoc.bsky.social Blood Pressure Genetic Risk and Incident Hypertension after Pregnancy 🗞️ Apr 20, 2026 article @jama.com 🔗 jamanetwork.com/journals/jam... #ACCRepOB #ACCCardioOB #CardioObstetrics #CardioSky
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Reposted by Michael Honigberg
JAMA Cardiology @jamacardiology.com · 02/04/2026
In a US cohort, higher systolic #BloodPressure genetic risk was associated with new-onset #Hypertension after pregnancy, but elevated postpartum body mass index and hypertensive disorders of pregnancy were stronger risk factors. ja.ma/4s7jJxK
Figure with title "Figure 2. Spline Model Depicting New-Onset Hypertension at 2 to 7 Years Post Partum With Body Mass Index (BMI) vs Systolic Blood Pressure (SBP) Genetic Risk" displaying two lines representing BMI groups <25 and >=25.
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Michael Honigberg @mchonig.bsky.social · 07/01/2026
📣 We’re hiring! My team at Mass General Brigham / @broadinstitute.org is growing: • Postdoc (PhD; human 🧬 & multi-omics) • Research fellow (clinical trials & epi; 2-yr) • Computational associate Join a collaborative, high-impact 🫀 precision medicine team. DM or email mhonigberg@mgb.org
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Reposted by Michael Honigberg
JAMA Cardiology @jamacardiology.com · 09/11/2025
💬 Invited Commentary: Flynn et al find non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) mutations most strongly associated with heart failure risk in UK Biobank data, supporting gene-specific risk assessment. #AHA25 @ahascience.bsky.social ja.ma/4p56SeB
A JAMA Cardiology article, published November 9, 2025, titled "Clonal Hematopoiesis—An Opportunity to Confront the Heart Failure Epidemic" by Domingo A. Pascual-Figal and José J. Fuster, discusses the relationship between CHIP and heart failure.
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Reposted by Michael Honigberg
JAMA Cardiology @jamacardiology.com · 09/11/2025
Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A. #AHA25 @ahascience.bsky.social ja.ma/3JQSveI
JAMA Cardiology graph titled, "Clonal Hematopoiesis and Incident Heart Failure."  It shows mediation analyses for clonal hematopoiesis of indeterminant potential(CHIP) and incident heart failure. Coronary artery disease, atrial fibrillation and combined model has highest %
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Reposted by Michael Honigberg
Nature Reviews Cardiology @natrevcardiol.nature.com · 14/10/2025
November issue now live, with Reviews on: -Clonal haematopoiesis in cardiovascular disease -Regulators of cardiomyocyte proliferation -Extracellular vesicles in cardiovascular homeostasis and disease -Factor XI inhibitors for venous and arterial thromboembolism www.nature.com/nrcardio/vol...
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Reposted by Michael Honigberg
JACC Journals @jaccjournals.bsky.social · 29/08/2025
In this exploratory analysis, treatment with low-dose colchicine was associated with an attenuated annual clonal growth in TET2 CH. These findings suggest the potential for colchicine to curb the proliferative advantage of key CH driver mutations bit.ly/3HWJL5M #ESCCongress #WCCardio #JACC
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Reposted by Michael Honigberg
JAMA Cardiology @jamacardiology.com · 30/08/2025
Among middle-aged adults, clonal hematopoiesis of indeterminate potential (CHIP) was linked to an increased risk of developing myocarditis and pericarditis. #ESCCongress #WCCardio ja.ma/45RBaJG
A graph titled Figure 1. Cumulative Incidence of Myocarditis and Pericarditis During Follow-Up by Clonal Hematopoiesis of Indeterminate Potential (CHIP) Status displays three lines: Large CHIP, Any CHIP, and No CHIP, charting cumulative incidence over follow-up time.
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Reposted by Michael Honigberg
Eric Topol @erictopol.bsky.social · 30/08/2025
New report that CHIP (clonal hematopoiesis of indeterminate potential, blood stem cell clones that increase with age) is an independent risk factor for myocarditis and pericarditis, promoting inflammation #ESC2025 @jama.com jamanetwork.com/journals/jam...
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Michael Honigberg @mchonig.bsky.social · 27/08/2025
The lab's first sim pub of #ESC2025 is now online in @jaccjournals.bsky.social #JACC! jacc.org/doi/10.1016/... Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study 👇 (1/X)
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Michael Honigberg @mchonig.bsky.social · 21/08/2025
Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs Honigberg lab is rapidly growing 📈 👇 @mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
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Reposted by Michael Honigberg
Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · 06/08/2025
Now accepting applications for the 2026-2027 Women's Heart Health Program Fellowship!🫀Click here for details: massgeneral.org/heart-center... @mdharringtonc.bsky.social @emilyswlau.bsky.social @mchonig.bsky.social
massgeneral.org
Women's Heart Health Fellowship Program
The Women’s Heart Health Fellowship Program at Massachusetts General Hospital provides advanced training in the prevention, diagnosis, and treatment of heart disease in women.
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Reposted by Michael Honigberg
Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · 30/07/2025
Registration is now open!📣We're co-hosting a patient SCAD Symposium with @scadalliance.bsky.social in October 🫀 Please click on the event page to register & for all of the details! massgeneral.org/heart-center... @emilyswlau.bsky.social @mdharringtonc.bsky.social @mchonig.bsky.social
massgeneral.org
SCAD Patient Symposium: Your Heart, Your Story
Join us October 18, 2025 for a day of building community with your peers, and hearing from renowned experts about all things SCAD.
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Michael Honigberg @mchonig.bsky.social · 03/07/2025
The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes journals.lww.com/greenjournal...
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Reposted by Michael Honigberg
Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · 05/06/2025
The inaugural MGB & Inova YIA was a huge success 🎉Please join us in congratulating 👏👏 Basic & Translational category: Winner: Maria Pabon (BWH) Honorable Mention: Amelie Vromman (BWH) Clinical Research category: Winner: Meesha Vullikanti (Yale) Honorable Mention: Izza Shahid (Houston Methodist)
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Michael Honigberg @mchonig.bsky.social · 29/05/2025
Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social
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Michael Honigberg @mchonig.bsky.social · 10/05/2025
Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social
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Reposted by Michael Honigberg
CardioOB @cardioob.bsky.social · 28/04/2025
Genetic Risk & 1st-Trimester CV Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women #CardioObstetrics #CardioSky #JACC www.jacc.org/doi/10.1016/... @mchonig.bsky.social @garimasharmamd.bsky.social @jaccjournals.bsky.social @csilvers.bsky.social @mdharringtonc.bsky.social
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Michael Honigberg @mchonig.bsky.social · 08/04/2025
Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP) overall and across levels of HDP genetic risk www.jacc.org/doi/10.1016/... #CardioObstetrics #CardioSky
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Reposted by Michael Honigberg
Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · 02/04/2025
We love our team ❤️ Check out @mchonig.bsky.social's latest review!
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Michael Honigberg @mchonig.bsky.social · 02/04/2025
Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social www.nature.com/articles/s41... Full text link: rdcu.be/ef9VW @mgbresearch.bsky.social @mgbwomenheart.bsky.social
nature.com
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target - Nature Reviews Cardiology
In this Review, Schuermans and Honigberg highlight the involvement of clonal haematopoiesis of indeterminate potential (CHIP) in cardiovascular diseases, such as atherosclerosis and heart failure, and...
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Michael Honigberg @mchonig.bsky.social · 02/04/2025
Check out our latest episode of HeartBEATS from the @americanheart.bsky.social focused on peripartum cardiomyopathy 🤰🫀 #PPCM ! @cardioob.bsky.social professional.heart.org/en/education...
professional.heart.org
Role of Cardiovascular Health in Maternal Health
Explore the role of cardiovascular health in maternal well-being. Learn warning signs, improve communication, and access life-saving tools.
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Reposted by Michael Honigberg
Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · 27/03/2025
Our team is gearing up for #ACC25! We'd love to see you! Come find us at one of our sessions! 🩺♥️ @mchonig.bsky.social @mdharringtonc.bsky.social @accintouch.bsky.social
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Michael Honigberg @mchonig.bsky.social · 22/03/2025
www.sciencedirect.com/science/arti... #CardioObstetrics
sciencedirect.com
Third-Trimester NT-proBNP for Pre-eclampsia Risk Prediction: A Comparison With sFlt-1/PlGF in a Population-Based Cohort
The association between lower first-trimester N-terminal pro B-type natriuretic peptide (NT-proBNP) levels and increased pre-eclampsia risk remains po…
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Reposted by Michael Honigberg
Parham Eshtehardi MD @cardioobdoc.bsky.social · 19/03/2025
Getting ready for #ACC25? ✅ Download #ACC25 app apps.apple.com/us/app/acc-2... ✅ Follow #ACC25 ambassadors bsky.app/profile/did:... #CardioSky @accintouch.bsky.social @jaccjournals.bsky.social @saraersozlu.bsky.social @thornsberryjd.bsky.social @cathlabedu.bsky.social @bakhshihooman.bsky.social
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Michael Honigberg @mchonig.bsky.social · 06/03/2025
Important trial of CAC scoring-guided CVD prevention (CAUGHT-CAD) out in @jama.com today: jamanetwork.com/journals/jam... In Australians w/ intermediate CVD risk (+ FHx) w/o clear statin indication, CAC score-guided prevention yielded reduced progression of total and non-calcified plaque over 3 y
jamanetwork.com
Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease
This clinical trial evaluates the efficacy of combining coronary artery calcium scoring with a prevention strategy to limit plaque progression in intermediate-risk patients with a family history of pr...
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Reposted by Michael Honigberg
TCTMD @tctmd.bsky.social · 03/03/2025
Danish Analysis Updates Stroke and MI Risks of Contemporary Contraceptives
tctmd.com
Danish Analysis Updates Stroke and MI Risks of Contemporary Contraceptives
Danish Analysis Updates Stroke and MI Risks of Contemporary Contraceptives hdellabella@crf.org Mon, 03/03/2025 - 15:41 L.A. McKeown Though arterial thrombotic risk was higher with hormonal contraception use, the absolute excess risks were low.
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Reposted by Michael Honigberg
Jeremy Berg @jeremymberg.bsky.social · 23/02/2025
Guardian story about Federal Register issue is up. www.theguardian.com/us-news/2025...
theguardian.com
Trump halts medical research funding in apparent violation of judge’s order
Health department orders NIH to hold Federal Register submissions – critical step in process for funding studies
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Reposted by Michael Honigberg
Thanh Neville, MD, MSHS @thanh-neville.bsky.social · 28/01/2025
Many of you may not be familiar with #NIH grants. Here are some facts to help you understand the magnitude of this disaster. 1) NIH grants are extremely difficult to get & not "free money". Researchers must have preliminary data & write detailed proposals. Mine was >200pages & took years to put
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Reposted by Michael Honigberg
Karen Hao @karenhao.bsky.social · 21/02/2025
Government funds account for more than *half* the R&D budget that US universities spend each year—in 2023, that was $60B out of $109B. The gov also does a lot of its own research at national labs like Oak Ridge & Los Alamos and agencies like NOAA and DoD. What are the returns on that investment? 3/
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Michael Honigberg @mchonig.bsky.social · 22/02/2025
The White House has ground NIH operations to a halt. E.g., the NHLBI’s CCHS study section, which evaluates large patient-oriented cardiovascular research proposals, was cancelled at the last minute this week. This is bad for science, scientists, patients/the public, and the economy.
votervoice.net
Tell Congress to Stop NIH Cuts
Please take 2 minutes today to ask Congress to take steps to stop funding cuts at the National Institutes of Health (NIH). The administration’s proposed cuts to federal research funding, particularly ...
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Reposted by Michael Honigberg
Colleen Harrington, MD @mdharringtonc.bsky.social · 17/02/2025
Proud to be part of such an important Go Red for Women issue in @ahajournals.bsky.social re Hypertensive Disorders of Pregnancy from @accintouch.bsky.social CVD in Women Committee & Cardio-OB/Repro Health Section led by Malamo Countouris and Zainab Mahmoud! Congrats! @mgbwomenheart.bsky.social
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Michael Honigberg @mchonig.bsky.social · 17/02/2025
Great in-depth review in this year's @ahajournals.bsky.social #Circulation Go Red for Women 💃 issue on HTN during & after 🤰 from the @accintouch.bsky.social CVD in Women Committee & Cardio-OB/Repro Health Section led by Malamo Countouris and Zainab Mahmoud 👇 www.ahajournals.org/doi/full/10....
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Reposted by Michael Honigberg
Mass General Brigham Women's Heart Health Program @mgbwomenheart.bsky.social · 13/02/2025
Our team was honored to co-host Dr. Leslie Cho of the Cleveland Clinic at MGH Cardiology's Grand Rounds. Dr. Cho's topic was Sex Differences in Cardiovascular Disease @mdharringtonc.bsky.social @mchonig.bsky.social @emilyswlau.bsky.social @clevelandclinic.bsky.social
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Reposted by Michael Honigberg
Parham Eshtehardi MD @cardioobdoc.bsky.social · 12/02/2025
East & South Asian-Specific BP Trajectories & CVD #CardioSky #cvPrev #Hypertension www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @pnatarajanmd.bsky.social @mchonig.bsky.social @romitb.bsky.social @somijemmacho.bsky.social @psatishmd.bsky.social @drmonalidesai.bsky.social
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CardioOB @cardioob.bsky.social · 06/02/2025
What’s New in Cardiac Care for Pregnancy? See Who’s Speaking at CPP 2025! #CardioObstetrics #CardioSky #OBSky 🔗 cppcongress.com 🎙 @obcriticalcare.bsky.social @mchonig.bsky.social @drklindley.bsky.social @isabellemalhame.bsky.social @garimasharmamd.bsky.social @csilvers.bsky.social
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CardioOB @cardioob.bsky.social · 25/01/2025
Follow #CardioObstetrics community Let us know if anyone is missing from list #CardioSky #OBSky bsky.app/profile/did:...
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Matt Alexander @vascularimmuno.bsky.social · 20/01/2025
Enjoyed writing this editorial with Jessica Faulkner on a really interesting paper by Maria Pabon and @mchonig.bsky.social on a role for METAP1 in preeclampsia. www.ahajournals.org/doi/10.1161/...
ahajournals.org
Endothelial METAP1: Tipping the Angiogenic Scales in Postpartum Preeclampsia | Circulation Research
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Reposted by Michael Honigberg
STITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 05/01/2025
This study identifies METAP1 as a key gene linked to endothelial dysfunction in preeclampsia through transcriptomic profiling. by Pabon MA, Weisbrod RM (...) Honigberg MC et 23 al. in Circ Res #MedSky 📖 read the article: www.ahajournals.org/doi/10.1161/CIR…
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Michael Honigberg @mchonig.bsky.social · 27/12/2024
In our latest led by Maria Pabon (MGB/BWH) now in Circ Res, we sequenced RNA from venous endothelial cells from 🤰 w/ or w/o preeclampsia We 👀 evidence that an aminopeptidase, METAP1, drives EC dysfunction in preeclampsia www.ahajournals.org/doi/10.1161/... #CardioObstetrics @mghcvrc.bsky.social
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Michael Honigberg @mchonig.bsky.social · 19/12/2024
Terrific holiday party / “Yankee swap” 🎁🔄🎁 with @mchonig.bsky.social @zhiyu.bsky.social Fahed + @pnatarajanmd.bsky.social labs 🎅 🎄 @massgeneralbrigham.bsky.social MGB Heart + @broadinstitute.org @broadinstitute.bsky.social
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Reposted by Michael Honigberg
Pradeep Natarajan @pnatarajanmd.bsky.social · 10/12/2024
HUGE congrats to @artschuermans.bsky.social for winning the 2024 @ukbiobank.bsky.social Early Career Researcher of the Year Award!! Wonderful and bright visiting medical student with @mchonig.bsky.social & me @broadinstitute.org / MGH!!
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Michael Honigberg @mchonig.bsky.social · 10/12/2024
So so incredibly proud of 🇧🇪’s finest @artschuermans.bsky.social for this incredibly well-deserved recognition as the @ukbiobank.bsky.social Early Career Researcher of the Year for 2024! ⭐️ Lots of high-impact work so quickly - and lots more to come CC @broadinstitute.org @pnatarajanmd.bsky.social
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Pradeep Natarajan @pnatarajanmd.bsky.social · 03/12/2024
Very nice summary of our study led by @artschuermans.bsky.social A. Pournamdari & with @mchonig.bsky.social www.massgeneralbrigham.org/en/about/new... @mgbresearch.bsky.social
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Reposted by Michael Honigberg
William J. Brady @williambrady.bsky.social · 28/11/2024
New paper out in @ScienceMagazine! In 8 studies (multiple platforms, methods, time periods) we find: misinformation evokes more outrage than trustworthy news, when it does it's shared more + ppl are less likely to read before sharing. w/ @killianmcl1 @Klonick @mollycrockett 🧵👇
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Eric Topol @erictopol.bsky.social · 22/11/2024
The power of proteomics Predicting cardiovascular outcomes www.nature.com/articles/s44...
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Michael Honigberg @mchonig.bsky.social · 21/11/2024
Excited to share our latest in Nature Cardiovascular Research led by ⭐️ @artschuermans.bsky.social ! #CardioSky #MedSky Open access paper here: www.nature.com/articles/s44... Great thread from Art below 👇
nature.com
Integrative proteomic analyses across common cardiac diseases yield mechanistic insights and enhanced prediction - Nature Cardiovascular Research
Schuermans et al. identify a causal relationship between the circulating proteins spondin-1 and atrial fibrillation and SPINT1 and coronary artery disease and show that adding proteomic data improves ...
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